{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:12:02Z","timestamp":1790053922182,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR\/02\/833\/1\\u202FGP-2024"],"award-info":[{"award-number":["ICMR\/02\/833\/1\\u202FGP-2024"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["Sept\/06\/22"],"award-info":[{"award-number":["Sept\/06\/22"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153865","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:30:33Z","timestamp":1777390233000},"page":"153865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["MASH associated lipotoxicity perturbs the expression of hepatic vitamin D bioactivating gene CYP2R1 in humans and mice"],"prefix":"10.1016","volume":"820","author":[{"given":"Abhishek","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-6336","authenticated-orcid":false,"given":"Ambuj","family":"Shahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-070X","authenticated-orcid":false,"given":"Rohit A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Medhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mable M.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-9381","authenticated-orcid":false,"given":"Amit","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153865_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186420","article-title":"MASH: the nexus of metabolism, inflammation, and fibrosis","volume":"135","author":"Steinberg","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.153865_bib2","first-page":"1036","article-title":"Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease","volume":"51","author":"Arai","year":"2019","journal-title":"Dig. Liver Dis., Off. J. Italian Soc. Gastroenterol. Italian Assoc. Study Liver"},{"key":"10.1016\/j.bbrc.2026.153865_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13063-019-3241-7","article-title":"Effects of vitamin D supplementation on liver fibrogenic factors in non-alcoholic fatty liver patients with steatohepatitis: study protocol for a randomized clinical trial","volume":"20","author":"Ebrahimpour-Koujan","year":"2019","journal-title":"Trials"},{"key":"10.1016\/j.bbrc.2026.153865_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12937-024-00911-x","article-title":"Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial","volume":"23","author":"Ebrahimpour-Koujan","year":"2024","journal-title":"Nutr. J."},{"key":"10.1016\/j.bbrc.2026.153865_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/ijpo.12293","article-title":"Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease","volume":"13","author":"Gibson","year":"2018","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.bbrc.2026.153865_bib6","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/ijc.35522","article-title":"Serum 25-hydroxyvitamin D, vitamin D-related variants, and risk of chronic liver disease","volume":"157","author":"Shen","year":"2025","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2026.153865_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jhep.2016.05.031","article-title":"Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis","volume":"65","author":"Bozic","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.153865_bib8","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.3748\/wjg.v26.i38.5812","article-title":"Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?","volume":"26","author":"Cao","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2026.153865_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098288","article-title":"Gene polymorphisms and biological effects of vitamin D receptor on nonalcoholic fatty liver disease development and progression","volume":"24","author":"Tourkochristou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153865_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40360-021-00485-y","article-title":"The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism","volume":"22","author":"Yaghooti","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2026.153865_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.livres.2024.03.002","article-title":"Targeting nuclear receptors for NASH\/MASH: from bench to bedside","volume":"8","author":"Sinha","year":"2024","journal-title":"Liver Res."},{"key":"10.1016\/j.bbrc.2026.153865_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3177\/jnsv.64.106","article-title":"Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced Obese mice","volume":"64","author":"Borges","year":"2018","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.bbrc.2026.153865_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbrc.2004.09.073","article-title":"Metabolism of vitamin D by human microsomal CYP2R1","volume":"324","author":"Shinkyo","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153865_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba4448","article-title":"Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis","volume":"12","author":"Govaere","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153865_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204409","article-title":"Calcifediol: mechanisms of action","volume":"15","author":"Donati","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.153865_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbrc.2026.153865_bib17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.aav3722","article-title":"Targeting a ceramide double bond improves insulin resistance and hepatic steatosis","volume":"365","author":"Chaurasia","year":"2019","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbrc.2026.153865_bib18","first-page":"9","article-title":"Actions of thyroid hormones and thyromimetics on the liver, Nature reviews","volume":"22","author":"Sinha","year":"2025","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2026.153865_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10397","article-title":"Obesity represses CYP2R1, the vitamin D 25-Hydroxylase, in the liver and extrahepatic tissues","volume":"4","author":"Elkhwanky","year":"2020","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bbrc.2026.153865_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/biof.1211","article-title":"High fat diet-Induced obesity alters vitamin D metabolizing enzyme expression in mice","volume":"41","author":"Park","year":"2015","journal-title":"Biofactors"},{"key":"10.1016\/j.bbrc.2026.153865_bib21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/jbmr.3686","article-title":"Obesity decreases hepatic 25-Hydroxylase activity causing low serum 25-Hydroxyvitamin D","volume":"34","author":"Roizen","year":"2019","journal-title":"J. Bone Miner. Res. : Off. J. Amer. Soc. Bone Min. Res."},{"key":"10.1016\/j.bbrc.2026.153865_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153865_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149122","article-title":"The role of vitamin D3 in modulating the interplay between NLRP3 inflammasome and autophagy in NASH","volume":"688","author":"Abdelrahman","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.153865_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118666","article-title":"MicroRNA-125a\/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis","volume":"264","author":"He","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.153865_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s004030050206","article-title":"Upregulation of vitamin D receptor levels by 1,25(OH)2 vitamin D3 in cultured human keratinocytes","volume":"289","author":"Solvsten","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.bbrc.2026.153865_bib26","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hep.25930","article-title":"Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus","volume":"56","author":"Barchetta","year":"2012","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2026.153865_bib27","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2337\/db18-1050","article-title":"Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes","volume":"68","author":"Aatsinki","year":"2019","journal-title":"Diabetes"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:05:15Z","timestamp":1783040715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26006297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":27,"alternative-id":["S0006291X26006297"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153865","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MASH associated lipotoxicity perturbs the expression of hepatic vitamin D bioactivating gene CYP2R1 in humans and mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153865"}}