{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:00:01Z","timestamp":1777622401307,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1808085QH277"],"award-info":[{"award-number":["1808085QH277"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2022AH050752"],"award-info":[{"award-number":["2022AH050752"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2025AHGXSK30094"],"award-info":[{"award-number":["2025AHGXSK30094"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801317"],"award-info":[{"award-number":["81801317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbrc.2026.153462","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:39:09Z","timestamp":1771000749000},"page":"153462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PACAP\/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway"],"prefix":"10.1016","volume":"808","author":[{"given":"Weipeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang'an","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-6973","authenticated-orcid":false,"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153462_bib1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153462_bib2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153462_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnana.2015.00093","article-title":"Central melanopsin projections in the diurnal rodent, Arvicanthis niloticus","volume":"9","author":"Langel","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbrc.2026.153462_bib4","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1113\/jphysiol.2013.262782","article-title":"Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells","volume":"592","author":"Zhao","year":"2014","journal-title":"J. Physiol-London"},{"key":"10.1016\/j.bbrc.2026.153462_bib5","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1038\/s41467-021-25378-w","article-title":"The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153462_bib6","doi-asserted-by":"crossref","first-page":"19998","DOI":"10.1073\/pnas.0808312105","article-title":"Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation","volume":"105","author":"Altimus","year":"2008","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2026.153462_bib7","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1081\/CBI-120026043","article-title":"Impaired masking responses to light in melanopsin-knockout mice","volume":"20","author":"Mrosovsky","year":"2003","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbrc.2026.153462_bib8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cne.20970","article-title":"Central projections of melanopsin-expressing retinal ganglion cells in the mouse","volume":"497","author":"Hattar","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbrc.2026.153462_bib9","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.peptides.2007.06.006","article-title":"PACAP: the road to discovery","volume":"28","author":"Arimura","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2026.153462_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054572","article-title":"Molecular and physiological functions of PACAP in sweat secretion","volume":"24","author":"Yamashita","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231169140","article-title":"Activation of the PACAP\/PAC1 signaling pathway accelerates the repair of impaired spatial memory caused by an ultradian light cycle","volume":"15","author":"Xu","year":"2023","journal-title":"Asn Neuro."},{"key":"10.1016\/j.bbrc.2026.153462_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2023.107792","article-title":"The functional heterogeneity of PACAP: stress, learning, and pathology","volume":"203","author":"Rajbhandari","year":"2023","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbrc.2026.153462_bib13","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad044","article-title":"Hypothalamic PACAP\/PAC1R involvement in feeding and body weight regulation","volume":"164","author":"Maunze","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2026.153462_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146981","article-title":"Altered circadian food anticipatory activity rhythms in PACAP receptor 1 (PAC1) deficient mice","volume":"11","author":"Hannibal","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153462_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168682","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) in physiological and pathological processes within the gastrointestinal tract: a review","volume":"22","author":"Karpiesiuk","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.732456","article-title":"PACAP-PAC1 signaling regulates serotonin 2A receptor internalization","volume":"12","author":"Hayata-Takano","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.153462_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s10194-018-0844-4","article-title":"PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache","volume":"19","author":"Holland","year":"2018","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.bbrc.2026.153462_bib18","article-title":"Differential effects of the stress peptides PACAP and CRF on sleep architecture in mice","author":"Foilb","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2026.153462_bib19","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s12031-022-01985-0","article-title":"Distribution of PACAP and PAC1 receptor in the human eye","volume":"72","author":"Patko","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153462_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1749-6632.2000.tb06959.x","article-title":"PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation","volume":"921","author":"Waschek","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1749-6632.1998.tb11175.x","article-title":"Mechanisms of pituitary adenylate cyclase activating polypeptide (PACAP)-induced depolarization of sympathetic superior cervical ganglion (SCG) neurons","volume":"865","author":"May","year":"1998","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/35010109","article-title":"Identification of sleep-promoting neurons in vitro","volume":"404","author":"Gallopin","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153462_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23062905","article-title":"The sleep-promoting ventrolateral preoptic nucleus: what have we learned over the past 25 years?","volume":"23","author":"Arrigoni","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbrc.2022.01.023","article-title":"Effects of light on the sleep-wakefulness cycle of mice mediated by intrinsically photosensitive retinal ganglion cells","volume":"592","author":"Wang","year":"2022","journal-title":"Biochem. Bioph. Res co."},{"key":"10.1016\/j.bbrc.2026.153462_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44358","article-title":"Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep","volume":"8","author":"Rupp","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2026.153462_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000125","article-title":"Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-\/-) mice","volume":"7","author":"Tsai","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrc.2026.153462_bib27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/0333102419893962","article-title":"Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: relation to migraine activated regions","volume":"40","author":"Warfvinge","year":"2020","journal-title":"Cephalalgia"},{"key":"10.1016\/j.bbrc.2026.153462_bib28","article-title":"Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations","volume":"10","author":"Zhang","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2026.153462_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13286","article-title":"Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP","volume":"35","author":"Bakalar","year":"2023","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbrc.2026.153462_bib30","article-title":"Relationships between constitutive and acute gene regulation, and physiological and behavioral responses, mediated by the neuropeptide PACAP","volume":"135","author":"Bakalar","year":"2022","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.bbrc.2026.153462_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.271.5246.216","article-title":"Activation of ventrolateral preoptic neurons during sleep","volume":"271","author":"Sherin","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153462_bib32","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1523\/JNEUROSCI.20-10-03830.2000","article-title":"Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep","volume":"20","author":"Lu","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153462_bib33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/smrv.2001.0170","article-title":"Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus","volume":"5","author":"McGinty","year":"2001","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.bbrc.2026.153462_bib34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature22350","article-title":"Identification of preoptic sleep neurons using retrograde labelling and gene profiling","volume":"545","author":"Chung","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153462_bib35","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1038\/s41467-018-06590-7","article-title":"Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice","volume":"9","author":"Kroeger","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153462_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098311","article-title":"Calcium dynamics of the ventrolateral preoptic GABAergic neurons during spontaneous sleep-waking and in response to homeostatic sleep demands","volume":"24","author":"Kostin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153462_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203395","article-title":"Divergent neural activity in the VLPO during anesthesia and sleep","volume":"10","author":"Luo","year":"2023","journal-title":"Adv. Sci."},{"issue":"11","key":"10.1016\/j.bbrc.2026.153462_bib38","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1523\/JNEUROSCI.22-11-04568.2002","article-title":"Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep","volume":"22","author":"Lu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153462_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231191016","article-title":"The alpha(2) adrenoceptor agonist and sedative\/anaesthetic dexmedetomidine excites diverse neuronal types in the ventrolateral preoptic area of Male mice","volume":"15","author":"Fan","year":"2023","journal-title":"Asn Neuro."},{"key":"10.1016\/j.bbrc.2026.153462_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00441-002-0574-3","article-title":"Neurotransmitters of the retino-hypothalamic tract","volume":"309","author":"Hannibal","year":"2002","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2026.153462_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00441-010-0950-3","article-title":"Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells","volume":"340","author":"Engelund","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2026.153462_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuron.2019.07.016","article-title":"Melanopsin and the intrinsically photosensitive retinal ganglion cells: biophysics to behavior","volume":"104","author":"Do","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2026.153462_bib43","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3389\/fnins.2019.01281","article-title":"Pituitary adenylate cyclase-activating peptide (PACAP)-glutamate Co-transmission drives circadian phase-advancing responses to intrinsically photosensitive retinal ganglion cell projections by suprachiasmatic nucleus","volume":"13","author":"Lindberg","year":"2019","journal-title":"Front. Neurosci.-Switz"},{"key":"10.1016\/j.bbrc.2026.153462_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-vision-100419-112009","article-title":"Feature detection by retinal ganglion cells","volume":"8","author":"Kerschensteiner","year":"2022","journal-title":"Annu. Rev. Vis. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26002263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26002263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:11:42Z","timestamp":1777414302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26002263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":44,"alternative-id":["S0006291X26002263"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153462","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PACAP\/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153462"}}