{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:04:05Z","timestamp":1780909445168,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019640","name":"Musashino University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K10836"],"award-info":[{"award-number":["23K10836"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbrc.2025.152874","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:59Z","timestamp":1761519119000},"page":"152874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fibroblast growth factor 21 affects the colocalization of post-synaptic density 95 and Kalirin7 through CYLD-expression regulation"],"prefix":"10.1016","volume":"789","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1981-4442","authenticated-orcid":false,"given":"Yuko","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Shinomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Hanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-3097","authenticated-orcid":false,"given":"Yoshifumi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152874_bib1","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1210\/en.2013-1191","article-title":"Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice","volume":"154","author":"Camporez","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2025.152874_bib2","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2025.152874_bib3","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.152874_bib4","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1073\/pnas.1006962107","article-title":"Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway","volume":"107","author":"Chau","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2025.152874_bib5","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cmet.2014.07.012","article-title":"FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss","volume":"20","author":"Owen","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152874_bib6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cmet.2015.12.008","article-title":"FGF21 regulates sweet and alcohol preference","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152874_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2020.06.008","article-title":"FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake","volume":"32","author":"Jensen-Cody","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152874_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-nutr-071816-064800","article-title":"Fibroblast growth factor 21: a versatile regulator of metabolic homeostasis,","volume":"38","author":"BonDurant","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbrc.2025.152874_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2023.07.041","article-title":"Neonatal malnutrition impacts fibroblast growth factor 21-induced neuron neurite outgrowth and growth hormone\u2013releasing hormone secretion in neonatal mouse brain","volume":"676","author":"Yoshida","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152874_bib10","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1177\/0271678X19878889","article-title":"Robust RBM3 and \u03b2-klotho expression in developing neurons in the human brain","volume":"39","author":"Jackson","year":"2019","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.bbrc.2025.152874_bib11","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.15252\/emmm.201607376","article-title":"KLB, encoding \u03b2-klotho, is mutated in patients with congenital hypogonadotropic hypogonadism","volume":"9","author":"Xu","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152874_bib12","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.neuron.2016.11.032","article-title":"Targeted intron retention and excision for rapid gene regulation in response to neuronal activity","volume":"92","author":"Mauger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.152874_bib13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1230612","article-title":"The evolutionary landscape of alternative splicing in vertebrate species,","volume":"338","author":"Barbosa-Morais","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152874_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113335","article-title":"Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2025.152874_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1101\/gad.188037.112","article-title":"Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention","volume":"26","author":"Yap","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.152874_bib16","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/ng1914","article-title":"Diversity of microRNAs in human and chimpanzee brain","volume":"38","author":"Berezikov","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.152874_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2025.152874_bib18","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1074\/jbc.275.9.6395","article-title":"An isoform of Kalirin, a brain-specific GDP\/GTP exchange factor, is enriched in the postsynaptic density fraction","volume":"275","author":"Penzes","year":"2000","journal-title":"JBC"},{"key":"10.1016\/j.bbrc.2025.152874_bib19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.molcel.2007.12.018","article-title":"The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module,","volume":"29","author":"Komander","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2025.152874_bib20","doi-asserted-by":"crossref","first-page":"E8760","DOI":"10.1073\/pnas.1620153114","article-title":"Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity","volume":"114","author":"Ma","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2025.152874_bib21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.neuron.2007.10.005","article-title":"Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines","volume":"56","author":"Xie","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.152874_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2012.10.131","article-title":"CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner","volume":"430","author":"Dosemeci","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152874_bib23","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s12035-016-9745-1","article-title":"Posttranslational modifications regulate the postsynaptic localization of PSD-95","volume":"54","author":"Vallejo","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.152874_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine-threonine protein kinase Akt","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152874_bib25","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.1175065","article-title":"The E3 ligase TRAF6 regulates Akt ubiquitination and activation,","volume":"325","author":"Yang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152874_bib26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41593-024-01616-4","article-title":"Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain","volume":"27","author":"Joglekar","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152874_bib27","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.1074\/jbc.M115.636746","article-title":"An N-terminal amphipathic helix binds phosphoinositides and enhances kalirin Sec14 domain-mediated membrane interactions","volume":"290","author":"Miller","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152874_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0896-6273(01)00193-3","article-title":"The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis,","volume":"29","author":"Penzes","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.152874_bib29","article-title":"Novel phospho-switch function of delta-catenin in dendrite development, J. Cell. Biol","author":"Baumert","year":"2020","journal-title":"219"},{"key":"10.1016\/j.bbrc.2025.152874_bib30","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acschemneuro.7b00076","article-title":"Brain region and isoform-specific phosphorylation alters Kalirin SH2 domain interaction sites and Calpain sensitivity, ACS","volume":"8","author":"Miller","year":"2017","journal-title":"Chem. Neurosci"},{"key":"10.1016\/j.bbrc.2025.152874_bib31","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41586-019-1700-7","article-title":"Alcohol metabolism contributes to brain histone acetylation","volume":"574","author":"Mews","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152874_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cmet.2010.02.001","article-title":"Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat","volume":"11","author":"Hondares","year":"2010","journal-title":"Cell Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25015906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25015906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:23:13Z","timestamp":1780906993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25015906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":32,"alternative-id":["S0006291X25015906"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152874","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast growth factor 21 affects the colocalization of post-synaptic density 95 and Kalirin7 through CYLD-expression regulation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152874","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152874"}}