{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:33:43Z","timestamp":1773232423108,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160613"],"award-info":[{"award-number":["82160613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbrc.2025.152786","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T23:18:25Z","timestamp":1759965505000},"page":"152786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Maternal vitamin A deficiency during pregnancy impairs gastrointestinal function and alters the colonic T and B cell immune repertoire in offspring rats"],"prefix":"10.1016","volume":"788","author":[{"given":"Lue","family":"Gou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9634-0222","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152786_bib1","series-title":"StatPearls","article-title":"Vitamin A deficiency","author":"Hodge","year":"2025"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152786_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nri2378","article-title":"Vitamin effects on the immune system: vitamins A and D take centre stage","volume":"8","author":"Mora","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152786_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250342","article-title":"Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation","volume":"54","author":"Jeong","year":"2024","journal-title":"Eur. J. Immunol."},{"issue":"5 Pt 2","key":"10.1016\/j.bbrc.2025.152786_bib4","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1301\/00296640260130722","article-title":"Micronutrient malnutrition, infection, and immunity: an overview","volume":"60","author":"Bhaskaram","year":"2002","journal-title":"Nutr. Rev."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152786_bib5","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1016\/S2214-109X(15)00039-X","article-title":"Trends and mortality effects of vitamin A deficiency in children in 138 low-income and middle-income countries between 1991 and 2013: a pooled analysis of population-based surveys","volume":"3","author":"Stevens","year":"2015","journal-title":"Lancet Global Health"},{"issue":"8","key":"10.1016\/j.bbrc.2025.152786_bib6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3945\/jn.114.191668","article-title":"Oral doses of alpha-retinyl ester track chylomicron uptake and distribution of vitamin A in a male piglet model for newborn infants","volume":"144","author":"Riabroy","year":"2014","journal-title":"J. Nutr."},{"issue":"5802","key":"10.1016\/j.bbrc.2025.152786_bib7","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1132742","article-title":"Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells","volume":"314","author":"Mora","year":"2006","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152786_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2004.08.011","article-title":"Retinoic acid imprints gut-homing specificity on T cells","volume":"21","author":"Iwata","year":"2004","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152786_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2011.03.003","article-title":"Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha","volume":"34","author":"Hall","year":"2011","journal-title":"Immunity"},{"issue":"22","key":"10.1016\/j.bbrc.2025.152786_bib10","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.1812069116","article-title":"Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity","volume":"116","author":"Gattu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152786_bib11","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.gendis.2023.03.032","article-title":"Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids","volume":"11","author":"Yan","year":"2024","journal-title":"Genes Dis"},{"issue":"8","key":"10.1016\/j.bbrc.2025.152786_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/nu14081563","article-title":"Transcriptional profiling of the small intestine and the Colon reveals modulation of gut infection with Citrobacter rodentium according to the vitamin A status","volume":"14","author":"Chai","year":"2022","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152786_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091128","article-title":"Modulation of intestinal immune and barrier functions by vitamin A: implications for current understanding of malnutrition and enteric infections in children","volume":"10","author":"de Medeiros","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152786_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jnutbio.2008.01.002","article-title":"Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet","volume":"20","author":"Amit-Romach","year":"2009","journal-title":"J. Nutr. Biochem."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152786_bib15","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jnutbio.2010.09.010","article-title":"Effect of marginal vitamin A deficiency during pregnancy on retinoic acid receptors and N-methyl-D-aspartate receptor expression in the offspring of rats","volume":"22","author":"Zhang","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152786_bib16","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.cell.2023.05.001","article-title":"The enteric nervous system relays psychological stress to intestinal inflammation","volume":"186","author":"Schneider","year":"2023","journal-title":"Cell"},{"issue":"17","key":"10.1016\/j.bbrc.2025.152786_bib17","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1080\/10408398.2016.1160362","article-title":"The vicious cycle of vitamin a deficiency: a review","volume":"57","author":"Wiseman","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbrc.2025.152786_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12937-016-0131-7","article-title":"Prevalence and influence factors of vitamin A deficiency of Chinese pregnant women","volume":"15","author":"Yang","year":"2016","journal-title":"Nutr. J."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152786_bib19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/inthealth\/ihad038","article-title":"Vitamin A deficiency among pregnant women in Ethiopia: a systematic review and meta-analysis","volume":"15","author":"Eyeberu","year":"2023","journal-title":"Int. Health"},{"issue":"23","key":"10.1016\/j.bbrc.2025.152786_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235038","article-title":"Immune impairment associated with vitamin A deficiency: insights from clinical studies and animal model research","volume":"14","author":"Amimo","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152786_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu9010068","article-title":"Retinoic acid and its role in modulating intestinal innate immunity","volume":"9","author":"Czarnewski","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152786_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s40168-024-01995-7","article-title":"Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice","volume":"12","author":"Liu","year":"2024","journal-title":"Microbiome"},{"issue":"36","key":"10.1016\/j.bbrc.2025.152786_bib23","article-title":"Lactobacillus intestinalis primes epithelial cells to suppress colitis-related Th17 response by host-microbe retinoic acid biosynthesis","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"11","key":"10.1016\/j.bbrc.2025.152786_bib24","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41590-022-01327-7","article-title":"Clonal expansion and epigenetic inheritance of long-lasting NK cell memory","volume":"23","author":"Ruckert","year":"2022","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152786_bib25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2020.09.048","article-title":"Detecting tumor antigen-specific T cells via interaction-dependent fucosyl-biotinylation","volume":"183","author":"Liu","year":"2020","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.bbrc.2025.152786_bib26","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1016\/j.cell.2024.05.003","article-title":"Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss","volume":"187","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152786_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.coi.2014.07.003","article-title":"The cross talk between microbiota and the immune system: metabolites take center stage","volume":"30","author":"Shapiro","year":"2014","journal-title":"Curr. Opin. Immunol."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152786_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu10081016","article-title":"Retinoic acid, leaky gut, and autoimmune diseases","volume":"10","author":"Abdelhamid","year":"2018","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.bbrc.2025.152786_bib29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/10409238.2019.1611734","article-title":"Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis","volume":"54","author":"Cantorna","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.152786_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.734171","article-title":"All-trans retinoic acid attenuates transmissible gastroenteritis virus-induced inflammation in IPEC-J2 cells via suppressing the RLRs\/NF-kappaB signaling pathway","volume":"13","author":"Pu","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152786_bib31","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.4049\/jimmunol.1901091","article-title":"Retinoic acid modulates hyperactive T cell responses and protects vitamin A-Deficient mice against persistent lymphocytic choriomeningitis virus infection","volume":"204","author":"Liang","year":"2020","journal-title":"J. Immunol."},{"issue":"17","key":"10.1016\/j.bbrc.2025.152786_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells14171300","article-title":"Retinoic acid modulates immune differentiation in a human small intestinal in vitro model","volume":"14","author":"Schimpel","year":"2025","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152786_bib33","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41423-022-00869-y","article-title":"Retinoic acid signaling acts as a rheostat to balance treg function","volume":"19","author":"Thangavelu","year":"2022","journal-title":"Cell. Mol. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25015025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25015025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:52:07Z","timestamp":1773157927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25015025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":33,"alternative-id":["S0006291X25015025"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152786","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal vitamin A deficiency during pregnancy impairs gastrointestinal function and alters the colonic T and B cell immune repertoire in offspring rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152786"}}