{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:14:47Z","timestamp":1793312087470,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPMJSP2109"],"award-info":[{"award-number":["JPMJSP2109"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19KK0399"],"award-info":[{"award-number":["19KK0399"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19368"],"award-info":[{"award-number":["22K19368"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K22515"],"award-info":[{"award-number":["25K22515"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN156393"],"award-info":[{"award-number":["FRN156393"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152609","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T06:32:20Z","timestamp":1757140340000},"page":"152609","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer"],"prefix":"10.1016","volume":"782","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6232-4636","authenticated-orcid":false,"given":"Zhiheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-7916","authenticated-orcid":false,"given":"Liye","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5537-3036","authenticated-orcid":false,"given":"Andy","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kranrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-3933","authenticated-orcid":false,"given":"John M.","family":"Seubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-0651","authenticated-orcid":false,"given":"Shigeki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152609_bib1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152609_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1243613","article-title":"The mechanisms of action of mitochondrial targeting agents in cancer: inhibiting oxidative phosphorylation and inducing apoptosis","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152609_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422281","article-title":"The critical role of glutamine and fatty acids in the metabolic reprogramming of anoikis-resistant melanoma cells","volume":"15","author":"Peppicelli","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152609_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55296-3","article-title":"Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner","volume":"9","author":"Shiratori","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152609_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2022.08.004","article-title":"PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells","volume":"625","author":"Miyazaki","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152609_bib6","article-title":"ATP production relies on fatty acid oxidation rather than glycolysis in pancreatic ductal adenocarcinoma","volume":"12","author":"Lee","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2025.152609_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1186\/s12967-024-05598-6","article-title":"Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells","volume":"22","author":"Mascaraque","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152609_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23081941","article-title":"Lipid droplets in cancer: guardians of fat in a stressful world","volume":"23","author":"Petan","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2025.152609_bib9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cmet.2019.02.011","article-title":"Mitochondria bound to lipid droplets: where mitochondrial dynamics regulate lipid storage and utilization","volume":"29","author":"Benador","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152609_bib10","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s42255-024-01047-2","article-title":"Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance beta-oxidation and tumor cell proliferation","volume":"6","author":"Meng","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbrc.2025.152609_bib11","article-title":"Diversity of mitochondrial networks in lung cancer imaged","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152609_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pbiomolbio.2025.05.002","article-title":"Lipid droplet - Organelle crosstalk and its implication in cancer","volume":"197","author":"Quan","year":"2025","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.152609_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41420-024-01933-4","article-title":"Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbrc.2025.152609_bib14","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301640RR","article-title":"Linoleic acid-derived diol 12,13-DiHOME enhances NLRP3 inflammasome activation in macrophages","volume":"38","author":"Valencia","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2025.152609_bib15","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-025-01814-3","article-title":"Alterations in mitochondria and cellular senescence in aged sEH null female kidneys","author":"Yousef","year":"2025","journal-title":"Geroscience"},{"key":"10.1016\/j.bbrc.2025.152609_bib16","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"Spinazzi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152609_bib17","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1038\/s41467-022-31324-1","article-title":"Modulating mitofusins to control mitochondrial function and signaling","volume":"13","author":"Zacharioudakis","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152609_bib18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41417-023-00598-y","article-title":"Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction","volume":"30","author":"Kim","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbrc.2025.152609_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152609_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93003-3","article-title":"A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism","volume":"11","author":"Sheraj","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152609_bib21","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152609_bib22","doi-asserted-by":"crossref","first-page":"R470","DOI":"10.1016\/j.cub.2015.04.004","article-title":"Expanding roles for lipid droplets","volume":"25","author":"Welte","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2025.152609_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1491815","article-title":"Molecular mechanisms of lipid droplets-mitochondria coupling in obesity and metabolic syndrome: insights and pharmacological implications","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2025.152609_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcancer.2024.03.004","article-title":"Hypoxic adaptation of mitochondria and its impact on tumor cell function","volume":"100","author":"Benej","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2025.152609_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1158\/2159-8290.CD-18-0567","article-title":"Acetyl-CoA metabolism supports multistep pancreatic tumorigenesis","volume":"9","author":"Carrer","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrc.2025.152609_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tem.2012.06.005","article-title":"The dynamic regulation of NAD metabolism in mitochondria","volume":"23","author":"Stein","year":"2012","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.152609_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/cr.2018.16","article-title":"UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication","volume":"28","author":"Melber","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2025.152609_bib28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bbamcr.2018.12.012","article-title":"Mitochondrial quality control as a key determinant of cell survival","volume":"1866","author":"Sedlackova","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbrc.2025.152609_bib29","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1126\/science.1230381","article-title":"Supercomplex assembly determines electron flux in the mitochondrial electron transport chain","volume":"340","author":"Lapuente-Brun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152609_bib30","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbabio.2013.10.006","article-title":"Functional role of cardiolipin in mitochondrial bioenergetics","volume":"1837","author":"Paradies","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2025.152609_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1562542","article-title":"The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions","volume":"13","author":"Han","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.152609_bib32","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics--mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.152609_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/112_2020_51","article-title":"Lipid droplets in cancer","volume":"185","author":"Petan","year":"2023","journal-title":"Rev. Physiol. Biochem. Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:06:44Z","timestamp":1772827604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":33,"alternative-id":["S0006291X25013257"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152609","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152609","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152609"}}