{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:33:02Z","timestamp":1789770782269,"version":"4.0.1"},"reference-count":190,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016355","name":"Xuzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["KC22037"],"award-info":[{"award-number":["KC22037"]}],"id":[{"id":"10.13039\/501100016355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bbrc.2026.153322","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:35:15Z","timestamp":1768894515000},"page":"153322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis"],"prefix":"10.1016","volume":"801","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-4182","authenticated-orcid":false,"given":"Jian","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-5711","authenticated-orcid":false,"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4153","authenticated-orcid":false,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153322_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/biomedicines12040843","article-title":"Osteoporosis, osteoarthritis, and subchondral insufficiency fracture: recent insights","volume":"12","author":"Yokota","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2026.153322_bib2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1359\/jbmr.091012","article-title":"Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: a prospective study","volume":"25","author":"Ding","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib3","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-932-2","article-title":"S-sulfhydration: novel insights into the antioxidant and antiinflammation in age-related diseases","author":"Liu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","article-title":"The immune microenvironment in cartilage injury and repair","volume":"140","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.153322_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/bs.apcsb.2024.10.013","article-title":"Immunotherapy in the management of inflammatory bone loss in osteoporosis","volume":"144","author":"Sapra","year":"2025","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1012508","article-title":"Osteopontin, a bridge links osteoarthritis and osteoporosis","volume":"13","author":"Bai","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2026.153322_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14397595.2016.1226471","article-title":"Epidemiology of the locomotive syndrome: the research on osteoarthritis\/osteoporosis against disability study 2005\u20132015","volume":"27","author":"Yoshimura","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.bbrc.2026.153322_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/6324348","article-title":"Diabetes is associated with musculoskeletal pain, osteoarthritis, osteoporosis, and rheumatoid arthritis","volume":"2019","author":"Rehling","year":"2019","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/216507991206000902","article-title":"Osteoarthritis, osteoporosis, and exercise","volume":"60","author":"Garrison","year":"2012","journal-title":"Workplace Health Saf."},{"key":"10.1016\/j.bbrc.2026.153322_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/13697137.2017.1286890","article-title":"Exercise and nutritional approaches to prevent frail bones, falls and fractures: an update","volume":"20","author":"Daly","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.bbrc.2026.153322_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1512966","article-title":"Research progress of macrophages in bone regeneration","volume":"2023","author":"Zhang","year":"2023","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41374-021-00723-1","article-title":"Clinical implications of exosome-derived noncoding RNAs in liver","volume":"102","author":"Zhou","year":"2022","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2026.153322_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2025.e41632","article-title":"Exosomal non-coding RNAs in the regulation of bone metabolism homeostasis: molecular mechanism and therapeutic potential","volume":"11","author":"Huang","year":"2025","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrc.2026.153322_bib14","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/cbin.11854","article-title":"Biology of macrophage fate decision: implication in inflammatory disorders","volume":"46","author":"Yadav","year":"2022","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2026.153322_bib15","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-induced macrophage polarization in inflammatory conditions","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib16","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.2001191","article-title":"TLR-4 agonist induces IFN-\u03b3 production selectively in proinflammatory human M1 macrophages through the PI3K-mTOR\u2013 and JNK-MAPK\u2013Activated p70S6K pathway","volume":"207","author":"Gajanayaka","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yjmcc.2015.04.025","article-title":"Curcumin induces M2 macrophage polarization by secretion IL-4 and\/or IL-13","volume":"85","author":"Gao","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2026.153322_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbrc.2026.153322_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib20","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.2147\/JIR.S423819","article-title":"Macrophage polarization and the regulation of bone immunity in bone homeostasis","volume":"16","author":"Hu","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib21","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20209488","article-title":"Modulation of Wnt\/\u03b2-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells","volume":"53","author":"Yuan","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2021.08.001","article-title":"Polarization of rheumatoid macrophages is regulated by the CDKN2B-AS1\/MIR497\/TXNIP axis","volume":"239","author":"Li","year":"2021","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbrc.2026.153322_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156768","article-title":"Contribution of macrophage polarization in bone metabolism: a literature review","volume":"184","author":"Yan","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2026.153322_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.778078","article-title":"Macrophage-osteoclast associations: origin, polarization, and subgroups","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib25","doi-asserted-by":"crossref","first-page":"886","DOI":"10.14348\/molcells.2015.0125","article-title":"NMAAP1 expressed in BCG-activated macrophage promotes M1 macrophage polarization","volume":"38","author":"Liu","year":"2015","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbrc.2026.153322_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1355012","article-title":"Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look","volume":"15","author":"Baig","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10637-024-01427-1","article-title":"The novel cytotoxic polybisphosphonate osteodex decreases bone resorption by enhancing cell death of mature osteoclasts without affecting osteoclastogenesis of RANKL-stimulated mouse bone marrow macrophages","volume":"42","author":"Henning","year":"2024","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.bbrc.2026.153322_bib28","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac80e3","article-title":"Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages","volume":"17","author":"Hang","year":"2022","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib29","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/jbm.a.37134","article-title":"Effect of the immune responses induced by implants in a integrated three\u2010dimensional micro\u2010nano topography on osseointegration","volume":"109","author":"Yang","year":"2020","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib30","first-page":"962","article-title":"Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration, tissue engineering","volume":"27","author":"Liu","year":"2021","journal-title":"Part. Accel."},{"key":"10.1016\/j.bbrc.2026.153322_bib31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/jcmm.14027","article-title":"Autocrine VEGF signalling on M2 macrophages regulates PD\u2010L1 expression for immunomodulation of T cells","volume":"23","author":"Lai","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110274","article-title":"Macrophage heterogeneity in myocardial infarction: evolution and implications for diverse therapeutic approaches","volume":"27","author":"Kanuri","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bbrc.2026.153322_bib33","article-title":"Single\u2010cell insights into macrophage subtypes in pulmonary infections","author":"Lin","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153322_bib34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.coi.2017.12.001","article-title":"Developmental control of macrophage function","volume":"50","author":"Bonnardel","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib35","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1186\/s12967-025-07015-y","article-title":"Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveal macrophage subpopulation characteristics and the role of STAT1 in rheumatoid arthritis","volume":"23","author":"Ye","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109302","article-title":"Single-cell RNA sequencing analysis dissected the osteo-immunology microenvironment and revealed key regulators in osteoporosis","volume":"113","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib37","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/CM9.0000000000002678","article-title":"Osteoimmunology research in rheumatoid arthritis: from single-cell omics approach","volume":"136","author":"Hu","year":"2023","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbrc.2026.153322_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2025.104993","article-title":"Macrophage heterogeneity in autoimmune diseases","volume":"414","author":"Li","year":"2025","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2024.100598","article-title":"Macrophage heterogeneity in bone metastasis","volume":"45","author":"Guo","year":"2024","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.bbrc.2026.153322_bib40","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/nu12102999","article-title":"Macrophage polarization and osteoporosis: a review","volume":"12","author":"Mu\u00f1oz","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.153322_bib41","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1302\/2046-3758.144.BJR-2024-0327.R1","article-title":"Carpaine ameliorates synovial inflammation by promoting p65 degradation and inhibiting the NF-kappaB signalling pathway","volume":"14","author":"Zhang","year":"2025","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.bbrc.2026.153322_bib42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1186\/s13018-024-05052-9","article-title":"Research progress on macrophage polarization during osteoarthritis disease progression: a review","volume":"19","author":"Yin","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s13018-025-05679-2","article-title":"Development of a macrophage polarization-modulating therapeutic agent for osteoarthritis treatment","volume":"20","author":"Wu","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/ATVBAHA.117.310333","article-title":"IL-1\u03b2 (Interleukin-1\u03b2) and TNF-\u03b1 (tumor necrosis Factor-\u03b1) impact abdominal aortic aneurysm formation by differential effects on macrophage polarization","volume":"38","author":"Batra","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib45","article-title":"Treatment with mesenchymal stem cell-derived Nanovesicle-Containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization","volume":"12","author":"Pang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-024-00318-8","article-title":"Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis","volume":"12","author":"Liu","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib47","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.7150\/ijbs.91519","article-title":"TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-kappaB\/CXCL3 axis","volume":"20","author":"Fang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13075-021-02512-z","article-title":"Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-kappaB pathways","volume":"23","author":"Lu","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3892\/etm.2020.9500","article-title":"miR-155-5p regulates macrophage M1 polarization and apoptosis in the synovial fluid of patients with knee osteoarthritis","volume":"21","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103494","article-title":"Decidual macrophage derived MMP3 contributes to extracellular matrix breakdown in spiral artery remodeling in early human pregnancy","volume":"150","author":"Pan","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib51","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/10717544.2022.2044936","article-title":"Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis","volume":"29","author":"Tan","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bbrc.2026.153322_bib52","doi-asserted-by":"crossref","first-page":"11730","DOI":"10.1021\/acs.jafc.5c00545","article-title":"Mechanistic insights into maltol-mediated reversal of postmenopausal osteoporosis via regulation of CDK14 ubiquitination in macrophages","volume":"73","author":"Jin","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.153322_bib53","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1302\/2046-3758.139.BJR-2024-0122.R1","article-title":"The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration","volume":"13","author":"Murayama","year":"2024","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.bbrc.2026.153322_bib54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lfs.2014.11.011","article-title":"Role of inflammation in the aging bones","volume":"123","author":"Abdelmagid","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10020-025-01186-6","article-title":"S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via inhibition of JAK\/STAT signaling","volume":"31","author":"Cai","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111929","article-title":"LAMP1 controls CXCL10-CXCR3 axis mediated inflammatory regulation of macrophage polarization during inflammatory stimulation","volume":"132","author":"Ye","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib57","first-page":"11","article-title":"MFG-E8 promotes tendon-bone healing by regulating macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction","volume":"34","author":"Geng","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbrc.2026.153322_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101661","article-title":"Long-term recruitment of endogenous M2 macrophages by platelet lysate-rich plasma macroporous hydrogel scaffold for articular cartilage defect repair","volume":"11","author":"Pan","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib59","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbrc.2026.153322_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114935","article-title":"Itaconate attenuates osteoarthritis by inhibiting STING\/NF-kappaB axis in chondrocytes and promoting M2 polarization in macrophages","volume":"198","author":"Ni","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib61","doi-asserted-by":"crossref","first-page":"20706","DOI":"10.18632\/oncotarget.14982","article-title":"Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-kappaB signaling","volume":"8","author":"Chiang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2026.153322_bib62","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.2147\/CMAR.S174899","article-title":"IL-17 induces macrophages to M2-like phenotype via NF-kappaB","volume":"10","author":"Shen","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-83198-6","article-title":"Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages","volume":"14","author":"Yu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153322_bib64","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/20477724.2022.2104055","article-title":"Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 macrophages through PI3K\/Akt\/mTOR signaling pathway","volume":"117","author":"Zhang","year":"2023","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.bbrc.2026.153322_bib65","doi-asserted-by":"crossref","first-page":"236","DOI":"10.14715\/cmb\/2021.67.6.31","article-title":"The expression of MDM2 gene promoted chondrocyte proliferation in rats with osteoarthritis via the Wnt\/beta-catenin pathway","volume":"67","author":"Jiang","year":"2022","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"},{"key":"10.1016\/j.bbrc.2026.153322_bib66","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13018-020-01881-6","article-title":"The beta-catenin\/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes","volume":"15","author":"Tian","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00018-024-05133-2","article-title":"FAM76B regulates PI3K\/Akt\/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA","volume":"81","author":"Wang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib68","first-page":"291","article-title":"Macrophage polarization and its impact on osteoporosis, results probl","volume":"74","author":"Yan","year":"2024","journal-title":"Cell Differ."},{"key":"10.1016\/j.bbrc.2026.153322_bib69","article-title":"Insights into the role of macrophage polarization in the pathogenesis of osteoporosis","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2026.153322_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.962114","article-title":"Sex differences in the therapeutic effect of unaltered versus NFkappaB sensing IL-4 over-expressing mesenchymal stromal cells in a murine model of chronic inflammatory bone loss","volume":"10","author":"Shen","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib71","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.reth.2025.04.013","article-title":"In vitro and in vivo study of concentrated growth factor (CGF) mediating macrophage polarization in bone defect repair","volume":"29","author":"Xin","year":"2025","journal-title":"Regen Ther"},{"key":"10.1016\/j.bbrc.2026.153322_bib72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12951-022-01314-y","article-title":"Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA","volume":"20","author":"Chen","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib73","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10719-022-10062-y","article-title":"Notch\/NICD\/RBP-J signaling axis regulates M1 polarization of macrophages mediated by advanced glycation end products","volume":"39","author":"Tan","year":"2022","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.bbrc.2026.153322_bib74","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainresbull.2021.02.015","article-title":"Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5","volume":"170","author":"Chang","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2026.153322_bib75","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s10020-024-00904-w","article-title":"BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136504","article-title":"Bilobalide ameliorates osteoporosis by influencing the SIRT3\/NF-kappaB axis in osteoclasts and promoting M2 polarization in macrophages","volume":"281","author":"Qin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2026.153322_bib77","article-title":"Single-cell RNA sequencing reveals multiple immune cell subpopulations promote the formation of abnormal bone microenvironment in osteoporosis","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153322_bib78","doi-asserted-by":"crossref","first-page":"9725","DOI":"10.2147\/JIR.S484529","article-title":"Inhibition of EGFR pathway suppresses M1 macrophage polarization and osteoclastogenesis, mitigating titanium particle-induced bone resorption","volume":"17","author":"Jia","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib79","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/00220345231221712","article-title":"Casp 11 deficiency alters subgingival microbiota and attenuates periodontitis","volume":"103","author":"Fu","year":"2024","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib80","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.7150\/ijms.94972","article-title":"Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption","volume":"21","author":"Yang","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib81","first-page":"231","article-title":"Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment","volume":"31","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2021.105042","article-title":"M2-like macrophage infiltration and transforming growth factor-beta secretion during socket healing process in mice","volume":"123","author":"Horibe","year":"2021","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib83","doi-asserted-by":"crossref","first-page":"rbad042","DOI":"10.1093\/rb\/rbad042","article-title":"Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization","volume":"10","author":"Lin","year":"2023","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.bbrc.2026.153322_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.106230","article-title":"A bi-layered asymmetric membrane loaded with demineralized dentin matrix for guided bone regeneration","volume":"149","author":"Zhou","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121037","article-title":"Immunolocalization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration","volume":"276","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.153322_bib86","article-title":"Immune regulation enhances osteogenesis and angiogenesis using an injectable thiolated hyaluronic acid hydrogel with lithium-doped nano-hydroxyapatite (Li-nHA) delivery for osteonecrosis","volume":"25","author":"Luo","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bbrc.2026.153322_bib87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13287-020-1561-x","article-title":"Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib88","doi-asserted-by":"crossref","first-page":"34378","DOI":"10.1021\/acsami.3c03446","article-title":"Selenium-doped mesoporous bioactive glass regulates macrophage metabolism and polarization by scavenging ROS and promotes bone regeneration in vivo","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bbrc.2026.153322_bib89","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actbio.2023.03.027","article-title":"Bio-inspired glycosylated nano-hydroxyapatites enhance endogenous bone regeneration by modulating macrophage M2 polarization","volume":"162","author":"Qiao","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.153322_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2017.19","article-title":"RANKL-induced M1 macrophages are involved in bone formation","volume":"5","author":"Huang","year":"2017","journal-title":"Bone Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib91","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4196\/kjpp.24.248","article-title":"Colla Carapacis et Plastri ameliorates postmenopausal osteoporosis and macrophage immunity by modulating the RANK\/RANKL\/OPG signaling pathway in ovariectomized rats","volume":"29","author":"Wan","year":"2025","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.bbrc.2026.153322_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122592","article-title":"Inhibition of NF-kappaB and ERK signaling pathways in osteoclasts and M1 macrophage polarization: mechanistic insights into the anti-osteoporotic effects of Pseudolaric acid B","volume":"345","author":"Liu","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111588","article-title":"Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING\/NF-kappaB pathway","volume":"129","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13287-022-02800-8","article-title":"Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K\/AKT pathway","volume":"13","author":"Lu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112788","article-title":"Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis","volume":"206","author":"Liu","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2026.153322_bib96","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1038\/s41598-023-29802-7","article-title":"The effect of postmenopausal osteoporosis on subchondral bone pathology in a rat model of knee osteoarthritis","volume":"13","author":"Wada","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153322_bib97","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/s00198-011-1859-8","article-title":"Differential responsiveness to 17\u03b2-estradiol of mesenchymal stem cells from postmenopausal women between osteoporosis and osteoarthritis","volume":"23","author":"Jin","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2026.153322_bib98","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jbmr.3364","article-title":"Estrogen deficiency\u2013mediated M2 macrophage osteoclastogenesis contributes to M1\/M2 ratio alteration in ovariectomized osteoporotic mice","volume":"33","author":"Dou","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib99","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00223-018-0433-1","article-title":"Ficus deltoidea prevented bone loss in preclinical osteoporosis\/osteoarthritis model by suppressing inflammation, calcif","volume":"103","author":"Che Ahmad Tantowi","year":"2018","journal-title":"Tissue Int"},{"key":"10.1016\/j.bbrc.2026.153322_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112614","article-title":"The interplay between osteoarthritis and osteoporosis: mechanisms, implications, and treatment considerations \u2013 a narrative review","volume":"197","author":"Huang","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2026.153322_bib101","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1515\/biol-2022-0079","article-title":"Monosodium iodoacetate-induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis","volume":"17","author":"Bao","year":"2022","journal-title":"Open Life Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib102","first-page":"211","article-title":"IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis","volume":"45","author":"Wang","year":"2024","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbrc.2026.153322_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114477","article-title":"Activated NETosis of bone marrow neutrophils up-regulates macrophage osteoclastogenesis via cGAS-STING\/AKT2 pathway to promote osteoporosis","volume":"446","author":"Guo","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib104","doi-asserted-by":"crossref","first-page":"158","DOI":"10.20517\/evcna.2024.91","article-title":"Gas-powered extracellular vesicles promote bone regeneration","volume":"6","author":"Holliday","year":"2025","journal-title":"Extracell Vesicles Circ Nucl Acids"},{"key":"10.1016\/j.bbrc.2026.153322_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12061262","article-title":"Obesity, metabolic syndrome, and osteoarthritis require integrative understanding and management","volume":"12","author":"Mocanu","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2026.153322_bib106","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41413-023-00301-9","article-title":"Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms","volume":"11","author":"Wei","year":"2023","journal-title":"Bone Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib107","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12967-025-06310-y","article-title":"Multi-omics analysis of synovial tissue and fluid reveals differentially expressed proteins and metabolites in osteoarthritis","volume":"23","author":"Ge","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib108","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10067-023-06742-1","article-title":"Role of lipid metabolism gene KLF4 in osteoarthritis","volume":"43","author":"Hu","year":"2023","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.bbrc.2026.153322_bib109","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1007\/s11010-025-05279-y","article-title":"The interplay between autophagy and programmed cell death in osteoarthritis: insights into mechanisms and therapeutic targets","volume":"480","author":"Wang","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2026.153322_bib110","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jocd.2022.08.002","article-title":"Inflammation and bone turnover markers in adult obesity","volume":"25","author":"Yerlikaya","year":"2022","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bbrc.2026.153322_bib111","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13018-025-05588-4","article-title":"Three signalling pathways for iron overload in osteoporosis: a narrative review","volume":"20","author":"Zou","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib112","article-title":"The role of lipid metabolism in osteoporosis: clinical implication and cellular mechanism","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2026.153322_bib113","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/metabo15050301","article-title":"Gut microbiota modulation in osteoporosis: probiotics, prebiotics, and natural compounds","volume":"15","author":"Chu","year":"2025","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrc.2026.153322_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1420325","article-title":"Mechanosensitivity of macrophage polarization: comparing small molecule leukadherin-1 to substrate stiffness","volume":"16","author":"Joshi","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib115","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202505061","article-title":"Micromotion\u2010driven \u201cMechanical\u2010Electrical\u2010Pharmaceutical Coupling\u201d bone\u2010guiding membrane modulates stress\u2010concentrating inflammation under diabetic fractures","volume":"37","author":"Sui","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib116","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/cells10030663","article-title":"Piezo1 channels contribute to the regulation of human atrial fibroblast mechanical properties and matrix stiffness sensing","volume":"10","author":"Emig","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.153322_bib117","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153322_bib118","doi-asserted-by":"crossref","first-page":"135","DOI":"10.34133\/bmr.0135","article-title":"A mechanically stimulated Co-culture in 3-Dimensional composite scaffolds promotes osteogenic and anti-osteoclastogenic activity and M2 macrophage polarization","volume":"29","author":"Kontogianni","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib119","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biomaterials.2018.04.035","article-title":"FAK- and YAP\/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds","volume":"171","author":"Wan","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.153322_bib120","article-title":"Heterogeneous responses to mechanical force of prostate cancer cells inducing different metastasis patterns","volume":"7","author":"Liu","year":"2020","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153322_bib121","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.actbio.2018.02.015","article-title":"Macrophage involvement affects matrix stiffness-related influences on cell osteogenesis under three-dimensional culture conditions","volume":"71","author":"He","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.153322_bib122","article-title":"Immunity in motion: the role of mechanics in macrophage biology","volume":"S2451\u20139456","author":"Khanmohammadi","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib123","doi-asserted-by":"crossref","DOI":"10.21037\/aoj-25-12","article-title":"Subchondral bone contribution to osteochondral health and injury","volume":"10","author":"H\u00f6ger","year":"2025","journal-title":"Annals of Joint"},{"key":"10.1016\/j.bbrc.2026.153322_bib124","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13075-025-03609-5","article-title":"Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice","volume":"27","author":"Fukuda","year":"2025","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib125","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1186\/s13018-025-06259-0","article-title":"Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4\/Stat5b\/NF-\u03baB signaling to alleviate osteoarthritis progression","volume":"20","author":"Jiang","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib126","doi-asserted-by":"crossref","DOI":"10.1186\/ar2099","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib127","doi-asserted-by":"crossref","first-page":"113","DOI":"10.31083\/j.fbl2903113","article-title":"Is osteoarthritis a vascular disease?","volume":"29","author":"Aaron","year":"2024","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"10.1016\/j.bbrc.2026.153322_bib128","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/s13287-025-04659-x","article-title":"The crosstalk among macrophages, chondrocytes and mesenchymal stem cells in osteoarthritis: the role of extracellular vesicles","volume":"16","author":"Kong","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109827","article-title":"Osteoclast-derived exosomal miR-212-3p suppressed the anabolism and accelerated the catabolism of chondrocytes in osteoarthritis by targeting TGF-\u03b21\/Smad 2 signaling","volume":"751","author":"Dai","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2026.153322_bib130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41392-025-02136-8","article-title":"Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis","volume":"10","author":"Liu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib131","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.3389\/fimmu.2019.02588","article-title":"Spatial distribution of macrophages during callus formation and maturation reveals close crosstalk between macrophages and newly forming vessels","volume":"10","author":"Stefanowski","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib132","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.2147\/JIR.S502604","article-title":"Crosstalk between H-Type vascular endothelial cells and macrophages: a potential regulator of bone homeostasis","volume":"18","author":"Fan","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib133","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1186\/s12951-024-02977-5","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib134","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1598022","article-title":"Macrophage polarization in disease therapy: insights from astragaloside IV and cycloastragenol","volume":"16","author":"Xiong","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib135","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301243","article-title":"A cyclodextrin\u2010based ph-responsive MicroRNA delivery platform targeting polarization of M1 to M2 macrophages for sepsis therapy","volume":"12","author":"Ding","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149455","article-title":"Clotrimazole reverses macrophage M2 polarization by disrupting the PI3K\/AKT\/mTOR pathway","volume":"696","author":"Nascimento J\u00fanior","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153322_bib137","article-title":"Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPAR\u03b3 dependent manner","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib138","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/2211-5463.13089","article-title":"Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma","volume":"11","author":"Jiang","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbrc.2026.153322_bib139","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00011-024-01853-0","article-title":"Tricarboxylic acid cycle metabolites: new players in macrophage","volume":"73","author":"Yang","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2025.106974","article-title":"Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension","volume":"272","author":"Chen","year":"2025","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbrc.2026.153322_bib141","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1469163","article-title":"Branched-chain amino acid catabolism promotes M2 macrophage polarization","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156709","article-title":"Natural alkaloids modulating macrophage polarization: innovative therapeutic strategies for inflammatory, cardiovascular, and cancerous diseases","volume":"141","author":"Lu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.153322_bib143","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1584035","article-title":"Natural saponins and macrophage polarization: mechanistic insights and therapeutic perspectives in disease management","volume":"16","author":"Xiong","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib144","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s40820-024-01455-9","article-title":"Nanomaterial-based repurposing of macrophage metabolism and its applications","volume":"16","author":"Meng","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.bbrc.2026.153322_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156043","article-title":"Shikonin ameliorated LPS-induced acute lung injury in mice via modulating MCU-mediated mitochondrial Ca2+ and macrophage polarization","volume":"135","author":"Bao-Yuan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.153322_bib146","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fimmu.2020.00151","article-title":"Estrogen receptor, inflammatory, and FOXO transcription factors regulate expression of myasthenia gravis-associated circulating microRNAs","volume":"11","author":"Fiorillo","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112466","article-title":"Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease","volume":"137","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2026.153322_bib148","doi-asserted-by":"crossref","first-page":"28433","DOI":"10.1074\/jbc.M114.599316","article-title":"Regulation of activation-associated MicroRNA accumulation rates during monocyte-to-macrophage differentiation","volume":"289","author":"Eigsti","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153322_bib149","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12951-023-01855-w","article-title":"Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X\/NLRP3 axis","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103016","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis mediated metabolic reprogramming of macrophages","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib151","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cbf.3679","article-title":"Advances on biological functions of exosomal non\u2010coding RNAs in osteoarthritis","volume":"40","author":"Chen","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bbrc.2026.153322_bib152","article-title":"Role of mesenchymal stem cell-derived exosomal non-coding RNAs in bone and bone-related disorders","volume":"17","author":"Chidambaram","year":"2025","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.bbrc.2026.153322_bib153","article-title":"Hypoxia induced changes of exosome cargo and subsequent biological effects","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156750","article-title":"Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis","volume":"141","author":"Tu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.153322_bib155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12951-024-02336-4","article-title":"M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis","volume":"22","author":"Qian","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib156","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12916-023-02778-x","article-title":"Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p\/Stat1 pathway","volume":"21","author":"Ning","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.bbrc.2026.153322_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.121998","article-title":"Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional recovery","volume":"294","author":"Xu","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.153322_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121003","article-title":"Role of circular RNA cdr1as in modulation of macrophage phenotype","volume":"309","author":"Gonzalez","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib159","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.7150\/ijbs.114222","article-title":"Decoding the tumor microenvironment: Exosome-mediated macrophage polarization and therapeutic frontiers","volume":"21","author":"Li","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib160","doi-asserted-by":"crossref","first-page":"32479","DOI":"10.1074\/jbc.M112.358226","article-title":"An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion","volume":"287","author":"Miyamoto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153322_bib161","article-title":"H3K36me3\u2010Guided m6A modification of oncogenic L1CAM\u2010AS1 drives macrophage polarization and immunotherapy resistance in hepatocellular carcinoma","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153322_bib162","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1054938","article-title":"Engineered M2a macrophages for the treatment of osteoarthritis","volume":"13","author":"Liang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114457","article-title":"Perspectives of exosomal ncRNAs in the treatment of bone metabolic diseases: focusing on osteoporosis, osteoarthritis, and rheumatoid arthritis","volume":"446","author":"Qiu","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib164","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","article-title":"Tissue macrophages: origin, heterogeneity, biological functions, diseases and therapeutic targets","volume":"10","author":"Guan","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib165","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.613116","article-title":"Non-genetic heterogeneity of macrophages in diseases\u2014A medical perspective","volume":"8","author":"Gessain","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153322_bib166","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1007\/s12272-016-0820-y","article-title":"Diverse macrophages polarization in tumor microenvironment","volume":"39","author":"Rhee","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.bbrc.2026.153322_bib167","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202100116","article-title":"Macrophage polarization as a facile strategy to enhance efficacy of macrophage membrane\u2010coated nanoparticles in osteoarthritis","volume":"2","author":"Teo","year":"2022","journal-title":"Small Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib168","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3390\/v16101563","article-title":"The role of macrophages in airway disease focusing on porcine reproductive and respiratory syndrome virus and the treatment with antioxidant nanoparticles","volume":"16","author":"Choi","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.bbrc.2026.153322_bib169","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.3390\/ijms24065355","article-title":"Metformin attenuates the inflammatory response via the regulation of synovial M1 macrophage in osteoarthritis","volume":"24","author":"Zheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153322_bib170","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jconrel.2025.02.005","article-title":"Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1\/M2 balance for osteoarthritis therapy","volume":"380","author":"Chen","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bbrc.2026.153322_bib171","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000525753","article-title":"Interferon regulatory factor 4 (IRF4) promotes lipopolysaccharide-induced colonic mucosal epithelial cell proliferation by regulating macrophage polarization","volume":"63","author":"Hu","year":"2022","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib172","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-7613(02)00449-1","article-title":"SOCS-1 participates in negative regulation of LPS responses","volume":"17","author":"Nakagawa","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.153322_bib173","first-page":"78","article-title":"Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4\/JAK\/STAT signaling pathway mediated macrophage M2 polarization","volume":"37","author":"Liu","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbrc.2026.153322_bib174","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.joca.2021.04.006","article-title":"Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization","volume":"29","author":"Xie","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbrc.2026.153322_bib175","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1021\/acsbiomaterials.3c01833","article-title":"M2 macrophage-derived extracellular vesicles encapsulated in hyaluronic acid alleviate osteoarthritis by modulating macrophage polarization","volume":"10","author":"Yuan","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bbrc.2026.153322_bib176","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709178","article-title":"New insights from single-cell sequencing data: synovial fibroblasts and synovial macrophages in rheumatoid arthritis","volume":"12","author":"Cheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib177","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.2147\/IJN.S417422","article-title":"Current knowledge and future perspectives of exosomes as nanocarriers in diagnosis and treatment of diseases","volume":"18","author":"Zou","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2026.153322_bib178","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1021\/acsbiomaterials.4c00856","article-title":"Engineering approaches for exosome cargo loading and targeted delivery: biological versus chemical perspectives","volume":"10","author":"Ahmed","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bbrc.2026.153322_bib179","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1007\/s12274-022-5275-5","article-title":"Native and engineered exosomes for inflammatory disease","volume":"16","author":"Ma","year":"2022","journal-title":"Nano Res."},{"key":"10.1016\/j.bbrc.2026.153322_bib180","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202101741","article-title":"Bone\u2010a\u2010Petite: engineering exosomes towards bone, osteochondral, and cartilage repair","volume":"17","author":"Bei","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.bbrc.2026.153322_bib181","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.2147\/IJN.S444582","article-title":"Engineered exosome for drug delivery: recent development and clinical applications","volume":"18","author":"Tian","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2026.153322_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2025.115522","article-title":"Breaking barriers in targeted therapy: advancing exosome isolation, Engineering, and imaging","volume":"218","author":"Kostyusheva","year":"2025","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrc.2026.153322_bib183","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biomaterials.2016.10.006","article-title":"Convective exosome-tracing microfluidics for analysis of cell-non-autonomous neurogenesis","volume":"112","author":"Oh","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.153322_bib184","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13287-025-04288-4","article-title":"The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration","volume":"16","author":"Dalle Carbonare","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153322_bib185","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12951-024-02593-3","article-title":"Mussel-inspired immunomodulatory and osteoinductive dual-functional hydroxyapatite nanoplatform for promoting bone regeneration","volume":"22","author":"Qin","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.153322_bib186","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1344697","article-title":"The potential role of hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization","volume":"14","author":"An","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153322_bib187","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1096\/fj.201902055R","article-title":"Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB\/BDNF\/TrkB signaling pathway","volume":"34","author":"Bi","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2026.153322_bib188","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1021\/nn4036014","article-title":"Selective nanovector mediated treatment of activated proinflammatory microglia\/macrophages in spinal cord injury","volume":"7","author":"Papa","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbrc.2026.153322_bib189","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400770","article-title":"Metabolic control during macrophage polarization by a citrate\u2010functionalized scaffold for maintaining bone homeostasis","volume":"13","author":"Wu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2026.153322_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136580","article-title":"PAARH promotes M2 macrophage polarization and immune evasion of liver cancer cells through VEGF protein","volume":"281","author":"Lu","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:10:02Z","timestamp":1773987002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":190,"alternative-id":["S0006291X26000860"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153322","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153322"}}