{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:23Z","timestamp":1786985063303,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004214","name":"Pamukkale University","doi-asserted-by":"publisher","award":["2025HZDP007"],"award-info":[{"award-number":["2025HZDP007"]}],"id":[{"id":"10.13039\/501100004214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbrc.2025.153110","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:19:53Z","timestamp":1765592393000},"page":"153110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A comparative analysis of CXCR4 gene expression from published datasets and cell surface protein levels in breast and prostate cancer models"],"prefix":"10.1016","volume":"795","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-6239","authenticated-orcid":false,"given":"Veli","family":"Kaan Ayd\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-4816","authenticated-orcid":false,"given":"Yasemin","family":"Adal\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-0436","authenticated-orcid":false,"given":"Aylin","family":"K\u00f6seler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.153110_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","article-title":"Targeting metastatic cancer","volume":"27","author":"Ganesh","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.153110_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2025.153110_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbrc.2025.153110_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrc1098","article-title":"The pathogenesis of cancer metastasis: the \u201cseed and soil\u201d hypothesis revisited","volume":"3","author":"Fidler","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.153110_bib5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10555-010-9256-x","article-title":"CXCL12\/CXCR4\/CXCR7 chemokine axis and cancer progression","volume":"29","author":"Sun","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbrc.2025.153110_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.574667","article-title":"The role of the CXCL12\/CXCR4\/CXCR7 chemokine axis in cancer","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.153110_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","article-title":"Involvement of chemokine receptors in breast cancer metastasis","volume":"410","author":"M\u00fcller","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.153110_bib8","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.18632\/oncotarget.3217","article-title":"CXCR4 over-expression and survival in cancer: a system review and meta-analysis","volume":"6","author":"Zhao","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.153110_bib9","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1158\/1078-0432.CCR-13-2686","article-title":"A phase I trial of LY2510924, a CXCR4 peptide antagonist, in patients with advanced cancer","volume":"20","author":"Galsky","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.153110_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2407-14-49","article-title":"Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbrc.2025.153110_bib11","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.2147\/DDDT.S82475","article-title":"The association of CXCR4 expression with clinicopathological significance and potential drug target in prostate cancer: a meta-analysis and literature review","author":"Chen","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2025.153110_bib12","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3390\/cells14181482","article-title":"Targeting the CXCR4\/CXCL12 axis to overcome drug resistance in triple-negative breast cancer","volume":"14","author":"Singh","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.153110_bib13","article-title":"Demystifying the CXCR4 conundrum in cancer biology: beyond the surface signaling paradigm","volume":"1877","author":"Nengroo","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.bbrc.2025.153110_bib14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/bib\/bbs037","article-title":"Batch effect removal methods for microarray gene expression data integration: a survey","volume":"14","author":"Lazar","year":"2013","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.bbrc.2025.153110_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2025.153110_bib16","unstructured":"H. Patel, M.U. Garcia, A. Talbot, Sateesh_Peri, M.E. Beber, E. Joshi, D.W. Han, nf-core bot, E. Miller, J.A.F. Yates, nicolae06, D. Carlson, R. Syme, P. Ewels, J. Espinosa-Carrasco, M. Borry, A. Domissy, McmandR, O. Ziff, jahdoos, K. Menden, sirclockalot, nf-core\/fetchngs: nf-core\/fetchngs v1.12.0 - Titanium Platypus, (n.d.). https:\/\/doi.org\/10.5281\/ZENODO.10728509."},{"key":"10.1016\/j.bbrc.2025.153110_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.153110_bib18","unstructured":"H. Patel, J. Manning, P. Ewels, M.U. Garcia, A. Peltzer, R. Hammar\u00e9n, O. Botvinnik, A. Talbot, G. Sturm, nf-core bot, M. Zepper, D. Moreno, P. Vemuri, M. Binzer-Panchal, E. Greenberg, silviamorins, L. Pantano, R. Syme, G. Kelly, L. Sola, F. Hanssen, J.A.F. Yates, G. Lichtenstein, J. Espinosa-Carrasco, rfenouil, L. Zappia, C. Cheshire, E. Miller, marchoeppner, P. Zhou, nf-core\/rnaseq: nf-core\/rnaseq v3.19.0 - tungsten turtle, (n.d.). https:\/\/doi.org\/10.5281\/ZENODO.15631172."},{"key":"10.1016\/j.bbrc.2025.153110_bib19","unstructured":"Homo_sapiens - Ensembl genome browser 114, (n.d.). https:\/\/www.ensembl.org\/Homo_sapiens\/Info\/Index (accessed July 7, 2025)."},{"key":"10.1016\/j.bbrc.2025.153110_bib20","series-title":"Techniques for More Effective and Strategic Drug Discovery","author":"Kenakin","year":"2014"},{"key":"10.1016\/j.bbrc.2025.153110_bib21","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(00)80577-2","article-title":"Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry","volume":"96","author":"Farzan","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.153110_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10585-007-9130-6","article-title":"The tumor cell\u2013host organ interface in the early onset of metastatic organ colonisation","volume":"25","author":"Gassmann","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bbrc.2025.153110_bib23","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbamem.2006.11.002","article-title":"Regulation of CXCR4 signaling","volume":"1768","author":"Busillo","year":"2007","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbrc.2025.153110_bib24","doi-asserted-by":"crossref","first-page":"45509","DOI":"10.1074\/jbc.C100527200","article-title":"Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting","volume":"276","author":"Marchese","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153110_bib25","doi-asserted-by":"crossref","first-page":"36971","DOI":"10.1074\/jbc.M705085200","article-title":"Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4","volume":"282","author":"Bhandari","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153110_bib26","doi-asserted-by":"crossref","first-page":"31076","DOI":"10.1074\/jbc.274.43.31076","article-title":"Trafficking of the HIV coreceptor CXCR4","volume":"274","author":"Orsini","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153110_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.semcancer.2022.03.019","article-title":"Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression","volume":"86","author":"Alsayed","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2025.153110_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13112582","article-title":"MiR-139 modulates cancer stem cell function of human breast cancer through targeting CXCR4","volume":"13","author":"Cheng","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2025.153110_bib29","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-021-03730-8","article-title":"CXCR4 intracellular protein promotes drug resistance and tumorigenic potential by inversely regulating the expression of death receptor 5","volume":"12","author":"Nengroo","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2025.153110_bib30","doi-asserted-by":"crossref","first-page":"21631","DOI":"10.1074\/jbc.M300609200","article-title":"NF-\u03ba B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4","volume":"278","author":"Helbig","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153110_bib31","first-page":"1347","article-title":"Emerging targets in cancer management: role of the CXCL12\/CXCR4 axis","volume":"6","author":"Cojoc","year":"2013","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbrc.2025.153110_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.153110_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.153110_bib34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.pharmthera.2010.08.009","article-title":"Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, MozobilTM) and potential of other CXCR4 antagonists as stem cell mobilizers","volume":"128","author":"De Clercq","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2025.153110_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrd4204","article-title":"PI3K and cancer: lessons, challenges and opportunities","volume":"13","author":"Fruman","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2025.153110_bib36","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.153110_bib37","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1158\/1078-0432.CCR-15-2889","article-title":"Intratumor heterogeneity affects gene expression profile test prognostic risk stratification in early breast cancer","volume":"22","author":"Gyanchandani","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.153110_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ccr.2006.06.002","article-title":"Activating alleles of JAK3 in acute megakaryoblastic leukemia","volume":"10","author":"Walters","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.153110_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.153110_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/bcr2889","article-title":"Choosing the right cell line for breast cancer research","volume":"13","author":"Holliday","year":"2011","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bbrc.2025.153110_bib41","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","article-title":"A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes","volume":"10","author":"Neve","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.153110_bib42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/jcb.10522","article-title":"Expression of CXCR4 and CXCL12 (SDF\u20101) in human prostate cancers (PCa) in vivo","volume":"89","author":"Sun","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2025.153110_bib43","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","article-title":"Mechanisms of endocytosis","volume":"78","author":"Doherty","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2025.153110_bib44","doi-asserted-by":"crossref","DOI":"10.3791\/51046-v","article-title":"In vitro cell migration and invasion assays","author":"Justus","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbrc.2025.153110_bib45","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.153110_bib46","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25018261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25018261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:07:07Z","timestamp":1781323627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25018261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"alternative-id":["S0006291X25018261"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153110","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative analysis of CXCR4 gene expression from published datasets and cell surface protein levels in breast and prostate cancer models","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153110"}}