{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:40:32Z","timestamp":1790286032477,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"The Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bbrc.2026.153614","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:42:42Z","timestamp":1773301362000},"page":"153614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["In differentiated HL-60 neutrophil-like cells, MRP1- (ABCC1-) mediated glutathione efflux stimulated by BzATP and P2X7 receptor signalling regulates exosome release through nSMase activity"],"prefix":"10.1016","volume":"813","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8554-3429","authenticated-orcid":false,"given":"Erica","family":"Muriana Tintor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2921-2570","authenticated-orcid":false,"given":"Anfal","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0513-4557","authenticated-orcid":false,"given":"L\u00facia","family":"Moreno-S\u03acnchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-1129","authenticated-orcid":false,"given":"Samuel","family":"Antwi-Baffour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-0363","authenticated-orcid":false,"given":"Jameel M.","family":"Inal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2026.153614_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1835","article-title":"Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy","volume":"15","author":"De Sousa","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.153614_bib2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s41423-025-01323-5","article-title":"The role of exosomes in immunopathology and potential therapeutic implications","volume":"22","author":"Wang","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.153614_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/ijms25010255","article-title":"The regulation of exosome generation and function in physiological and pathological processes","volume":"25","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bbrc.2026.153614_bib4","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.3390\/jcm9082380","article-title":"Exosome: a new player in translational nanomedicine","volume":"9","author":"Aheget","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbrc.2026.153614_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u03b2 secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbrc.2026.153614_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0297758","article-title":"Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation","volume":"19","author":"Bhakta","year":"2024","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bbrc.2026.153614_bib7","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3390\/cells9102145","article-title":"TNF production and release from microglia via extracellular vesicles: impact on brain functions","volume":"9","author":"Raffaele","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.153614_bib8","article-title":"Crosstalk between oxidative stress and exosomes","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.bbrc.2026.153614_bib9","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3390\/biology14111578","article-title":"Extracellular vesicles from the myocyte secretome contribute in vitro to creating an unfavourable environment for migrating lung carcinoma cells","volume":"14","author":"Mannaperuma","year":"2025","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.bbrc.2026.153614_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1697124","article-title":"Plasma mEV levels in ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets","volume":"9","author":"Antwi-Baffour","year":"2019","journal-title":"J. Extracell. Vesicles"},{"issue":"9","key":"10.1016\/j.bbrc.2026.153614_bib11","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001884","article-title":"A coxsackievirus B1-mediated nonlytic extracellular vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release","volume":"104","author":"Jorfi","year":"2023","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.bbrc.2026.153614_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70014","article-title":"Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-\u03b21","volume":"13","author":"Ansa-Addo","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"2","key":"10.1016\/j.bbrc.2026.153614_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2017-000599","article-title":"Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1\u03b2 signalling: a potential strategy for preventing cardiovascular events?","volume":"4","author":"DiNicolantonio","year":"2017","journal-title":"Open Heart"},{"issue":"5","key":"10.1016\/j.bbrc.2026.153614_bib14","doi-asserted-by":"crossref","first-page":"jcs259324","DOI":"10.1242\/jcs.259324","article-title":"Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification","volume":"135","author":"Choezom","year":"2022","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2026.153614_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"5867","key":"10.1016\/j.bbrc.2026.153614_bib16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bbrc.2026.153614_bib17","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1194\/jlr.M700227-JLR200","article-title":"Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation","volume":"48","author":"Rutkute","year":"2007","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.bbrc.2026.153614_bib18","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0006-3495(00)76640-9","article-title":"Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes","volume":"78","author":"Holopainen","year":"2000","journal-title":"Biophys. J."},{"issue":"26","key":"10.1016\/j.bbrc.2026.153614_bib19","doi-asserted-by":"crossref","first-page":"16281","DOI":"10.1074\/jbc.272.26.16281","article-title":"Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione","volume":"272","author":"Liu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153614_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.654023","article-title":"Role of ATP in extracellular vesicle biogenesis and dynamics","volume":"12","author":"Lombardi","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.153614_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0006-2952(01)00660-8","article-title":"Influences of glutathione on anionic substrate efflux in tumour cells expressing the multidrug resistance-associated protein, MRP1","volume":"62","author":"Bagrij","year":"2001","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bbrc.2026.153614_bib22","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.3390\/ijms22073603","article-title":"Intracellular redox-modulated pathways as targets for effective approaches in the treatment of viral infection","volume":"22","author":"Fraternale","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26003785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26003785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:14:34Z","timestamp":1775074474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26003785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":22,"alternative-id":["S0006291X26003785"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153614","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In differentiated HL-60 neutrophil-like cells, MRP1- (ABCC1-) mediated glutathione efflux stimulated by BzATP and P2X7 receptor signalling regulates exosome release through nSMase activity","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"153614"}}