{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:14:42Z","timestamp":1793751282092,"version":"4.6.1"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001428","name":"Amity University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbrc.2025.153027","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:27:40Z","timestamp":1763659660000},"page":"153027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A review on pathological implications and therapeutic interventions of sepsis-associated encephalopathy"],"prefix":"10.1016","volume":"794","author":[{"given":"Dharmanka","family":"Bandyopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-0574","authenticated-orcid":false,"given":"Lucy","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narahari N.","family":"Palei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.153027_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbrc.2025.153027_bib2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/jcm9030703","article-title":"Sepsis-associated encephalopathy: from delirium to dementia","volume":"9","author":"Chung","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s13311-020-00862-1","article-title":"Septic-associated encephalopathy: a comprehensive review","volume":"17","author":"Mazeraud","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbrc.2025.153027_bib4","article-title":"Sepsis associated encephalopathy","volume":"2014","author":"Chaudhry","year":"2014","journal-title":"Adv. Met. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib6","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12974-020-01850-0","article-title":"ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4+ T cells","volume":"17","author":"Luo","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.768108","article-title":"Blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy","volume":"11","author":"Peng","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnmol.2016.00019","article-title":"Molecular mechanisms regulating LPS-induced inflammation in the brain","volume":"9","author":"Lykhmus","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2025.153027_bib11","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.0808698106","article-title":"VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown","volume":"106","author":"Argaw","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2025.153027_bib12","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1172\/JCI60842","article-title":"Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease","volume":"122","author":"Argaw","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.153027_bib13","article-title":"The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib14","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2025.153027_bib15","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1074\/jbc.M117.796631","article-title":"Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent toll-like receptor 4 internalization and LPS-induced TBK1\u2013IKK\u03f5\u2013IRF3 axis activation","volume":"293","author":"Tsukamoto","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153027_bib16","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1074\/jbc.M113.521161","article-title":"Lipopolysaccharide activates toll-like receptor 4 (TLR4)-mediated NF-\u03baB signaling pathway and proinflammatory response in human pericytes","volume":"289","author":"Guijarro-Mu\u00f1oz","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153027_bib17","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"1773","author":"Cuenda","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.879021","article-title":"The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases","volume":"14","author":"Blevins","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2025.153027_bib19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2025.153027_bib20","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.3390\/biomedicines11092488","article-title":"Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities","volume":"11","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2025.153027_bib21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s41586-024-07314-2","article-title":"Brain endothelial GSDMD activation mediates inflammatory BBB breakdown","volume":"629","author":"Wei","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.153027_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12035-013-8433-7","article-title":"Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood\u2013brain barrier dysfunction in an animal model of severe sepsis","volume":"48","author":"Dal-Pizzol","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib23","article-title":"Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.153027_bib24","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1038\/s41467-024-50466-y","article-title":"Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.153027_bib25","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1016\/j.cell.2024.06.028","article-title":"Innate immune memory after brain injury drives inflammatory cardiac dysfunction","volume":"187","author":"Simats","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.153027_bib26","first-page":"20","article-title":"Septic encephalopathy: when cytokines interact with acetylcholine in the brain","volume":"1","author":"Zhang","year":"2014","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.expneurol.2007.01.003","article-title":"Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model","volume":"204","author":"Semmler","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2025.153027_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12871-020-01204-6","article-title":"AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study","volume":"20","author":"Zujalovic","year":"2020","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","article-title":"Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central \u03b12A adrenoceptor","volume":"91","author":"Mei","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2025.153027_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111770","article-title":"GABA regulates IL-1\u03b2 production in macrophages","volume":"41","author":"Fu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2025.153027_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbi.2021.09.017","article-title":"Systemic LPS-induced microglial activation results in increased GABAergic tone: a mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice","volume":"99","author":"Jiang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2025.153027_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12974-023-02756-3","article-title":"HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy","volume":"20","author":"Yin","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.153027_bib34","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.immuni.2021.01.007","article-title":"Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties","volume":"54","author":"Tang","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2025.153027_bib35","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2018.08.016","article-title":"The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis","volume":"49","author":"Deng","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2025.153027_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq7806","article-title":"Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy","volume":"9","author":"Chung","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2025.153027_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106814","article-title":"A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment","volume":"87","author":"Li","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib38","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1038\/s41598-019-45971-w","article-title":"PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment","volume":"9","author":"Coley","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.153027_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fncel.2019.00293","article-title":"Activation of \u03b22-adrenoceptor attenuates sepsis-induced hippocampus-dependent cognitive impairments by reversing neuroinflammation and synaptic abnormalities","volume":"13","author":"Zong","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2025.153027_bib40","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.ymthe.2022.03.011","article-title":"lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta","volume":"30","author":"Wu","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2025.153027_bib41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/381706a0","article-title":"Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus","volume":"381","author":"Figurov","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.153027_bib42","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1172\/JCI124485","article-title":"Circulating heparan sulfate fragments mediate septic cognitive dysfunction","volume":"129","author":"Hippensteel","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.153027_bib43","first-page":"42","article-title":"Sepsis associated encephalopathy: pathology, diagnosis and therapeutic interventions","volume":"4","author":"Bandyopadhyay","year":"2024","journal-title":"Int. J. Adv. Pharm. Sci. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib44","doi-asserted-by":"crossref","DOI":"10.4161\/21688370.2014.978720","article-title":"Blood cells and endothelial barrier function","volume":"3","author":"Rodrigues","year":"2015","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.bbrc.2025.153027_bib45","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jss.2007.07.021","article-title":"Injury of the blood brain barrier and up-regulation of icam-1 in polymicrobial sepsis","volume":"146","author":"Hofer","year":"2008","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib46","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.rvsc.2012.10.002","article-title":"Interleukin-1\u03b2, tumour necrosis factor-\u03b1 and lipopolysaccharide induce C-type natriuretic peptide from canine aortic endothelial cells","volume":"94","author":"Osterbur","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.bbrc.2025.153027_bib47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00395-013-0347-z","article-title":"Physiological levels of A-, B- and C-type natriuretic peptide shed the endothelial glycocalyx and enhance vascular permeability","volume":"108","author":"Jacob","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2018.11.014","article-title":"Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy","volume":"692","author":"Ehler","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2025.153027_bib49","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/brain\/awab094","article-title":"Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease","volume":"144","author":"Asby","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.bbrc.2025.153027_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s44231-022-00023-2","article-title":"Research progress of biomarkers of sepsis-associated encephalopathy","volume":"3","author":"Tang","year":"2023","journal-title":"Intensive Care Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib51","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s12017-014-8320-z","article-title":"Phosphoinositide 3-kinase \u03b3 affects LPS-induced disturbance of blood\u2013brain barrier via lipid kinase-independent control of cAMP in microglial cells","volume":"16","author":"Frister","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib52","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neulet.2017.10.064","article-title":"Individual differences in the brain are associated with resilience versus susceptibility to lipopolysaccharide-induced memory impairment","volume":"662","author":"Tang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2025.153027_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jcrc.2019.04.018","article-title":"Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication","volume":"52","author":"Wu","year":"2019","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.bbrc.2025.153027_bib54","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/SHK.0000000000001473","article-title":"Plasma miR-370-3p as a biomarker of sepsis-associated encephalopathy, the transcriptomic profiling analysis of microrna-arrays from mouse brains","volume":"54","author":"Visitchanakun","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.bbrc.2025.153027_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13054-017-1850-7","article-title":"Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study","volume":"21","author":"Ehler","year":"2017","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbrc.2025.153027_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11357-019-00089-9","article-title":"Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\u03b2 plaque and phosphorylated tau deposition and corresponding behavioral deficits","volume":"41","author":"Kirk","year":"2019","journal-title":"Geroscience"},{"key":"10.1016\/j.bbrc.2025.153027_bib57","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s12035-016-9708-6","article-title":"Biomarkers of delirium in a low-risk community-acquired pneumonia-induced sepsis","volume":"54","author":"Tomasi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/cc11902","article-title":"Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury","volume":"16","author":"Ritter","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbrc.2025.153027_bib59","first-page":"395","article-title":"Perspectives on the immune system in sepsis","volume":"17","author":"Stancioiu","year":"2022","journal-title":"Maedica"},{"key":"10.1016\/j.bbrc.2025.153027_bib60","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s12035-014-8918-z","article-title":"Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy","volume":"52","author":"Wu","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib61","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12974-019-1689-8","article-title":"Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy","volume":"17","author":"Haileselassie","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110009","article-title":"Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2\/YY1 complex promoting HO-1 expression","volume":"118","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib63","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/ijms23020961","article-title":"Disease outcome and brain metabolomics of cyclophilin-D knockout mice in sepsis","volume":"23","author":"Kobayashi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.153027_bib64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12944-024-02116-x","article-title":"Lipid peroxidation-induced ferroptosis as a therapeutic target for mitigating neuronal injury and inflammation in sepsis-associated encephalopathy: insights into the hippocampal PEBP-1\/15-LOX\/GPX4 pathway","volume":"23","author":"Wang","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbrc.2025.153027_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70156","article-title":"Yap1 alleviates sepsis associated encephalopathy by inhibiting hippocampus ferroptosis via maintaining mitochondrial dynamic homeostasis","volume":"28","author":"Yang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib66","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12974-019-1564-7","article-title":"The endotoxin hypothesis of neurodegeneration","volume":"16","author":"Brown","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib67","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1074\/jbc.M117.786756","article-title":"Receptor for advanced glycation end products mediates sepsis-triggered amyloid-\u03b2 accumulation, Tau phosphorylation, and cognitive impairment","volume":"293","author":"Gasparotto","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153027_bib68","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jaci.2014.01.032","article-title":"APO\u03b54 is associated with enhanced in vivo innate immune responses in human subjects","volume":"134","author":"Gale","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2025.153027_bib69","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12028-018-0581-1","article-title":"Neuroimaging findings in sepsis-induced brain dysfunction: association with clinical and laboratory findings","volume":"30","author":"Orhun","year":"2019","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.bbrc.2025.153027_bib70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00101-020-00853-z","article-title":"Sepsis-assoziierte enzephalopathie","volume":"70","author":"Klawitter","year":"2021","journal-title":"Anaesthesist"},{"key":"10.1016\/j.bbrc.2025.153027_bib71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(18)30062-6","article-title":"Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study","volume":"6","author":"Girard","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14787210.2020.1812384","article-title":"Sepsis-associated encephalopathy and septic encephalitis: an update","volume":"19","author":"Tauber","year":"2021","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.bbrc.2025.153027_bib73","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1177\/0885066619828293","article-title":"Cerebral autoregulation\u2013guided optimal blood pressure in sepsis-associated encephalopathy: a case series","volume":"35","author":"Rosenblatt","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib74","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.37267","article-title":"Evaluation of the 3-minute diagnostic confusion assessment method for identification of postoperative delirium in older patients","volume":"4","author":"Oberhaus","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbrc.2025.153027_bib75","article-title":"Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study","volume":"344","author":"Van den Boogaard","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.bbrc.2025.153027_bib76","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.jamda.2022.06.020","article-title":"Machine learning\u2013based prediction models for delirium: a systematic review and meta-analysis","volume":"23","author":"Xie","year":"2022","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.bbrc.2025.153027_bib77","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s11064-014-1308-0","article-title":"Serum S100\u03b2 is a better biomarker than neuron-specific enolase for sepsis-associated encephalopathy and determining its prognosis: a prospective and observational study","volume":"39","author":"Yao","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib78","article-title":"The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy\u2013A prospective, pilot observational study","volume":"14","author":"Ehler","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.153027_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1128476","article-title":"Extracellular proteins as potential biomarkers in sepsis-related cerebral injury","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.153027_bib80","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jnnp-2012-302883","article-title":"Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors","volume":"84","author":"Semmler","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbrc.2025.153027_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14853-z","article-title":"Clinical features, electroencephalogram, and biomarkers in pediatric sepsis-associated encephalopathy","volume":"12","author":"de Ara\u00fajo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.153027_bib82","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.7150\/ijbs.102234","article-title":"Sepsis-associated encephalopathy: mechanisms, diagnosis, and treatments update","volume":"21","author":"Li","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2025.153027_bib83","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/SHK.0000000000000465","article-title":"Metabolomic analyses of brain tissue in sepsis induced by cecal ligation reveal specific redox alterations\u2014protective effects of the oxygen radical scavenger edaravone","volume":"44","author":"Hara","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.bbrc.2025.153027_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102745","article-title":"\u03b2-Nicotinamide mononucleotide activates NAD+\/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice","volume":"63","author":"Li","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2025.153027_bib85","article-title":"Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K\/Akt signaling pathway","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.153027_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-017-0933-x","article-title":"Neuroglobin protects rats from sepsis-associated encephalopathy via a PI3K\/Akt\/Bax-dependent mechanism","volume":"63","author":"Deng","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2025.153027_bib87","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1177\/0300060518773265","article-title":"Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3\/9 and Bax\/Bcl signaling pathway in a rat model of sepsis","volume":"46","author":"Bedirli","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib88","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1002\/jcb.27983","article-title":"Attractylone attenuates sepsis\u2010associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation","volume":"120","author":"Tian","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2025.153027_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112840","article-title":"Dichloroacetate attenuates brain injury through inhibiting neuroinflammation and mitochondrial fission in a rat model of sepsis-associated encephalopathy","volume":"140","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib90","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bbi.2019.05.038","article-title":"Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis","volume":"80","author":"Xu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2025.153027_bib91","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1159\/000493819","article-title":"Omi\/HtrA2 regulates a mitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy","volume":"49","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2025.153027_bib92","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/revneuro-2017-0065","article-title":"Mechanisms of action of intravenous immunoglobulin in septic encephalopathy","volume":"29","author":"Esen","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.153027_bib93","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1111\/jcmm.15313","article-title":"Sestrin 2 attenuates sepsis\u2010associated encephalopathy through the promotion of autophagy in hippocampal neurons","volume":"24","author":"Luo","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib94","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1007\/s12035-017-0706-0","article-title":"Vitamin B6 reduces neurochemical and long-term cognitive alterations after polymicrobial sepsis: involvement of the kynurenine pathway modulation","volume":"55","author":"Danielski","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib95","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100074R","article-title":"GYY4137 protected the integrity of the blood\u2010brain barrier via activation of the Nrf2\/ARE pathway in mice with sepsis","volume":"35","author":"Cui","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2025.153027_bib96","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2018.02.008","article-title":"Possible involvement of tetrahydrobiopterin in the disturbance of redox homeostasis in sepsis\u2013induced brain dysfunction","volume":"1685","author":"Gamal","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib97","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.717157","article-title":"Kynurenic acid and its synthetic derivatives protect against sepsis-associated neutrophil activation and brain mitochondrial dysfunction in rats","volume":"12","author":"Poles","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.153027_bib98","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s12640-014-9475-y","article-title":"Effects of organoselenium compounds on early and late brain biochemical alterations in sepsis-survivor rats","volume":"26","author":"Silvestre","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib99","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2011.07.020","article-title":"The effects of hyperbaric oxygen therapy on blood\u2013brain barrier permeability in septic rats","volume":"1412","author":"Avtan","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10753-017-0708-0","article-title":"Short-and long-term protective effects of melatonin in a mouse model of sepsis-associated encephalopathy","volume":"41","author":"Ji","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib101","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01399-21","article-title":"Sepsis-induced gut dysbiosis mediates the susceptibility to sepsis-associated encephalopathy in mice","volume":"7","author":"Fang","year":"2022","journal-title":"mSystems"},{"key":"10.1016\/j.bbrc.2025.153027_bib102","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.2147\/JIR.S350566","article-title":"Gut microbiota mediates the susceptibility of mice to sepsis-associated encephalopathy by butyric acid","author":"Zhang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib103","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1111\/bph.13569","article-title":"Butein provides neuroprotective and anti\u2010neuroinflammatory effects through Nrf2\/ARE\u2010dependent haem oxygenase 1 expression by activating the PI3K\/Akt pathway","volume":"173","author":"Lee","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib104","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.taap.2018.10.013","article-title":"SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress","volume":"363","author":"Zhu","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155119","article-title":"Puerarin prevents sepsis-associated encephalopathy by regulating the AKT1 pathway in microglia","volume":"121","author":"Lin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.153027_bib106","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11064-024-04269-8","article-title":"Morin ameliorates lipopolysaccharides-induced sepsis-associated encephalopathy and cognitive impairment in albino mice","volume":"50","author":"Mohamed","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113813","article-title":"Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis","volume":"177","author":"Wang","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2025.153027_bib108","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1567202619666220414093130","article-title":"Anti-inflammatory effect of ginsenoside Rg1 on LPS-induced septic encephalopathy and associated mechanism","volume":"19","author":"Chen","year":"2022","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib109","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s12013-024-01488-2","article-title":"Ginsenoside Rh2 alleviate sepsis-related encephalopathy via up-regulating Nrf2\/HO-1 pathway and apoptosis inhibition","volume":"83","author":"Zhu","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2025.153027_bib110","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/1440-1681.13683","article-title":"Dihydroartemisinin protects blood\u2013brain barrier permeability during sepsis by inhibiting the transcription factor SNAI1","volume":"49","author":"Liu","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117345","article-title":"Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-\u039ab-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice","volume":"319","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib112","first-page":"407","article-title":"Curcumin modulates leukocyte and platelet adhesion in murine sepsis","volume":"17","author":"Vachharajani","year":"2010","journal-title":"Microcirculation"},{"key":"10.1016\/j.bbrc.2025.153027_bib113","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10735-023-10147-4","article-title":"J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4\/NF-\u03baB signaling pathway","volume":"54","author":"Qiu","year":"2023","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.bbrc.2025.153027_bib114","first-page":"188","article-title":"Effect of chicoric acid on cognitive function in mice with sepsis-associated encephalopathy","volume":"38","author":"Gao","year":"2022","journal-title":"J. Clin. Anesthesiol."},{"key":"10.1016\/j.bbrc.2025.153027_bib115","first-page":"1189","article-title":"Mechanism of resveratrol on ameliorating the cognitive dysfunction induced by sepsis associated encephalopathy in rats","volume":"32","author":"Liu","year":"2020","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.bbrc.2025.153027_bib116","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jss.2022.03.008","article-title":"Polydatin improves sepsis-associated encephalopathy by activating Sirt1 and reducing p38 phosphorylation","volume":"276","author":"Huang","year":"2022","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbrc.2025.153027_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155987","article-title":"Quercetin protects against sepsis-associated encephalopathy by inhibiting microglia-neuron crosstalk via the CXCL2\/CXCR2 signaling pathway","volume":"134","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.153027_bib118","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cns.13765","article-title":"Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis\u2010associated encephalopathy","volume":"28","author":"Ding","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbrc.2025.153027_bib119","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s00540-017-2392-5","article-title":"Effects of epigallocatechin-3-gallate on systemic inflammation-induced cognitive dysfunction in aged rats","volume":"31","author":"Yamanaka","year":"2017","journal-title":"J. Anesth."},{"key":"10.1016\/j.bbrc.2025.153027_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279964","article-title":"\u03b2-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1\/Nrf2 signaling pathway","volume":"18","author":"Tian","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.153027_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112036","article-title":"Berberine alleviates neuroinflammation by downregulating NFkB\u03ba\u03baNF\/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation","volume":"133","author":"Gong","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib122","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10753-018-0899-z","article-title":"The protective effects and the involved mechanisms of tanshinone IIA on sepsis-induced brain damage in mice","volume":"42","author":"Xiong","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2025.153027_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110111","article-title":"Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3\/caspase-1\/gasdermin D-mediated pyroptosis","volume":"118","author":"Song","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.153027_bib124","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000520281","article-title":"Emodin promotes autophagy and prevents apoptosis in sepsis-associated encephalopathy through activating BDNF\/TrkB signaling","volume":"89","author":"Gao","year":"2022","journal-title":"Pathobiology"},{"key":"10.1016\/j.bbrc.2025.153027_bib125","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2657713","article-title":"(\u2212)\u2010Epicatechin reduces neuroinflammation, protects mitochondria function, and prevents cognitive impairment in sepsis\u2010associated encephalopathy","volume":"2022","author":"Ling","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2025.153027_bib126","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.3390\/ijms26136477","article-title":"Polyphenols in the central nervous system: cellular effects and liposomal delivery approaches","volume":"26","author":"Kaluza","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.153027_bib127","first-page":"3415","article-title":"Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood\u2013brain barrier permeability","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2025.153027_bib128","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa242","article-title":"Glucocorticoids and the brain after critical illness","volume":"162","author":"Hill","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2025.153027_bib129","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.2016.14799","article-title":"Effect of hydrocortisone on development of shock among patients with severe sepsis: the hypress randomized clinical trial","volume":"316","author":"Keh","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2025.153027_bib130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis: a review","volume":"319","author":"Prescott","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2025.153027_bib131","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/jama.2017.2088","article-title":"Effect of dexmedetomidine on mortality and Ventilator-free days in patients requiring mechanical ventilation with sepsis","volume":"317","author":"Kawazoe","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2025.153027_bib132","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1056\/NEJMoa2024922","article-title":"Dexmedetomidine or propofol for sedation in mechanically ventilated adults with sepsis","volume":"384","author":"Hughes","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib133","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bja.2022.06.020","article-title":"Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials","volume":"129","author":"Heybati","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbrc.2025.153027_bib134","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.34290","article-title":"Epidemiology and costs of postsepsis morbidity, nursing care dependency, and mortality in Germany, 2013 to 2017","volume":"4","author":"Fleischmann-Struzek","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbrc.2025.153027_bib135","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1164\/rccm.201406-1170OC","article-title":"Association of postdischarge rehabilitation with mortality in intensive care unit survivors of sepsis","volume":"190","author":"Chao","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2025.153027_bib138","author":"Yan"},{"key":"10.1016\/j.bbrc.2025.153027_bib147","author":"Li"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25017437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25017437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:26:53Z","timestamp":1781270813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25017437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":136,"alternative-id":["S0006291X25017437"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153027","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review on pathological implications and therapeutic interventions of sepsis-associated encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153027"}}