{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:20:18Z","timestamp":1783048818580,"version":"3.54.6"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["25XHYD-06"],"award-info":[{"award-number":["25XHYD-06"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["Yjzdxk2025-06"],"award-info":[{"award-number":["Yjzdxk2025-06"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300959"],"award-info":[{"award-number":["82300959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012157","name":"Shanghai Key Discipline Construction Project","doi-asserted-by":"publisher","award":["PWZxk2022-08"],"award-info":[{"award-number":["PWZxk2022-08"]}],"id":[{"id":"10.13039\/501100012157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154021","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T06:45:45Z","timestamp":1779518745000},"page":"154021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatic Senp2 deletion resolves the angiogenic switch in fibrosis via \u03b2-catenin\/LECT2"],"prefix":"10.1016","volume":"827","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8345-9904","authenticated-orcid":false,"given":"Xin","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baishen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154021_bib1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12072-024-10704-3","article-title":"Epidemiology and diagnosis of metabolic dysfunction-associated fatty liver disease","volume":"18","author":"Fouad","year":"2024","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.bbrc.2026.154021_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154021_bib3","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/s41467-023-37459-z","article-title":"Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154021_bib4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/hep.32332","article-title":"Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase","volume":"76","author":"Fang","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154021_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.903740","article-title":"Mouse models of liver parenchyma injuries and regeneration","volume":"10","author":"Du","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.154021_bib6","article-title":"Non-parenchymal cells: key targets for modulating chronic liver diseases","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154021_bib7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.32299","article-title":"A strategy of vascular-targeted therapy for liver fibrosis","volume":"76","author":"Lin","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154021_bib8","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1136\/gutjnl-2024-334318","article-title":"Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2","volume":"74","author":"Xu","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2026.154021_bib9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2337\/db13-0728","article-title":"LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance","volume":"63","author":"Lan","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2026.154021_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41598-020-80689-0","article-title":"LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH","volume":"11","author":"Takata","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154021_bib11","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cell.2019.07.021","article-title":"LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis","volume":"178","author":"Xu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154021_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/hep.20286","article-title":"Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver","volume":"40","author":"Ovejero","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154021_bib13","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/hep.31881","article-title":"Hepatic small ubiquitin-related modifier (SUMO)-specific protease 2 controls systemic metabolism through SUMOylation-Dependent regulation of liver-adipose tissue crosstalk","volume":"74","author":"Liu","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154021_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154021_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137405","article-title":"Exploring fibrosis pathophysiology in lean and obese metabolic-associated fatty liver disease: an In-Depth comparison","volume":"25","author":"Veskovi\u0107","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154021_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2003.09.020","article-title":"The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance","volume":"40","author":"Rinella","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154021_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155182","article-title":"Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt\/\u03b2-catenin pathway","volume":"123","author":"Sharma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.154021_bib18","first-page":"960","article-title":"Targeting the wnt signaling pathway in liver fibrosis for drug options: an update","volume":"9","author":"Duspara","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154021_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ebiom.2019.01.009","article-title":"Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-\u03b2 signaling","volume":"40","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2026.154021_bib20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/HEP.0000000000000569","article-title":"Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A\/HIF-1\u03b1 transcriptional complex","volume":"79","author":"Wang","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154021_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101544","article-title":"The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPK\u03b1","volume":"298","author":"Dou","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154021_bib22","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1038\/s41467-022-34993-0","article-title":"SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation","volume":"13","author":"Yan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154021_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113067","article-title":"SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL","volume":"28","author":"Xiong","year":"2025","journal-title":"iScience"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:12:12Z","timestamp":1783048332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"alternative-id":["S0006291X26007850"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154021","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic Senp2 deletion resolves the angiogenic switch in fibrosis via \u03b2-catenin\/LECT2","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154021"}}