{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:17:20Z","timestamp":1783099040247,"version":"3.54.6"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360014"],"award-info":[{"award-number":["82360014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["2025-23-zdfy-004"],"award-info":[{"award-number":["2025-23-zdfy-004"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Hospital","doi-asserted-by":"publisher","award":["CY2023-MS-B05"],"award-info":[{"award-number":["CY2023-MS-B05"]}],"id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153869","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:46:48Z","timestamp":1777535208000},"page":"153869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of key driver genes in idiopathic pulmonary arterial hypertension by single-cell RNA sequencing and experimental validation"],"prefix":"10.1016","volume":"821","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4420-2099","authenticated-orcid":false,"given":"Binbin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enpeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9995-0027","authenticated-orcid":false,"given":"Yating","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153869_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbrc.2026.153869_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000137","article-title":"Pathophysiology and new advances in pulmonary hypertension","volume":"2","author":"Bousseau","year":"2023","journal-title":"BMJ. Med"},{"key":"10.1016\/j.bbrc.2026.153869_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrc.2026.153869_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13048","article-title":"ERK\/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension","volume":"54","author":"Feng","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbrc.2026.153869_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12931-023-02454-x","article-title":"HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo","volume":"24","author":"Zhang","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vph.2018.12.006","article-title":"HMGB1\/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling","volume":"117","author":"Wang","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153869_bib7","article-title":"Pulmonary arterial hypertension: pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.bbrc.2026.153869_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/0113892029320249240830060611","article-title":"Rank aggregation methods and tools in genomic data analysis","volume":"26","author":"Zou","year":"2025","journal-title":"Curr. Genom."},{"key":"10.1016\/j.bbrc.2026.153869_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.694","article-title":"Single-cell RNA sequencing technologies and applications: a brief overview","volume":"12","author":"Jovic","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153869_bib10","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.3390\/ijms24032943","article-title":"The evolution of single-cell RNA sequencing technology and application: progress and perspectives","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153869_bib11","article-title":"Exploring the immune-related molecular mechanisms underlying the comorbidity of temporal lobe epilepsy and major depressive disorder through integrated data set analysis","volume":"17","author":"Yan","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153869_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/0109298665351592250106062250","article-title":"ZNF165: a pan-cancer biomarker with prognostic and therapeutic potential, protein","volume":"32","author":"Lyu","year":"2025","journal-title":"Pept. Lett."},{"key":"10.1016\/j.bbrc.2026.153869_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/0113892029311725240911065539","article-title":"JAG2: a potential biomarker for Microtia identified by integrated RNA transcriptome analysis","volume":"26","author":"Wu","year":"2025","journal-title":"Curr. Genom."},{"key":"10.1016\/j.bbrc.2026.153869_bib14","first-page":"866","article-title":"New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data, Protein","volume":"11","author":"Shao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153869_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-8794-3-21","article-title":"SEURAT: visual analytics for the integrated analysis of microarray data","volume":"3","author":"Gribov","year":"2010","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.bbrc.2026.153869_bib16","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188746","article-title":"Current best practices in single\u2010cell RNA\u2010seq analysis: a tutorial","volume":"15","author":"Luecken","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbrc.2026.153869_bib17","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153869_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giy083","article-title":"Clustering trees: a visualization for evaluating clusterings at multiple resolutions","volume":"7","author":"Zappia","year":"2018","journal-title":"GigaScience"},{"key":"10.1016\/j.bbrc.2026.153869_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13059-019-1861-6","article-title":"Feature selection and dimension reduction for single-cell RNA-seq based on a multinomial model","volume":"20","author":"Townes","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrc.2026.153869_bib20","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","article-title":"CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data","volume":"51","author":"Hu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020908782","article-title":"Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension","volume":"10","author":"Saygin","year":"2020","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbrc.2026.153869_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41576-018-0088-9","article-title":"Challenges in unsupervised clustering of single-cell RNA-seq data","volume":"20","author":"Kiselev","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2026.153869_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12859-018-2435-4","article-title":"Single sample scoring of molecular phenotypes","volume":"19","author":"Foroutan","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2026.153869_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2026.153869_bib25","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s12967-024-05304-6","article-title":"A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153869_bib26","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov. Camb. Mass."},{"key":"10.1016\/j.bbrc.2026.153869_bib27","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.bbrc.2026.153869_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/112_2022_70","article-title":"Cell-to-cell crosstalk: a new insight into pulmonary hypertension","volume":"184","author":"Zhang","year":"2023","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153869_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7150\/ijbs.66472","article-title":"MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension","volume":"18","author":"Chi","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2026.153869_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139067","article-title":"Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension","volume":"6","author":"Ntokou","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2026.153869_bib31","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02308-2018","article-title":"CCR2\/CCR5-mediated macrophage-smooth muscle cell crosstalk in pulmonary hypertension","volume":"54","author":"Abid","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbrc.2026.153869_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12931-021-01708-w","article-title":"The alveolar epithelial cells are involved in pulmonary vascular remodeling and constriction of hypoxic pulmonary hypertension","volume":"22","author":"Wang","year":"2021","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib33","article-title":"Exosomes derived from hypoxic alveolar epithelial cells promote the phenotypic transformation of pulmonary artery smooth muscle cells via the Rap1 pathway, Exp. Lung","volume":"50","author":"G","year":"2024","journal-title":"Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.toxlet.2020.07.010","article-title":"Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS\/ERK\/ELK1\/MLCK and ROS\/p38 MAPK signaling pathways","volume":"332","author":"Liu","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbrc.2026.153869_bib35","first-page":"230","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation, Acta","volume":"42","author":"Song","year":"2021","journal-title":"Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2026.153869_bib36","first-page":"494","article-title":"Activated focal adhesion kinase involved in adhesion and migration of vascular smooth muscle cells stimulated by fibronectin","volume":"115","author":"Yin","year":"2002","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbrc.2026.153869_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102778","article-title":"Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases","volume":"64","author":"Li","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2026.153869_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/19336918.2017.1319545","article-title":"Actin cytoskeleton regulates functional anchorage-migration switch during T-cadherin-induced phenotype modulation of vascular smooth muscle cells","volume":"12","author":"Frismantiene","year":"2018","journal-title":"Cell Adhes. Migrat."},{"key":"10.1016\/j.bbrc.2026.153869_bib39","doi-asserted-by":"crossref","DOI":"10.2174\/0118761429283384240226074921","article-title":"siRNA targeting ECE-1 partially reverses pulmonary arterial hypertension associated damage in a monocrotaline model","volume":"17","author":"Blancas-Napoles","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153869_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210004","article-title":"Reviewing the regulators of COL1A1","volume":"24","author":"Devos","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153869_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/japplphysiol.00325.2016","article-title":"Pulmonary vascular collagen content, not cross-linking, contributes to right ventricular pulsatile afterload and overload in early pulmonary hypertension","volume":"122","author":"Wang","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbrc.2026.153869_bib42","doi-asserted-by":"crossref","first-page":"H1322","DOI":"10.1152\/ajpheart.00136.2018","article-title":"Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension","volume":"315","author":"Thenappan","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2026.153869_bib43","article-title":"MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine","volume":"17","author":"Huang","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153869_bib44","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3892\/ol.2016.4976","article-title":"Celecoxib exhibits an anti-gastric cancer effect by targeting focal adhesion and leukocyte transendothelial migration-associated genes","volume":"12","author":"Jin","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbrc.2026.153869_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1465-9921-12-14","article-title":"Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2\/3 and increasing MYL-9 expression","volume":"12","author":"Xu","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12890-023-02306-w","article-title":"Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice","volume":"23","author":"Song","year":"2023","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bbrc.2026.153869_bib47","article-title":"Machine learning-based integration develops an immune-derived signature for diagnosing high-altitude pulmonary hypertension","volume":"12","author":"Yang","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrc.2026.153869_bib48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/biomedicines12030596","article-title":"RhoA\/ROCK pathway is upregulated in experimental autoimmune myocarditis and is inhibited by simvastatin at the stage of myosin light chain phosphorylation","volume":"12","author":"Skrzypiec-Spring","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2026.153869_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.yexcr.2015.11.017","article-title":"Mechanosensitive components of integrin adhesions: role of vinculin","volume":"343","author":"Atherton","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/IJGM.S442004","article-title":"Relevance analysis of TPM2 and clinicopathological characteristics in breast cancer","volume":"17","author":"Zhou","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.bbrc.2026.153869_bib51","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1021\/pr200141c","article-title":"Using proteomic approach to identify tumor-associated proteins as biomarkers in human esophageal squamous cell carcinoma","volume":"10","author":"Zhang","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib52","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.1007\/s13277-016-5103-1","article-title":"Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation","volume":"37","author":"Cui","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bbrc.2026.153869_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6936262","article-title":"Tropomyosin is potential markers for the diagnosis and prognosis of bladder cancer","volume":"2022","author":"Yan","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbrc.2026.153869_bib54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jprot.2013.06.016","article-title":"Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer","volume":"89","author":"Tang","year":"2013","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.bbrc.2026.153869_bib55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12931-021-01730-y","article-title":"Tropomyosin 2.1 collaborates with fibronectin to promote TGF-\u03b21-induced contraction of human lung fibroblasts","volume":"22","author":"Bradbury","year":"2021","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib56","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.3390\/ijms23084436","article-title":"Inhibition of KIF23 alleviates IPAH by targeting pyroptosis and proliferation of PASMCs","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153869_bib57","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/CIRCRESAHA.123.322740","article-title":"Altered smooth muscle cell histone acetylome by the SPHK2\/S1P axis promotes pulmonary hypertension","volume":"133","author":"Ranasinghe","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2026.153869_bib58","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.125.326235","article-title":"Deficiency of smooth muscle Adar1 exacerbates vascular remodeling and pulmonary hypertension","volume":"138","author":"Kim","year":"2026","journal-title":"Circ. Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:26:25Z","timestamp":1783095985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26006339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":58,"alternative-id":["S0006291X26006339"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153869","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of key driver genes in idiopathic pulmonary arterial hypertension by single-cell RNA sequencing and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153869"}}