{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:19:03Z","timestamp":1783055943502,"version":"3.54.6"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB978"],"award-info":[{"award-number":["2024AFB978"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2026AFC0551"],"award-info":[{"award-number":["2026AFC0551"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153858","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:35:49Z","timestamp":1777332949000},"page":"153858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["40\u202fHz light flicker stimulation for neurodegenerative diseases: Mechanisms and clinical perspectives"],"prefix":"10.1016","volume":"821","author":[{"given":"Ya","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-hua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-2977","authenticated-orcid":false,"given":"Xiao-qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-9460","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153858_bib1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153858_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153858_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110568","article-title":"Current understanding of protein aggregation in neurodegenerative diseases","volume":"26","author":"Hu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10571-025-01544-2","article-title":"Alpha-Synuclein pathophysiology in neurodegenerative disorders: a review focusing on molecular mechanisms and treatment advances in Parkinson's disease","volume":"45","author":"Yaribash","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.153858_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310809","article-title":"Unraveling molecular and genetic insights into neurodegenerative diseases: advances in understanding lzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis","volume":"24","author":"Ciurea","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/0113892037275221240327042353","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of bioactive peptides","volume":"25","author":"Singh","year":"2024","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jconrel.2020.11.021","article-title":"Neurodegenerative diseases and effective drug delivery: a review of challenges and novel therapeutics","volume":"330","author":"Akhtar","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bbrc.2026.153858_bib8","doi-asserted-by":"crossref","first-page":"35223","DOI":"10.1021\/acsomega.4c01774","article-title":"Current overview on the use of nanosized drug delivery systems in the treatment of neurodegenerative diseases","volume":"9","author":"Ozceylan","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbrc.2026.153858_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib10","series-title":"Guidelines, Dementia: Assessment, Management and Support for People Living with Dementia and Their Carers","year":"2018"},{"key":"10.1016\/j.bbrc.2026.153858_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12640-013-9398-z","article-title":"Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease","volume":"24","author":"Parsons","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbrc.2026.153858_bib12","article-title":"Immunotherapies for Alzheimer's Disease-A review","volume":"10","author":"Valiukas","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.bbrc.2026.153858_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004568","article-title":"Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer's disease: a systematic review and meta-analysis","volume":"22","author":"Tonegawa-Kuji","year":"2025","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbrc.2026.153858_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153858_bib15","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"Levodopa dose equivalency in Parkinson's disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbrc.2026.153858_bib16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00702-025-03006-x","article-title":"COMT inhibition with entacapone for patients with Parkinson's disease and motor complications: the novelty of continuous infusion","volume":"133","author":"Jenner","year":"2026","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bbrc.2026.153858_bib17","article-title":"A review of the recent advances in the pharmacological management of Parkinson's disease","volume":"17","author":"Li","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.bbrc.2026.153858_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311022","article-title":"Are therapies that target \u03b1-Synuclein effective at halting parkinson's Disease progression? A systematic review","volume":"24","author":"Rodger","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1684885","article-title":"Levodopa-induced dyskinesia in Parkinson's disease: an updated review of pharmacological treatments","volume":"17","author":"Chen","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00348","article-title":"Neuroscience fundamentals relevant to neuromodulation: neurobiology of deep brain stimulation in Parkinson's disease","volume":"21","author":"Davidson","year":"2024","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbrc.2026.153858_bib21","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1038\/s41467-025-59113-6","article-title":"Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice","volume":"16","author":"Xu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153858_bib22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/joim.13541","article-title":"Deep brain stimulation for Parkinson's disease","volume":"292","author":"Hariz","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbrc.2026.153858_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1270746","article-title":"Premature drug reduction after subthalamic nucleus deep brain stimulation leading to worse depression in patients with Parkinson's disease","volume":"14","author":"Diao","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbrc.2026.153858_bib24","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1056\/NEJMoa0907083","article-title":"Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease","volume":"362","author":"Follett","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.153858_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/1756286419838096","article-title":"An update on best practice of deep brain stimulation in Parkinson's disease","volume":"12","author":"Hartmann","year":"2019","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.bbrc.2026.153858_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jhin.2023.06.004","article-title":"The incidence of surgical site infections in China","volume":"146","author":"Lin","year":"2024","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.bbrc.2026.153858_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183711","article-title":"Postoperative lead migration in deep brain stimulation surgery: incidence, risk factors, and clinical impact","volume":"12","author":"Morishita","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153858_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1095081","article-title":"An update on the use of gamma (multi)sensory stimulation for Alzheimer's disease treatment","volume":"14","author":"Manippa","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2021.782399","article-title":"Gamma oscillations in Alzheimer's disease and their potential therapeutic role","volume":"15","author":"Traikapi","year":"2021","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13195-025-01709-7","article-title":"Effects of 52 weeks of precuneus rTMS in Alzheimer's disease patients: a randomized trial","volume":"17","author":"Koch","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153858_bib31","first-page":"383","article-title":"Factors affecting the efficacy of repetitive transcranial magnetic stimulation for patients with Alzheimer's disease","volume":"50","author":"Wang","year":"2021","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.bbrc.2026.153858_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10072-023-07162-4","article-title":"Transcranial direct current stimulation for global cognition in Alzheimer's disease: a systemic review and meta-analysis","volume":"45","author":"Wang","year":"2024","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.bbrc.2026.153858_bib33","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1017\/S104161022300039X","article-title":"Electroconvulsive therapy in individuals with dementia\/major NCD presenting with behavioral symptoms: a systematic review","volume":"36","author":"Bachu","year":"2024","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.bbrc.2026.153858_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/mds.28335","article-title":"Electroconvulsive therapy for Parkinson's disease: a systematic review and meta-analysis","volume":"36","author":"Takamiya","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbrc.2026.153858_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75448-4","article-title":"Light-based gamma entrainment with novel invisible spectral flicker stimuli","volume":"14","author":"Hansen","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153858_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neurom.2022.11.004","article-title":"Effects of contralateral deep brain stimulation and levodopa on subthalamic nucleus oscillatory activity and phase-amplitude coupling","volume":"26","author":"Farokhniaee","year":"2023","journal-title":"Neuromodulation"},{"key":"10.1016\/j.bbrc.2026.153858_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11060547","article-title":"Combined and sequential treatment with deep brain stimulation and continuous intrajejunal levodopa infusion for Parkinson's disease","volume":"11","author":"van Poppelen","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.bbrc.2026.153858_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2023.1146687","article-title":"Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead","volume":"17","author":"Sahu","year":"2023","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","article-title":"Gamma frequency entrainment attenuates amyloid load and modifies microglia","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153858_bib55","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuron.2019.04.011","article-title":"Gamma entrainment binds higher-order brain regions and offers neuroprotection","volume":"102","author":"Adaikkan","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2026.153858_bib45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","article-title":"Multi-sensory Gamma stimulation ameliorates Alzheimer's-Associated pathology and improves cognition","volume":"177","author":"Martorell","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153858_bib50","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1038\/s41467-020-16826-0","article-title":"Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity","volume":"11","author":"Zheng","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153858_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114396","article-title":"Non-invasive auditory and visual stimulation attenuates \u03b1-Synuclein deposition and improves motor and non-motor symptoms in PD mice","volume":"364","author":"Liu","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2026.153858_bib71","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1021\/acsbiomaterials.5c01162","article-title":"Color dependence of OLED phototherapy for cognitive function and beta-amyloid reduction through ADAM17 and BACE1","volume":"11","author":"Noh","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bbrc.2026.153858_bib52","article-title":"Parvalbumin interneuron-dependent hippocampal neurogenesis evoked by prolonged rhythmic light flicker","volume":"12","author":"Yan","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153858_bib51","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2419364122","article-title":"40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease","volume":"122","author":"Paulson","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.153858_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78528-7","article-title":"40 Hz light preserves synaptic plasticity and mitochondrial function in Alzheimer's disease model","volume":"14","author":"Barzegar Behrooz","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153858_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2021.746859","article-title":"Sensory-evoked 40-Hz gamma oscillation improves sleep and daily living activities in Alzheimer's disease patients","volume":"15","author":"Cimenser","year":"2021","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib83","article-title":"A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease","volume":"7","author":"He","year":"2021","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bbrc.2026.153858_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzs\u00e1ki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2811","article-title":"Gamma oscillations and application of 40-Hz audiovisual stimulation to improve brain function","volume":"12","author":"Chen","year":"2022","journal-title":"Brain Behav."},{"key":"10.1016\/j.bbrc.2026.153858_bib41","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.tins.2023.07.003","article-title":"Gamma oscillations and episodic memory","volume":"46","author":"Griffiths","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0166-2236(96)10023-0","article-title":"Neuronal networks for induced '40 Hz' rhythms","volume":"19","author":"Jefferys","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278412","article-title":"Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: results of feasibility and pilot studies","volume":"17","author":"Chan","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153858_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40708-020-00119-9","article-title":"Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study","volume":"7","author":"Sharpe","year":"2020","journal-title":"Brain Inform."},{"key":"10.1016\/j.bbrc.2026.153858_bib46","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s42003-025-08766-6","article-title":"Visual gamma stimulation induces 40 Hz neural oscillations in the human hippocampus and alters phase synchrony and lag","volume":"8","author":"Mlinari\u010d","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbrc.2026.153858_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tins.2019.11.001","article-title":"Gamma entrainment: impact on neurocircuits, glia, and therapeutic opportunities","volume":"43","author":"Adaikkan","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib48","article-title":"Brain Gamma-stimulation: mechanisms and optimization of impact","volume":"14","author":"Lushnikov","year":"2025","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.bbrc.2026.153858_bib49","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0452-25.2026","article-title":"Fast spiking interneurons autonomously generate fast gamma oscillations in the medial entorhinal cortex with excitation strength tuning ING-PING transitions","volume":"13","author":"Williams","year":"2026","journal-title":"eNeuro"},{"key":"10.1016\/j.bbrc.2026.153858_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf5672","article-title":"Brain rhythms control microglial response and cytokine expression via NF-\u03baB signaling","volume":"9","author":"Prichard","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.153858_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003046","article-title":"Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease","volume":"23","author":"Park","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrc.2026.153858_bib57","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41573-024-01105-0","article-title":"Targeting mitophagy in neurodegenerative diseases","volume":"24","author":"Antico","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2026.153858_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13024-024-00785-x","article-title":"Mystery of gamma wave stimulation in brain disorders","volume":"19","author":"Deng","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbrc.2026.153858_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13573","article-title":"Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing \u03b2-amyloid load in Alzheimer's disease model","volume":"21","author":"Shen","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2026.153858_bib61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-024-07132-6","article-title":"Multisensory gamma stimulation promotes glymphatic clearance of amyloid","volume":"627","author":"Murdock","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153858_bib62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40035-025-00515-3","article-title":"Roles of TREM2 in Alzheimer's disease","volume":"14","author":"Qi","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbrc.2026.153858_bib63","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0257-22.2022","article-title":"BrainWAVE: a flexible method for noninvasive stimulation of brain rhythms across species","volume":"10","author":"Attokaren","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.bbrc.2026.153858_bib64","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1523\/JNEUROSCI.1511-19.2019","article-title":"Gamma visual stimulation induces a neuroimmune signaling profile distinct from acute neuroinflammation","volume":"40","author":"Garza","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib65","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0271678X20949286","article-title":"Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington's disease","volume":"41","author":"Klinkmueller","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbrc.2026.153858_bib66","article-title":"Optimal flickering light stimulation for entraining gamma waves in the human brain","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153858_bib67","article-title":"Optimal flickering light stimulation for entraining gamma rhythms in older adults","volume":"12","author":"Park","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153858_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332310","article-title":"Exploring neural entrainment and synchrony in response to repeated 60 Hz flickering white light in healthy volunteers","volume":"20","author":"Alamalhoda","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153858_bib70","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.12677\/ACM.2021.1112835","article-title":"Research progress of photobiomodulation in the treatment of Alzheimer's disease","volume":"11","author":"Li Y","year":"2021","journal-title":"Adv. Clin. Med."},{"key":"10.1016\/j.bbrc.2026.153858_bib72","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1038\/s41467-025-64269-2","article-title":"Chronic 40 Hz light flicker mitigates epileptogenesis through a visual pathway associated with the dorsal lateral geniculate nucleus shell","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153858_bib73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12915-025-02360-2","article-title":"Non-invasive light flickering reinstates visual plasticity in adult mice via lipocalin 2","volume":"23","author":"Ma","year":"2025","journal-title":"BMC Biol."},{"key":"10.1016\/j.bbrc.2026.153858_bib74","first-page":"1142","article-title":"[Study on effects of 40 Hz light flicker stimulation on spatial working memory in rats and its neural mechanism]","volume":"40","author":"Wang","year":"2023","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"key":"10.1016\/j.bbrc.2026.153858_bib75","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1460-9568.2008.06606.x","article-title":"Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathway","volume":"29","author":"Luo","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040735","article-title":"Dopamine: the neuromodulator of long-term synaptic plasticity, reward and movement control","volume":"10","author":"Speranza","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.153858_bib77","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.bbrc.2017.03.140","article-title":"Visual deprivation induce cross-modal enhancement of olfactory perception","volume":"486","author":"Zhou","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153858_bib78","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.1038\/s41467-025-62253-4","article-title":"Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation","volume":"16","author":"You","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.153858_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137958","article-title":"Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickering","volume":"842","author":"Hu","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2026.153858_bib80","article-title":"TrkB modulates parvalbumin interneuron excitability and spatial memory enhancement induced by long-term rhythmic light flicker","volume":"28","author":"Wang","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.bbrc.2026.153858_bib81","doi-asserted-by":"crossref","DOI":"10.1063\/5.0261497","article-title":"Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice","volume":"9","author":"Bitarafan","year":"2025","journal-title":"APL Bioeng."},{"key":"10.1016\/j.bbrc.2026.153858_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1250626","article-title":"Study on the effect of 40 Hz non-invasive light therapy system. A protocol for a randomized, double-blinded, placebo-controlled clinical trial","volume":"15","author":"Agger","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2026.153858_bib84","doi-asserted-by":"crossref","DOI":"10.1002\/alz70856_097702","article-title":"Sensory evoked gamma oscillation reduces white matter loss and preserves myelin in Alzheimer's disease: neuroimaging and proteomics findings","volume":"21","author":"Hajos","year":"2025","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bbrc.2026.153858_bib85","article-title":"CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment","volume":"11","author":"Haj\u00f3s","year":"2025","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bbrc.2026.153858_bib86","article-title":"Sensory neurostimulation promotes stress resilience with frequency-specificity","author":"Tina C Franklin","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2026.153858_bib87","series-title":"Time Saved in Activities of Daily Living and whole-brain Volume: Post Hoc Analysis of a Randomized Feasibility Trial of Gamma Oscillation Treatment in Participants with Mild or Moderate Alzheimer's disease","author":"Christian","year":"2025"},{"key":"10.1016\/j.bbrc.2026.153858_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162735","article-title":"The role of alternating bilateral stimulation in establishing positive cognition in EMDR therapy: a multi-channel near-infrared spectroscopy Study","volume":"11","author":"Amano","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153858_bib89","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-019-0931-y","article-title":"Neural circuits underlying a psychotherapeutic regimen for fear disorders","volume":"566","author":"Baek","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153858_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114383","article-title":"Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit","volume":"43","author":"Lei","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.153858_bib91","article-title":"A superior colliculus-originating circuit prevents cocaine reinstatement via VR-based eye movement desensitization treatment","volume":"12","author":"Liu","year":"2025","journal-title":"Natl. Sci. Rev."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:44:09Z","timestamp":1783053849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26006224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":92,"alternative-id":["S0006291X26006224"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153858","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"40\u202fHz light flicker stimulation for neurodegenerative diseases: Mechanisms and clinical perspectives","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"153858"}}