{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:35:20Z","timestamp":1793680520329,"version":"4.5.1"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Foundation for Scientific and Technological Development and Support of Cear\u00e1","doi-asserted-by":"publisher","award":["FPD-0213-00088.01.00\/23"],"award-info":[{"award-number":["FPD-0213-00088.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Foundation for Scientific and Technological Development and Support of Cear\u00e1","doi-asserted-by":"publisher","award":["FPD-0213-00369.01.00\/23"],"award-info":[{"award-number":["FPD-0213-00369.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Foundation for Scientific and Technological Development and Support of Cear\u00e1","doi-asserted-by":"publisher","award":["UNI-0210-00337.01.00\/23"],"award-info":[{"award-number":["UNI-0210-00337.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Foundation for Scientific and Technological Development and Support of Cear\u00e1","doi-asserted-by":"publisher","award":["ITR-0214-00060.01.00\/23"],"award-info":[{"award-number":["ITR-0214-00060.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbrc.2025.152728","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:07:40Z","timestamp":1759162060000},"page":"152728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies"],"prefix":"10.1016","volume":"786","author":[{"given":"Ivana Carneiro","family":"Rom\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5660-7824","authenticated-orcid":false,"given":"Amanda Maria Barros","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tain\u00e1","family":"de Sousa Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Machado","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Silva","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Nunes","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja\u00edza Maria Lima","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gliciane Cunha","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco das Chagas Lima","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-064X","authenticated-orcid":false,"given":"Andreia Ferreira","family":"de Castro Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Eire Silva Alencar","family":"de Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia Maria Costa","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-164X","authenticated-orcid":false,"given":"Helcio Silva","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152728_bib1","first-page":"165","article-title":"Comportamento de zebrafish exposto a benzodiazep\u00ednicos","volume":"36","author":"dos Santos","year":"2018","journal-title":"J. Health Sci. Inst."},{"key":"10.1016\/j.bbrc.2025.152728_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173205","article-title":"Unconventional anxiety pharmacology in zebrafish: drugs beyond traditional anxiogenic and anxiolytic spectra","volume":"207","author":"de Abreu","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbrc.2025.152728_bib3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ardp.201400045","article-title":"Design, synthesis, and biological evaluation of hydrazone incorporated 1, 2, 4\u2010Triazines as anticonvulsant agents","volume":"347","author":"Amir","year":"2014","journal-title":"Arch. Pharmazie"},{"key":"10.1016\/j.bbrc.2025.152728_bib5","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.3390\/molecules27217374","article-title":"Zebrafish: a pharmacological model for learning and memory research","volume":"27","author":"Tan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2025.152728_bib6","first-page":"642","article-title":"Preparation of hydrazone and n-acylhydrazone using commercial drugs as reagents: practical classes of bioactive compound synthesis","volume":"43","author":"Arruda","year":"2020","journal-title":"Quim. Nova"},{"key":"10.1016\/j.bbrc.2025.152728_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.amjcard.2011.03.041","article-title":"Older blood pressure medications\u2014do they still have a place?","volume":"108","author":"Slim","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbrc.2025.152728_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejphar.2016.03.021","article-title":"In vitro and in vivo study of hydralazine, a potential anti-angiogenic agent","volume":"779","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152728_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11224-016-0867-x","article-title":"Theoretical and experimental analysis of the antioxidant features of diarylhydrazones","volume":"28","author":"Peerannawar","year":"2017","journal-title":"Struct. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.132064","article-title":"Structural and spectroscopic analysis, ADMET study, and anxiolytic-like effect in adult zebrafish (Danio rerio) of 4\u2032-[(1E, 2E)-1-(2-(2\u2032, 4\u2032-dinitrophenyl) hydrazone-3-(4-methoxyphenyl) allyl) aniline","volume":"1251","author":"de Souza","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"14","key":"10.1016\/j.bbrc.2025.152728_bib11","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1016\/j.bmc.2011.05.056","article-title":"Synthesis and antidepressant-like activity evaluation of sulphonamides and sulphonyl-hydrazones","volume":"19","author":"de Oliveira","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib12","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.1016\/j.bmc.2006.06.049","article-title":"Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2\/4-quinolinecarbaldehyde derivatives","volume":"14","author":"Nayyar","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejmech.2018.03.083","article-title":"Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives","volume":"151","author":"Lino","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejps.2019.04.016","article-title":"Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages","volume":"134","author":"Debnath","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.bbrc.2025.152728_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biocel.2019.02.004","article-title":"Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on Colon cancer cell lines","volume":"110","author":"Narayanan","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152728_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104014","article-title":"Antimicrobial and antiproliferative activity studies of some new quinoline-3-carbaldehyde hydrazone derivatives","volume":"101","author":"Puskullu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib17","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1016\/j.bmcl.2006.07.060","article-title":"Synthesis of N1-arylidene-N2-quinolyl-and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains","volume":"16","author":"Gemma","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbrc.2025.152728_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107881","article-title":"Chalcones reverse the anxiety and convulsive behavior of adult zebrafish","volume":"117","author":"Ferreira","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.bbrc.2025.152728_bib19","first-page":"1","article-title":"Test 203: fish, acute toxicity test. OECD guidelines test","volume":"2","year":"1992","journal-title":"Chem. Sect."},{"key":"10.1016\/j.bbrc.2025.152728_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103772","article-title":"Protein fraction from Artocarpus altilis pulp exhibits antioxidant properties and reverses anxiety behavior in adult zebrafish via the serotoninergic system","volume":"66","author":"Gon\u00e7alves","year":"2020","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.bbrc.2025.152728_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.pbb.2011.04.021","article-title":"Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol","volume":"99","author":"Gebauer","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbrc.2025.152728_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jep.2017.06.012","article-title":"Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish\u2014Involvement of GABAergic and 5-HT systems","volume":"207","author":"Benneh","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152728_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/zeb.2014.1004","article-title":"Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish","volume":"12","author":"Siebel","year":"2015","journal-title":"Zebrafish"},{"key":"10.1016\/j.bbrc.2025.152728_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pnpbp.2019.03.006","article-title":"Taurine prevents memory consolidation deficits in a novel alcohol-induced blackout model in zebrafish","volume":"93","author":"Bertoncello","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbrc.2025.152728_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P","article-title":"Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94","volume":"17","author":"Halgren","year":"1996","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib26","article-title":"Structure-based virtual screening of new antitumor natural berberines: bioactivity against pancreas cancer by HIF1 inhibition effect","volume":"1294","author":"da Rocha","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrc.2025.152728_bib27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","article-title":"GABAA receptor signalling mechanisms revealed by structural pharmacology","volume":"565","author":"Masiulis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152728_bib28","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.1080\/07391102.2023.2167116","article-title":"GABA A and serotonergic receptors participation in anxiolytic effect of chalcones in adult zebrafish","volume":"41","author":"Mendes","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bbrc.2025.152728_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104365","article-title":"Virtual screening based on molecular docking of possible inhibitors of Covid-19 main protease","volume":"148","author":"Marinho","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbrc.2025.152728_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12033-023-00748-5","article-title":"In silico study in MPO and molecular docking of the synthetic drynaran analogues against the chronic tinnitus: modulation of the M1 muscarinic acetylcholine receptor","volume":"66","author":"da Rocha","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152728_bib31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/cn100008c","article-title":"Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties","volume":"1","author":"Wager","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152728_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/cn100007x","article-title":"Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes","volume":"1","author":"Wager","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152728_bib33","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/bioinformatics\/btp140","article-title":"Site of metabolism prediction for six biotransformations mediated by cytochromes P450","volume":"25","author":"Zheng","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2025.152728_bib34","article-title":"ChEMBL deposited data set - az_dataset","author":"Hersey","year":"2015","journal-title":"EMBL-EBI"},{"key":"10.1016\/j.bbrc.2025.152728_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.insi.2025.100021","article-title":"Aryl thiophenyl-sulfonamides as potential therapeutics for multiple sclerosis: PAMPA-Based pharmacokinetic predictions and multiligand screening against S1PR3","volume":"1","author":"da Silva Mendes","year":"2025","journal-title":"Silico Res. Biomed."},{"key":"10.1016\/j.bbrc.2025.152728_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.128817","article-title":"Synthesis, characterization, toxic substructure prediction, hepatotoxicity evaluation, marine pathogenic bacteria inhibition, and DFT calculations of a new hydrazone derived from isoniazid","volume":"1221","author":"Mokhnache","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrc.2025.152728_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/ijoc.2020.101001","article-title":"Novel hydralazine Schiff base derivatives and their antimicrobial, antioxidant and antiplasmodial properties","volume":"10","author":"Awantu","year":"2020","journal-title":"Int. J. Org Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib38","series-title":"Introduction to Spectroscopy","author":"Pavia","year":"2009"},{"key":"10.1016\/j.bbrc.2025.152728_bib39","article-title":"Spectroscopic analysis by NMR, FT-Raman, ATR-FTIR, and UV-Vis, evaluation of antimicrobial activity, and in silico studies of chalcones derived from 2-hydroxyacetophenone","volume":"1241","author":"da Cunha Xavier","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrc.2025.152728_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2015.12.037","article-title":"The role of taurine on anxiety-like behaviors in zebrafish: a comparative study using the novel tank and the light\u2013dark tasks","volume":"613","author":"Mezzomo","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2025.152728_bib41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2025.152728_bib42","first-page":"12","article-title":"Zebrafish as toxicological model for screening and recapitulate human diseases","volume":"4","author":"Caballero","year":"2016","journal-title":"JUMD"},{"key":"10.1016\/j.bbrc.2025.152728_bib43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bioorg.2018.03.001","article-title":"Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents","volume":"78","author":"Dehestani","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114367","article-title":"Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury","volume":"363","author":"Quan","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2025.152728_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202303089","article-title":"Discovery of hydrazone scaffolds as potent and selective multitarget\u2010directed ligands for the treatment of neurodegenerative disorders","volume":"8","author":"Younas","year":"2023","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bbrc.2025.152728_bib46","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1021\/acs.jmedchem.0c01504","article-title":"New 2-pyrazoline and hydrazine derivatives as potent and selective monoamine oxidase A inhibitors","volume":"64","author":"Salgin-Goksen","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13765-024-00917-3","article-title":"Synthesis, biochemistry, and in silico investigations of isatin-based hydrazone derivatives as monoamine oxidase inhibitors","volume":"67","author":"Maliyakkal","year":"2024","journal-title":"Appl. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114097","article-title":"Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors","volume":"229","author":"Evren","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/molecules23010113","article-title":"Design, synthesis and biological evaluation of novel N-pyridyl-hydrazone derivatives as potential monoamine oxidase (MAO) inhibitors","volume":"23","author":"Turan-Zitouni","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2025.152728_bib50","doi-asserted-by":"crossref","first-page":"13385","DOI":"10.1021\/acs.jmedchem.2c01271","article-title":"Development of MAO-A and 5-HT2AR dual inhibitors with improved antidepressant activity","volume":"65","author":"Sun","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054515","article-title":"Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization","volume":"8","author":"Mussulini","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152728_bib52","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.yebeh.2013.01.018","article-title":"Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish","volume":"27","author":"Banote","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.bbrc.2025.152728_bib53","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/0250-474X.117432","article-title":"Effect of Eclipta alba on acute seizure models: a GABAA-mediated effect","volume":"75","author":"Shaikh","year":"2013","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.bbrc.2025.152728_bib54","first-page":"64","article-title":"Medications for alcohol use disorders: an overview","volume":"185","author":"Akbar","year":"2018","journal-title":"IJP"},{"key":"10.1016\/j.bbrc.2025.152728_bib55","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1038\/s41598-017-03087-z","article-title":"Optical mapping of neuronal activity during seizures in zebrafish","volume":"7","author":"Turrini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152728_bib56","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0021-5198(19)43467-7","article-title":"Suppression of pentylenetetrazol-induced seizures by hydralazine associated with 5-Hydroxytryptaminergic System in Rat brain","volume":"44","author":"Hara","year":"1987","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152728_bib57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0223-5234(00)00123-9","article-title":"Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds","volume":"35","author":"Dimmock","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib58","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.ejmech.2009.05.026","article-title":"A new class of anticonvulsants possessing 6 Hz activity: 3, 4-dialkyloxy thiophene bishydrazones","volume":"44","author":"Kulandasamy","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134704","article-title":"Synthesis of 2-aryl-3-triazolyl-indoles from phenacyltriazole-derived hydrazones: exploring new scaffolds for anticonvulsant activity","volume":"1276","author":"Hashemi","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrc.2025.152728_bib60","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s00044-022-02923-w","article-title":"Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents","volume":"31","author":"Singh","year":"2022","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bbrc.2025.152728_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.bbrc.2025.152728_bib62","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/acschemneuro.6b00029","article-title":"Central nervous system multiparameter optimization desirability: application in drug discovery","volume":"7","author":"Wager","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152728_bib63","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1208\/s12248-017-0096-2","article-title":"Breaking bad: the structure and function of the blood-brain barrier in epilepsy","volume":"19","author":"Han","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.bbrc.2025.152728_bib64","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/s41467-022-29657-y","article-title":"Microvascular stabilization via blood-brain barrier regulation prevents seizure activity","volume":"13","author":"Greene","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152728_bib65","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.nlm.2009.07.001","article-title":"A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory","volume":"92","author":"Blank","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbrc.2025.152728_bib66","first-page":"2214","article-title":"Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory","volume":"20","author":"Wan","year":"2004","journal-title":"EJN"},{"key":"10.1016\/j.bbrc.2025.152728_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106432","article-title":"Design, synthesis, and evaluation of hydrazones as dual inhibitors of ryanodine receptors and acetylcholinesterases for Alzheimer's disease","volume":"133","author":"Yang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107144","article-title":"Synthesis, biochemical and computational evaluations of novel bis-acylhydrazones of 2, 2\u2032-(1, 1\u2032-biphenyl)-4, 4\u2032-diylbis (oxy)) di (acetohydrazide) as dual cholinesterase inhibitors","volume":"144","author":"Ibrahim","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fphar.2015.00225","article-title":"The role of serotonin 5-HT2A receptors in memory and cognition","volume":"6","author":"Zhang","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152728_bib70","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(03)00087-X","article-title":"The neurobiology and control of anxious states","volume":"70","author":"Millan","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.152728_bib71","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.3390\/ijms26062495","article-title":"Therapeutic effects of pharmacological modulation of serotonin brain system in human patients and animal models of fragile X syndrome","volume":"26","author":"Ciranna","year":"2025","journal-title":"IJMS"},{"key":"10.1016\/j.bbrc.2025.152728_bib72","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fphar.2015.00143","article-title":"Serotonin, neural markers, and memory","volume":"6","author":"Meneses","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152728_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109706","article-title":"Hydralazine inhibits neuroinflammation and oxidative stress in APP\/PS1 mice via TLR4\/NF-\u03baB and Nrf 2 pathways","volume":"240","author":"Wang","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2025.152728_bib74","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3390\/ijms14011890","article-title":"Neuroprotection for ischemic stroke: moving past shortcomings and identifying promising directions","volume":"14","author":"Turner","year":"2013","journal-title":"IJMS"},{"key":"10.1016\/j.bbrc.2025.152728_bib75","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12872-023-03304-w","article-title":"Meta-analysis of differences in neutrophil to lymphocyte ratio between hypertensive and non-hypertensive individuals","volume":"23","author":"Sarejloo","year":"2023","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.bbrc.2025.152728_bib76","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2022-002156","article-title":"Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects","volume":"8","author":"Wu","year":"2023","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.bbrc.2025.152728_bib77","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1021\/ci800084x","article-title":"An alternative method for the evaluation of docking performance: RSR vs RMSD","volume":"48","author":"Yusuf","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bbrc.2025.152728_bib78","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/AABC.S63749","article-title":"In silico predictive model to determine vector-mediated transport properties for the blood\u2013brain barrier choline transporter","volume":"7","author":"Shityakov","year":"2014","journal-title":"AABC."},{"key":"10.1016\/j.bbrc.2025.152728_bib79","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/glycob\/1.6.631","article-title":"Molecular modelling of protein-carbohydrate interactions. Docking of monosaccharides in the binding site of concanavalin A","volume":"1","author":"Imberty","year":"1991","journal-title":"Glycobiology"},{"key":"10.1016\/j.bbrc.2025.152728_bib80","series-title":"Methods and Principles in Medicinal Chemistry","doi-asserted-by":"crossref","DOI":"10.1002\/9783527621286.ch5","article-title":"Polar surface area","author":"Ertl","year":"2007"},{"key":"10.1016\/j.bbrc.2025.152728_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117203","article-title":"Ionization and lipophilicity in nonpolar media mimicking the cell membrane interior","volume":"81","author":"Vallaro","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib82","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1134\/S1607672916050173","article-title":"Prediction of blood-brain barrier permeability of organic compounds","volume":"470","author":"Dyabina","year":"2016","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2025.152728_bib83","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1016\/j.bmcl.2009.08.045","article-title":"Using the golden triangle to optimize clearance and oral absorption","volume":"19","author":"Johnson","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbrc.2025.152728_bib84","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1021\/acs.jmedchem.6b00027","article-title":"Quantitative assessment of the impact of fluorine substitution on P-Glycoprotein (P-gp) mediated efflux, permeability, lipophilicity, and metabolic stability","volume":"59","author":"Pettersson","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106514","article-title":"Extending the limitations in the prediction of PAMPA permeability with machine learning algorithms","volume":"188","author":"R\u00e1cz","year":"2023","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.bbrc.2025.152728_bib86","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae416","article-title":"ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries","volume":"40","author":"Swanson","year":"2024","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2025.152728_bib87","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1016\/j.bmcl.2008.07.071","article-title":"Physiochemical drug properties associated with in vivo toxicological outcomes","volume":"18","author":"Hughes","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbrc.2025.152728_bib88","first-page":"500","article-title":"Predictive model of blood-brain barrier penetration of organic compounds 1","volume":"26","author":"Ma","year":"2005","journal-title":"APS"},{"key":"10.1016\/j.bbrc.2025.152728_bib89","series-title":"Computational Drug Discovery and Design. Methods in Molecular Biology","article-title":"Prediction and optimization of pharmacokinetic and toxicity properties of the ligand","author":"Pires","year":"2018"},{"key":"10.1016\/j.bbrc.2025.152728_bib90","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/bioinformatics\/btw617","article-title":"Site of metabolism prediction for oxidation reactions mediated by oxidoreductases based on chemical bond","volume":"33","author":"He","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2025.152728_bib91","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/acscentsci.5b00131","article-title":"Modeling epoxidation of drug-like molecules with a deep machine learning network","volume":"1","author":"Hughes","year":"2015","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.bbrc.2025.152728_bib92","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.3390\/ijms24043651","article-title":"Melatonin activation by cytochrome P450 isozymes: how does CYP1A2 compare to CYP1A1?","volume":"24","author":"Mokkawes","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.bbrc.2025.152728_bib93","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12668-017-0499-7","article-title":"Prediction of aromatic hydroxylation sites for human CYP1A2 substrates using condensed graph of reactions","volume":"8","author":"Madzhidov","year":"2018","journal-title":"BioNanoScience"},{"key":"10.1016\/j.bbrc.2025.152728_bib94","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/bi962129k","article-title":"Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor","volume":"36","author":"Stresser","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2025.152728_bib95","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/1389200023337360","article-title":"On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics","volume":"3","author":"Kalgutkar","year":"2002","journal-title":"CDM"},{"key":"10.1016\/j.bbrc.2025.152728_bib96","doi-asserted-by":"crossref","first-page":"8545","DOI":"10.1021\/acs.jmedchem.1c00514","article-title":"Mechanism-based insights into removing the mutagenicity of aromatic amines by small structural alterations","volume":"64","author":"Shamovsky","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.152728_bib97","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1021\/tx300075j","article-title":"Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for> 200 compounds","volume":"25","author":"Sakatis","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbrc.2025.152728_bib98","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1021\/acsomega.3c07126","article-title":"Structure modification converts the hepatotoxic tacrine into novel hepatoprotective analogs","volume":"9","author":"Sorour","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbrc.2025.152728_bib99","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vascn.2016.10.006","article-title":"Harmonised high throughput microsomal stability assay","volume":"84","author":"Williamson","year":"2017","journal-title":"J. Pharmacol. Toxicol. Methods"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25014445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25014445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:11:11Z","timestamp":1773133871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25014445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":98,"alternative-id":["S0006291X25014445"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152728","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152728"}}