{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:02:04Z","timestamp":1781766124831,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2023-00251250"],"award-info":[{"award-number":["RS-2023-00251250"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152624","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T07:49:09Z","timestamp":1757490549000},"page":"152624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Intermittent fasting mitigates kidney fibrosis following ischemia-reperfusion injury by suppressing cellular senescence"],"prefix":"10.1016","volume":"783","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3552-0519","authenticated-orcid":false,"given":"Seo Rin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1731-6357","authenticated-orcid":false,"given":"Il Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152624_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbrc.2025.152624_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.23876\/j.krcp.22.159","article-title":"An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles","volume":"42","author":"Wang","year":"2023","journal-title":"Kidney Res. Clin. Pract."},{"key":"10.1016\/j.bbrc.2025.152624_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.mnh.0000441051.36783.f3","article-title":"The link between acute kidney injury and chronic kidney disease","volume":"23","author":"Belayev","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbrc.2025.152624_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.601325","article-title":"Cellular senescence in kidney fibrosis: pathologic significance and therapeutic strategies","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152624_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111191","article-title":"Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies","volume":"135","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152624_bib6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphar.2020.00755","article-title":"Cellular senescence and senotherapies in the kidney: current evidence and future directions","volume":"11","author":"Docherty","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152624_bib7","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1681\/ASN.2018121251","article-title":"Cellular senescence in the kidney","volume":"30","author":"Docherty","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2025.152624_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mad.2018.10.005","article-title":"Caloric restriction and cellular senescence","volume":"176","author":"Fontana","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2025.152624_bib9","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1056\/NEJMra1905136","article-title":"Effects of intermittent fasting on health, aging, and disease","volume":"381","author":"de Cabo","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.152624_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2023.100676","article-title":"Lifestyle interventions to delay senescence","volume":"47","author":"Martel","year":"2024","journal-title":"Biomed. J."},{"key":"10.1016\/j.bbrc.2025.152624_bib11","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jaci.2020.07.035","article-title":"Fasting, dietary restriction, and immunosenescence","volume":"146","author":"Longo","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2025.152624_bib12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3904\/kjim.2020.198","article-title":"Role of Akt 1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease","volume":"36","author":"Kim","year":"2021","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.bbrc.2025.152624_bib13","article-title":"Time-restricted feeding protects against renal ischemia-reperfusion injury in mice","volume":"25","author":"Kim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152624_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/03946320241288426","article-title":"A gradient model of renal ischemia reperfusion injury to investigate renal interstitial fibrosis","volume":"38","author":"Yang","year":"2024","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152624_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbrc.2025.152624_bib16","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1523-1755.2004.00438.x","article-title":"Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney","volume":"65","author":"Melk","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2025.152624_bib17","doi-asserted-by":"crossref","first-page":"10830","DOI":"10.1073\/pnas.96.19.10830","article-title":"The lack of a functional p21(WAF1\/CIP1) gene ameliorates progression to chronic renal failure","volume":"96","author":"Megyesi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152624_bib18","doi-asserted-by":"crossref","first-page":"F1563","DOI":"10.1152\/ajprenal.90302.2008","article-title":"Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy","volume":"295","author":"Verzola","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2025.152624_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.152624_bib20","doi-asserted-by":"crossref","first-page":"F183","DOI":"10.1152\/ajprenal.00407.2011","article-title":"INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury","volume":"302","author":"Lee","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2025.152624_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123151","article-title":"Transcriptional trajectories of human kidney injury progression","volume":"3","author":"Cippa","year":"2018","journal-title":"JCI Insight."},{"key":"10.1016\/j.bbrc.2025.152624_bib22","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI45785","article-title":"NF-kappaB inhibition delays DNA damage-induced senescence and aging in mice","volume":"122","author":"Tilstra","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.152624_bib23","doi-asserted-by":"crossref","first-page":"C1201","DOI":"10.1152\/ajpcell.00471.2010","article-title":"NF-kappaB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells","volume":"301","author":"Shimizu","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2025.152624_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.mad.2013.11.006","article-title":"Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage","volume":"134","author":"Ning","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2025.152624_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315224","article-title":"Calorie restriction provides kidney ischemic tolerance in senescence-accelerated OXYS rats","volume":"23","author":"Andrianova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152624_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116480","article-title":"SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation","volume":"10","author":"Hayakawa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152624_bib27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1017\/S0007114518002684","article-title":"Energy restriction in renal protection","volume":"120","author":"Wang","year":"2018","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbrc.2025.152624_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114098","article-title":"Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation","volume":"245","author":"Chou","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:01:16Z","timestamp":1773097276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"alternative-id":["S0006291X25013403"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152624","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intermittent fasting mitigates kidney fibrosis following ischemia-reperfusion injury by suppressing cellular senescence","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152624"}}