{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:17:04Z","timestamp":1793121424439,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502061"],"award-info":[{"award-number":["82502061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX0540"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0540"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbrc.2025.152981","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:27:55Z","timestamp":1763537275000},"page":"152981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4"],"prefix":"10.1016","volume":"792","author":[{"given":"Rong","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-2598","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2025.152981_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.6004\/jnccn.2023.0025","article-title":"Acute myeloid leukemia, version 3.2023, NCCN clinical practice guidelines in oncology","volume":"21","author":"Pollyea","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1182\/asheducation-2017.1.37","article-title":"Classification and risk assessment in AML: integrating cytogenetics and molecular profiling","volume":"2017","author":"Moarii","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"16","key":"10.1016\/j.bbrc.2025.152981_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/cells13161392","article-title":"Common driver mutations in AML: biological impact, clinical considerations, and treatment strategies","volume":"13","author":"Nong","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152981_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2021.106727","article-title":"A concise review on the molecular genetics of acute myeloid leukemia","volume":"111","author":"Padmakumar","year":"2021","journal-title":"Leuk. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152981_bib5","first-page":"507","article-title":"Advances in clinical studies of FLT3 inhibitors in acute myeloid leukemia","volume":"51","author":"Yuan","year":"2022","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"2","key":"10.1016\/j.bbrc.2025.152981_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S1470-2045(18)30010-X","article-title":"Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study","volume":"19","author":"Dinardo","year":"2018","journal-title":"Lancet Oncol."},{"issue":"18","key":"10.1016\/j.bbrc.2025.152981_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15184618","article-title":"Venetoclax with hypomethylating agents in newly diagnosed acute myeloid leukemia: a systematic review and meta-analysis of survival data from real-world studies","volume":"15","author":"Ucciero","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11864-019-0694-6","article-title":"Current and future molecular targets for acute myeloid leukemia therapy","volume":"21","author":"Sami","year":"2020","journal-title":"Curr. Treat. Options Oncol."},{"issue":"7483","key":"10.1016\/j.bbrc.2025.152981_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MOH.0000000000000626","article-title":"Genetic heterogeneity and clonal evolution in acute myeloid leukemia","volume":"28","author":"Romer-Seibert","year":"2021","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbrc.2025.152981_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.blre.2019.04.005","article-title":"Epidemiology of acute myeloid leukemia: recent progress and enduring challenges","volume":"36","author":"Shallis","year":"2019","journal-title":"Blood Rev."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib12","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1002\/cpcy.73","article-title":"Acute myeloid leukemia minimal residual disease detection: the difference from normal approach","volume":"93","author":"Wood","year":"2020","journal-title":"Curr Protoc Cytom"},{"issue":"757","key":"10.1016\/j.bbrc.2025.152981_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk1731","article-title":"Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models","volume":"16","author":"Larrue","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152981_bib14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152981_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3892\/ol.2024.14707","article-title":"Ferroptosis: potential therapeutic targets and prognostic predictions for acute myeloid leukemia","volume":"28","author":"Zhang","year":"2024","journal-title":"Oncol. Lett."},{"issue":"7784","key":"10.1016\/j.bbrc.2025.152981_bib17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152981_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/mc.70016","article-title":"Pregnane X receptor activation induces ferroptosis resistance through upregulation of FSP1","author":"Shang","year":"2025","journal-title":"Mol. Carcinog."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152981_bib21","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s12276-023-01077-y","article-title":"An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152981_bib22","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-24-4207","article-title":"Lipid composition alters ferroptosis sensitivity","author":"Park","year":"2025","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s10020-024-01028-x","article-title":"GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK\/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152981_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.freeradbiomed.2024.06.014","article-title":"Mifepristone protects acetaminophen induced liver injury through NRF2\/GSH\/GST mediated ferroptosis suppression","volume":"222","author":"Shi","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.152981_bib25","article-title":"7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K\/Akt\/NRF2\/GPX4 mediated ferroptosis suppression","author":"Pei","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"22","key":"10.1016\/j.bbrc.2025.152981_bib26","article-title":"Donafenib and GSK-J4 synergistically induce ferroptosis in liver cancer by upregulating HMOX1 expression","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2025.152981_bib27","series-title":"Bethesda (MD); National Institute of Diabetes and Digestive and Kidney Diseases","article-title":"LiverTox: clinical and research information on drug-induced liver injury","author":"Regorafenib","year":"2012"},{"issue":"9863","key":"10.1016\/j.bbrc.2025.152981_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0140-6736(12)61900-X","article-title":"Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial","volume":"381","author":"Grothey","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41420-023-01338-9","article-title":"Regorafenib induces bim-mediated intrinsic apoptosis by blocking AKT-Mediated FOXO3a nuclear export","volume":"9","author":"Sun","year":"2023","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152981_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152981_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jha2.408","article-title":"A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies","volume":"3","author":"How","year":"2022","journal-title":"EJHaem"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152981_bib32","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41375-023-02117-2","article-title":"Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia","volume":"38","author":"Akiyama","year":"2024","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152981_bib33","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152981_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3324\/haematol.2020.259531","article-title":"APR-246 induces early cell death by ferroptosis in acute myeloid leukemia","volume":"107","author":"Birsen","year":"2022","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.bbrc.2025.152981_bib35","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/mc.23550","article-title":"PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia","volume":"62","author":"Zhou","year":"2023","journal-title":"Mol. Carcinog."},{"issue":"23","key":"10.1016\/j.bbrc.2025.152981_bib36","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1158\/1078-0432.CCR-24-0796","article-title":"Combinations of HDAC inhibitor and PPAR agonist induce ferroptosis of leukemic stem cell-like cells in acute myeloid leukemia","volume":"30","author":"Zhou","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12943-025-02394-8","article-title":"NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis","volume":"24","author":"Ye","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s43018-023-00653-5","article-title":"Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia","volume":"5","author":"Bruedigam","year":"2024","journal-title":"Nat. Cancer"},{"issue":"10","key":"10.1016\/j.bbrc.2025.152981_bib39","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41420-024-02196-9","article-title":"Targeting oncogenic MAGEA6 sensitizes triple negative breast cancer to doxorubicin through its autophagy and ferroptosis by stabling AMPK\u03b11","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbrc.2025.152981_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152981_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 drive resistance to sorafenib in hepatocellular carcinoma by preventing ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152981_bib43","article-title":"Hippo pathway effectors YAP\/TAZ as novel determinants of ferroptosis","volume":"7","author":"Yang","year":"2020","journal-title":"Mol. Cell. Oncol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152981_bib44","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11596-025-00013-7","article-title":"NOX4 suppresses ferroptosis through regulation of the pentose phosphate pathway in colorectal cancer","volume":"45","author":"Zhu","year":"2025","journal-title":"Curr. Med. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25016973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25016973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:52:02Z","timestamp":1773323522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25016973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S0006291X25016973"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152981","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152981"}}