{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:17:18Z","timestamp":1788628638235,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100021112","name":"Utkal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["305\/249\/OSHEC"],"award-info":[{"award-number":["305\/249\/OSHEC"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["17.03.2025"],"award-info":[{"award-number":["17.03.2025"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153920","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T14:23:37Z","timestamp":1778423017000},"page":"153920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Organometallic Iridium(III) complex interacts with DNA and exhibits anticancer potential: Insights from biophysical, cell-based and computational studies"],"prefix":"10.1016","volume":"823","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0253-5697","authenticated-orcid":false,"given":"Diptesh","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvasmita","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2137-8670","authenticated-orcid":false,"given":"Nibedita","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth S.","family":"Nial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanhu Charan","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umakanta","family":"Subudhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagneshwar","family":"Dandapat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayan","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6490-9729","authenticated-orcid":false,"given":"Jyotsnarani","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153920_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15010107","article-title":"Targets, mechanisms and cytotoxicity of half-sandwich Ir(III) complexes are modulated by structural modifications on the benzazole ancillary ligand","volume":"15","author":"Acu\u00f1a","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2026.153920_bib2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/ar400266c","article-title":"Organoiridium complexes: anticancer agents and catalysts","volume":"47","author":"Liu","year":"2014","journal-title":"Acc. Chem. Res."},{"issue":"29","key":"10.1016\/j.bbrc.2026.153920_bib3","doi-asserted-by":"crossref","first-page":"17752","DOI":"10.1039\/C7RA00732A","article-title":"Photoinduced ROS regulation of apoptosis and mechanism studies of iridium(iii) complex against SGC-7901 cells","volume":"7","author":"Zhang","year":"2017","journal-title":"RSC Advances"},{"key":"10.1016\/j.bbrc.2026.153920_bib4","article-title":"N-Heterocyclic carbene-iridium complexes as photosensitizers for in vitro photodynamic therapy to trigger non-apoptotic cell death in cancer cells","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib5","article-title":"Current status of iridium-based complexes against lung cancer","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153920_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415579","article-title":"Anticancer activity, reduction mechanism and G-Quadruplex DNA binding of a redox-activated Platinum(IV)\u2013Salphen complex","volume":"23","author":"Vigna","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib7","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1039\/D0SC00197J","article-title":"Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(iv) prodrugs","volume":"11","author":"Zhang","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib8","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1080\/14756366.2020.1821676","article-title":"DNA topoisomerases as molecular targets for anticancer drugs","volume":"35","author":"Buzun","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib9","doi-asserted-by":"crossref","first-page":"19261","DOI":"10.1021\/acs.inorgchem.2c03015","article-title":"Liposomal binuclear Ir(III)\u2013Cu(II) coordination compounds with phosphino-fluoroquinolone conjugates for human prostate carcinoma treatment","volume":"61","author":"Komarnicka","year":"2022","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib10","doi-asserted-by":"crossref","first-page":"17635","DOI":"10.1039\/D0DT03414B","article-title":"Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes","volume":"49","author":"Ramos","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bbrc.2026.153920_bib11","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.1021\/acs.inorgchem.8b02161","article-title":"Half-Sandwich iridium and ruthenium complexes: effective tracking in cells and anticancer studies","volume":"57","author":"Li","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib12","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib13","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1039\/D5QI00746A","article-title":"Iridium complex-based ferroptosis inducer for cancer sonodynamic therapy","volume":"12","author":"Ren","year":"2025","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.bbrc.2026.153920_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30040801","article-title":"Cytotoxic organometallic Iridium(III) complexes","volume":"30","author":"Kostova","year":"2025","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.bbrc.2026.153920_bib15","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.3390\/molecules24152739","article-title":"Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells","volume":"24","author":"Ma","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molstruc.2011.07.027","article-title":"Investigations of drug\u2013DNA interactions using molecular docking, cyclic voltammetry and UV\u2013Vis spectroscopy","volume":"1004","author":"Perveen","year":"2011","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrc.2026.153920_bib17","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1039\/C7SC03216A","article-title":"Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes","volume":"8","author":"Venkatesh","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib18","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1039\/C5CC07619F","article-title":"High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides","volume":"52","author":"Gamba","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bbrc.2026.153920_bib19","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1039\/C8AN02094A","article-title":"Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation","volume":"144","author":"Wootton","year":"2019","journal-title":"The Analyst"},{"key":"10.1016\/j.bbrc.2026.153920_bib20","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1039\/D4DT00171K","article-title":"Iridium(iii)-based minor groove binding complexes as DNA photocleavage agents","volume":"53","author":"Aderinto","year":"2024","journal-title":"Dalton Trans."},{"issue":"28","key":"10.1016\/j.bbrc.2026.153920_bib21","doi-asserted-by":"crossref","first-page":"22875","DOI":"10.1039\/D5RA03076E","article-title":"Anticancer efficacy of bis-heteroleptic iridium(iii) complexes with difluoro-substituted phenylpyridine ligands","volume":"15","author":"Behera","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrc.2026.153920_bib22","article-title":"Spectroscopic and viscometric determination of DNA-Binding modes of some bioactive dibenzodioxins and phenazines","volume":"18","author":"Phadte","year":"2019","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bbrc.2026.153920_bib23","article-title":"Antioxidative ability and mechanism of L-ascorbyl palmitate synthesized by lipases as biocatalyst: experimental and molecular simulation investigations","volume":"59","author":"Zhang","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.bbrc.2026.153920_bib24","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.jorganchem.2010.12.013","article-title":"Synthesis, spectrophotometric pH titrations and DNA binding properties of a cyclometalated iridium(III) complex of tetrapyrido[3,2-a:2\u2032,3\u2032-c:3\u2033,2\u2033-h:2","volume":"696","author":"Chen","year":"2011","journal-title":"3\u2034-j]phenazine, J. Organomet. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.119224","article-title":"Unveiling the interaction between PDT active squaraines with ctDNA: a spectroscopic study","volume":"250","author":"Butnarasu","year":"2021","journal-title":"Spectrochim. Acta. A. Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bbrc.2026.153920_bib26","doi-asserted-by":"crossref","first-page":"34160","DOI":"10.1039\/C7RA05579J","article-title":"New cyclometalated Ir(iii) complexes with NCN pincer and meso-phenylcyanamide BODIPY ligands as efficient photodynamic therapy agents","volume":"7","author":"Tabrizi","year":"2017","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.bbrc.2026.153920_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2533\/chimia.2017.102","article-title":"Investigation of Non-covalent Interactions of Metal Complexes with DNA in Cell-free Systems","volume":"71","author":"Erxleben","year":"2017","journal-title":"CHIMIA"},{"key":"10.1016\/j.bbrc.2026.153920_bib28","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1039\/C4DT02642J","article-title":"Binding of Ru(terpyridine)(pyridine)dipyridophenazine to DNA studied with polarized spectroscopy and calorimetry","volume":"44","author":"M\u00e5rtensson","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bbrc.2026.153920_bib29","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0006-3495(93)81263-3","article-title":"Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd","volume":"65","author":"Duguid","year":"1993","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2026.153920_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.inoche.2015.02.024","article-title":"Photocleavage of DNA and adenine\u2013thymine inclined binding by a novel ruthenium(II) complex with 3,4-dibromo-imidazo[4,5-f][1,10]phenanthroline ligand","volume":"55","author":"Wang","year":"2015","journal-title":"Inorg. Chem. Commun."},{"issue":"10","key":"10.1016\/j.bbrc.2026.153920_bib31","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1007\/s10895-025-04222-0","article-title":"DNA Binding, Molecular Docking and Antimicrobial Studies of Co(III) Polypyridyl Complexes","volume":"35","author":"Perka","year":"2025","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.bbrc.2026.153920_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032563","article-title":"Antiproliferative activity of antibiotics through DNA binding mechanism: evaluation and molecular docking studies","volume":"24","author":"Magklaras","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib33","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.3390\/molecules180910829","article-title":"An Insight into the anticancer activities of Ru(II)-Based metallocompounds using docking methods","volume":"18","author":"Adeniyi","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nprot.2006.5","article-title":"The comet assay: a method to measure DNA damage in individual cells","volume":"1","author":"Olive","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2026.153920_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153920_bib36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molliq.2017.10.044","article-title":"Studies of DNA- and HSA-binding properties of new nano-scale green synthesized Ni (II) complex as anticancer agent using spectroscopic methods, viscosity measurement, molecular docking, MD simulation and QM\/MM","volume":"248","author":"Dehkhodaei","year":"2017","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bbrc.2026.153920_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1039\/C7QI00446J","article-title":"Mononuclear Pd(ii) and pt(ii) complexes with an \u03b1-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media","volume":"5","author":"Matesanz","year":"2018","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.bbrc.2026.153920_bib38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ejmech.2018.07.055","article-title":"\u03b2-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders","volume":"157","author":"Vaidergorn","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib39","doi-asserted-by":"crossref","first-page":"25387","DOI":"10.1039\/C8RA03231A","article-title":"Comparative studies on the interaction of anticancer drug irinotecan with dsDNA and ssDNA","volume":"8","author":"Temerk","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrc.2026.153920_bib40","doi-asserted-by":"crossref","first-page":"36056","DOI":"10.1039\/C7RA05874H","article-title":"Coumarin centered copper(ii) complex with appended-imidazole as cancer chemotherapeutic agents against lung cancer: molecular insight via DFT-Based vibrational analysis","volume":"7","author":"Usman","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrc.2026.153920_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-13995-0","article-title":"In-vitro antiproliferative evaluation of newly synthesized titanium(IV) metallacyclic complexes on HeLa and MCF7 cell lines","volume":"15","author":"Salimath","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.153920_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2019.119048","article-title":"DNA binding interaction studies of flavonoid complexes of Cu(II) and Fe(II) and determination of their chemotherapeutic potential","volume":"496","author":"Jabeen","year":"2019","journal-title":"Inorganica Chim. Acta"},{"key":"10.1016\/j.bbrc.2026.153920_bib43","doi-asserted-by":"crossref","first-page":"12059","DOI":"10.1002\/anie.201905389","article-title":"A triangular Platinum(II) multinuclear complex with cytotoxicity towards breast cancer stem cells","volume":"58","author":"Eskandari","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bbrc.2026.153920_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112363","article-title":"Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) schiff base complexes","volume":"248","author":"Me\u0111edovi\u0107","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bbrc.2026.153920_bib45","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1021\/ic900407n","article-title":"Sensitivity of Ru(bpy)2dppz2+Luminescence to DNA defects","volume":"48","author":"Lim","year":"2009","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2015.00025","article-title":"Flexibility of short ds-DNA intercalated by a dipyridophenazine ligand","volume":"3","author":"Jia","year":"2015","journal-title":"Front. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124265","article-title":"The crucial role of stability of intercalating agent for DNA binding studies in DMSO\/water system","volume":"315","author":"Bandyopadhyay","year":"2024","journal-title":"Spectrochim. Acta. A. Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bbrc.2026.153920_bib48","first-page":"1","article-title":"DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands","volume":"2011","author":"Shahabadi","year":"2011","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.bbrc.2026.153920_bib49","doi-asserted-by":"crossref","DOI":"10.1039\/b915081a","article-title":"Microwave synthesis of mixed ligand diimine\u2013thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity","author":"Beckford","year":"2009","journal-title":"Dalton Trans"},{"key":"10.1016\/j.bbrc.2026.153920_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0968-0896(95)00053-J","article-title":"Criteria for the mode of binding of DNA binding agents","volume":"3","author":"Suh","year":"1995","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib51","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/bip.1977.360160614","article-title":"The viscometric behavior of native and relaxed closed circular PM2 DNAs at intermediate and high ethidium bromide concentrations","volume":"16","author":"Watson","year":"1977","journal-title":"Biopolymers"},{"key":"10.1016\/j.bbrc.2026.153920_bib52","doi-asserted-by":"crossref","first-page":"110281","DOI":"10.1016\/j.cbi.2022.110281","article-title":"Thermodynamics of benzoquinone-induced conformational changes in nucleic acids and human serum albumin","volume":"369","author":"Jena","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2026.153920_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0020-1693(00)84165-1","article-title":"Ultraviolet difference spectral study of the interaction of DNA with platinum complexes","volume":"46","author":"Inagaki","year":"1980","journal-title":"Inorganica Chim. Acta"},{"key":"10.1016\/j.bbrc.2026.153920_bib54","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1039\/D3MA00708A","article-title":"Induced chiroptical properties of helical Eu(iii) complex by electrostatic interaction with DNA","volume":"5","author":"Li","year":"2024","journal-title":"Mater. Adv."},{"key":"10.1016\/j.bbrc.2026.153920_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22101772","article-title":"Ni(II) complexes with schiff base ligands: preparation, characterization, DNA\/protein interaction and cytotoxicity studies","volume":"22","author":"Yu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0301-4622(82)87016-6","article-title":"The pH-dependent structure of calf thymus DNA studied by raman spectroscopy","volume":"15","author":"O'Connor","year":"1982","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib57","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1093\/nar\/11.16.5747","article-title":"Characterization of DNA structures by raman spectroscopy: high-salt and low-salt forms of double helical poly(dG-dC) in H2O and D2O solutions and application to B, Z and A-DNA","volume":"11","author":"Benevides","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153920_bib58","article-title":"Raman spectroscopy analysis of the biochemical characteristics of molecules associated with the malignant transformation of gastric mucosa","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.153920_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031834","article-title":"Effect of arylazo sulfones on DNA: binding, cleavage, photocleavage, molecular docking studies and interaction with A375 melanoma and non-cancer cells","volume":"24","author":"Mikra","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0147-619X(81)90012-3","article-title":"Simple procedure for distinguishing CCC, OC, and L forms of plasmid DNA by agarose gel electrophoresis","volume":"5","author":"Hintermann","year":"1981","journal-title":"Plasmid"},{"key":"10.1016\/j.bbrc.2026.153920_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28135217","article-title":"DNA-interactive and damage study with meso-Tetra(2-thienyl)porphyrins coordinated with polypyridyl Pd(II) and Pt(II) complexes","volume":"28","author":"Iglesias","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103046","article-title":"Arene Ru(II) complexes acted as potential KRAS G-Quadruplex DNA stabilizer induced DNA damage mediated apoptosis to inhibit breast cancer progress","volume":"27","author":"Qian","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib63","doi-asserted-by":"crossref","first-page":"9872","DOI":"10.1039\/D3SC03096B","article-title":"Interrogating bioinspired ESIPT\/PCET-based Ir(iii)-complexes as organelle-targeted phototherapeutics: a redox-catalysis under hypoxia to evoke synergistic ferroptosis\/apoptosis","volume":"14","author":"Shee","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib64","doi-asserted-by":"crossref","first-page":"12016","DOI":"10.1039\/C9CC03822A","article-title":"Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity","volume":"55","author":"Parveen","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bbrc.2026.153920_bib65","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1021\/acs.jmedchem.5b00451","article-title":"Detailed biological profiling of a photoactivated and apoptosis inducing pdppz Ruthenium(II) polypyridyl complex in cancer cells","volume":"58","author":"Cloonan","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.153920_bib66","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1039\/D0DT00180E","article-title":"Cyclometalated iridium(iii) complexes for mitochondria-targeted combined chemo-photodynamic therapy","volume":"49","author":"Qin","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bbrc.2026.153920_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27175434","article-title":"Synthesis, characterization and anticancer efficacy studies of iridium (III) polypyridyl complexes against Colon cancer HCT116 cells","volume":"27","author":"Xie","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib68","article-title":"Design, synthesis, and anticancer effect studies of Iridium(III) polypyridyl complexes against SGC-7901 cells","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.153920_bib69","doi-asserted-by":"crossref","first-page":"34945","DOI":"10.1039\/C7RA05103D","article-title":"DNA-binding, molecular docking studies and biological activity studies of ruthenium(ii) polypyridyl complexes","volume":"7","author":"Tang","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrc.2026.153920_bib70","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1039\/C6SC02901A","article-title":"Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes","volume":"8","author":"Cao","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbrc.2026.153920_bib71","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1021\/cb400070a","article-title":"Organometallic Iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis","volume":"8","author":"Hearn","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bbrc.2026.153920_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15071997","article-title":"From the discovery of targets to delivery systems: how to decipher and improve the metallodrugs' actions at a molecular level","volume":"15","author":"Iacobucci","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbrc.2026.153920_bib73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1039\/C7MT00242D","article-title":"Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action","volume":"10","author":"Hearn","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.bbrc.2026.153920_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16080997","article-title":"Prediction of protein targets in ovarian cancer using a Ru-Complex and carbon dot drug delivery therapeutic nanosystems: a bioinformatics and \u03bc-FTIR spectroscopy approach","volume":"16","author":"Ne\u0161i\u0107","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbrc.2026.153920_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122637","article-title":"RNA-Seq analysis of Cisplatin and the monofunctional Platinum(II) complex, phenanthriplatin, in A549 non-small cell lung cancer and IMR90 lung fibroblast cell lines","volume":"9","author":"Monroe","year":"2020","journal-title":"Cells"},{"issue":"51","key":"10.1016\/j.bbrc.2026.153920_bib76","doi-asserted-by":"crossref","first-page":"e46660","DOI":"10.1097\/MD.0000000000046660","article-title":"Exploring the mechanism of Inula japonica Thunb. against non-small cell lung cancer using a computer-aided drug design approach","volume":"104","author":"Qian","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.bbrc.2026.153920_bib77","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-023-02931-7","article-title":"Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy","volume":"43","author":"Alcal\u00e1","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26006844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:12:55Z","timestamp":1783131175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26006844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":77,"alternative-id":["S0006291X26006844"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153920","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organometallic Iridium(III) complex interacts with DNA and exhibits anticancer potential: Insights from biophysical, cell-based and computational studies","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153920"}}