{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:47:01Z","timestamp":1772898421036,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-111072"],"award-info":[{"award-number":["MOP-111072"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-130373"],"award-info":[{"award-number":["MOP-130373"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152586","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:16:54Z","timestamp":1756855014000},"page":"152586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional validation of the Nav1.5\/R1432G Brugada syndrome variant using a Nav1.5 knockout iPSC-derived cardiomyocyte model"],"prefix":"10.1016","volume":"782","author":[{"given":"Quentin","family":"Plumereau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Pouliot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-2839","authenticated-orcid":false,"given":"Mohamed","family":"Chahine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152586_bib1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2018.06.037","article-title":"Present status of Brugada syndrome: JACC state-of-the-art review","volume":"72","author":"Brugada","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2025.152586_bib2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/heartjnl-2020-318258","article-title":"Brugada syndrome: update and future perspectives","volume":"108","author":"Marsman","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.bbrc.2025.152586_bib3","first-page":"425","article-title":"Loss of function associated with novel mutations of the SCN5A gene in patients with Brugada syndrome","volume":"20","author":"Baroudi","year":"2004","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.bbrc.2025.152586_bib4","first-page":"II","article-title":"Novel biophysical mechanisms implicated in Brugada syndrome","volume":"106","author":"Baroudi","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2025.152586_bib5","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1161\/hh1201.093270","article-title":"Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G)","volume":"88","author":"Baroudi","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.152586_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0008-6363(00)00006-7","article-title":"Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes","volume":"46","author":"Deschenes","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2025.152586_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048690","article-title":"The beta1-subunit of Na(v)1.5 cardiac sodium channel is required for a dominant negative effect through alpha-alpha interaction","volume":"7","author":"Mercier","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152586_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96474-6","article-title":"Na(V)1.5 knockout in iPSCs: a novel approach to study Na(V)1.5 variants in a human cardiomyocyte environment","volume":"11","author":"Pierre","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152586_bib9","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.hrthm.2024.09.013","article-title":"Exploring SCN5A variants associated with atrial fibrillation in atrial cardiomyocytes derived from human induced pluripotent stem cells: a characterization study","volume":"22","author":"Pierre","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bbrc.2025.152586_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22208-x","article-title":"De novo Y1460C missense variant in Na(V)1.1 impedes the pore region and results in epileptic encephalopathy","volume":"12","author":"Plumereau","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152586_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2017.10.002","article-title":"Sodium channel current loss of function in induced pluripotent stem cell-derived cardiomyocytes from a Brugada syndrome patient","volume":"114","author":"Selga","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2025.152586_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2019.11.041","article-title":"Structure of the Cardiac sodium channel","volume":"180","author":"Jiang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152586_bib13","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3389\/fphar.2019.01374","article-title":"Pharmacological profile of the sodium current in human stem cell-derived cardiomyocytes compares to heterologous Nav1.5+beta1 model","volume":"10","author":"Van de Sande","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152586_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197051","article-title":"Mechanisms of Arrhythmias in the Brugada syndrome","volume":"21","author":"Blok","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:22:44Z","timestamp":1772828564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":14,"alternative-id":["S0006291X25013014"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152586","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional validation of the Nav1.5\/R1432G Brugada syndrome variant using a Nav1.5 knockout iPSC-derived cardiomyocyte model","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152586"}}