{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:55:01Z","timestamp":1788360901738,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFBA069425"],"award-info":[{"award-number":["2025GXNSFBA069425"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260715"],"award-info":[{"award-number":["82260715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbrc.2026.153380","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:21:24Z","timestamp":1769790084000},"page":"153380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Deep learning predicts and in vitro experiments validates the synergistic anti-liver cancer effect of vincristine and lenvatinib: Mechanism involving apoptosis induction via the TNF-\u03b1\/Caspase-8 pathway"],"prefix":"10.1016","volume":"805","author":[{"given":"Wenbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8106-2284","authenticated-orcid":false,"given":"Manqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-4758","authenticated-orcid":false,"given":"Lichuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153380_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024, CA A","volume":"74","author":"Siegel","year":"2024","journal-title":"Cancer J Clinicians"},{"key":"10.1016\/j.bbrc.2026.153380_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ctrv.2018.11.002","article-title":"Updated use of TACE for hepatocellular carcinoma treatment: how and when to use it based on clinical evidence","volume":"72","author":"Raoul","year":"2019","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.bbrc.2026.153380_bib3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","article-title":"Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial","volume":"391","author":"Kudo","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2026.153380_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/hepr.13243","volume":"49","author":"Hiraoka","year":"2019","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.bbrc.2026.153380_bib5","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1158\/0008-5472.CAN-21-4140","article-title":"Inhibition of EGFR overcomes acquired lenvatinib resistance driven by STAT3\u2013ABCB1 signaling in hepatocellular carcinoma","volume":"82","author":"Hu","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2026.153380_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001474","article-title":"NEK7-induced phosphorylation of EGFR on serine 1070 drives the acquired lenvatinib resistance in hepatocellular carcinoma","author":"Huang","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.153380_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13046-025-03386-8","article-title":"Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications","volume":"44","author":"Zhao","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2026.153380_bib8","article-title":"DNMT2-m5C-ACLY axis promotes lenvatinib resistance in hepatocellular carcinoma through histone acetylation-mediated notch pathway","author":"Yang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153380_bib9","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41419-025-08250-3","article-title":"Targeting CREB3L2-mediated lipid metabolism overcomes lenvatinib resistance and attenuates the progression of hepatocellular carcinoma","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.153380_bib10","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/s41388-025-03371-7","article-title":"Syntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma","volume":"44","author":"Zhang","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2026.153380_bib11","article-title":"The MASTL\/YBX1\/PAK4 axis regulated by stress-activated STK24 triggers lenvatinib resistance and tumor progression in HCC","author":"Liang","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.153380_bib12","article-title":"Targeting STARD4\/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma","volume":"12","author":"Liu","year":"2025","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2026.153380_bib13","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s11831-021-09617-3","article-title":"A comprehensive review on deep synergistic drug prediction techniques for cancer","volume":"29","author":"Kumar","year":"2022","journal-title":"Arch. Comput. Methods Eng."},{"key":"10.1016\/j.bbrc.2026.153380_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad177","article-title":"MARSY: a multitask deep-learning framework for prediction of drug combination synergy scores","volume":"39","author":"El Khili","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2026.153380_bib15","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1109\/TCBB.2021.3086702","article-title":"MatchMaker: a deep learning framework for drug synergy prediction","volume":"19","author":"Kuru","year":"2022","journal-title":"IEEE ACM Trans. Comput. Biol. Bioinf"},{"key":"10.1016\/j.bbrc.2026.153380_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1026045100219","article-title":"Antimicrotubular drugs binding to vinca domain of tubulin","volume":"253","author":"Gupta","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2026.153380_bib17","doi-asserted-by":"crossref","unstructured":"M. Chintagumpala S.P. Eckel M. Krailo M. Morris A. Adesina R. Packer C. Lau A. Gajjar. A Pilot study using carboplatin, vincristine, and temozolomide in children with progressive\/symptomatic low-grade glioma: a children's oncology group study\u2020 | Neuro-oncol. 2015;17(8):1132-8. doi: 10.1093\/neuonc\/nov057.","DOI":"10.1093\/neuonc\/nov057"},{"key":"10.1016\/j.bbrc.2026.153380_bib18","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.transproceed.2005.03.024","article-title":"Successful treatment of liver transplant-associated kaposi's sarcoma with long-term vincristine","volume":"37","author":"Akay","year":"2005","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.bbrc.2026.153380_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/bcp.13126","article-title":"Microtubule destabilising agents: far more than just antimitotic anticancer drugs","volume":"83","author":"Bates","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153380_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115466","article-title":"Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib","volume":"44","author":"Xie","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.153380_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114454","article-title":"UPLC-TOF-MS\/MDF oriented isolation of calonyctins K-R: Resin glycosides from ipomoea muricata with cytotoxic and multidrug resistance reversal activities","volume":"235","author":"Li","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bbrc.2026.153380_bib22","article-title":"Overcoming multidrug resistance in cancer cells targeting ABC transporter ABCB1 with tyrosine kinase inhibitor: olverembatinib","volume":"455","author":"Zhang","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2026.153380_bib23","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/bioinformatics\/btt105","article-title":"ChemoPy: freely available python package for computational biology and chemoinformatics","volume":"29","author":"Cao","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2026.153380_bib24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153380_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1137\/S0895480102412856","article-title":"Comparing top k lists","volume":"17","author":"Fagin","year":"2003","journal-title":"SIAM J. Discrete Math."},{"key":"10.1016\/j.bbrc.2026.153380_bib26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","article-title":"Searching for drug synergy in complex dose\u2013response landscapes using an interaction potency model","volume":"13","author":"Yadav","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.bbrc.2026.153380_bib27","doi-asserted-by":"crossref","first-page":"W488","DOI":"10.1093\/nar\/gkaa216","article-title":"SynergyFinder 2.0: visual analytics of multi-drug combination synergies","volume":"48","author":"Ianevski","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153380_bib30","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","article-title":"Oxidative cell death in cancer: mechanisms and therapeutic opportunities","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.153380_bib31","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1096\/fj.08-111005","article-title":"Life and death by death receptors","volume":"23","author":"Guicciardi","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2026.153380_bib32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-Dependent formation of Apaf-1\/Caspase-9 complex initiates an apoptotic protease Cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153380_bib33","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1111\/jcmm.14949","article-title":"SIRT3, PP2A and TTP protein stability in the presence of TNF\u2010\u03b1 on vincristine\u2010induced apoptosis of leukaemia cells","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153380_bib34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41419-022-05537-7","article-title":"TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.153380_bib35","article-title":"Mitochondria and tumorigenesis: molecular basis and therapeutic implications","volume":"13","author":"Huang","year":"2026","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2026.153380_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153380_bib37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:54:12Z","timestamp":1773996852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26001440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"alternative-id":["S0006291X26001440"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153380","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep learning predicts and in vitro experiments validates the synergistic anti-liver cancer effect of vincristine and lenvatinib: Mechanism involving apoptosis induction via the TNF-\u03b1\/Caspase-8 pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153380"}}