{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:51:35Z","timestamp":1784098295742,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR224U"],"award-info":[{"award-number":["JPMJFR224U"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005694","name":"Hori Sciences and Arts Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H05747"],"award-info":[{"award-number":["19H05747"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K06581"],"award-info":[{"award-number":["JP23K06581"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04090"],"award-info":[{"award-number":["17H04090"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154026","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T23:42:44Z","timestamp":1779752564000},"page":"154026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Satb1 enforces CD4+ effector T cell lineage stability by repressing Foxp3 via DNA methylation"],"prefix":"10.1016","volume":"827","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-166X","authenticated-orcid":false,"given":"Wooseok","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4802-723X","authenticated-orcid":false,"given":"Chengcheng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krutula","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Koseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-0669","authenticated-orcid":false,"given":"Terumi","family":"Kohwi-Shigematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-9068","authenticated-orcid":false,"given":"Ichiro","family":"Taniuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154026_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ni.3646","article-title":"Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment","volume":"18","author":"Kitagawa","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.immuni.2016.12.015","article-title":"SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells","volume":"46","author":"Stephen","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1101\/gad.14.5.521","article-title":"The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development","volume":"14","author":"Alvarez","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.154026_bib4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.20142207","article-title":"An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development","volume":"212","author":"Hao","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2026.154026_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4049\/jimmunol.1501429","article-title":"SATB1 plays a critical role in establishment of immune tolerance","volume":"196","author":"Kondo","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.celrep.2017.04.038","article-title":"Essential roles of SATB1 in specifying T lymphocyte subsets","volume":"19","author":"Kakugawa","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154026_bib7","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1038\/s41467-022-34345-y","article-title":"The 3D enhancer network of the developing T cell genome is shaped by SATB1","volume":"13","author":"Zelenka","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154026_bib8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng1913","article-title":"SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes","volume":"38","author":"Cai","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154026_bib9","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/s41467-020-15375-w","article-title":"Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity","volume":"11","author":"Seo","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154026_bib10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.immuni.2021.03.020","article-title":"A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance","volume":"54","author":"Dikiy","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib11","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2021.04.005","article-title":"Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells","volume":"54","author":"Kawakami","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib12","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/ni.2084","article-title":"Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation","volume":"12","author":"Beyer","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni.2523","article-title":"Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes","volume":"14","author":"Mucida","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib14","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301897","article-title":"Identification of a novel enhancer essential for Satb1 expression in T(H)2 cells and activated ILC2s","volume":"6","author":"Nomura","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.bbrc.2026.154026_bib15","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41590-020-0700-y","article-title":"Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity","volume":"21","author":"Tanaka","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/83730","article-title":"Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation","volume":"27","author":"Jackson-Grusby","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154026_bib17","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.4049\/jimmunol.180.3.1565","article-title":"Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells","volume":"180","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2011.12.012","article-title":"Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells","volume":"36","author":"Miyao","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib19","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ni1549","article-title":"Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer","volume":"9","author":"Tone","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2014.07.031","article-title":"Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus","volume":"158","author":"Feng","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154026_bib21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1084\/jem.20151438","article-title":"Control of Foxp3 stability through modulation of TET activity","volume":"213","author":"Yue","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2026.154026_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.immuni.2007.11.021","article-title":"A two-step process for thymic regulatory T cell development","volume":"28","author":"Lio","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib23","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.immuni.2013.02.022","article-title":"Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals","volume":"38","author":"Tai","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41590-018-0289-6","article-title":"Thymic regulatory T cells arise via two distinct developmental programs","volume":"20","author":"Owen","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib25","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154026_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.immuni.2006.07.011","article-title":"Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms","volume":"25","author":"Li","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.immuni.2006.07.012","article-title":"Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor","volume":"25","author":"Marie","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154026_bib28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4049\/jimmunol.1301892","article-title":"TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2","volume":"192","author":"Ogawa","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2026.154026_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2021.12.007","article-title":"TGF-beta-mediated silencing of genomic organizer SATB1 promotes tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures","volume":"55","author":"Chaurio","year":"2022","journal-title":"Immunity"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:29:21Z","timestamp":1783175361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":29,"alternative-id":["S0006291X26007904"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154026","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Satb1 enforces CD4+ effector T cell lineage stability by repressing Foxp3 via DNA methylation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154026"}}