{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:03:41Z","timestamp":1790481821492,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270242"],"award-info":[{"award-number":["82270242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570475"],"award-info":[{"award-number":["82570475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbrc.2025.153181","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:48:16Z","timestamp":1766508496000},"page":"153181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Streptococcus mutans-derived extracellular vesicles disrupt endothelial function via eNOS and endothelin-1 modulation"],"prefix":"10.1016","volume":"797","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshuo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-9926","authenticated-orcid":false,"given":"Huina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.153181_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0022034518814829","article-title":"Tooth loss predicts myocardial infarction, heart failure, stroke, and death","volume":"98","author":"Lee","year":"2019","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbrc.2025.153181_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bbrc.2025.153181_bib3","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1128\/JCM.00377-06","article-title":"Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens","volume":"44","author":"Nakano","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bbrc.2025.153181_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/0022034511435101","article-title":"Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice","volume":"91","author":"Kesavalu","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbrc.2025.153181_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-018-0024-z","article-title":"Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages","volume":"10","author":"Song","year":"2018","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bbrc.2025.153181_bib6","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1161\/STROKEAHA.120.029607","article-title":"Oral carriage of Streptococcus mutans harboring the cnm gene relates to an increased incidence of cerebral microbleeds","volume":"51","author":"Hosoki","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2025.153181_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/cei\/uxac094","article-title":"Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model","volume":"210","author":"Taniguchi","year":"2022","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbrc.2025.153181_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12159","article-title":"Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo","volume":"10","author":"Bittel","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bbrc.2025.153181_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12395","article-title":"Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier","volume":"12","author":"Ou","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bbrc.2025.153181_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12306","article-title":"Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling","volume":"12","author":"Xie","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bbrc.2025.153181_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2489069","article-title":"Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis","volume":"17","author":"Niu","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbrc.2025.153181_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.archoralbio.2014.12.009","article-title":"Rho kinase mediates Porphyromonas gingivalis outer membrane vesicle-induced suppression of endothelial nitric oxide synthase through ERK1\/2 and p38 MAPK","volume":"60","author":"Jia","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2025.153181_bib13","doi-asserted-by":"crossref","first-page":"H2084","DOI":"10.1152\/ajpheart.00675.2001","article-title":"Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension","volume":"282","author":"Iwakiri","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2025.153181_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3892\/br.2022.1560","article-title":"Cilostazol regulates the expressions of endothelin-1 and endothelial nitric oxide synthase via activation of the p38 MAPK signaling pathway in HUVECs","volume":"17","author":"Xue","year":"2022","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.bbrc.2025.153181_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.2041-1014.2010.00597.x","article-title":"Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production","volume":"26","author":"Nagata","year":"2011","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.bbrc.2025.153181_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncomms1491","article-title":"The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke","volume":"2","author":"Nakano","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.153181_bib17","article-title":"Dental caries as a cause of primary hypertension among children and adolescents","volume":"17","author":"Haroon","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.bbrc.2025.153181_bib18","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/odi.13700","article-title":"Dental caries-related primary hypertension in children and adolescents: cross-sectional study","volume":"27","author":"Ostalska-Nowicka","year":"2021","journal-title":"Oral Dis."},{"key":"10.1016\/j.bbrc.2025.153181_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/CIRCRESAHA.122.321253","article-title":"Gut microbially produced Indole-3-Propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to atherosclerotic cardiovascular disease","volume":"131","author":"Xue","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.153181_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101706","article-title":"Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases","volume":"81","author":"Hu","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbrc.2025.153181_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104552","article-title":"Prevention and treatment of chronic heart failure through traditional Chinese medicine: role of the gut microbiota","volume":"151","author":"Jia","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2025.153181_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.add5787","article-title":"Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.153181_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12328","article-title":"Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model","volume":"12","author":"Chen","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bbrc.2025.153181_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jare.2023.02.006","article-title":"Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment","volume":"54","author":"Ma","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbrc.2025.153181_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s41232-022-00224-8","article-title":"Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer's disease","volume":"42","author":"Park","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrc.2025.153181_bib26","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1902\/jop.2005.76.6.972","article-title":"Outer membrane vesicles from Porphyromonas gingivalis affect the growth and function of cultured human gingival fibroblasts and umbilical vein endothelial cells","volume":"76","author":"Bartruff","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bbrc.2025.153181_bib27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/FJC.0b013e31827fe46e","article-title":"Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids","volume":"61","author":"Wong","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.153181_bib28","doi-asserted-by":"crossref","first-page":"17625","DOI":"10.1074\/jbc.C100122200","article-title":"Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase","volume":"276","author":"Michell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.153181_bib29","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14192","article-title":"Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways","volume":"10","author":"Song","year":"2022","journal-title":"PeerJ"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25018972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25018972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:18:52Z","timestamp":1786479532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25018972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"alternative-id":["S0006291X25018972"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153181","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Streptococcus mutans-derived extracellular vesicles disrupt endothelial function via eNOS and endothelin-1 modulation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.153181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153181"}}