{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:42:32Z","timestamp":1793112152102,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JQ-883"],"award-info":[{"award-number":["2022JQ-883"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102185"],"award-info":[{"award-number":["82102185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471179"],"award-info":[{"award-number":["81471179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152627","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:36:09Z","timestamp":1757734569000},"page":"152627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["SPP1 exacerbates ischemic stroke by promoting ferroptosis induced brain injury"],"prefix":"10.1016","volume":"783","author":[{"given":"Yunfei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinning","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-6366","authenticated-orcid":false,"given":"Jiaxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152627_bib1","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2025.152627_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib3","doi-asserted-by":"crossref","first-page":"8646","DOI":"10.1021\/acsnano.3c01497","article-title":"Tailored apoptotic vesicle delivery platform for inflammatory regulation and tissue repair to ameliorate ischemic stroke","volume":"17","author":"You","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbrc.2025.152627_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: Molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","article-title":"The therapeutic potential of targeting regulated non-apoptotic cell death","volume":"22","author":"Hadian","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2025.152627_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2024.03.013","article-title":"Osteopontin drives neuroinflammation and cell loss in Mapt-N279k frontotemporal dementia patient neurons","volume":"31","author":"Al-Dalahmah","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2025.152627_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12950-025-00430-4","article-title":"The injury effect of osteopontin in sepsis-associated lung injury","volume":"22","author":"Wang","year":"2025","journal-title":"J. Inflamm."},{"key":"10.1016\/j.bbrc.2025.152627_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106528","article-title":"The Lrrk2-G2019s mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles","volume":"197","author":"An","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2025.152627_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/imr.13081","article-title":"Osteopontin\/secreted Phosphoprotein-1 harnesses Glial-, Immune-, and neuronal cell ligand-receptor interactions to sense and regulate acute and chronic neuroinflammation","volume":"311","author":"Yim","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2025.152627_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/j.gastro.2023.03.228","article-title":"Macrophage-derived osteopontin (Spp1) protects from nonalcoholic steatohepatitis","volume":"165","author":"Han","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2025.152627_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2024.01.008","article-title":"Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury","volume":"57","author":"Lan","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2025.152627_bib12","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.5498\/wjp.v14.i8.1254","article-title":"Botulinum toxin type a-Targeted Spp1 contributes to neuropathic pain by the activation of microglia pyroptosis","volume":"14","author":"Chen","year":"2024","journal-title":"World J. Psychiatr."},{"key":"10.1016\/j.bbrc.2025.152627_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107259","article-title":"Identification of an osteopontin-derived peptide that binds Neuropilin-1 and activates vascular repair responses and angiogenesis","volume":"205","author":"Chen","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2025.152627_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-022-04806-9","article-title":"Osteopontin promotes hepatocellular carcinoma progression through inducing Jak2\/Stat3\/Nox1-Mediated ros production","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2025.152627_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41421-023-00622-3","article-title":"The E3 ubiquitin ligase March2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of Pgam5\/Mavs\/Nlrp3 axis","volume":"10","author":"Liu","year":"2024","journal-title":"Cell Discov"},{"key":"10.1016\/j.bbrc.2025.152627_bib16","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"Gpx4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.152627_bib17","article-title":"Targeted macrophage Crispr-Cas13 mrna editing in immunotherapy for tendon Injury","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bbrc.2025.152627_bib18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152627_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136576","article-title":"Inhibition of Prmt5 attenuates Cerebral Ischemia\/reperfusion-induced inflammation and pyroptosis through suppression of Nf-Kappab\/Nlrp3 axis","volume":"776","author":"Wu","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2025.152627_bib20","article-title":"Targeted Spp1 inhibition of tumor-associated myeloid cells effectively decreases tumor sizes","volume":"12","author":"Kartal","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2025.152627_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12974-023-02980-x","article-title":"Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion","volume":"20","author":"Xu","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.152627_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1114663","article-title":"Single-cell analyses reveal the dynamic functions of Itgb2(+) microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral occlusion mice model","volume":"14","author":"Zeng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.152627_bib23","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s12931-024-02989-7","article-title":"Spp1 induces idiopathic pulmonary fibrosis and nsclc progression via the Pi3k\/Akt\/Mtor pathway","volume":"25","author":"Yue","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2025.152627_bib24","doi-asserted-by":"crossref","unstructured":"A. Palma, The landscape of Spp1(+) macrophages across tissues and diseases: a comprehensive review, Immunology 176\uff082\uff09(2025) 179-196.","DOI":"10.1111\/imm.13952"},{"key":"10.1016\/j.bbrc.2025.152627_bib25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12943-024-02086-9","article-title":"Targeting Circ-0034880-Enriched tumor extracellular vesicles to impede Spp1(High)Cd206(+) pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis","volume":"23","author":"Zhou","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2025.152627_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70113","article-title":"Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell rna sequencing","volume":"14","author":"Huo","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152627_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102698","article-title":"Nox4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in parkinson's disease","volume":"62","author":"Boonpraman","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2025.152627_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152627_bib29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152627_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.152627_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib32","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib33","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.152627_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107797","article-title":"Cocaine use disorder: a look at metabotropic glutamate receptors and glutamate transporters","volume":"221","author":"Niedzielska-Andres","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib35","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.ymthe.2020.08.021","article-title":"Xct: a critical molecule that links cancer metabolism to redox signaling","volume":"28","author":"Liu","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2025.152627_bib36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/15548627.2023.2259732","article-title":"The lipid basis of cell death and autophagy","volume":"20","author":"Lin","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.152627_bib37","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tips.2024.05.006","article-title":"Targeting Gpx4 in ferroptosis and cancer: chemical strategies and challenges","volume":"45","author":"Liu","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2025.152627_bib38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152627_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.semcancer.2021.04.001","article-title":"Role of iron in cancer","volume":"76","author":"Salnikow","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2025.152627_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.298","article-title":"Iron homeostasis imbalance and ferroptosis in brain diseases","volume":"4","author":"Long","year":"2023","journal-title":"MedComm"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152627_bib41","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tem.2024.09.003","article-title":"Targeting acsls to modulate ferroptosis and cancer immunity","volume":"36","author":"Lin","year":"2024","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.152627_bib42","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1097\/CM9.0000000000002533","article-title":"Acyl-coa synthase Acsl4: an essential target in ferroptosis and fatty acid metabolism","volume":"136","author":"Ding","year":"2023","journal-title":"Chin Med J (Engl)."},{"key":"10.1016\/j.bbrc.2025.152627_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122109","article-title":"Spermidine suppresses oxidative stress and ferroptosis by Nrf2\/Ho-1\/Gpx4 and Akt\/Fhc\/Acsl4 pathway to alleviate ovarian damage","volume":"332","author":"Niu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2025.152627_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155360","article-title":"Nobiletin targets Srebp1\/Acly to induce autophagy-dependent cell death of gastric cancer cells through Pi3k\/Akt\/Mtor signaling pathway","volume":"128","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.152627_bib45","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1007\/s10495-023-01870-0","article-title":"Microrna-944 inhibits breast cancer cell proliferation and promotes cell apoptosis by reducing Spp1 through inactivating the Pi3k\/Akt pathway","volume":"28","author":"Zhang","year":"2023","journal-title":"Apoptosis"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:04:58Z","timestamp":1760141098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":45,"alternative-id":["S0006291X25013439"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152627","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SPP1 exacerbates ischemic stroke by promoting ferroptosis induced brain injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152627"}}