{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:57:35Z","timestamp":1785700655082,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K22350"],"award-info":[{"award-number":["25K22350"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K14852"],"award-info":[{"award-number":["22K14852"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K01706"],"award-info":[{"award-number":["24K01706"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004087","name":"Shizuoka University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154027","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:01:05Z","timestamp":1779721265000},"page":"154027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ethanol antagonizes human olfactory receptors through receptor-dependent competitive and noncompetitive mechanisms"],"prefix":"10.1016","volume":"828","author":[{"given":"Chinatsu","family":"Kasahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichie","family":"Ojiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoma","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2323-3854","authenticated-orcid":false,"given":"Hiroaki","family":"Negoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-9635","authenticated-orcid":false,"given":"Keisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154027_bib1","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1016\/j.cub.2014.11.044","article-title":"Aversion and attraction through olfaction","volume":"25","author":"Li","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2026.154027_bib2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2174\/1570159X17666181206095626","article-title":"Sense of smell: structural, functional, mechanistic advancements and challenges in human olfactory research","volume":"17","author":"Sharma","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbrc.2026.154027_bib3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1126\/science.1249168","article-title":"Humans can discriminate more than 1 trillion olfactory stimuli","volume":"343","author":"Bushdid","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154027_bib4","doi-asserted-by":"crossref","first-page":"D1370","DOI":"10.1093\/nar\/gkad886","article-title":"M2OR: a database of olfactory receptor\u2013odorant pairs for understanding the molecular mechanisms of olfaction","volume":"52","author":"Lalis","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.154027_bib5","doi-asserted-by":"crossref","first-page":"W507","DOI":"10.1093\/nar\/gkae305","article-title":"Pred-O3, a web server to predict molecules, olfactory receptors and odor relationships","volume":"52","author":"Ollitrault","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.154027_bib6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/nar\/30.1.354","article-title":"Olfactory receptor database: a metadata-driven automated population from sources of gene and protein sequences","volume":"30","author":"Crasto","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.154027_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-024-08126-0","article-title":"Engineered odorant receptors illuminate the basis of odour discrimination","volume":"635","author":"de March","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154027_bib8","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1126\/science.1080376","article-title":"Identification of a testicular odorant receptor mediating human sperm chemotaxis","volume":"299","author":"Spehr","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154027_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16001-4","article-title":"Dynamical binding modes determine agonistic and antagonistic ligand effects in the prostate-specific G-protein coupled receptor (PSGR)","volume":"7","author":"Wolf","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154027_bib10","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.cub.2023.04.072","article-title":"Antagonistic interactions between odorants alter human odor perception","volume":"33","author":"Fukutani","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2026.154027_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131077","article-title":"Computational approaches for decoding select odorant\u2013olfactory receptor interactions using mini-virtual screening","volume":"10","author":"Harini","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.154027_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.emboj.7600032","article-title":"Olfactory receptor antagonism between odorants","volume":"23","author":"Oka","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2026.154027_bib13","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.cub.2020.04.086","article-title":"Odorant receptor inhibition is fundamental to odor encoding","volume":"30","author":"Pfister","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2026.154027_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12078-017-9238-2","article-title":"Effects of ethanol on flavor perception in alcoholic beverages","volume":"10","author":"Ickes","year":"2017","journal-title":"Chemosens. Percept."},{"key":"10.1016\/j.bbrc.2026.154027_bib15","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3390\/foods13162623","article-title":"Comparison of different deodorizing treatments on the flavor of paddy field carp, analyzed by the E-nose, E-tongue and gas chromatography-ion mobility spectrometry","volume":"13","author":"Fu","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.bbrc.2026.154027_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.112431","article-title":"Development of a novel cooking wine with high-efficiency deodorizing capability via a rapid fermentation strategy","volume":"153","author":"Fu","year":"2022","journal-title":"LWT \u2013 Food Sci. Technol."},{"key":"10.1016\/j.bbrc.2026.154027_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/beverages10040116","article-title":"Ethanol's pharmacodynamic effect on odorant detection in distilled spirits models","volume":"10","author":"Wang","year":"2024","journal-title":"Beverages"},{"key":"10.1016\/j.bbrc.2026.154027_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.70199","article-title":"Flavor interactions in wine: current status and future directions from interdisciplinary and crossmodal perspectives","volume":"24","author":"Li","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.bbrc.2026.154027_bib19","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/bbb\/zbab035","article-title":"A new screening method for identifying chemosensory receptors responding to agonist","volume":"85","author":"Tsuchiya","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bbrc.2026.154027_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151459","article-title":"Odorants have the potential to enhance the heterologous expression of human olfactory receptors: evidence from ethyl 3-phenylglycidate","volume":"752","author":"Ojiro","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154027_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0306029","article-title":"Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors","volume":"19","author":"Ojiro","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.154027_bib22","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1038\/s41586-024-08416-7","article-title":"Addendum: accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"636","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154027_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41422-024-00991-8","article-title":"AI accurately predicting the structure of biomolecular interactions","volume":"34","author":"Peng","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2026.154027_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154027_bib25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/bbb\/zbaf029","article-title":"Combinatory breeding of sake yeast strains with mutations that enhance Ginjo aroma production","volume":"89","author":"Gong","year":"2025","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bbrc.2026.154027_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/chemse\/bjw117","article-title":"The broadly tuned odorant receptor OR1A1 is highly selective for 3-methyl-2,4-nonanedione","volume":"42","author":"Geithe","year":"2017","journal-title":"Chem. Senses"},{"key":"10.1016\/j.bbrc.2026.154027_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131680","article-title":"The key food odorant receptive range of broadly tuned receptor OR2W1","volume":"375","author":"Haag","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2026.154027_bib28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/chemse\/bjp044","article-title":"Odor interaction between bourgeonal and its antagonist undecanal","volume":"34","author":"Brodin","year":"2009","journal-title":"Chem. Senses"},{"key":"10.1016\/j.bbrc.2026.154027_bib29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fonc.2018.00162","article-title":"A testosterone metabolite induces neuroendocrine trans-differentiation via an ectopic olfactory receptor","volume":"8","author":"Abaffy","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2026.154027_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1124\/molpharm.123.000843","article-title":"Intracellular allosteric antagonist of the olfactory receptor OR51E2","volume":"106","author":"Abaffy","year":"2024","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154027_bib31","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41586-023-05798-y","article-title":"Structural basis of odorant recognition by a human odorant receptor","volume":"615","author":"Billesb\u00f8lle","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154027_bib32","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1039\/C8OB00205C","article-title":"Carbon chain shape selectivity by the mouse olfactory receptor OR-I7","volume":"16","author":"Liu","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bbrc.2026.154027_bib33","series-title":"Fermented Foods and Beverages of the World","year":"2010"},{"key":"10.1016\/j.bbrc.2026.154027_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2147\/RMHP.S495493","article-title":"Alcohol in daily products: health risks, cultural considerations, and economic impacts","volume":"18","author":"Herdiana","year":"2025","journal-title":"Risk Manag. Healthc. Policy"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26007916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:43:28Z","timestamp":1785699808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26007916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"alternative-id":["S0006291X26007916"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154027","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol antagonizes human olfactory receptors through receptor-dependent competitive and noncompetitive mechanisms","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154027"}}