{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:34:34Z","timestamp":1789785274353,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014743","name":"Jaypee University of Information Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbrc.2026.153414","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:02:16Z","timestamp":1770624136000},"page":"153414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Response surface methodology based Box-Behnken Design for statistical optimization of Curcuma caesia mediated copper oxide nanoparticles synthesis"],"prefix":"10.1016","volume":"807","author":[{"given":"Sakshi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-7541","authenticated-orcid":false,"given":"Saurabh","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153414_bib1","first-page":"617","volume":"3","author":"Szab\u00f3","year":"2011"},{"key":"10.1016\/j.bbrc.2026.153414_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-8258.111590","article-title":"Pharmacological activities of Curcuma caesia","volume":"7","author":"Baghel","year":"2013","journal-title":"Int. J. Green Pharm."},{"key":"10.1016\/j.bbrc.2026.153414_bib3","first-page":"65","article-title":"Curcuma longa and curcumin: a review article","volume":"55","author":"Akram","year":"2010","journal-title":"Rom. J. Biol. Plant Biol."},{"key":"10.1016\/j.bbrc.2026.153414_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2023.116363","article-title":"Endangered Curcuma caesia Roxb.: qualitative and quantitative analysis for identification of industrially important elite genotypes","volume":"195","author":"Benya","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.bbrc.2026.153414_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.17635","article-title":"Synthesis and characterization of turmeric extract-\u03b2-cyclodextrin inclusion complexes: metabolite profiling and antioxidant activity","volume":"90","author":"Reddy","year":"2025","journal-title":"J. Food Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib6","first-page":"1354","article-title":"Medicinal properties of turmeric (Curcuma longa L.): a review","volume":"6","author":"Verma","year":"2018","journal-title":"Int. J. Chem. Stud."},{"key":"10.1016\/j.bbrc.2026.153414_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/7006565","article-title":"A comprehensive review with future prospects on the medicinal properties and biological activities of Curcuma caesia roxb","volume":"2023","author":"Ibrahim","year":"2023","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.bbrc.2026.153414_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.indcrop.2018.12.035","article-title":"Chemical composition, antioxidant, anti-inflammatory, anti-microbial and in-vitro cytotoxic efficacy of essential oil of Curcuma caesia Roxb. leaves: an endangered medicinal plant of North East India","volume":"129","author":"Borah","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.bbrc.2026.153414_bib9","first-page":"50","article-title":"The healing powers of curcuma caesia: traditional uses and modern perspectives","volume":"8","author":"Spoorti","year":"2025","journal-title":"Int. Res. J. of Pha. and Med. Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: a review of its effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"10.1016\/j.bbrc.2026.153414_bib11","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/ijc.24967","article-title":"The dark side of curcumin","volume":"126","author":"Burgos\u2010Mor\u00f3n","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2026.153414_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2023.100668","article-title":"Inclusion complex of turmeric essential oil with hydroxypropyl-\u03b2-cyclodextrin: preparation, characterization and release kinetics","volume":"8","author":"Qiang","year":"2024","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib13","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/ptr.7794","article-title":"Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets","volume":"37","author":"Ghobadi","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/JEP.S427818","article-title":"Investigating bioavailability of curcumin and piperine combination in comparison to turmeric rhizomes: an in vitro study","volume":"16","author":"Pratti","year":"2024","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153414_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/ijar.ijar_30_24","article-title":"Preparation, evaluation, and in vitro studies of sustained-release topical hydrogel of Curcuma longa L. targeting skin disorders","volume":"5","author":"Narwaria","year":"2024","journal-title":"Int. J. Ayurveda Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib16","first-page":"9","article-title":"Review on phytosomes: an innovative method of medication administration","volume":"84","author":"Yadav","year":"2024","journal-title":"Int. J. Pharmaceut. Sci. Rev. Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib17","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in drug delivery: progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer"},{"key":"10.1016\/j.bbrc.2026.153414_bib18","doi-asserted-by":"crossref","DOI":"10.1021\/acs.molpharmaceut.2c00983","article-title":"Co-administration of intravenous drugs: rapidly troubleshooting the solid form composition of a precipitate in a multi-drug mixture using On-Site raman spectroscopy","volume":"20","author":"Nilsson","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbrc.2026.153414_bib19","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.3390\/nano12224073","article-title":"Improved activity of herbal medicines through nanotechnology","volume":"12","author":"Dewi","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bbrc.2026.153414_bib20","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.3390\/ijms25115842","article-title":"Nanoformulations in pharmaceutical and biomedical applications: green perspectives","volume":"25","author":"Petrovic","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2022.102336","article-title":"Green synthesis of nanoparticles: current developments and limitations","volume":"26","author":"Ying","year":"2022","journal-title":"Environ. Technol. Innov."},{"key":"10.1016\/j.bbrc.2026.153414_bib22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/02726351.2023.2281452","article-title":"Green synthesis: an eco-friendly approach for metallic nanoparticles synthesis","volume":"42","author":"Kandav","year":"2024","journal-title":"Part. Sci. Technol."},{"key":"10.1016\/j.bbrc.2026.153414_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.22159\/ijcpr.2021v13i2.41556","article-title":"Overview on methods of synthesis of nanoparticles","author":"Patil","year":"2021","journal-title":"Int. J. Curr. Pharmaceut. Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1080\/21691401.2019.1577878","article-title":"Advances in green synthesis of nanoparticles","volume":"47","author":"Gour","year":"2019","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.153414_bib25","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.matpr.2021.04.564","article-title":"Green synthesis of nanomaterials: an overview","volume":"47","author":"Aarthye","year":"2021","journal-title":"Mater. Today Proc."},{"key":"10.1016\/j.bbrc.2026.153414_bib26","series-title":"Advances in Nano-fertilizers and Nano-pesticides in Agriculture","first-page":"459","article-title":"Economic considerations and limitations of green synthesis vs chemical synthesis of nanomaterials","author":"Kulkarni","year":"2021"},{"key":"10.1016\/j.bbrc.2026.153414_bib27","series-title":"Presented at the Proceedings of the 1st International Conference on Mechanical Engineering and Applied Science (ICMEAS 2017)","article-title":"Limitations and possibilities of green synthesis and long-term stability of colloidal Ag nanoparticles","author":"Velgosov\u00e1","year":"2017"},{"key":"10.1016\/j.bbrc.2026.153414_bib28","doi-asserted-by":"crossref","first-page":"28155","DOI":"10.1039\/D5RA03940A","volume":"15","author":"Islam","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrc.2026.153414_bib29","article-title":"Using large datasets to understand nanotechnology","volume":"31","author":"Paunovska","year":"2019","journal-title":"Adv. Mater. Deerfield Beach Fla"},{"key":"10.1016\/j.bbrc.2026.153414_bib30","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.190896","article-title":"Application of statistical design to evaluate critical process parameters and optimize formulation technique of polymeric nanoparticles","volume":"6","author":"Sarkar","year":"2019","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102512","article-title":"Antimicrobial susceptibility testing to evaluate minimum inhibitory concentration values of clinically relevant antibiotics","volume":"4","author":"Barnes V","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbrc.2026.153414_bib32","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically","first-page":"12","author":"Zimmer","year":"2024"},{"key":"10.1016\/j.bbrc.2026.153414_bib33","first-page":"105","article-title":"The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against Staphylococcus aureus","volume":"7","author":"Parvekar","year":"2020","journal-title":"Biomater. Investig. Dent."},{"key":"10.1016\/j.bbrc.2026.153414_bib34","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.1021\/jf071291z","article-title":"A new procedure to measure the antioxidant activity of insoluble food components","volume":"55","author":"Serpen","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.153414_bib35","first-page":"8","article-title":"In-vitro and ex-vivo studies on the antioxidant, anti-inflammatory and antiarthritic properties of camellia sinensis, hibiscus rosa sinensis, matricaria chamomilla, rosa sp., zingiber officinale tea extracts","volume":"9","author":"Singh","year":"2018","journal-title":"Int. J. Pharmaceut. Sci. Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11051-020-04903-w","article-title":"Sodium hexametaphosphate\u2013induced enhancement of silver nanoparticle toxicity towards leukemia cells","volume":"22","author":"Ocwieja","year":"2020","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.bbrc.2026.153414_bib37","article-title":"Green biosynthesis of silver nanoparticles using novel endophytic Rothia endophytica: characterization and anticandidal activity","volume":"62","author":"Elbahnasawy","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bbrc.2026.153414_bib38","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1021\/acsomega.1c05410","article-title":"In vivo analgesic, anti-inflammatory, and anti-diabetic screening of Bacopa monnieri -Synthesized copper oxide nanoparticles","volume":"7","author":"Faisal","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbrc.2026.153414_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/00401706.1960.10489912","article-title":"Some new three level designs for the study of quantitative variables","volume":"2","author":"Box","year":"1960","journal-title":"Technometrics"},{"key":"10.1016\/j.bbrc.2026.153414_bib40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/coatings11070849","article-title":"Curcuma longa mediated synthesis of copper oxide, nickel oxide and Cu-Ni bimetallic hybrid nanoparticles: characterization and evaluation for antimicrobial, anti-parasitic and cytotoxic potentials","volume":"11","author":"Faisal","year":"2021","journal-title":"Coatings"},{"key":"10.1016\/j.bbrc.2026.153414_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2023.104661","article-title":"Proximate composition and mineral content analysis of Curcuma caesia rhizome","volume":"109","author":"Bhardwaj","year":"2023","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.bbrc.2026.153414_bib42","article-title":"Easy and green synthesis of TiO2 (anatase and rutile): estimation of crystallite size using scherrer equation, williamson-hall plot, monshi-scherrer model, size-strain plot, Halder- wagner model","volume":"20","author":"Hossain","year":"2023","journal-title":"Results Mater."},{"key":"10.1016\/j.bbrc.2026.153414_bib43","first-page":"2089","article-title":"A physical chemistry study of black powder materials by solution combustion synthesis method, biology","volume":"10","author":"Hidayanti","year":"2021","journal-title":"Medicine & Natural ProductChemistry"},{"key":"10.1016\/j.bbrc.2026.153414_bib44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.17344\/acsi.2018.4877","article-title":"Vortex-assisted deep eutectic solvent-based liquid-liquid microextraction for the analysis of alkyl gallates in vegetable oils","volume":"66","author":"Cabuk","year":"2019","journal-title":"Acta Chim. Slov."},{"key":"10.1016\/j.bbrc.2026.153414_bib45","series-title":"National Chemical Laboratory","article-title":"Fungal mediated biotransformations of organic (carbonyl group) and inorganic compounds","author":"Mandal","year":"2003"},{"key":"10.1016\/j.bbrc.2026.153414_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/md13010141","article-title":"Does the use of chitosan contribute to oxalate kidney stone formation?","volume":"13","author":"Queiroz","year":"2025","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbrc.2026.153414_bib47","series-title":"IR Spectrum and Characteristic Absorption Bands","author":"Liu","year":"2021"},{"key":"10.1016\/j.bbrc.2026.153414_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2024.101719","article-title":"Fluorescent properties of chitosan-stabilized bisdemethoxycurcumin-silver nanoparticles: synthesis and characterization","volume":"10","author":"Ahmad","year":"2024","journal-title":"Results Chem."},{"key":"10.1016\/j.bbrc.2026.153414_bib49","article-title":"Infrared spectra of some common functional groups","author":"Farmer","year":"2025","journal-title":"Org. Chem."},{"key":"10.1016\/j.bbrc.2026.153414_bib50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/microorganisms11020369","article-title":"Silver nanoparticles: bactericidal and mechanistic approach against drug resistant pathogens","volume":"11","author":"More","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbrc.2026.153414_bib51","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3390\/pathogens10091187","article-title":"Oxidative stress response in Pseudomonas aeruginosa","volume":"10","author":"Da Cruz Nizar","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.bbrc.2026.153414_bib52","first-page":"1","article-title":"Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol. J Hematol. Oncol"},{"key":"10.1016\/j.bbrc.2026.153414_bib53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/microorganisms10010061","article-title":"Antimicrobials functioning through ROS-mediated mechanisms: current insights","volume":"10","author":"Vaishampayan","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbrc.2026.153414_bib54","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.3390\/pr11082248","article-title":"DPPH radical scavenging assay","volume":"11","author":"Gulcin","year":"2023","journal-title":"Processes"},{"key":"10.1016\/j.bbrc.2026.153414_bib55","series-title":"Nonsteroidal Anti-inflammatory Drugs (Nsaids), in StatPearls, Treasure Island (FL)","author":"Ghlichloo","year":"2025"},{"key":"10.1016\/j.bbrc.2026.153414_bib56","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2147\/IJN.S121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2026.153414_bib57","first-page":"15","article-title":"Zinc sulphate and nano-zinc oxide effects on some physiological parameters of rosmarinus officinalis","volume":"8","author":"Mohsenzaden","year":"2017","journal-title":"Am. J. Plant Sci."},{"key":"10.1016\/j.bbrc.2026.153414_bib58","series-title":"Xpharm: the Comprehensive Pharmacology Reference","first-page":"1","article-title":"Acarbose","author":"Furman","year":"2007"},{"key":"10.1016\/j.bbrc.2026.153414_bib59","series-title":"Coefficient of Determination (R2), Calculation & Interpretation","author":"Turney","year":"2025"},{"key":"10.1016\/j.bbrc.2026.153414_bib60","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1167\/iovs.12-10598","article-title":"The coefficient of determination: what determines a useful R 2 statistic?","volume":"53","author":"Saunders","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26001786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:09:23Z","timestamp":1782274163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26001786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":60,"alternative-id":["S0006291X26001786"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153414","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Response surface methodology based Box-Behnken Design for statistical optimization of Curcuma caesia mediated copper oxide nanoparticles synthesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153414","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153414"}}