{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:47:09Z","timestamp":1777312029295,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202401AY070001-303"],"award-info":[{"award-number":["202401AY070001-303"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202501BC070005"],"award-info":[{"award-number":["202501BC070005"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018637","name":"Yunnan Key Research and Development Program","doi-asserted-by":"publisher","award":["202403AC100033"],"award-info":[{"award-number":["202403AC100033"]}],"id":[{"id":"10.13039\/501100018637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007846","name":"Yunnan Provincial Department of Education","doi-asserted-by":"publisher","award":["2024Y209"],"award-info":[{"award-number":["2024Y209"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013114","name":"Yunnan Key Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477108"],"award-info":[{"award-number":["22477108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20805"],"award-info":[{"award-number":["U24A20805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrc.2026.153724","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:07:12Z","timestamp":1775315232000},"page":"153724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation"],"prefix":"10.1016","volume":"817","author":[{"given":"Xin","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Xuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Xiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin-Bao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Cong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-1993","authenticated-orcid":false,"given":"Wei-Lie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-0324","authenticated-orcid":false,"given":"Yong-Tang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153724_bib1","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke Statistics-2020 update: a report from the American heart association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2026.153724_bib2","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-023-02925-4","article-title":"Global, regional, and national burden of cardiovascular diseases in youths and young adults aged 15-39 years in 204 countries\/territories, 1990-2019: a systematic analysis of global burden of disease study 2019","volume":"21","author":"Sun","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.bbrc.2026.153724_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cmet.2020.12.003","article-title":"The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure","volume":"33","author":"Cluntun","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2026.153724_bib4","article-title":"Heart Failure-Do we need new drugs or have them already? A case of Coenzyme Q10","volume":"9","author":"Filipiak","year":"2022","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.bbrc.2026.153724_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41440-021-00826-8","article-title":"Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension","volume":"45","author":"Grabowski","year":"2022","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/ars.2007.1474","article-title":"Cardiac hypertrophy: mechanisms and therapeutic opportunities","volume":"9","author":"Gupta","year":"2007","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2026.153724_bib7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","article-title":"Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib8","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/CIRCRESAHA.119.315268","article-title":"The medical and device-related treatment of heart failure","volume":"124","author":"Willerson","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4187\/respcare.06510403","article-title":"Congestive heart failure: diagnosis, pathophysiology, therapy, and implications for respiratory care - PubMed","author":"Michael S Figueroa","year":"2006","journal-title":"Respir. Care"},{"key":"10.1016\/j.bbrc.2026.153724_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00268-013-2284-2","article-title":"Value of plasma brain natriuretic peptide levels for predicting postoperative atrial fibrillation: a systemic review and meta-analysis","volume":"38","author":"Cai","year":"2014","journal-title":"World J. Surg."},{"key":"10.1016\/j.bbrc.2026.153724_bib11","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1161\/CIRCULATIONAHA.118.037803","article-title":"Lin28a regulates pathological cardiac hypertrophic growth through Pck2-Mediated enhancement of anabolic synthesis","volume":"139","author":"Ma","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2026.153724_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCRESAHA.115.306567","article-title":"New management strategies in heart failure","volume":"118","author":"Owens","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2840-13-43","article-title":"Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats","volume":"13","author":"Miyoshi","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbrc.2026.153724_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12199-007-0007-8","article-title":"Epigenetic abnormalities in cardiac hypertrophy and heart failure","volume":"13","author":"Mano","year":"2008","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.bbrc.2026.153724_bib15","article-title":"Epigenetic reader bromodomain containing protein 2 facilitates pathological cardiac hypertrophy via regulating the expression of citrate cycle genes","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153724_bib16","first-page":"976","article-title":"Epigenetics in cardiac hypertrophy and heart failure, JACC basic to transl","volume":"4","author":"Liu","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153724_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41401-018-0044-4","article-title":"PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy","volume":"40","author":"Li","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2026.153724_bib18","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.apsb.2020.12.012","article-title":"The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrc.2026.153724_bib19","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1172\/JCI46277","article-title":"The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice","volume":"121","author":"Zhang","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.153724_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105104","article-title":"Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L\/\u03b2-catenin","volume":"161","author":"Cai","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22020968","article-title":"The functions of the demethylase JMJD3 in cancer","volume":"22","author":"Sanchez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153724_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.gde.2016.03.010","article-title":"Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX","volume":"36","author":"Arcipowski","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbrc.2026.153724_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111046","article-title":"The JMJD family of histone demethylase and their intimate links to cardiovascular disease","volume":"116","author":"Xie","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2026.153724_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2018.05.009","article-title":"JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing \u03b2-MHC expression","volume":"477","author":"Guo","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2026.153724_bib25","unstructured":"World Health Statistics, (n.d.). https:\/\/www.who.int\/data\/gho\/publications\/world-health-statistics (accessed April 20, 2021)."},{"key":"10.1016\/j.bbrc.2026.153724_bib26","first-page":"1188","article-title":"Hepatorenal dysfunction identifies high-risk patients with acute heart failure: insights from the RELAX-AHF trial, ESC hear","volume":"6","author":"Biegus","year":"2019","journal-title":"Fail"},{"key":"10.1016\/j.bbrc.2026.153724_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jjcc.2022.08.015","article-title":"Prognostic impact of the coexistence of hepato-renal dysfunction and frailty in patients with heart failure","volume":"81","author":"Noda","year":"2023","journal-title":"J. Cardiol."},{"key":"10.1016\/j.bbrc.2026.153724_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/000331979004101101","article-title":"Cardiogenic hepatorenal syndrome","volume":"41","author":"Naschitz","year":"1990","journal-title":"Angiology"},{"key":"10.1016\/j.bbrc.2026.153724_bib29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phrs.2010.07.003","article-title":"Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?","volume":"62","author":"Balakumar","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2026.153724_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","article-title":"Cytoplasmic signaling pathways that regulate cardiac hypertrophy","volume":"63","author":"Molkentin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2026.153724_bib31","first-page":"47","article-title":"The pharmacology of prazosin, an alpha 1-adrenoceptor antagonist and the basis for its use in the treatment of essential hypertension","volume":"4","author":"Davey","year":"1982","journal-title":"Clin. Exp. Hypertens. A."},{"key":"10.1016\/j.bbrc.2026.153724_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155970","article-title":"Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18","volume":"134","author":"Feng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.153724_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/sj.bjp.0707350","article-title":"Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli","volume":"152","author":"Patrizio","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153724_bib34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF01857749","article-title":"Left ventricular hypertrophy reversal with labetalol and propranolol: a prospective randomized, double-blind study","volume":"4","author":"Szlachcic","year":"1990","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26004882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26004882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:10:06Z","timestamp":1777309806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26004882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"alternative-id":["S0006291X26004882"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153724","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the anti-hypertrophic and toxicological effects of quinoxaline derivative N8 mediated by H3K27me3 upregulation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153724"}}