{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:16:22Z","timestamp":1774005382841,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010251","name":"Youth Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB215001"],"award-info":[{"award-number":["20224ACB215001"]}],"id":[{"id":"10.13039\/501100010251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["S20258619"],"award-info":[{"award-number":["S20258619"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022957","name":"Double Thousand Plan of Jiangxi Province","doi-asserted-by":"publisher","award":["jxsq2023201122"],"award-info":[{"award-number":["jxsq2023201122"]}],"id":[{"id":"10.13039\/100022957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012259","name":"Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20204BCJL23043"],"award-info":[{"award-number":["20204BCJL23043"]}],"id":[{"id":"10.13039\/501100012259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021183","name":"Science Fund for Distinguished Young Scholars of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370896"],"award-info":[{"award-number":["32370896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900597"],"award-info":[{"award-number":["31900597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560418"],"award-info":[{"award-number":["82560418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbrc.2026.153339","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:42:37Z","timestamp":1769042557000},"page":"153339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Simetryn induces arteriovenous malformations in zebrafish embryos through activation of Erk signaling"],"prefix":"10.1016","volume":"804","author":[{"given":"Zhonghao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weitao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingrong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-1933","authenticated-orcid":false,"given":"Sizhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-4996","authenticated-orcid":false,"given":"Zigang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153339_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.det.2022.06.012","article-title":"Arteriovenous malformations","volume":"40","author":"AlShamekh","year":"2022","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.bbrc.2026.153339_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22169037","article-title":"Arteriovenous malformations-current understanding of the pathogenesis with implications for treatment","volume":"22","author":"Schimmel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153339_bib3","article-title":"Genotypes and phenotypes of capillary malformation-arteriovenous malformation: characterization and correlation analysis","author":"Chen","year":"2024","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.bbrc.2026.153339_bib4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/cvr\/cvv264","article-title":"Arteriovenous malformations in hereditary haemorrhagic telangiectasia: looking beyond ALK1-NOTCH interactions","volume":"109","author":"Peacock","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2026.153339_bib5","first-page":"195","article-title":"Hereditary haemorrhagic telangiectasia","volume":"53","author":"Rimmer","year":"2015","journal-title":"Rhinology"},{"key":"10.1016\/j.bbrc.2026.153339_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtha.2024.07.013","article-title":"Targeted treatments for vascular malformations: current state of the art","author":"Seront","year":"2024","journal-title":"J. Thromb. Haemostasis : JTH"},{"key":"10.1016\/j.bbrc.2026.153339_bib7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/jth.15715","article-title":"A precision medicine approach to hereditary hemorrhagic telangiectasia and complex vascular anomalies","volume":"20","author":"Al-Samkari","year":"2022","journal-title":"J. Thromb. Haemostasis : JTH"},{"key":"10.1016\/j.bbrc.2026.153339_bib8","doi-asserted-by":"crossref","DOI":"10.1242\/dev.201820","article-title":"rasa1-related arteriovenous malformation is driven by aberrant venous signalling","volume":"150","author":"Greysson-Wong","year":"2023","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.bbrc.2026.153339_bib9","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1172\/JCI67084","article-title":"RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity","volume":"124","author":"Kawasaki","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.153339_bib10","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/hmg\/ddy218","article-title":"Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly","volume":"27","author":"Li","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2026.153339_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41392-023-01571-9","article-title":"Temporospatial inhibition of Erk signaling is required for lymphatic valve formation","volume":"8","author":"Meng","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153339_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0006-8993(89)91071-8","article-title":"A model of the pathophysiology of cerebral arteriovenous malformations by a carotid-jugular fistula in the rat","volume":"496","author":"Morgan","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2026.153339_bib13","article-title":"Advances in the study of heart development and disease using zebrafish","volume":"3","author":"Brown","year":"2016","journal-title":"J. Cardiovas. Develop. Dis."},{"key":"10.1016\/j.bbrc.2026.153339_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fped.2018.00183","article-title":"Zebrafish as a model for drug screening in genetic kidney diseases","volume":"6","author":"Gehrig","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bbrc.2026.153339_bib15","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006684","article-title":"Vascular development in the zebrafish","volume":"2","author":"Gore","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbrc.2026.153339_bib16","doi-asserted-by":"crossref","first-page":"9840","DOI":"10.1038\/s41598-018-27791-6","article-title":"Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development","volume":"8","author":"Karthik","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153339_bib17","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"118","article-title":"Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration","author":"Cao","year":"2021"},{"key":"10.1016\/j.bbrc.2026.153339_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/1947-2714.100998","article-title":"Western blot: technique, theory, and trouble shooting","volume":"4","author":"Mahmood","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2026.153339_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.semcdb.2014.04.037","article-title":"Angiogenesis in zebrafish","volume":"31","author":"Schuermann","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153339_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/dbio.2000.9995","article-title":"The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development","volume":"230","author":"Isogai","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153339_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2011.06.037","article-title":"Neurovascular development in the embryonic zebrafish hindbrain","volume":"357","author":"Ulrich","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153339_bib22","first-page":"2070","article-title":"Development of the larval lymphatic system in zebrafish","volume":"144","author":"Jung","year":"2017","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.bbrc.2026.153339_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.sempedsurg.2014.07.005","article-title":"Arteriovenous malformations","volume":"23","author":"Uller","year":"2014","journal-title":"Semin. Pediatr. Surg."},{"key":"10.1016\/j.bbrc.2026.153339_bib24","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006635","article-title":"Arteriovenous malformations and other vascular malformation syndromes","volume":"3","author":"Whitehead","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbrc.2026.153339_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s10456-024-09934-8","article-title":"Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition","author":"Kapp","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbrc.2026.153339_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2025.07.033","article-title":"Trametinib treatment for early-stage extracranial arteriovenous malformations: a multicenter, prospective, single-arm pilot study","author":"Sun","year":"2025","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:08:22Z","timestamp":1773997702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26001038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":26,"alternative-id":["S0006291X26001038"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153339","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simetryn induces arteriovenous malformations in zebrafish embryos through activation of Erk signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153339"}}