{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:21:30Z","timestamp":1783138890730,"version":"3.54.6"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104096"],"award-info":[{"award-number":["22104096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154047","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:37:38Z","timestamp":1779925058000},"page":"154047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated single-nucleus transcriptomics reveals stage-dependent neuronal and oligodendroglial remodeling in the Alzheimer's disease prefrontal cortex"],"prefix":"10.1016","volume":"827","author":[{"given":"Changqing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiannian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10284","key":"10.1016\/j.bbrc.2026.154047_bib1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154047_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National institute on aging\u2013alzheimer\u2019s association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154047_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2026.154047_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"7761","key":"10.1016\/j.bbrc.2026.154047_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154047_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41593-020-00764-7","article-title":"Molecular characterization of selectively vulnerable neurons in Alzheimer's disease","volume":"24","author":"Leng","year":"2021","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154047_bib7","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.neuron.2022.03.008","article-title":"Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease","volume":"110","author":"Sadick","year":"2022","journal-title":"Neuron"},{"issue":"8026","key":"10.1016\/j.bbrc.2026.154047_bib8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41586-024-07606-7","article-title":"Single-cell multiregion dissection of Alzheimer's disease","volume":"632","author":"Mathys","year":"2024","journal-title":"Nature"},{"issue":"41","key":"10.1016\/j.bbrc.2026.154047_bib9","doi-asserted-by":"crossref","first-page":"25800","DOI":"10.1073\/pnas.2008762117","article-title":"Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease","volume":"117","author":"Lau","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154047_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41588-021-00894-z","article-title":"Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease","volume":"53","author":"Morabito","year":"2021","journal-title":"Nat. Genet."},{"issue":"622","key":"10.1016\/j.bbrc.2026.154047_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe3947","article-title":"AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation","volume":"13","author":"Sayed","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154047_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154047_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: computational identification of cell doublets in single-cell transcriptomic data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.bbrc.2026.154047_bib14","first-page":"1438","article-title":"From reads to genes to pathways: differential expression analysis of RNA-seq experiments using Rsubread and the edgeR quasi-likelihood pipeline","volume":"5","author":"Chen","year":"2016","journal-title":"F1000Res"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154047_bib15","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41467-021-27150-6","article-title":"scCODA is a Bayesian model for compositional single-cell data analysis","volume":"12","author":"B\u00fcttner","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154047_bib16","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.bbrc.2026.154047_bib17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pharmthera.2018.11.006","article-title":"Synaptic dysfunction in Alzheimer's disease: mechanisms and therapeutic strategies","volume":"195","author":"Chen","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154047_bib18","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020479","article-title":"Oligodendrocytes: myelination and axonal support","volume":"8","author":"Simons","year":"2016","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154047_bib19","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1172\/JCI90610","article-title":"Oligodendroglia: metabolic supporters of neurons","volume":"127","author":"Philips","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"7964","key":"10.1016\/j.bbrc.2026.154047_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer's disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:06:19Z","timestamp":1783137979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26008119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"alternative-id":["S0006291X26008119"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154047","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated single-nucleus transcriptomics reveals stage-dependent neuronal and oligodendroglial remodeling in the Alzheimer's disease prefrontal cortex","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154047"}}