{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:35:54Z","timestamp":1784043354464,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152644","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:36:24Z","timestamp":1757734584000},"page":"152644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK\/MAPK signaling pathway"],"prefix":"10.1016","volume":"783","author":[{"given":"Mei","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbrc.2025.152644_bib1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/CIRCRESAHA.122.321768","article-title":"Blood vessel organoids for development and disease","volume":"132","author":"Salewskij","year":"2023","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152644_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/cvr\/cvz301","article-title":"Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction","volume":"116","author":"Konijnenberg","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2025.152644_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102629","article-title":"Regulated cell death in acute myocardial infarction: molecular mechanisms and therapeutic implications","volume":"104","author":"Zhu","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbrc.2025.152644_bib4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","article-title":"Cardiac fibrosis: myofibroblast-Mediated pathological regulation and drug delivery strategies","volume":"173","author":"Liu","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152644_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091386","article-title":"Properties and functions of fibroblasts and myofibroblasts in myocardial infarction","volume":"11","author":"Venugopal","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152644_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071716","article-title":"Cardiac fibrosis and fibroblasts","volume":"10","author":"Kurose","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152644_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol. Aspect. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11418-014-0857-5","article-title":"Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora","volume":"69","author":"Zhu","year":"2015","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.bbrc.2025.152644_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108824","article-title":"Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-\u03baB\/NLRP3 pathway in methotrexate-induced enteritis","volume":"109","author":"Zhang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.152644_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116334","article-title":"Albiflorin ameliorates thioacetamide-induced hepatic fibrosis: the involvement of NURR1-mediated inflammatory signaling cascades in hepatic stellate cells activation","volume":"276","author":"Song","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbrc.2025.152644_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113245","article-title":"Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K\/AKT signaling pathway","volume":"142","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib12","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1080\/10717544.2021.1986604","article-title":"Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery","volume":"28","author":"Xu","year":"2021","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00011-022-01666-z","article-title":"Albiflorin attenuates high glucose-induced endothelial apoptosis via suppressing PARP1\/NF-\u03baB signaling pathway","volume":"72","author":"Yang","year":"2023","journal-title":"Inflamm. Res."},{"issue":"39","key":"10.1016\/j.bbrc.2025.152644_bib14","article-title":"Protective function of albiflorin against ferroptosis in exhaustive exerciseinduced myocardial injury via the AKT\/Nrf2\/HO-1 signaling","volume":"12","author":"Tian","year":"2024","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.bbrc.2025.152644_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155341","article-title":"Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy","volume":"128","author":"Bao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.152644_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153767","article-title":"Aqueous extract of Paeoniae Radix rubra prevents deep vein thrombosis by ameliorating inflammation through inhibiting GSK3\u03b2 activity","volume":"92","author":"Lu","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1517\/14728222.2011.645805","article-title":"Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy","volume":"16","author":"Santarpia","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152644_bib18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/eci.12441","article-title":"The Ras\/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications","volume":"45","author":"Delire","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s10020-021-00337-9","article-title":"The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion","volume":"27","author":"Zhang","year":"2021","journal-title":"Mol Med"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152644_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071080","article-title":"Photobiomodulation at 660 nm Stimulates in Vitro Diabetic wound healing via the Ras\/MAPK pathway","volume":"12","author":"Kasowanjete","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib21","first-page":"22","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152644_bib22","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2025.152644_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155118","article-title":"Ethyl ferulate suppresses post-myocardial infarction myocardial fibrosis by inhibiting transforming growth factor receptor 1","volume":"121","author":"Zeng","year":"2023","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152644_bib24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jgr.2023.06.007","article-title":"20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways","volume":"47","author":"Xu","year":"2023","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.bbrc.2025.152644_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113825","article-title":"Atractylenolide-III restrains cardiac fibrosis after myocardial infarction via suppression of the RhoA\/ROCK1 and ERK1\/2 pathway","volume":"145","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.152644_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154277","article-title":"Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways","volume":"104","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Briefings Bioinf."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152644_bib28","article-title":"Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective","volume":"5","author":"Prajapati","year":"2025","journal-title":"RSC Med. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152644_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4196\/kjpp.2020.24.3.259","article-title":"D-Limonene mitigate myocardial injury in rats through MAPK\/ERK\/NF-\u03baB pathway inhibition","volume":"24","author":"Younis","year":"2020","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152644_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.atherosclerosis.2008.05.056","article-title":"Reconstituted high-density lipoprotein attenuates postinfarction left ventricular remodeling in rats","volume":"203","author":"Kiya","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2025.152644_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijcard.2018.12.077","article-title":"MicroRNA-26b relieves inflammatory response and myocardial remodeling of mice with myocardial infarction by suppression of MAPK pathway through binding to PTGS2","volume":"280","author":"Ge","year":"2019","journal-title":"Int. J. Cardiol."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152644_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/adbi.202300517","article-title":"EPHB2 knockdown mitigated myocardial infarction by inhibiting MAPK signaling","volume":"8","author":"Jiang","year":"2024","journal-title":"Adv Biol"},{"key":"10.1016\/j.bbrc.2025.152644_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156298","article-title":"Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation","volume":"136","author":"Han","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.152644_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116413","article-title":"Targeting MAPK-ERK\/JNK pathway: a potential intervention mechanism of myocardial fibrosis in heart failure","volume":"173","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152644_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102306","article-title":"ANO1 regulates cardiac fibrosis via ATI-Mediated MAPK pathway","volume":"92","author":"Tian","year":"2020","journal-title":"Cell Calcium"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25013609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:04:49Z","timestamp":1760141089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25013609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":35,"alternative-id":["S0006291X25013609"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152644","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK\/MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152644"}}