{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:22:21Z","timestamp":1783117341677,"version":"3.54.6"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773001"],"award-info":[{"award-number":["81773001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016308","name":"Wuxi Health and Family Planning Commission","doi-asserted-by":"publisher","award":["ZDXK2021007"],"award-info":[{"award-number":["ZDXK2021007"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154058","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T23:57:59Z","timestamp":1780012679000},"page":"154058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RBM46 promotes meiotic initiation during oogenesis"],"prefix":"10.1016","volume":"827","author":[{"given":"Jiawei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-5815","authenticated-orcid":false,"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154058_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/biolre\/ioy021","article-title":"Meiosis: the chromosomal foundation of reproduction","volume":"99","author":"Bolcun-Filas","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbrc.2026.154058_bib2","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1042\/BCJ20210412","article-title":"Meiosis initiation: a story of two sexes in all creatures great and small","volume":"478","author":"Sou","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2026.154058_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10324","article-title":"Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts","volume":"7","author":"Abby","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154058_bib4","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1073\/pnas.0510813103","article-title":"Retinoic acid regulates sex-specific timing of meiotic initiation in mice","volume":"103","author":"Koubova","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.154058_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.devcel.2010.09.010","article-title":"The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells","volume":"19","author":"Matson","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib6","first-page":"4137","article-title":"Regulation of mitosis-meiosis transition by the ubiquitin ligase beta-TrCP in male germ cells","volume":"144","author":"Nakagawa","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2026.154058_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006704","article-title":"Meioc maintains an extended meiotic prophase I in mice","volume":"13","author":"Soh","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2026.154058_bib8","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.0807297105","article-title":"Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice","volume":"105","author":"Anderson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.154058_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.devcel.2020.01.010","article-title":"MEIOSIN directs the switch from mitosis to meiosis in Mammalian germ cells","volume":"52","author":"Ishiguro","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26116","article-title":"The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline","volume":"6","author":"Bailey","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2026.154058_bib11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2026.154058_bib12","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.molcel.2022.02.034","article-title":"The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m(6)A recognition","volume":"82","author":"Li","year":"2022","journal-title":"Mol Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib13","doi-asserted-by":"crossref","first-page":"eabq2945","DOI":"10.1126\/sciadv.abq2945","article-title":"RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis","volume":"8","author":"Qian","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154058_bib14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/biolre\/ioab016","article-title":"Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis","volume":"104","author":"Dai","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbrc.2026.154058_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149779","article-title":"Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy","volume":"708","author":"Zhong","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154058_bib16","first-page":"51","article-title":"RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits","volume":"14","author":"Lv","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010416","article-title":"The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice","volume":"18","author":"Peart","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2026.154058_bib18","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1101\/gad.329705","article-title":"Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation","volume":"19","author":"de Vries","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.154058_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1097-2765(00)80404-9","article-title":"The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility","volume":"5","author":"Yuan","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/85830","article-title":"Recombinational DNA double-strand breaks in mice precede synapsis","volume":"27","author":"Mahadevaiah","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154058_bib21","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1038\/onc.2009.170","article-title":"Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms","volume":"28","author":"Satyanarayana","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2026.154058_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/dev.205037","article-title":"MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis","volume":"153","author":"Ushuhuda","year":"2026","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2026.154058_bib23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0092-8674(00)81876-0","article-title":"Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family","volume":"88","author":"Keeney","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154058_bib24","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/stem.1584","article-title":"LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion","volume":"32","author":"Chakraborty","year":"2014","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2026.154058_bib25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/stem.1343","article-title":"Lin28a regulates germ cell pool size and fertility","volume":"31","author":"Shinoda","year":"2013","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2026.154058_bib26","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/stem.3433","article-title":"Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells","volume":"39","author":"Uranishi","year":"2021","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2026.154058_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.242701","article-title":"LIN28A binds to meiotic gene transcripts and modulates their translation in male germ cells","volume":"133","author":"Wang","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2026.154058_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004797","article-title":"Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila","volume":"10","author":"Chen","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2026.154058_bib29","article-title":"Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells","author":"Pfaltzgraff","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2026.154058_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11056","article-title":"Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells","volume":"7","author":"Suzuki","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154058_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/molehr\/gas025","article-title":"The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?","volume":"18","author":"Aeckerle","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bbrc.2026.154058_bib32","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1210\/en.2012-1745","article-title":"Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism","volume":"154","author":"Gaytan","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2026.154058_bib33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-213X-9-38","article-title":"The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse","volume":"9","author":"Zheng","year":"2009","journal-title":"BMC Dev. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:55:04Z","timestamp":1783115704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26008223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["S0006291X26008223"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154058","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RBM46 promotes meiotic initiation during oogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154058"}}