{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:17:17Z","timestamp":1788628637829,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009053","name":"Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Government of India Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001410","name":"CSIR - Human Resource Development Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrc.2026.153808","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:20:59Z","timestamp":1776525659000},"page":"153808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ultra-sensitive detection of somatic mutations in androgen receptor conferring resistance to anti-androgen therapy in prostate cancer"],"prefix":"10.1016","volume":"819","author":[{"given":"Sushmita","family":"Kundu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-0723","authenticated-orcid":false,"given":"Atin","family":"Singhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-3012","authenticated-orcid":false,"given":"Apul","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-9773","authenticated-orcid":false,"given":"Bushra","family":"Ateeq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153808_bib1","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1101\/gad.819500","article-title":"Molecular genetics of prostate cancer","volume":"14","author":"Abate-Shen","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.153808_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nrurol.2011.67","article-title":"Targeting 5alpha-reductase for prostate cancer prevention and treatment","volume":"8","author":"Nacusi","year":"2011","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.bbrc.2026.153808_bib3","first-page":"232","article-title":"Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate","volume":"22","author":"Huggins","year":"1972","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2026.153808_bib4","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1158\/0008-5472.CAN-16-2169","article-title":"Disrupting androgen receptor signaling induces snail-mediated epithelial-mesenchymal plasticity in prostate cancer","volume":"77","author":"Miao","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2026.153808_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41391-018-0079-0","article-title":"Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations","volume":"22","author":"Crawford","year":"2019","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.bbrc.2026.153808_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMoa1315815","article-title":"AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer","volume":"371","author":"Antonarakis","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nm972","article-title":"Molecular determinants of resistance to antiandrogen therapy","volume":"10","author":"Chen","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib8","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1038\/onc.2013.206","article-title":"Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches","volume":"32","author":"Karantanos","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2026.153808_bib9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.juro.2014.08.043","article-title":"The cistrome and gene signature of androgen receptor splice variants in castration resistant prostate cancer cells","volume":"193","author":"Lu","year":"2015","journal-title":"J. Urol."},{"key":"10.1016\/j.bbrc.2026.153808_bib10","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.eururo.2013.12.062","article-title":"Overdiagnosis and overtreatment of prostate cancer","volume":"65","author":"Loeb","year":"2014","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bbrc.2026.153808_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.euo.2023.09.008","article-title":"Digital rectal examination is not a useful screening test for prostate cancer","volume":"6","author":"Krilaviciute","year":"2023","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.bbrc.2026.153808_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.euo.2023.12.005","article-title":"Comparing the performance of digital rectal examination and prostate-specific antigen as a screening test for prostate cancer: a systematic review and meta-analysis","volume":"7","author":"Matsukawa","year":"2024","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.bbrc.2026.153808_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11934-024-01218-4","article-title":"Digital rectal exam in prostate cancer screening and elevated PSA work-up-is there a role anymore?","volume":"25","author":"Shish","year":"2024","journal-title":"Curr. Urol. Rep."},{"key":"10.1016\/j.bbrc.2026.153808_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00345-007-0145-z","article-title":"Overdiagnosis and overtreatment of early detected prostate cancer","volume":"25","author":"Bangma","year":"2007","journal-title":"World J. Urol."},{"key":"10.1016\/j.bbrc.2026.153808_bib15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41392-024-02021-w","article-title":"Liquid biopsy in cancer current: status, challenges and future prospects","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153808_bib16","first-page":"646","article-title":"Free DNA in the serum of cancer patients and the effect of therapy","volume":"37","author":"Leon","year":"1977","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2026.153808_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-022-01543-7","article-title":"Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments","volume":"21","author":"Lone","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2026.153808_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/gm434","article-title":"Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing","volume":"5","author":"Heitzer","year":"2013","journal-title":"Genome Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx118","article-title":"Concordance of circulating tumor DNA and matched metastatic tissue biopsy in prostate cancer","volume":"109","author":"Wyatt","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2026.153808_bib20","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1158\/2159-8290.CD-17-0937","article-title":"Circulating tumor DNA genomics correlate with resistance to abiraterone and enzalutamide in prostate cancer","volume":"8","author":"Annala","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrc.2026.153808_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-022-04975-9","article-title":"Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer","volume":"608","author":"Herberts","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153808_bib22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM199505253322101","article-title":"Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer","volume":"332","author":"Taplin","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib23","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1158\/1078-0432.CCR-14-2666","article-title":"Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer","volume":"21","author":"Azad","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2026.153808_bib24","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1073\/pnas.0500381102","article-title":"Structural basis for antagonism and resistance of bicalutamide in prostate cancer","volume":"102","author":"Bohl","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.153808_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40291-021-00562-2","article-title":"Current and emerging applications of droplet digital PCR in oncology: an updated review","volume":"26","author":"Olmedillas-Lopez","year":"2022","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.bbrc.2026.153808_bib26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nprot.2017.006","article-title":"Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencing","volume":"12","author":"Stahlberg","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2026.153808_bib27","doi-asserted-by":"crossref","first-page":"312re310","DOI":"10.1126\/scitranslmed.aac9511","article-title":"Plasma AR and abiraterone-resistant prostate cancer","volume":"7","author":"Romanel","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib28","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.eururo.2018.12.042","article-title":"Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer","volume":"75","author":"Vandekerkhove","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bbrc.2026.153808_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac9511","article-title":"Plasma AR and abiraterone-resistant prostate cancer","volume":"7","author":"Romanel","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib30","doi-asserted-by":"crossref","first-page":"djx118","DOI":"10.1093\/jnci\/djx118","article-title":"Concordance of circulating tumor DNA and matched metastatic tissue biopsy in prostate cancer","volume":"109","author":"Wyatt","year":"2017","journal-title":"JNCI: J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2026.153808_bib31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM199505253322101","article-title":"Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer","volume":"332","author":"Taplin","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.153808_bib32","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1073\/pnas.0500381102","article-title":"Structural basis for antagonism and resistance of bicalutamide in prostate cancer","volume":"102","author":"Bohl","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2026.153808_bib33","doi-asserted-by":"crossref","first-page":"37839","DOI":"10.18632\/oncotarget.9341","article-title":"Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer","volume":"7","author":"Salvi","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2026.153808_bib34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41391-024-00805-3","article-title":"Clinical implications of AR alterations in advanced prostate cancer: a multi-institutional collaboration","volume":"28","author":"Zengin","year":"2025","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.bbrc.2026.153808_bib35","article-title":"Genetic alterations detected in cell-free DNA are associated with enzalutamide and abiraterone resistance in castration-resistant prostate cancer","volume":"3","author":"Torquato","year":"2019","journal-title":"JCO Precis. Oncol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26005723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26005723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:00:47Z","timestamp":1778140847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26005723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S0006291X26005723"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153808","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultra-sensitive detection of somatic mutations in androgen receptor conferring resistance to anti-androgen therapy in prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153808"}}