{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:26Z","timestamp":1791461306609,"version":"4.3.4"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010820","name":"Changshu Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Korea Ministry of Trade Industry and Energy","doi-asserted-by":"publisher","award":["20012378"],"award-info":[{"award-number":["20012378"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["22C0618L1"],"award-info":[{"award-number":["22C0618L1"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152638","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:36:09Z","timestamp":1757734569000},"page":"152638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Impact of circadian rhythm on differentiation and maturation of insulin-producing cells"],"prefix":"10.1016","volume":"784","author":[{"given":"Ji Eun","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehui","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyong","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Cheol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152638_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152638_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.756548","article-title":"Partners in crime: Beta-Cells and autoimmune responses complicit in type 1 diabetes pathogenesis","volume":"12","author":"Toren","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.152638_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.152638_bib4","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.2337\/dc15-1988","article-title":"Clinical islet transplantation consortium, phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia","volume":"39","author":"Hering","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2025.152638_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI200423235","article-title":"Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus","volume":"114","author":"Rother","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.152638_bib6","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1038\/s41596-021-00560-y","article-title":"Generation of insulin-producing pancreatic \u03b2 cells from multiple human stem cell lines","volume":"16","author":"Hogrebe","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152638_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.scr.2011.10.002","article-title":"Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells","volume":"8","author":"Kunisada","year":"2012","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2025.152638_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jbiotec.2020.10.030","article-title":"Differentiation of induced pluripotent stem cells into definitive endoderm on activin A-functionalized gradient surfaces","volume":"325","author":"Andreasson","year":"2021","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152638_bib9","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1089\/scd.2011.0416","article-title":"A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells","volume":"21","author":"Wang","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.bbrc.2025.152638_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.biocel.2011.12.013","article-title":"A portrait of transforming growth factor \u03b2 superfamily signalling: background matters","volume":"44","author":"Horbelt","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152638_bib11","doi-asserted-by":"crossref","first-page":"16806","DOI":"10.1073\/pnas.0603916103","article-title":"Wnt and TGF-\u03b2 signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells","volume":"103","author":"Gadue","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib12","author":"Tsaniras"},{"key":"10.1016\/j.bbrc.2025.152638_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.15283\/ijsc.2011.4.1.35","article-title":"Differentiation into endoderm lineage: pancreatic differentiation from embryonic stem cells","volume":"4","author":"Lee","year":"2011","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.bbrc.2025.152638_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mod.2005.10.001","article-title":"FGF signaling is necessary for establishing gut tube domains alongthe anterior\u2013posterior axis in vivo","volume":"123","author":"Dessimoz","year":"2006","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbrc.2025.152638_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/nyas.12369","article-title":"Generation of \u03b2 cells from human pluripotent stem cells: are we there yet?","volume":"1311","author":"Schiesser","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41467-017-00129-y","article-title":"ROCKII inhibition promotes the maturation of human pancreatic beta-like cells","volume":"8","author":"Ghazizadeh","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152638_bib17","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1038\/s41467-021-23525-x","article-title":"Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional \u03b2 cells","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152638_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13619-022-00125-8","article-title":"Stepwise differentiation of functional pancreatic \u03b2 cells from human pluripotent stem cells","volume":"11","author":"Jin","year":"2022","journal-title":"Cell Regen."},{"key":"10.1016\/j.bbrc.2025.152638_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s13287-022-02977-y","article-title":"Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges","volume":"13","author":"Silva","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152638_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic \u03b2 cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.biomaterials.2018.05.031","article-title":"3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform","volume":"177","author":"Candiello","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2025.152638_bib22","doi-asserted-by":"crossref","first-page":"E263","DOI":"10.1073\/pnas.1708806115","article-title":"Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes","volume":"115","author":"An","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scr.2010.09.005","article-title":"Stem cell integrins: implications for ex-vivo culture and cellular therapies","volume":"6","author":"Prowse","year":"2011","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2025.152638_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.967765","article-title":"In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo","volume":"10","author":"Fantuzzi","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.152638_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41556-018-0271-4","article-title":"Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived \u03b2 cells","volume":"21","author":"Nair","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152638_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.stemcr.2018.12.012","article-title":"Acquisition of dynamic function in human stem cell-derived \u03b2 cells","volume":"12","author":"Velazco-Cruz","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bbrc.2025.152638_bib27","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41587-022-01219-z","article-title":"Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells","volume":"40","author":"Balboa","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152638_bib28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41587-020-0430-6","article-title":"Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells","volume":"38","author":"Hogrebe","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152638_bib29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cmet.2016.03.005","article-title":"ERR\u03b3 is required for the metabolic maturation of therapeutically functional glucose-responsive \u03b2 cells","volume":"23","author":"Yoshihara","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152638_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107623","article-title":"Glucose response by stem cell-derived \u03b2 cells in vitro is inhibited by a bottleneck in glycolysis","volume":"31","author":"Davis","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2025.152638_bib31","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.18632\/aging.204929","article-title":"Reorganization of pancreas circadian transcriptome with aging","volume":"15","author":"Sharma","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.bbrc.2025.152638_bib32","article-title":"Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152638_bib33","article-title":"An adult clock component links circadian rhythms to pancreatic \u03b2-cell maturation","author":"Montalvo","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2025.152638_bib34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2337\/db17-0850","article-title":"Postnatal ontogenesis of the islet circadian clock plays a contributory role in \u03b2-Cell maturation process","volume":"67","author":"Rakshit","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2025.152638_bib35","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/312752a0","article-title":"Restoration of circadian behavioural rhythms by gene transfer in drosophila","volume":"312","author":"Bargiello","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152638_bib36","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1073\/pnas.81.7.2142","article-title":"Molecular genetics of a biological clock in drosophila","volume":"81","author":"Bargiello","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152638_bib37","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.8128244","article-title":"Negative feedback defining a circadian clock: autoregulation of the clock gene frequency","volume":"263","author":"Aronson","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152638_bib38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/endrev\/bnaa014","article-title":"Transcriptional control of circadian rhythms and metabolism: a matter of time and space","volume":"41","author":"Kim","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2025.152638_bib39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the Mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2025.152638_bib40","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib41","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(01)00610-9","article-title":"Posttranslational mechanisms regulate the mammalian circadian clock","volume":"107","author":"Lee","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1738","article-title":"Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian dbp transcription and chromatin transitions","volume":"38","author":"Ripperger","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.152638_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005882","article-title":"NPAS2 compensates for loss of CLOCK in peripheral circadian oscillators","volume":"12","author":"Landgraf","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2025.152638_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-9-1","article-title":"A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes","volume":"9","author":"Nakahata","year":"2008","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.152638_bib45","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1146\/annurev.neuro.23.1.713","article-title":"Molecular genetics of circadian rhythms in mammals","volume":"23","author":"King","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152638_bib46","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse metabolic and cardiovascular consequences of circadian misalignment","volume":"106","author":"Scheer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152638_bib47","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0092-8674(00)81199-X","article-title":"A serum shock induces circadian gene expression in mammalian tissue culture cells","volume":"93","author":"Balsalobre","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/isl.3.6.18157","article-title":"Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in \u03b2-cells","volume":"3","author":"Lee","year":"2011","journal-title":"Islets"},{"key":"10.1016\/j.bbrc.2025.152638_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.aac4250","article-title":"Pancreatic \u03b2 cell enhancers regulate rhythmic transcription of genes controlling insulin secretion","volume":"350","author":"Perelis","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152638_bib50","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature09253","article-title":"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes","volume":"466","author":"Marcheva","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152638_bib51","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152638_bib52","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/35088576","article-title":"Time zones: a comparative genetics of circadian clocks","volume":"2","author":"Young","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2025.152638_bib53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152638_bib54","series-title":"Handbook of Behavioral Neurobiology","article-title":"Handbook of behavioral neurobiology","author":"Js","year":"2001"},{"key":"10.1016\/j.bbrc.2025.152638_bib55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.pharmtox.47.120505.105208","article-title":"Circadian rhythms: mechanisms and therapeutic implications","volume":"47","author":"Levi","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2025.152638_bib56","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/ijc.26124","article-title":"An RNAi screen identifies USP2 as a factor required for TNF-\u03b1-induced NF-\u03baB signaling","volume":"129","author":"Metzig","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152638_bib57","article-title":"TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.bbrc.2025.152638_bib58","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress\u2013glucocorticoid\u2013TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.152638_bib59","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1242\/bio.20121990","article-title":"Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2","volume":"1","author":"Yang","year":"2012","journal-title":"Biology Open"},{"key":"10.1016\/j.bbrc.2025.152638_bib60","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1242\/dev.137075","article-title":"Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination","volume":"143","author":"Yu","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2025.152638_bib61","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fimmu.2012.00228","article-title":"Akt and mTOR in B cell activation and differentiation","volume":"3","author":"Limon","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.152638_bib62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00125-010-1920-8","article-title":"An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice","volume":"54","author":"Sadacca","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2025.152638_bib63","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/0748730419865436","article-title":"Human circadian molecular oscillation development using induced pluripotent stem cells","volume":"34","author":"Umemura","year":"2019","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.bbrc.2025.152638_bib64","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.15252\/embr.201743897","article-title":"Circadian networks in human embryonic stem cell-derived cardiomyocytes","volume":"18","author":"Dierickx","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2025.152638_bib65","doi-asserted-by":"crossref","first-page":"E7479","DOI":"10.1073\/pnas.1703170114","article-title":"Involvement of posttranscriptional regulation of clock in the emergence of circadian clock oscillation during mouse development","volume":"114","author":"Umemura","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib66","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1523\/JNEUROSCI.2006-17.2017","article-title":"Ontogeny of circadian rhythms and synchrony in the suprachiasmatic nucleus","volume":"38","author":"Carmona-Alcocer","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152638_bib67","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/07420528.2014.986576","article-title":"Embryonic development and maternal regulation of murine circadian clock function","volume":"32","author":"Landgraf","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbrc.2025.152638_bib68","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0748730414545086","article-title":"Embryonic development of circadian oscillations in the mouse hypothalamus","volume":"29","author":"Wreschnig","year":"2014","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.bbrc.2025.152638_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067241","article-title":"An in vitro ES cell-based clock recapitulation assay model identifies CK2\u03b1 as an endogenous clock regulator","volume":"8","author":"Umemura","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152638_bib70","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/er.2007-0016","article-title":"An illustrated review of early pancreas development in the mouse","volume":"28","author":"J\u00f8rgensen","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2025.152638_bib71","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib72","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib73","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.stem.2019.11.011","article-title":"Circadian entrainment triggers maturation of human in vitro islets","volume":"26","author":"Alvarez-Dominguez","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib74","doi-asserted-by":"crossref","first-page":"17582","DOI":"10.1073\/pnas.0909733106","article-title":"Glucocorticoid regulation of the circadian clock modulates glucose homeostasis","volume":"106","author":"So","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152638_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms16014","article-title":"Loss of mTORC1 signalling impairs \u03b2-cell homeostasis and insulin processing","volume":"8","author":"Blandino-Rosano","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152638_bib76","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-5793(03)00360-0","article-title":"MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation","volume":"542","author":"Akiyama","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2025.152638_bib77","doi-asserted-by":"crossref","first-page":"E5039","DOI":"10.1073\/pnas.1419272111","article-title":"Transcriptional program of Kpna2\/Importin-\u03b12 regulates cellular differentiation-coupled circadian clock development in Mammalian cells","volume":"111","author":"Umemura","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib78","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1073\/pnas.0913256107","article-title":"Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro","volume":"107","author":"Yagita","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152638_bib79","article-title":"DEC1 regulates human \u03b2 cell functional maturation and circadian rhythm","author":"Preza","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2025.152638_bib80","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1096\/fj.14-257667","article-title":"LKB1 and AMPK differentially regulate pancreatic \u03b2-cell identity","volume":"28","author":"Kone","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2025.152638_bib81","doi-asserted-by":"crossref","first-page":"9304","DOI":"10.1523\/JNEUROSCI.2733-05.2005","article-title":"Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus","volume":"25","author":"Nahm","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152638_bib82","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2021.12.016","article-title":"The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells","volume":"589","author":"Tian","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152638_bib83","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2008.06.050","article-title":"SIRT1 regulates circadian clock gene expression through PER2 deacetylation","volume":"134","author":"Asher","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib84","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152638_bib85","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4093\/dmj.2013.37.5.315","article-title":"SIRT1 in type 2 diabetes: mechanisms and therapeutic potential","volume":"37","author":"Kitada","year":"2013","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.bbrc.2025.152638_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.735007","article-title":"Editorial: development of circadian clock functions","volume":"15","author":"Myung","year":"2021","journal-title":"Front. Neurosci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:31:20Z","timestamp":1780302680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":86,"alternative-id":["S0006291X25013543"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152638","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of circadian rhythm on differentiation and maturation of insulin-producing cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152638"}}