{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:23:23Z","timestamp":1783092203245,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["25K11508"],"award-info":[{"award-number":["25K11508"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153840","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:51:28Z","timestamp":1777161088000},"page":"153840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["USP40 protects podocytes by deubiquitylating integrin \u03b21"],"prefix":"10.1016","volume":"821","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-7174","authenticated-orcid":false,"given":"Naoaki","family":"Mikami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-9805","authenticated-orcid":false,"given":"Toshiaki","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-9500","authenticated-orcid":false,"given":"Hiromu","family":"Takematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-7512","authenticated-orcid":false,"given":"Zentaro","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-4841","authenticated-orcid":false,"given":"Daisuke","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-4954","authenticated-orcid":false,"given":"Eriko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Suehiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Fukutomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Pastan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Matsusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0281-4150","authenticated-orcid":false,"given":"Yoshihiro","family":"Akimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-3467","authenticated-orcid":false,"given":"Kunio","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-3863","authenticated-orcid":false,"given":"Kunimasa","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153840_bib1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","article-title":"Podocyte injury and its consequences","volume":"89","author":"Nagata","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2026.153840_bib2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.ajpath.2013.06.033","article-title":"New insights into the pathology of podocyte loss: mitotic catastrophe","volume":"183","author":"Liapis","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2026.153840_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fendo.2014.00160","article-title":"The importance of podocyte adhesion for a healthy glomerulus","volume":"5","author":"Lennon","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2026.153840_bib4","doi-asserted-by":"crossref","first-page":"18908","DOI":"10.1016\/S0021-9258(19)37047-4","article-title":"The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3\/beta 1","volume":"267","author":"Dedhar","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153840_bib5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ydbio.2007.10.047","article-title":"Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus","volume":"313","author":"Kanasaki","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153840_bib6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ydbio.2008.01.022","article-title":"Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity","volume":"316","author":"Pozzi","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.153840_bib7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.tibs.2017.09.002","article-title":"The ubiquitin code in the ubiquitin-proteasome system and autophagy","volume":"42","author":"Kwon","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2026.153840_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235997","article-title":"Deubiquitinating enzymes: a critical regulator of mitosis","volume":"20","author":"Park","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153840_bib9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.cell.2005.11.007","article-title":"A genomic and functional inventory of deubiquitinating enzymes","volume":"123","author":"Nijman","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153840_bib10","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00197.2016","article-title":"USP40 gene knockdown disrupts glomerular permeability in zebrafish","volume":"312","author":"Takagi","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2026.153840_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2022.05.043","article-title":"USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage","volume":"614","author":"Takahashi","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153840_bib12","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1242\/jcs.204628","article-title":"The deubiquitylase USP10 regulates integrin \u03b21 and \u03b25 and fibrotic wound healing","volume":"130","author":"Gillespie","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2026.153840_bib13","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1038\/s44319-024-00300-9","article-title":"The USP12\/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation","volume":"25","author":"Yu","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2026.153840_bib14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1681\/ASN.2004080720","article-title":"Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury","volume":"16","author":"Matsusaka","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2026.153840_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153840_bib16","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1038\/ncomms7780","article-title":"Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity","volume":"6","author":"Fukushima","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153840_bib17","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1007\/s00125-012-2661-7","article-title":"Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin","volume":"55","author":"Hara","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2026.153840_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104810","article-title":"A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell\/tissue type-dependent action of sulforaphane","volume":"299","author":"Etoh","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153840_bib19","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1074\/jbc.M807920200","article-title":"N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-glycosylation requirement for alpha5beta1","volume":"284","author":"Isaji","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.153840_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-025-02501-7","article-title":"The role of ER-associated degradation and ER-phagy in health and disease","volume":"11","author":"Jeon","year":"2026","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153840_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1127085","article-title":"Proteasome-independent functions of ubiquitin in endocytosis and signaling","volume":"315","author":"Mukhopadhyay","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153840_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.devcel.2007.05.003","article-title":"Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3","volume":"13","author":"Nishimura","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2026.153840_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2012.08.011","article-title":"Governance of endocytic trafficking and signaling by reversible ubiquitylation","volume":"23","author":"Clague","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2026.153840_bib24","article-title":"Monoubiquitination in homeostasis and cancer","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153840_bib25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrm.2017.132","article-title":"Mechanisms of clathrin-mediated endocytosis","volume":"19","author":"Kaksonen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:10:50Z","timestamp":1783091450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26006042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":25,"alternative-id":["S0006291X26006042"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153840","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP40 protects podocytes by deubiquitylating integrin \u03b21","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153840"}}