{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:15:16Z","timestamp":1783066516620,"version":"3.54.6"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC2311700"],"award-info":[{"award-number":["2025YFC2311700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.153958","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:56:59Z","timestamp":1779299819000},"page":"153958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dynamic regulation-based stabilizing mutations are highly effective for designing RSV pre-fusion F mRNA vaccines"],"prefix":"10.1016","volume":"825","author":[{"given":"Shuai","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze Yuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Yao","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Qin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Ge","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Guo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-7106","authenticated-orcid":false,"given":"Qi Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153958_bib1","article-title":"Respiratory syncytial virus: a comprehensive review of transmission, pathophysiology, and manifestation","volume":"15","author":"Kaler","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.bbrc.2026.153958_bib3","article-title":"RSV vaccine development: advances and fusion protein-focused strategies","volume":"17","author":"Xu","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.153958_bib4","article-title":"Respiratory syncytial virus under the lens of structure: from prefusion stabilization to next-generation immunotherapies","volume":"00","author":"Cheng","year":"2026","journal-title":"iNew Med."},{"key":"10.1016\/j.bbrc.2026.153958_bib5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1243283","article-title":"Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus","volume":"342","author":"McLellan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153958_bib6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nsmb.3267","article-title":"Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV","volume":"23","author":"Joyce","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.153958_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade6422","article-title":"Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine","volume":"15","author":"Che","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153958_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg6050","article-title":"The RSVPreF3-AS01 vaccine elicits broad neutralization of contemporary and antigenically distant respiratory syncytial virus strains","volume":"15","author":"Sacconnay","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153958_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2025.127589","article-title":"Design and preclinical assessment of mRNA-1345 prefusion F glycoprotein-encoding mRNA vaccine for respiratory syncytial virus","volume":"63","author":"Shaw","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2026.153958_bib10","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.adp2362","article-title":"Mutating a flexible region of the RSV F protein can stabilize the prefusion conformation","volume":"385","author":"Liang","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153958_bib11","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1016\/j.vaccine.2023.05.062","article-title":"Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: preclinical studies and phase 1 clinical testing in healthy adults","volume":"41","author":"Nussbaum","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2026.153958_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2025.128154","article-title":"A combination of new prefusion mRNA and protein vaccines enhances neutralizing antibodies and protection against respiratory syncytial virus","volume":"73","author":"Pal","year":"2026","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2026.153958_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.aav9033","article-title":"A proof of concept for structure-based vaccine design targeting RSV in humans","volume":"365","author":"Crank","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.153958_bib14","first-page":"5","article-title":"Ionizable lipid compounds, lipid nanoparticles comprising the same, pharmaceutical compositions, pharmaceutical formulations, and applications thereof [P]","author":"Kang","year":"2025","journal-title":"CN: 202411204254"},{"key":"10.1016\/j.bbrc.2026.153958_bib15","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/nar\/15.3.1281","article-title":"The codon adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications","volume":"15","author":"Sharp","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153958_bib16","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.jmb.2019.04.021","article-title":"Codon and codon-pair usage tables (CoCoPUTs): facilitating genetic variation analyses and recombinant gene design","volume":"431","author":"Alexaki","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.153958_bib17","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1093\/nar\/gkh834","article-title":"Solving the riddle of codon usage preferences: a test for translational selection","volume":"32","author":"dos Reis","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.153958_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA package 2.0","volume":"6","author":"Lorenz","year":"2011","journal-title":"Algorithm Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.153958_bib19","series-title":"Respiratory Syncytial Virus mRNA Vaccines","author":"Shaw","year":"2022"},{"key":"10.1016\/j.bbrc.2026.153958_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jamainternmed.2025.6355","article-title":"Durability of respiratory syncytial virus vaccine effectiveness among US veterans","volume":"186","author":"Bajema","year":"2026","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbrc.2026.153958_bib21","doi-asserted-by":"crossref","DOI":"10.7326\/ANNALS-25-05485","article-title":"Respiratory syncytial virus vaccines in adults who are not pregnant or immunocompromised: rapid practice points from the American college of physicians","author":"Qaseem","year":"2026","journal-title":"Ann. Intern. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:15:29Z","timestamp":1783062929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"alternative-id":["S0006291X26007229"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153958","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic regulation-based stabilizing mutations are highly effective for designing RSV pre-fusion F mRNA vaccines","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153958"}}