{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:15:26Z","timestamp":1783106126266,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1800700"],"award-info":[{"award-number":["2023YFA1800700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1803302"],"award-info":[{"award-number":["2024YFA1803302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370897"],"award-info":[{"award-number":["32370897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32522030"],"award-info":[{"award-number":["32522030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82088101"],"award-info":[{"award-number":["82088101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015361","name":"University of the Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007820","name":"Hangzhou Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007820","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153946","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:33:24Z","timestamp":1778654004000},"page":"153946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genetic tools for targeting neuroendocrine cells: Unveiling their plasticity in lung regeneration"],"prefix":"10.1016","volume":"823","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5895-4789","authenticated-orcid":false,"given":"Zhongxiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglin","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-6191","authenticated-orcid":false,"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153946_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115428","article-title":"Role of calcitonin gene-related peptide in pain regulation in the parabrachial nucleus of naive rats and rats with neuropathic pain","volume":"414","author":"Wang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.153946_bib2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0306-4522(88)90018-8","article-title":"Differential expression of alpha-CGRP and beta-CGRP by primary sensory neurons and enteric autonomic neurons of the rat","volume":"25","author":"Mulderry","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2026.153946_bib3","unstructured":"Transcriptional atlas of intestinal immune cells reveals that neuropeptide \u03b1-CGRP modulates group 2 innate lymphoid cell responses: immunity, (n.d.). https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(19)30375-9 (accessed August 15, 2025)."},{"key":"10.1016\/j.bbrc.2026.153946_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2025.02.046","article-title":"A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis","volume":"196","author":"Li","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.153946_bib5","unstructured":"Calcitonin gene-related peptide-mediated Pharmacological Effects in Cardiovascular and Gastrointestinal Diseases (Review). - Abstract - Europe PMC, (n.d.). https:\/\/europepmc.org\/article\/MED\/33179114 (accessed August 15, 2025)."},{"key":"10.1016\/j.bbrc.2026.153946_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2023.103127","article-title":"Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles","volume":"251","author":"Chen","year":"2024","journal-title":"Auton Neurosci. Basic Clin."},{"key":"10.1016\/j.bbrc.2026.153946_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114152","article-title":"From spreading depolarization to epilepsy with neuroinflammation: the role of CGRP in cortex","volume":"356","author":"Gimeno-Ferrer","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2026.153946_bib8","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3390\/cells13141199","article-title":"Excess dally-like induces malformation of drosophila legs","volume":"13","author":"Zhang","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.153946_bib9","unstructured":"Loss of calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias \u201cgepant\u201d antagonism | bioRxiv, (n.d.). https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.25.620369v1 (accessed August 15, 2025)."},{"key":"10.1016\/j.bbrc.2026.153946_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137402","article-title":"Long-term effects of streptozotocin-induced gestational diabetes mellitus on mechanical sensitivity and intraepidermal nerve fibers in female and male mice offspring","volume":"812","author":"Mu\u00f1oz-Islas","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2026.153946_bib11","doi-asserted-by":"crossref","unstructured":"Mechanism of calcitonin gene related peptide against acute pancreatitis in rats by modulating amino acid metabolism based on metabonomics | Sci. Rep., (n.d.). https:\/\/www.nature.com\/articles\/s41598-025-87707-z (accessed August 15, 2025).","DOI":"10.1038\/s41598-025-87707-z"},{"key":"10.1016\/j.bbrc.2026.153946_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/03331024231206375","article-title":"An exploratory analysis of clinical and sociodemographic factors in CGRP-induced migraine attacks: a REFORM study","volume":"43","author":"Al-Khazali","year":"2023","journal-title":"Cephalalgia Int. J. Headache"},{"issue":"1","key":"10.1016\/j.bbrc.2026.153946_bib13","first-page":"73","article-title":"Argyrophilia of bright cell system in bronchial tree in man","author":"Feyrter","year":"1954","journal-title":"Z. Mikrosk.-Anat. Forsch. (Leipz.)"},{"key":"10.1016\/j.bbrc.2026.153946_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.153946_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/labinvest.3700412","article-title":"Functional facets of the pulmonary neuroendocrine system","volume":"86","author":"Linnoila","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2026.153946_bib16","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cell.2015.09.021","article-title":"Formation of a neurosensory organ by epithelial cell slithering","volume":"163","author":"Kuo","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153946_bib17","doi-asserted-by":"crossref","first-page":"17531","DOI":"10.1073\/pnas.1207238109","article-title":"Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis","volume":"109","author":"Song","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2026.153946_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1465-9921-6-115","article-title":"A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium","volume":"6","author":"Weichselbaum","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.153946_bib19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1164\/ajrccm.154.3.8810616","article-title":"Number and proliferation of neuroendocrine cells in normal human airway epithelium","volume":"154","author":"Boers","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2026.153946_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.aad7969","article-title":"Pulmonary neuroendocrine cells function as airway sensors to control lung immune response","volume":"351","author":"Branchfield","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153946_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1165\/rcmb.2013-0199OC","article-title":"Chemosensory functions for pulmonary neuroendocrine cells","volume":"50","author":"Gu","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.153946_bib22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2350\/07-04-0267.1","article-title":"Pulmonary neuroendocrine cell system in pediatric lung disease\u2014recent advances","volume":"10","author":"Cutz","year":"2007","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.bbrc.2026.153946_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2019.09.010","article-title":"Rare pulmonary neuroendocrine cells are stem cells regulated by Rb, p53, and notch","volume":"179","author":"Ouadah","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153946_bib24","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1101\/gad.263145.115","article-title":"Origins, genetic landscape, and emerging therapies of small cell lung cancer","volume":"29","author":"Semenova","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.153946_bib25","unstructured":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes | Nature, (n.d.). https:\/\/www.nature.com\/articles\/s41586-018-0393-7 (accessed August 12, 2025)."},{"key":"10.1016\/j.bbrc.2026.153946_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.celrep.2015.06.011","article-title":"Clonal dynamics reveal two distinct populations of basal cells in slow-turnover airway epithelium","volume":"12","author":"Watson","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.153946_bib27","first-page":"L486","article-title":"Cell proliferation contributes to PNEC hyperplasia after acute airway injury","volume":"272","author":"Stevens","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2026.153946_bib28","first-page":"L791","article-title":"Plasticity of airway cell proliferation and gene expression after acute naphthalene injury","volume":"269","author":"Stripp","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2026.153946_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9440(10)64727-X","article-title":"Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration","volume":"156","author":"Reynolds","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2026.153946_bib30","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.cell.2024.03.010","article-title":"Tracing the origin of alveolar stem cells in lung repair and regeneration","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.153946_bib31","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.stem.2024.08.005","article-title":"Alveolar regeneration by airway secretory-cell-derived p63+ progenitors","volume":"31","author":"Lv","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2026.153946_bib32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41588-019-0346-6","article-title":"Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.153946_bib33","doi-asserted-by":"crossref","first-page":"eadt1310","DOI":"10.1126\/science.adt1310","article-title":"Stem cell control in the lung by an autocrine injury-activated Igf complex","volume":"392","author":"Zhang","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153946_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-019-0132-8","article-title":"Bi-directional differentiation of single bronchioalveolar stem cells during lung repair","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Discov."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:17:10Z","timestamp":1783102630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"alternative-id":["S0006291X26007102"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153946","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic tools for targeting neuroendocrine cells: Unveiling their plasticity in lung regeneration","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"153946"}}