{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:24:32Z","timestamp":1783085072701,"version":"3.54.6"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023-YBSF-153"],"award-info":[{"award-number":["2023-YBSF-153"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154049","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T14:58:57Z","timestamp":1779980337000},"page":"154049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Knocking-down testis-specific protein Y-encoded-like 2 alleviates hypertension through down-regulating the transcription of GluN2A\/B in hypothalamic paraventricular nucleus"],"prefix":"10.1016","volume":"827","author":[{"given":"Jin-Hong","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-4768","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154049_bib1","volume":"3.16","year":"2023","journal-title":"Fact Sheets"},{"key":"10.1016\/j.bbrc.2026.154049_bib2","article-title":"Impaired hypothalamic regulation of sympathetic outflow in primary hypertension","volume":"35","author":"Zhou","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154049_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11906-017-0776-4","article-title":"Glutamatergic regulation of hypothalamic presympathetic neurons in hypertension","volume":"19","author":"Li","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154049_bib4","doi-asserted-by":"crossref","first-page":"H1200","DOI":"10.1152\/ajpheart.00216.2018","article-title":"Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states","volume":"315","author":"Dampney","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154049_bib5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1113\/jphysiol.2007.149732","article-title":"Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats","volume":"586","author":"Li","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2026.154049_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuropharm.2015.08.012","article-title":"Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats","volume":"99","author":"Zhou","year":"2015","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154049_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/MNH.0000000000000862","article-title":"Targeting inflammation in hypertension","volume":"32","author":"Deussen","year":"2023","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154049_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12974-018-1131-7","article-title":"Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats","volume":"15","author":"Wang","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154049_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1113\/expphysiol.2014.079855","article-title":"Mechanisms of renal sympathetic activation in renovascular hypertension","volume":"100","author":"Campos","year":"2015","journal-title":"Exp. Physiol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154049_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00424-012-1173-0","article-title":"SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats","volume":"465","author":"Yuan","year":"2013","journal-title":"Pflugers Arch"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154049_bib11","article-title":"Altered gut Microbiota is involved in the anti-hypertensive effects of vitamin C in spontaneously hypertensive rat","volume":"65","author":"Li","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbrc.2026.154049_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175343","article-title":"Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation","volume":"936","author":"Wang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154049_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/01.HYP.0000259666.99449.74","article-title":"Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension","volume":"49","author":"Li","year":"2007","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154049_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/HYPERTENSIONAHA.116.07947","article-title":"Src kinases regulate glutamatergic input to hypothalamic presympathetic neurons and sympathetic outflow in hypertension","volume":"69","author":"Qiao","year":"2017","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"issue":"22","key":"10.1016\/j.bbrc.2026.154049_bib15","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1523\/JNEUROSCI.1147-11.2011","article-title":"Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension","volume":"31","author":"Ye","year":"2011","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"issue":"30","key":"10.1016\/j.bbrc.2026.154049_bib16","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1523\/JNEUROSCI.0346-21.2021","article-title":"\u03b12\u03b4-1\u2013Dependent NMDA receptor activity in the hypothalamus is an effector of genetic-environment interactions that drive persistent hypertension","volume":"41","author":"Zhou","year":"2021","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154049_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/1096-9861(20000703)422:3<352::AID-CNE3>3.0.CO;2-F","article-title":"Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat","volume":"422","author":"Herman","year":"2000","journal-title":"J. Comp. Neurol."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154049_bib18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/ajh\/hpab047","article-title":"Chronic blockade of NMDAR subunit 2A in the hypothalamic Paraventricular Nucleus alleviates hypertension through suppression of MEK\/ERK\/CREB pathway","volume":"34","author":"Li","year":"2021","journal-title":"Am. J. Hypertens."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154049_bib19","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1074\/jbc.M111.331165","article-title":"Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension","volume":"287","author":"Ye","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.bbrc.2026.154049_bib20","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1523\/JNEUROSCI.2301-14.2015","article-title":"NMDA receptor plasticity in the hypothalamic Paraventricular nucleus contributes to the elevated blood pressure produced by angiotensin II","volume":"35","author":"Glass","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154049_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.805070","article-title":"Effects of Nrf1 in hypothalamic paraventricular nucleus on regulating the blood pressure during hypertension","volume":"15","author":"Yu","year":"2021","journal-title":"Front. Neurosci."},{"issue":"19","key":"10.1016\/j.bbrc.2026.154049_bib22","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1113\/JP270831","article-title":"Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension","volume":"593","author":"Li","year":"2015","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154049_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/CIRCRESAHA.122.320976","article-title":"Calcineurin controls hypothalamic NMDA receptor activity and sympathetic outflow","volume":"131","author":"Zhou","year":"2022","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154049_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1139\/o06-088","article-title":"Structure and function of nucleosome assembly proteins","volume":"84","author":"Park","year":"2006","journal-title":"Biochem. Cell. Biol."},{"issue":"23","key":"10.1016\/j.bbrc.2026.154049_bib25","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1128\/MCB.20.23.8933-8943.2000","article-title":"Functional interaction between nucleosome assembly proteins and p300\/CREB-binding protein family coactivators","volume":"20","author":"Shikama","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154049_bib26","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1038\/srep03654","article-title":"The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B","volume":"4","author":"Tsang","year":"2014","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154049_bib27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cne.20825","article-title":"Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain","volume":"494","author":"Lin","year":"2006","journal-title":"J. Comp. Neurol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154049_bib28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/ajh\/hpae067","article-title":"Testis specific protein, Y-encoded-like 2 activates JAK2\/STAT3 pathway in hypothalamic paraventricular nucleus to sustain hypertension","volume":"37","author":"Li","year":"2024","journal-title":"Am. J. Hypertens."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154049_bib29","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12012-021-09641-6","article-title":"Nrf1 knock-down in the hypothalamic Paraventricular Nucleus alleviates hypertension through intervention of superoxide production-removal balance and mitochondrial function","author":"Li","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bbrc.2026.154049_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114953","article-title":"Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats","volume":"394","author":"Huo","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154049_bib31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajh\/hpad012","article-title":"Hypothalamic paraventricular Nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway","volume":"36","author":"Xia","year":"2023","journal-title":"Am. J. Hypertens."},{"issue":"19","key":"10.1016\/j.bbrc.2026.154049_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu14193968","article-title":"Exercise training attenuates hypertension via suppressing ROS\/MAPK\/NF-\u03baB\/AT-1R pathway in the hypothalamic paraventricular nucleus","volume":"14","author":"Qi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154049_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2011.00089","article-title":"A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus","volume":"5","author":"Babu","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154049_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12727","article-title":"Sensitive red protein calcium indicators for imaging neural activity","volume":"5","author":"Dana","year":"2016","journal-title":"eLife"},{"issue":"16","key":"10.1016\/j.bbrc.2026.154049_bib35","doi-asserted-by":"crossref","first-page":"11722","DOI":"10.1074\/jbc.M609623200","article-title":"Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1\/Cip1) by activating p53 and MEK\/ERK1\/2 MAPK pathways","volume":"282","author":"Tu","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154049_bib36","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1007\/s12035-018-1238-y","article-title":"TSPYL2 regulates the expression of EZH2 target genes in neurons","volume":"56","author":"Liu","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154049_bib37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jjcc.2016.01.004","article-title":"Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension","volume":"69","author":"Takesue","year":"2017","journal-title":"J. Cardiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:10:59Z","timestamp":1783084259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26008132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"alternative-id":["S0006291X26008132"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154049","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knocking-down testis-specific protein Y-encoded-like 2 alleviates hypertension through down-regulating the transcription of GluN2A\/B in hypothalamic paraventricular nucleus","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154049"}}