{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:40:24Z","timestamp":1793241624471,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K00099"],"award-info":[{"award-number":["25K00099"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K12417"],"award-info":[{"award-number":["24K12417"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K12310"],"award-info":[{"award-number":["24K12310"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K14085"],"award-info":[{"award-number":["23K14085"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K12808"],"award-info":[{"award-number":["24K12808"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"The Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008889","name":"Ube Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016983","name":"Yamaguchi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bbrc.2026.153591","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:25:43Z","timestamp":1773073543000},"page":"153591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Necrotic-cell\u2013activated macrophages drive an ERK\u2013Bcl-xL survival pathway in osteoclasts and confer bisphosphonate resistance"],"prefix":"10.1016","volume":"812","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-0777","authenticated-orcid":false,"given":"Kazuya","family":"Uehara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3169-4647","authenticated-orcid":false,"given":"Shunya","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-1352","authenticated-orcid":false,"given":"Kiminori","family":"Yukata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-3646","authenticated-orcid":false,"given":"Akihiko","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genta","family":"Togawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Imanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-2057","authenticated-orcid":false,"given":"Yukihiro","family":"Hitaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-3463","authenticated-orcid":false,"given":"Takashi","family":"Nawata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-8456","authenticated-orcid":false,"given":"Keiko","family":"Iwaisako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-9760","authenticated-orcid":false,"given":"Ryoji","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Asagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153591_bib1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2026.153591_bib2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1001\/jama.1960.03030080028005","article-title":"Avascular (aseptic) bone necrosis associated with systemic lupus erythematosus","volume":"174","author":"Dubois","year":"1960","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2026.153591_bib3","first-page":"100","article-title":"Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)","volume":"21","author":"Zhao","year":"2020","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbrc.2026.153591_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114403","article-title":"Suppression of apoptosis in osteocytes, the potential way of natural medicine in the treatment of osteonecrosis of the femoral head","volume":"162","author":"Meng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.153591_bib5","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2106\/JBJS.I.00575","article-title":"The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review","volume":"92","author":"Mont","year":"2010","journal-title":"J. Bone Joint Surg. Am"},{"key":"10.1016\/j.bbrc.2026.153591_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2023.04.005","article-title":"Application of biomaterials in treating early osteonecrosis of the femoral head: research progress and future perspectives","volume":"164","author":"Quan","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.153591_bib7","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.arth.2020.04.092","article-title":"Diagnosis of osteonecrosis of the femoral head: too little, too late, and independent of etiology","volume":"35","author":"Boontanapibul","year":"2020","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.bbrc.2026.153591_bib8","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/os.12979","article-title":"Difference in therapeutic strategies for joint-preserving surgery for non-traumatic osteonecrosis of the femoral head between the United States and Japan: a review of the literature","volume":"13","author":"Kuroda","year":"2021","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.bbrc.2026.153591_bib9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1302\/0301-620X.82B4.0820512","article-title":"Prediction of the outcome of transtrochanteric rotational osteotomy for osteonecrosis of the femoral head","volume":"82","author":"Miyanishi","year":"2000","journal-title":"J. Bone Joint Surg. Br"},{"key":"10.1016\/j.bbrc.2026.153591_bib10","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.arth.2023.03.071","article-title":"Trends in surgical management of osteonecrosis of the femoral head: a 2010 to 2020 nationwide study","volume":"38","author":"Ng","year":"2023","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.bbrc.2026.153591_bib11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.joca.2008.07.013","article-title":"The effects of alendronate in the treatment of experimental osteonecrosis of the hip in adult rabbits","volume":"17","author":"Hofstaetter","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbrc.2026.153591_bib12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.arth.2009.05.022","article-title":"Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea","volume":"24","author":"Kang","year":"2009","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.bbrc.2026.153591_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2024.1408343","article-title":"Incidence and risk factors for unplanned readmission after total hip arthroplasty for osteonecrosis of the femoral head","volume":"11","author":"Wang","year":"2024","journal-title":"Front. Surg."},{"key":"10.1016\/j.bbrc.2026.153591_bib14","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1007\/s11999-010-1292-x","article-title":"Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head","volume":"468","author":"Fukushima","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5435\/JAAOS-20-08-487","article-title":"Total hip arthroplasty in the very young patient","volume":"20","author":"Polkowski","year":"2012","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.bbrc.2026.153591_bib16","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.arth.2023.12.029","article-title":"Effect of patient age on total hip arthroplasty outcomes in patients who have osteonecrosis of the femoral head compared to patients who have hip osteoarthritis","volume":"39","author":"Zhang","year":"2024","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.bbrc.2026.153591_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11999-011-2050-4","article-title":"Which factors influence preservation of the osteonecrotic femoral head?","volume":"470","author":"Lieberman","year":"2012","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bmb\/ldab006","article-title":"Failure and progression to total hip arthroplasty among the treatments for femoral head osteonecrosis: a Bayesian network meta-analysis","volume":"138","author":"Migliorini","year":"2021","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbrc.2026.153591_bib19","first-page":"28","article-title":"Evolutionary course of the femoral head osteonecrosis: histopathological - radiologic characteristics and clinical staging systems","volume":"32","author":"Chen","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbrc.2026.153591_bib20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/416744a","article-title":"RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta","volume":"416","author":"Takayanagi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153591_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2026.153591_bib22","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jor.20802","article-title":"Distribution of TRAP-positive cells and expression of HIF-1alpha, VEGF, and FGF-2 in the reparative reaction in patients with osteonecrosis of the femoral head","volume":"27","author":"Li","year":"2009","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib23","article-title":"Bone microstructure and regional distribution of osteoblast and osteoclast activity in the osteonecrotic femoral head","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153591_bib24","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1172\/JCI134214","article-title":"Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin","volume":"130","author":"Andreev","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.153591_bib25","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1007\/s11999-015-4172-6","article-title":"Development of a mouse model of ischemic osteonecrosis","volume":"473","author":"Kamiya","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7150\/ijbs.18334","article-title":"Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse","volume":"14","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2026.153591_bib27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00428-012-1331-y","article-title":"Histological characteristics of the human femoral head in patients with femoral neck fracture","volume":"461","author":"Sakai","year":"2012","journal-title":"Virchows Arch."},{"key":"10.1016\/j.bbrc.2026.153591_bib28","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1359\/jbmr.060905","article-title":"RANKL inhibition: a novel strategy to decrease femoral head deformity after ischemic osteonecrosis","volume":"21","author":"Kim","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib29","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jbmr.5650101008","article-title":"Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo","volume":"10","author":"Hughes","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pharmtox.38.1.375","article-title":"Mechanisms of action of bisphosphonates","volume":"38","author":"Rodan","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2026.153591_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","article-title":"Bisphosphonates: the first 40 years","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2026.153591_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068033","article-title":"Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials","volume":"381","author":"Handel","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.bbrc.2026.153591_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: a living systematic review and network meta-analysis for the American college of physicians","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2026.153591_bib34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7326\/0003-4819-148-3-200802050-00198","article-title":"Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis","volume":"148","author":"MacLean","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2026.153591_bib35","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.orthres.2004.11.015","article-title":"Zoledronic acid improves femoral head sphericity in a rat model of perthes disease","volume":"23","author":"Little","year":"2005","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib36","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/jor.23402","article-title":"Material properties of bone in the femoral head treated with ibandronate and BMP-2 following ischemic osteonecrosis","volume":"35","author":"Aruwajoye","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib37","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2147\/DDDT.S286610","article-title":"Alendronate alleviated femoral head necrosis and upregulated BMP2\/EIF2AK3\/EIF2A\/ATF4 pathway in liquid nitrogen treated rats","volume":"15","author":"Rong","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2026.153591_bib38","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s41598-018-19884-z","article-title":"Efficacy of bisphosphonates in the treatment of femoral head osteonecrosis: a PRISMA-compliant meta-analysis of animal studies and clinical trials","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153591_bib39","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/art.33498","article-title":"Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study","volume":"64","author":"Chen","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2026.153591_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/716538","article-title":"Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis","volume":"2014","author":"Hong","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2026.153591_bib41","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2106\/JBJS.N.01157","article-title":"Does zoledronate prevent femoral head collapse from osteonecrosis? A prospective, randomized, open-label, multicenter study","volume":"97","author":"Lee","year":"2015","journal-title":"J. Bone Joint Surg. Am"},{"key":"10.1016\/j.bbrc.2026.153591_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.11005\/jbm.2019.26.1.13","article-title":"Is there a role of pharmacological treatments in the prevention or treatment of osteonecrosis of the femoral head?: a systematic review","volume":"26","author":"Lee","year":"2019","journal-title":"J. Bone Metab."},{"key":"10.1016\/j.bbrc.2026.153591_bib43","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.arth.2018.02.037","article-title":"Impact of operative time on adverse events following primary total joint arthroplasty","volume":"33","author":"Bohl","year":"2018","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.bbrc.2026.153591_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116645","article-title":"PDGF-BB prevents destructive repair and promotes reparative osteogenesis of steroid-associated osteonecrosis of the femoral head in rabbits","volume":"167","author":"Cao","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2026.153591_bib45","first-page":"2907","article-title":"Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip","volume":"85","author":"Weinstein","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2026.153591_bib46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bone.2012.11.038","article-title":"Osteocyte apoptosis","volume":"54","author":"Jilka","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2026.153591_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122045","article-title":"Cell death in chondrocytes, osteoblasts, and osteocytes","volume":"17","author":"Komori","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153591_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.777697","article-title":"Steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153591_bib49","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1074\/jbc.M310175200","article-title":"mRNA is an endogenous ligand for toll-like receptor 3","volume":"279","author":"Karik\u00f3","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153591_bib50","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2006.09.108","article-title":"Necrotic neuronal cells induce inflammatory schwann cell activation via TLR2 and TLR3: implication in wallerian degeneration","volume":"350","author":"Lee","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153591_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74739-0","article-title":"Detectability of cytokine and chemokine using ELISA, following sample-inactivation using Triton X-100 or heat","volume":"14","author":"Labossiere","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153591_bib52","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbrc.2018.05.153","article-title":"Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation","volume":"503","author":"Fuji","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153591_bib53","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/art.21236","article-title":"Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2","volume":"52","author":"Zhang","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2026.153591_bib54","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.41666","article-title":"Characterization and function of tumor necrosis factor and interleukin-6-induced osteoclasts in rheumatoid arthritis","volume":"73","author":"Yokota","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbrc.2026.153591_bib55","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s42255-020-00318-y","article-title":"Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution","volume":"2","author":"Tsukasaki","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbrc.2026.153591_bib56","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1073\/pnas.0701971104","article-title":"Pathological role of osteoclast costimulation in arthritis-induced bone loss","volume":"104","author":"Ochi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.153591_bib57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41413-024-00354-4","article-title":"SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion","volume":"12","author":"Kim","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib58","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s12276-020-0427-8","article-title":"Spi-C positively regulates RANKL-mediated osteoclast differentiation and function","volume":"52","author":"Go","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153591_bib59","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s42003-022-03271-6","article-title":"Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head","volume":"5","author":"Liao","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbrc.2026.153591_bib60","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1126\/science.1150110","article-title":"Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis","volume":"319","author":"Asagiri","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153591_bib61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/art.38218","article-title":"Combination of tumor necrosis factor alpha and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo","volume":"66","author":"Yokota","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbrc.2026.153591_bib62","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2147\/JIR.S281941","article-title":"Inflammation, bone healing and osteonecrosis: from bedside to bench","volume":"13","author":"Goodman","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.153591_bib63","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.148.2.333","article-title":"Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts","volume":"148","author":"Miyazaki","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.153591_bib64","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1210\/en.2009-0813","article-title":"Transforming growth factor-beta coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis","volume":"151","author":"Ruan","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2026.153591_bib65","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2026.153591_bib66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bone.2014.07.003","article-title":"Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors","volume":"67","author":"Tai","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2026.153591_bib67","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.cdd.4401285","article-title":"M-CSF, TNF alpha and RANK ligand promote osteoclast survival by signaling through mTOR\/S6 kinase","volume":"10","author":"Glantschnig","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2026.153591_bib68","first-page":"3149","article-title":"The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice","volume":"119","author":"Iwasawa","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.153591_bib69","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bone.2010.07.011","article-title":"Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate","volume":"49","author":"Allen","year":"2011","journal-title":"Bone"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26003554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26003554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:17:26Z","timestamp":1776143846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26003554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":69,"alternative-id":["S0006291X26003554"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153591","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Necrotic-cell\u2013activated macrophages drive an ERK\u2013Bcl-xL survival pathway in osteoclasts and confer bisphosphonate resistance","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"153591"}}