{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:51:45Z","timestamp":1760237505381,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K08627"],"award-info":[{"award-number":["JP24K08627"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020953","name":"Co-creation place formation support program","doi-asserted-by":"publisher","award":["JPMJPF2213"],"award-info":[{"award-number":["JPMJPF2213"]}],"id":[{"id":"10.13039\/501100020953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152604","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T22:09:59Z","timestamp":1757110199000},"page":"152604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of rosmarinic acid on the fibrotic toxicity of amylin in a zebrafish model"],"prefix":"10.1016","volume":"783","author":[{"given":"Xiaoyu","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-8753","authenticated-orcid":false,"given":"Chaobao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gegentuya","family":"Huanood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kuragano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-4808","authenticated-orcid":false,"given":"Kiyotaka","family":"Tokuraku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2025.152604_bib1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.4103\/1673-5374.268927","article-title":"Rosmarinic acid ameliorates hypoxia\/ischemia induced cognitive deficits and promotes remyelination","volume":"15","author":"Li","year":"2020","journal-title":"Neural. Regen Res."},{"key":"10.1016\/j.bbrc.2025.152604_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106421","article-title":"Anxiolytic and antidepressive potentials of rosmarinic acid: a review with a focus on antioxidant and anti-inflammatory effects","volume":"184","author":"Dahchour","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2025.152604_bib3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.ejmech.2017.07.026","article-title":"Structure-activity relations of rosmarinic acid derivatives for the amyloid \u03b2 aggregation inhibition and antioxidant properties","volume":"138","author":"Taguchi","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152604_bib4","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1038\/s41598-019-45168-1","article-title":"Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid \u03b2 aggregation by increasing monoamine secretion","volume":"9","author":"Hase","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152604_bib5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"14","key":"10.1016\/j.bbrc.2025.152604_bib6","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1021\/acs.chemrev.1c00941","article-title":"Second sphere interactions in amyloidogenic diseases","volume":"122","author":"Roy","year":"2022","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152604_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3233\/JAD-220953","article-title":"Effects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia: a randomized controlled trial","volume":"91","author":"Noguchi-Shinohara","year":"2023","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152604_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/cells7080095","article-title":"Role and cytotoxicity of amylin and protection of pancreatic islet \u03b2-cells from amylin cytotoxicity","volume":"7","author":"Kiriyama","year":"2018","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152604_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40035-023-00363-z","article-title":"Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models","volume":"12","author":"Drobny","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152604_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3233\/JAD-180917","article-title":"Tau protein and zebrafish models for tau-induced neurodegeneration","volume":"69","author":"Ding","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbrc.2025.152604_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1483192","article-title":"Advantages of the zebrafish tumor xenograft model: the evaluation of efficacy in cancer therapy and the application to the study of lncRNAs","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152604_bib12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/19382014.2022.2149206","article-title":"Genome-edited zebrafish model of ABCC8 loss-of-function disease","volume":"14","author":"Ikle","year":"2022","journal-title":"Islets"},{"issue":"20","key":"10.1016\/j.bbrc.2025.152604_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011132","article-title":"Analyzing amylin aggregation inhibition through quantum dot fluorescence imaging","volume":"25","author":"Yin","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.bbrc.2025.152604_bib14","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1039\/C8CS00034D","article-title":"Effects of in vivo conditions on amyloid aggregation","volume":"48","author":"Owen","year":"2019","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152604_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2131\/jts.44.347","article-title":"Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio","volume":"44","author":"Kubota","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2025.152604_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125738","article-title":"Developmental circulatory failure caused by metabolites of organophosphorus flame retardants in zebrafish, Danio rerio","volume":"246","author":"Lee","year":"2020","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152604_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.scib.2018.11.012","article-title":"Physical and toxicological profiles of human IAPP amyloids and plaques","volume":"64","author":"Kakinen","year":"2019","journal-title":"Sci. Bull. (Beijing)."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152604_bib18","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1021\/acs.nanolett.9b02771","article-title":"Single-molecular heteroamyloidosis of human islet amyloid polypeptide","volume":"19","author":"Kakinen","year":"2019","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152604_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1423-0127-19-104","article-title":"Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates","volume":"19","author":"Sharoar","year":"2012","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152604_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13024-023-00651-2","article-title":"Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases","volume":"19","author":"Rinauro","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152604_bib21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of Thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"23","key":"10.1016\/j.bbrc.2025.152604_bib22","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.3390\/ijms21238916","article-title":"Effect of ionic strength on thioflavin-T affinity to amyloid fibrils and its fluorescence intensity","volume":"21","author":"Mikalauskaite","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152604_bib23","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acsptsci.1c00028","article-title":"Rosmarinic acid potently detoxifies amylin amyloid and ameliorates diabetic pathology in a transgenic rat model of type 2 diabetes","volume":"4","author":"Wu","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152604_bib24","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acs.nanolett.8b02446","article-title":"In vivo mitigation of amyloidogenesis through functional-pathogenic double-protein coronae","volume":"18","author":"Javed","year":"2018","journal-title":"Nano Lett."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152604_bib25","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00210-023-02661-9","article-title":"Brain oxidative stress mediates anxiety-like behavior induced by indomethacin in zebrafish: protective effect of alpha-tocopherol","volume":"397","author":"Pinheiro","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbrc.2025.152604_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5639875","article-title":"Molecular structure, membrane interactions, and toxicity of the islet amyloid polypeptide in type 2 diabetes mellitus","volume":"2016","author":"Caillon","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"20","key":"10.1016\/j.bbrc.2025.152604_bib27","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1111\/jcmm.17560","article-title":"CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating the IRE1\u03b1\/XBP1s pathway","volume":"26","author":"Kong","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152604_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijbiomac.2022.11.038","article-title":"An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes","volume":"225","author":"Mahboob","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152604_bib29","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152604_bib30","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1096\/fj.14-251744","article-title":"The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet \u03b2 cells","volume":"28","author":"Zhang","year":"2014","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152604_bib31","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/nu9070788","article-title":"Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP)","volume":"9","author":"Sequeira","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.152604_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8419810","article-title":"Oxidative stress mediates anxiety-like behavior induced by high caffeine intake in zebrafish: protective effect of alpha-tocopherol","volume":"2019","author":"de Carvalho","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"47","key":"10.1016\/j.bbrc.2025.152604_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201802825","article-title":"Mitigating human IAPP amyloidogenesis in vivo with chiral silica nanoribbons","volume":"14","author":"Faridi","year":"2018","journal-title":"Small"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152604_bib34","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.apsb.2024.01.003","article-title":"Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation","volume":"14","author":"Chen","year":"2024","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:01:54Z","timestamp":1760140914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":34,"alternative-id":["S0006291X25013208"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152604","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of rosmarinic acid on the fibrotic toxicity of amylin in a zebrafish model","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152604"}}