{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:19:59Z","timestamp":1777436399819,"version":"3.51.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"publisher","award":["403-249-1443"],"award-info":[{"award-number":["403-249-1443"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152569","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:01:17Z","timestamp":1756767677000},"page":"152569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Alantolactone prevents testosterone-induced benign prostatic hyperplasia in rats via modulation of PTEN\/PI3K\/AKT axis"],"prefix":"10.1016","volume":"782","author":[{"given":"Basma G.","family":"Eid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmohsin J.","family":"Alamoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Sirwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma T.","family":"Alharthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasheed A.","family":"Shaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-9075","authenticated-orcid":false,"given":"Ashraf B.","family":"Abdel-Naim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152569_bib1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/1008-682X.140966","article-title":"Testosterone and benign prostatic hyperplasia","volume":"17","author":"Jarvis","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.bbrc.2025.152569_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ajur.2017.06.004","article-title":"Epidemiology of clinical benign prostatic hyperplasia","volume":"4","author":"Lim","year":"2017","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.bbrc.2025.152569_bib3","first-page":"613","article-title":"Benign prostatic hyperplasia: rapid evidence review","volume":"107","author":"Arnold","year":"2023","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.bbrc.2025.152569_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/nau.70090","article-title":"BPH registry and patient survey steering Committee, relative impact of Male urinary conditions on overall quality of life","author":"Vasudevan","year":"2025","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.bbrc.2025.152569_bib5","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2197293","article-title":"Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States","volume":"55","author":"Suarez Arbelaez","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbrc.2025.152569_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-83483-4","article-title":"Magnitude and factors associated with benign prostatic hyperplasia among adult Male patients visiting Wolaita Sodo university comprehensive specialized hospital southern Ethiopia","volume":"14","author":"Tiruneh","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152569_bib7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1159\/000496289","article-title":"Pathophysiology of benign prostatic hyperplasia and benign prostatic enlargement: a mini-review","volume":"65","author":"Madersbacher","year":"2019","journal-title":"Gerontology"},{"key":"10.1016\/j.bbrc.2025.152569_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ucl.2021.12.003","article-title":"Medical treatment of benign prostatic hyperplasia","volume":"49","author":"Plochocki","year":"2022","journal-title":"Urol. Clin."},{"key":"10.1016\/j.bbrc.2025.152569_bib9","first-page":"843","article-title":"Current treatment for benign prostatic hyperplasia, dtsch","volume":"117","author":"Miernik","year":"2020","journal-title":"Arzteblatt Int."},{"key":"10.1016\/j.bbrc.2025.152569_bib10","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/cbdd.13972","article-title":"Alantolactone: a sesquiterpene lactone with diverse pharmacological effects","volume":"98","author":"Liu","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bbrc.2025.152569_bib11","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/ptr.5354","article-title":"Alantolactone from Saussurea lappa exerts antiinflammatory effects by inhibiting chemokine production and STAT1 phosphorylation in TNF-\u03b1 and IFN-\u03b3-induced in HaCaT cells","volume":"29","author":"Lim","year":"2015","journal-title":"Phytother. Res. PTR"},{"key":"10.1016\/j.bbrc.2025.152569_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jep.2017.11.018","article-title":"Anti-allergic effects of sesquiterpene lactones from saussurea costus (falc.) lipsch. Determined using in vivo and in vitro experiments","volume":"213","author":"Lee","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152569_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202000173","article-title":"Bioassay-guided fractionation, chemical compositions and antibacterial activity of extracts from rhizomes of Globba schomburgkii hook.f","volume":"17","author":"Suekaew","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bbrc.2025.152569_bib14","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1080\/14786419.2020.1739677","article-title":"Helenin from stevia lucida. The first report of this natural eudesmanolide mixture in eupatorieae tribe","volume":"35","author":"Chac\u00f3n-Morales","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bbrc.2025.152569_bib15","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.3390\/ijms23158466","article-title":"An overview of NRF2-Activating compounds bearing \u03b1,\u03b2-Unsaturated moiety and their antioxidant effects","volume":"23","author":"Egbujor","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152569_bib16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00044-019-02337-1","article-title":"Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents","volume":"28","author":"Kumar","year":"2019","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bbrc.2025.152569_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.37796\/2211-8039.1457","article-title":"Effect of alantolactones on cardiac parameters of animals under artificially induced oxidative stress","volume":"14","author":"Fatima","year":"2024","journal-title":"Biomedicine"},{"key":"10.1016\/j.bbrc.2025.152569_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11033-025-10620-1","article-title":"Alantolactone protects against doxorubicin-induced nephrotoxicity by modulating Nrf2\/HO-1, NF-\u03baB, and Bax\/Bcl-2 activity: molecular and in silico insights","volume":"52","author":"Abuzinadah","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbrc.2025.152569_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41387-024-00300-7","article-title":"Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease","volume":"14","author":"Wang","year":"2024","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.bbrc.2025.152569_bib20","first-page":"368","article-title":"Alantolactone plays neuroprotective roles in traumatic brain injury in rats via anti-inflammatory, anti-oxidative and anti-apoptosis pathways","volume":"10","author":"Wang","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbrc.2025.152569_bib21","article-title":"A comprehensive review of anticancer mechanisms of action of alantolactone","volume":"136","author":"Babaei","year":"2021","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152569_bib22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12032-025-02740-2","article-title":"Natural sesquiterpene lactones in prostate cancer therapy: mechanisms and sources","volume":"42","author":"Kaushal","year":"2025","journal-title":"Med. Oncol. Northwood Lond. Engl."},{"key":"10.1016\/j.bbrc.2025.152569_bib23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.canlet.2014.11.049","article-title":"Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells","volume":"357","author":"Chun","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2025.152569_bib24","first-page":"675","article-title":"Alantolactone suppresses human osteosarcoma through the PI3K\/AKT signaling pathway","volume":"21","author":"Zhang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2025.152569_bib25","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1007\/s11010-021-04247-6","article-title":"Alantolactone exhibits antiproliferative and apoptosis-promoting properties in Colon cancer model via activation of the MAPK-JNK\/c-Jun signaling pathway","volume":"476","author":"Ren","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2025.152569_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12967-023-04188-2","article-title":"Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152569_bib27","first-page":"7719","article-title":"Pharmacokinetics, tissue distribution and excretion of isoalantolactone and alantolactone in rats after oral administration of Radix inulae extract","volume":"20","author":"Xu","year":"2015","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.bbrc.2025.152569_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175993","article-title":"Canagliflozin alleviates experimentally induced benign prostate hyperplasia in a rat model: exploring potential mechanisms involving mir-128b\/EGFR\/EGF and JAK2\/STAT3 signaling pathways through in silico and in vivo investigations","volume":"957","author":"Elbaz","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152569_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/srep15639","article-title":"Metformin attenuates testosterone-induced prostatic hyperplasia in rats: a pharmacological perspective","volume":"5","author":"Mosli","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152569_bib30","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.3390\/nu13114142","article-title":"Mokko lactone attenuates doxorubicin-induced hepatotoxicity in rats: emphasis on Sirt-1\/FOXO1\/NF-\u03baB axis","volume":"13","author":"Sirwi","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.152569_bib31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods San Diego Calif"},{"key":"10.1016\/j.bbrc.2025.152569_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/13880209.2021.1876102","article-title":"Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling","volume":"59","author":"Chen","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bbrc.2025.152569_bib33","first-page":"616","article-title":"Alantolactone suppresses proliferation and the inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced skin lesions in a psoriasis-like mouse model","volume":"11","author":"Chuo","year":"2021","journal-title":"Life Basel Switz"},{"key":"10.1016\/j.bbrc.2025.152569_bib34","first-page":"240","article-title":"Altholactone inhibits NF-\u03baB and STAT3 activation and induces reactive oxygen species-mediated apoptosis in prostate cancer DU145 cells","volume":"22","author":"Jiang","year":"2017","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.bbrc.2025.152569_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4103\/1735-5362.301340","article-title":"Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells through STAT3 signaling pathway","volume":"15","author":"Babaei","year":"2020","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.bbrc.2025.152569_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000366210","article-title":"Oxidative stress in benign prostatic hyperplasia: a systematic review","volume":"94","author":"Minciullo","year":"2015","journal-title":"Urol. Int."},{"key":"10.1016\/j.bbrc.2025.152569_bib37","first-page":"53","article-title":"Oxidative stress in benign prostatic hyperplasia: mechanisms, clinical relevance and therapeutic perspectives","volume":"13","author":"Kaltsas","year":"2025","journal-title":"Dis. Basel Switz."},{"key":"10.1016\/j.bbrc.2025.152569_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/and.12420","article-title":"Oxidative stress in benign prostate hyperplasia","volume":"48","author":"Zabaiou","year":"2016","journal-title":"Andrologia"},{"key":"10.1016\/j.bbrc.2025.152569_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/pros.23100","article-title":"Oxidative stress promotes benign prostatic hyperplasia","volume":"76","author":"Vital","year":"2016","journal-title":"Prostate"},{"key":"10.1016\/j.bbrc.2025.152569_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22502","article-title":"Protocatechuic acid ameliorates testosterone-induced benign prostatic hyperplasia through the regulation of inflammation and oxidative stress in castrated rats","volume":"34","author":"Akanni","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrc.2025.152569_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108082","article-title":"Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: effect on oxidative stress, inflammation and apoptosis","volume":"100","author":"El-Sherbiny","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.152569_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149203","article-title":"Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing A\u03b2 levels","volume":"1845","author":"Chen","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2025.152569_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202401798","article-title":"Synthetic and pharmacological activities of alantolactone and its derivatives","volume":"22","author":"Zhao","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bbrc.2025.152569_bib44","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/bju.12118","article-title":"The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH)","volume":"112","author":"Gandaglia","year":"2013","journal-title":"BJU Int."},{"key":"10.1016\/j.bbrc.2025.152569_bib45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MOU.0b013e32835abd4a","article-title":"Correlation between benign prostatic hyperplasia and inflammation","volume":"23","author":"Bostanci","year":"2013","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.bbrc.2025.152569_bib46","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.2353\/ajpath.2007.070199","article-title":"Sex hormones induce direct epithelial and inflammation-mediated oxidative\/nitrosative stress that favors prostatic carcinogenesis in the noble rat","volume":"171","author":"Tam","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2025.152569_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7958316","article-title":"Review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia","volume":"2020","author":"Tong","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbrc.2025.152569_bib48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12931-020-01358-4","article-title":"Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2\/HO-1 and inhibition of the NF-\u03baB pathways","volume":"21","author":"Dang","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2025.152569_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.730312","article-title":"Selective STAT3 inhibitor alantolactone ameliorates osteoarthritis via regulating chondrocyte autophagy and cartilage homeostasis","volume":"12","author":"Pei","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152569_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53305-z","article-title":"Activation of PXR by alantolactone ameliorates DSS-Induced experimental colitis via suppressing NF-\u03baB signaling pathway","volume":"9","author":"Ren","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152569_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176458","article-title":"Alantolactone derivatives inhibit the tumor necrosis factor \u03b1-induced nuclear factor \u03baB pathway by a different mechanism from alantolactone","volume":"969","author":"Vu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152569_bib52","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3390\/pharmaceutics14081652","article-title":"Cordycepin attenuates testosterone-induced benign prostatic hyperplasia in rats via modulation of AMPK and AKT activation","volume":"14","author":"Alamoudi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbrc.2025.152569_bib53","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s00210-024-03405-z","article-title":"Asiatic acid mitigates testosterone-induced benign prostatic hyperplasia in rats via activation of PPAR-\u03b3","volume":"398","author":"Kamal","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbrc.2025.152569_bib54","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3390\/ijms17081311","article-title":"Apoptotic pathways linked to endocrine system as potential therapeutic targets for benign prostatic hyperplasia","volume":"17","author":"Minutoli","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152569_bib55","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.fct.2012.06.014","article-title":"Alantolactone induces activation of apoptosis in human hepatoma cells","volume":"50","author":"Lei","year":"2012","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.bbrc.2025.152569_bib56","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.3892\/ol.2016.4511","article-title":"Alantolactone induces apoptosis of human cervical cancer cells via reactive oxygen species generation, glutathione depletion and inhibition of the Bcl-2\/Bax signaling pathway","volume":"11","author":"Jiang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbrc.2025.152569_bib57","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/1871520622666220519100054","article-title":"Alantolactone inhibits melanoma cell culture viability and migration and promotes apoptosis by inhibiting Wnt\/\u03b2-Catenin signaling","volume":"23","author":"Zhang","year":"2023","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152569_bib58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","author":"Song","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152569_bib59","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tibs.2014.02.006","article-title":"PTEN function: the long and the short of it","volume":"39","author":"Hopkins","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2025.152569_bib60","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00210-014-1040-y","article-title":"Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1\u03b1, and NF-\u03baB","volume":"387","author":"Atawia","year":"2014","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbrc.2025.152569_bib61","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1080\/21691401.2019.1661849","article-title":"PTEN negatively regulates the expression of pro-inflammatory cytokines and chemokines of fibroblast-like synoviocytes in adjuvant-induced arthritis","volume":"47","author":"Li","year":"2019","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152569_bib62","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00018-023-04940-3","article-title":"Reciprocal negative feedback regulation of ATF6\u03b1 and PTEN promotes prostate cancer progression","volume":"80","author":"Feng","year":"2023","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.bbrc.2025.152569_bib63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/13685538.2018.1519014","article-title":"Over expression of PI3K-AkT reduces apoptosis and increases prostate size in benign prostatic hyperplasia, aging Male off","volume":"23","author":"Sreenivasulu","year":"2020","journal-title":"J. Int. Soc. Study Aging Male"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25012847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25012847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:58:41Z","timestamp":1777377521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25012847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":63,"alternative-id":["S0006291X25012847"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152569","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alantolactone prevents testosterone-induced benign prostatic hyperplasia in rats via modulation of PTEN\/PI3K\/AKT axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152569"}}