{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:24:05Z","timestamp":1783164245507,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771340"],"award-info":[{"award-number":["81771340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbrc.2026.153966","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:01:10Z","timestamp":1778860870000},"page":"153966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Heat shock preconditioning potentiates the therapeutic efficacy of mesenchymal stem cells for traumatic brain injury"],"prefix":"10.1016","volume":"824","author":[{"given":"Jiarong","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1747-9246","authenticated-orcid":false,"given":"Donghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-6337","authenticated-orcid":false,"given":"Qiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.153966_bib1","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.apmr.2010.05.017","article-title":"Position statement: definition of traumatic brain injury","volume":"91","author":"Menon","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbrc.2026.153966_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-7091-4147-2_2","article-title":"Head injury in man and experimental animals: neuropathology","volume":"32","author":"Adams","year":"1983","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.bbrc.2026.153966_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/bja\/aem131","article-title":"Pathophysiology of traumatic brain injury","volume":"99","author":"Werner","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbrc.2026.153966_bib4","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano","year":"2015","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.bbrc.2026.153966_bib5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/1570159X15666170828165711","article-title":"Combination therapy for multi-target manipulation of secondary brain injury mechanisms","volume":"16","author":"Somayaji","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbrc.2026.153966_bib6","article-title":"Mesenchymal stem cells for neurological disorders","volume":"8","author":"Andrzejewska","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153966_bib7","article-title":"Mesenchymal stromal cell secretome and its key bioactive metabolites induce long-term neuroprotection after traumatic brain injury in mice","volume":"12","author":"Pischiutta","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.153966_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4252\/wjsc.v16.i6.641","article-title":"Safety and efficiency of Wharton's jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury: first results of a phase I study","volume":"16","author":"Kabatas","year":"2024","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.bbrc.2026.153966_bib9","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209797","article-title":"Mesenchymal stromal cell implants for chronic motor deficits after traumatic brain injury: post hoc analysis of a randomized trial","volume":"103","author":"Okonkwo","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2026.153966_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12974-018-1383-2","article-title":"Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury","volume":"16","author":"Peruzzaro","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2026.153966_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12964-022-00931-2","article-title":"Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6","volume":"20","author":"Feng","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bbrc.2026.153966_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-10-106","article-title":"Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury","volume":"10","author":"Zhang","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2026.153966_bib13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13287-021-02328-3","article-title":"Heat shock preconditioning mesenchymal stem cells attenuate acute lung injury via reducing NLRP3 inflammasome activation in macrophages","volume":"12","author":"Lv","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2026.153966_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70084","article-title":"Heat shock strengthens the protective potential of MSCs in liver injury by promoting EV release through upregulated autophagosome formation","volume":"14","author":"Wang","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bbrc.2026.153966_bib15","doi-asserted-by":"crossref","first-page":"12822","DOI":"10.3748\/wjg.v21.i45.12822","article-title":"Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy","volume":"21","author":"Qiao","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2026.153966_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s40824-023-00448-w","article-title":"Mild heat treatment in vitro potentiates human adipose stem cells: delayed aging and improved quality for long term culture","volume":"27","author":"Ryu","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bbrc.2026.153966_bib17","article-title":"Intravenous administration of heat shock-treated MSCs can improve neuroprotection and neuroregeneration in canine spinal cord injury model","volume":"10","author":"Kim","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.bbrc.2026.153966_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12014-020-09279-6","article-title":"Effects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells","volume":"17","author":"Fu","year":"2020","journal-title":"Clin. Proteom."},{"key":"10.1016\/j.bbrc.2026.153966_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13036-022-00304-w","article-title":"Exosomes derived from heat shock preconditioned bone marrow mesenchymal stem cells alleviate cisplatin-induced ototoxicity in mice","volume":"16","author":"Yang","year":"2022","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.bbrc.2026.153966_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12929-024-01083-w","article-title":"CCL5 is essential for axonogenesis and neuronal restoration after brain injury","volume":"31","author":"Ho","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbrc.2026.153966_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12974-020-01863-9","article-title":"Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2026.153966_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/neur.2025.0016","article-title":"Early-life mild traumatic brain injury alters neurodevelopment and behavior in mice","volume":"6","author":"Corrigan","year":"2025","journal-title":"Neurotrauma Rep."},{"key":"10.1016\/j.bbrc.2026.153966_bib23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/1545968320926164","article-title":"Mesenchymal stem cell-derived exosomes improve functional recovery in rats after traumatic brain injury: a dose-response and therapeutic window study","volume":"34","author":"Zhang","year":"2020","journal-title":"Neurorehabilitation Neural Repair"},{"key":"10.1016\/j.bbrc.2026.153966_bib24","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.7150\/thno.111512","article-title":"Neutrophil extracellular traps aggravate neuronal apoptosis and neuroinflammation via neddylation after traumatic brain injury","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2026.153966_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.apsb.2015.01.010","article-title":"Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-kappaB and iNOS signaling pathways","volume":"5","author":"Wu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrc.2026.153966_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bbrc.2026.153966_bib27","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.jcyt.2018.10.002","article-title":"Immunogenic potential of human bone marrow mesenchymal stromal cells is enhanced by hyperthermia","volume":"20","author":"McClain-Caldwell","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bbrc.2026.153966_bib28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/scd.2024.0102","article-title":"Safety and potential efficacy of expanded umbilical cord-derived mesenchymal stromal cells in luminal ulcerative colitis patients","volume":"33","author":"Jafar","year":"2024","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.bbrc.2026.153966_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","article-title":"Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies","volume":"10","author":"Han","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.153966_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122647","article-title":"Therapeutic applications of mesenchymal\/medicinal stem\/signaling cells preconditioned with external factors: are there more efficient approaches to utilize their regenerative potential?","volume":"346","author":"Strecanska","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.153966_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/stem.1571","article-title":"Heat shock improves Sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: a critical role for HSF1\/miR-34a\/HSP70 pathway","volume":"32","author":"Feng","year":"2014","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2026.153966_bib32","first-page":"375","article-title":"Heat shock proteins: protective effect and potential therapeutic use","volume":"2","author":"Latchman","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2026.153966_bib33","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1182\/blood-2006-10-051060","article-title":"MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines","volume":"109","author":"Ries","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2026.153966_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12013-014-0228-6","article-title":"Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K\/Akt and ERK1\/2 pathways","volume":"71","author":"Gao","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2026.153966_bib35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuropharm.2018.08.004","article-title":"Pathophysiology and treatment of cerebral edema in traumatic brain injury","volume":"145","author":"Jha","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2026.153966_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2565","article-title":"Regulation of innate immune responses in the brain","volume":"9","author":"Rivest","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.153966_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.it.2025.09.009","article-title":"Neuroimmune dynamics and cytokines in traumatic brain injury","volume":"47","author":"Davis","year":"2026","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbrc.2026.153966_bib38","doi-asserted-by":"crossref","first-page":"161ra150","DOI":"10.1126\/scitranslmed.3004660","article-title":"Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury","volume":"4","author":"Menge","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.153966_bib39","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1007\/s12035-022-03055-3","article-title":"Heat shock-induced extracellular vesicles derived from neural stem cells confer marked neuroprotection against oxidative stress and amyloid-beta-caused neurotoxicity","volume":"59","author":"Huber","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.153966_bib40","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2026.153966_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nbd.2018.05.016","article-title":"Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury","volume":"117","author":"Xu","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2026.153966_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12974-020-01778-5","article-title":"The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target","volume":"17","author":"O'Brien","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2026.153966_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.24475","article-title":"Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses","volume":"72","author":"Packer","year":"2024","journal-title":"Glia"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:08:45Z","timestamp":1783163325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"alternative-id":["S0006291X26007308"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153966","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat shock preconditioning potentiates the therapeutic efficacy of mesenchymal stem cells for traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.153966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"153966"}}