{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:04:32Z","timestamp":1793167472355,"version":"4.5.0"},"reference-count":137,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbrc.2026.154097","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:51:32Z","timestamp":1780530692000},"page":"154097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Plant-derived molecules as multitarget modulators of NF-\u03baB, PI3K\/Akt, MAPK, and AMPK\/mTOR signaling in chronic diseases"],"prefix":"10.1016","volume":"828","author":[{"given":"Kaushik","family":"Modak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6485-3867","authenticated-orcid":false,"given":"Krishna Kumar","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-9581","authenticated-orcid":false,"given":"Manish Kumar","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha Pratim","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Gangwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154097_bib1","first-page":"3292","article-title":"Conceptual evolution of cell signaling","volume":"20","author":"Nair","year":"2019","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib2","unstructured":"S. Susan, Cell signaling: its mechanisms in cells communication, Molecular Pathways and Cellular Responses, (n.d.)."},{"key":"10.1016\/j.bbrc.2026.154097_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2022.01.011","article-title":"Signalling dynamics, cell decisions, and homeostatic control in health and disease","volume":"75","author":"Valls","year":"2022","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154097_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s43556-023-00151-1","article-title":"JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions","volume":"4","author":"Sarapultsev","year":"2023","journal-title":"Mol Biomed"},{"key":"10.1016\/j.bbrc.2026.154097_bib5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrd.2017.201","article-title":"JAK inhibition as a therapeutic strategy for immune and inflammatory diseases","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2026.154097_bib7","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1101\/gad.17421911","article-title":"Cooperation between both Wnt\/\u03b2-catenin and PTEN\/PI3K\/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion","volume":"25","author":"Perry","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.154097_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jcmgh.2020.04.007","article-title":"Are Wnt\/\u03b2-Catenin and PI3K\/AKT\/mTORC1 distinct pathways in colorectal cancer?","volume":"10","author":"Prossomariti","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154097_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2026.154097_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2026.154097_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154097_bib12","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.3390\/biomedicines12081802","article-title":"mTOR dysregulation, insulin resistance, and hypertension","volume":"12","author":"Stanciu","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2026.154097_bib13","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1111\/febs.14379","article-title":"The role of Nrf2 signaling in counteracting neurodegenerative diseases","volume":"285","author":"Dinkova\u2010Kostova","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2026.154097_bib14","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3390\/cancers15153980","article-title":"Targeting cell signaling pathways in lung cancer by bioactive phytocompounds","volume":"15","author":"Choudhary","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2026.154097_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108634","article-title":"Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways","volume":"93","author":"Jantan","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2026.154097_bib16","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1002\/ptr.70051","article-title":"Current insights of the potential plant bioactive compounds on modulating the mTOR signaling pathway in regulating oncological disorders","volume":"39","author":"Khanal","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib17","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.3390\/ijms26115206","article-title":"Anti-inflammatory actions of plant-derived compounds and prevention of chronic diseases: from molecular mechanisms to applications","volume":"26","author":"Nakadate","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/molecules23020258","article-title":"Action of phytochemicals on insulin signaling pathways accelerating glucose transporter (GLUT4) protein translocation","volume":"23","author":"Sayem","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3390\/antiox14040457","article-title":"Signaling pathways in oxidative stress-induced neurodegenerative diseases: a review of phytochemical therapeutic interventions","volume":"14","author":"Sebghatollahi","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2026.154097_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/separations11060184","article-title":"Paeoniae Radix Alba and network pharmacology approach for osteoarthritis: a review","volume":"11","author":"Wang","year":"2024","journal-title":"Separations"},{"key":"10.1016\/j.bbrc.2026.154097_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.105922","article-title":"Bioactive alkaloidal and phenolic phytochemicals as promising epidrugs for diabetes mellitus 2: a review of recent development","volume":"175","author":"Ayipo","year":"2024","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bbrc.2026.154097_bib22","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.3390\/molecules25245986","article-title":"A compressive review about taxol\u00ae: history and future challenges","volume":"25","author":"Gallego-Jara","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.54254\/2753-8818\/2024.19390","article-title":"Review of the research progress of paclitaxel","volume":"72","author":"Zhou","year":"2025","journal-title":"TNS"},{"key":"10.1016\/j.bbrc.2026.154097_bib24","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12951-018-0351-4","article-title":"Paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal formulations exhibit enhanced synergistic antitumor efficacy","volume":"16","author":"Alemi","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2026.154097_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10787-024-01635-4","article-title":"Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review","volume":"33","author":"Kannan","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2026.154097_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154097_bib28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2026.154097_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/embr.201337983","article-title":"The I\u03baB kinase complex in NF \u2010\u03baB regulation and beyond","volume":"15","author":"Hinz","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2026.154097_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib31","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4110\/in.2016.16.2.85","article-title":"Regulatory roles of MAPK phosphatases in cancer","volume":"16","author":"Low","year":"2016","journal-title":"Immune Netw."},{"key":"10.1016\/j.bbrc.2026.154097_bib35","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib36","doi-asserted-by":"crossref","unstructured":"R. Wang, Z. Qu, Y. Lv, L. Yao, Y. Qian, X. Zhang, L. Xiang, Important roles of PI3K\/AKT signaling pathway and relevant inhibitors in prostate cancer progression, (n.d.). https:\/\/doi.org\/10.1002\/cam4.70354.","DOI":"10.1002\/cam4.70354"},{"key":"10.1016\/j.bbrc.2026.154097_bib55","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3390\/cells12141830","article-title":"A role of PI3K\/Akt signaling in oocyte maturation and early embryo development","volume":"12","author":"Kalous","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.154097_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pharep.2016.12.011","article-title":"The Nrf2-ARE signaling pathway: an update on its regulation and possible role in cancer prevention and treatment","volume":"69","author":"Krajka-Ku\u017aniak","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbrc.2026.154097_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37545","article-title":"Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in heavy metals-induced oxidative stress","volume":"10","author":"Tripathi","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrc.2026.154097_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1110765","article-title":"JAK\/STAT pathway: extracellular signals, diseases, immunity, and therapeutic regimens","volume":"11","author":"Hu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.154097_bib56","first-page":"523","article-title":"JAK-STAT signaling in autoimmunity and cancer","volume":"14","author":"Parveen","year":"2025","journal-title":"Interpreter Transl. Train. (ITT)"},{"key":"10.1016\/j.bbrc.2026.154097_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lfs.2016.04.004","article-title":"HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: the role of AMP-activated protein kinase","volume":"153","author":"Xue","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.33549\/physiolres.934618","article-title":"The role of AMPK\/mTOR signaling pathway in anticancer activity of metformin","volume":"70","author":"Chomanicova","year":"2021","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/wasj.2025.391","article-title":"Deciphering the critical roles of the AMPK\/mTOR signaling pathway in cancer cell metabolism","volume":"7","author":"Alasadi","year":"2025","journal-title":"World Academy of Sciences Journal"},{"key":"10.1016\/j.bbrc.2026.154097_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13619-020-00072-2","article-title":"The interaction of Notch and Wnt signaling pathways in vertebrate regeneration","volume":"10","author":"Gao","year":"2021","journal-title":"Cell Regen."},{"key":"10.1016\/j.bbrc.2026.154097_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154097_bib54","article-title":"The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib32","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jpha.2021.07.002","article-title":"Phytochemicals targeting NF-\u03baB signaling: potential anti-cancer interventions","volume":"12","author":"Chauhan","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.bbrc.2026.154097_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fmicb.2016.00183","article-title":"The mitogen-activated protein kinase (MAPK) pathway: role in immune evasion by trypanosomatids","volume":"7","author":"Soares-Silva","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbrc.2026.154097_bib37","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/ptr.7794","article-title":"Co\u2010administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets","volume":"37","author":"Ghobadi","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib41","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.3390\/molecules26092824","article-title":"Phytochemicals targeting JAK\u2013STAT pathways in inflammatory bowel disease: insights from animal models","volume":"26","author":"Moon","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib42","article-title":"Exploring the JAK\/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications","volume":"24","author":"Park","year":"2023","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12727","article-title":"The roles of SOCS 3 and STAT 3 in bacterial infection and inflammatory diseases","volume":"88","author":"Gao","year":"2018","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib44","article-title":"Exploring the JAK\/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications","volume":"24","author":"Park","year":"2023","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib46","first-page":"1","article-title":"Nutrient sensing of mTORC1 signaling in cancer and aging","volume":"vols. 106\u2013107","author":"Jiang","year":"2024"},{"key":"10.1016\/j.bbrc.2026.154097_bib48","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/EBC20240007","article-title":"New developments in AMPK and mTORC1 cross-talk","volume":"68","author":"Smiles","year":"2024","journal-title":"Essays Biochem."},{"key":"10.1016\/j.bbrc.2026.154097_bib51","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1158\/2159-8290.CD-21-0190","article-title":"WNT as a driver and dependency in cancer","volume":"11","author":"Parsons","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrc.2026.154097_bib52","first-page":"8018","article-title":"Wnt pathway: an integral hub for developmental and oncogenic signaling networks","volume":"21","author":"Sharma","year":"2020","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.806470","article-title":"Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action","volume":"13","author":"Rudrapal","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118020","article-title":"Exploring the links between polyphenols, Nrf2, and diabetes: a review","volume":"186","author":"Ebrahimi","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154097_bib59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","article-title":"Cellular and molecular mechanisms of curcumin in prevention and treatment of disease","volume":"60","author":"Patel","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbrc.2026.154097_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1548073","article-title":"Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway","volume":"16","author":"Cui","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib61","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/molecules27010167","article-title":"Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects","volume":"27","author":"Shahcheraghi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib62","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.3390\/ijms23073966","article-title":"In silico and in vitro screening of 50 curcumin compounds as EGFR and NF-\u03baB inhibitors","volume":"23","author":"Saeed","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib63","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1002\/ptr.8220","article-title":"Curcumin and its anti-colorectal cancer potential: from mechanisms of action to autophagy","volume":"38","author":"Brockmueller","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110234","article-title":"The therapeutic effect of resveratrol: focusing on the Nrf2 signaling pathway","volume":"127","author":"Farkhondeh","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154097_bib65","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/molecules26010229","article-title":"Anti-Inflammatory action and mechanisms of resveratrol","volume":"26","author":"Meng","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15586\/aei.v52i1.963","article-title":"Resveratrol modulates the Nrf2\/NF-\u03baB pathway and inhibits TSLP-mediated atopic march","volume":"52","author":"He","year":"2024","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.bbrc.2026.154097_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119025","article-title":"Astaxanthin attenuates AFB1-induced hepatotoxicity by activating Nrf2 and inhibiting the NF-\u03baB signaling pathway","volume":"303","author":"Kang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbrc.2026.154097_bib68","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3390\/molecules29051000","article-title":"Quercetin, a flavonoid with great pharmacological capacity","volume":"29","author":"Carrillo-Martinez","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73075-7","article-title":"Quercetin as a therapeutic agent activate the Nrf2\/Keap1 pathway to alleviate lung ischemia-reperfusion injury","volume":"14","author":"Yousefi Zardak","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154097_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1185","article-title":"Quercetin attenuates inflammation in LPS\u2010induced lung epithelial cells via the Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.bbrc.2026.154097_bib90","first-page":"138","article-title":"The alleviating impacts of Quercetin on inflammation and oxidant-antioxidant imbalance in rats with allergic asthma","volume":"22","author":"Rajizadeh","year":"2023","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib71","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/ijms25010251","article-title":"Resources for human health from the plant kingdom: the potential role of the flavonoid apigenin in cancer counteraction","volume":"25","author":"Fossatelli","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib72","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.3390\/molecules27248864","article-title":"Therapeutic importance of kaempferol in the treatment of cancer through the modulation of cell signalling pathways","volume":"27","author":"Qattan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib73","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3390\/molecules27041347","article-title":"Alkaloids in future drug discovery","volume":"27","author":"Ferreira","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib74","first-page":"1225","article-title":"Berberine pharmacological properties and therapeutic potential across cancer, digestive, metabolic, cardiovascular, and neurological diseases: an update review","volume":"24","author":"Cheng","year":"2025","journal-title":"EXCLI J."},{"key":"10.1016\/j.bbrc.2026.154097_bib75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s43088-022-00196-1","article-title":"Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials","volume":"11","author":"Tripathi","year":"2022","journal-title":"Beni Suef Univ J Basic Appl Sci"},{"key":"10.1016\/j.bbrc.2026.154097_bib76","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/fsn3.3308","article-title":"Phytobioactive compounds as therapeutic agents for human diseases: a review","volume":"11","author":"Riaz","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bbrc.2026.154097_bib78","article-title":"Current research on the control mechanisms of cell survival and proliferation as potential interaction sites with pentacyclic triterpenoids in ovarian cancer","volume":"26","author":"Orchel","year":"2025","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312804","article-title":"Therapeutic potential of natural compounds to modulate WNT\/\u03b2-Catenin signaling in cancer: current State of art and challenges","volume":"25","author":"Gajos-Michniewicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1250893","article-title":"Natural compounds: wnt pathway inhibitors with therapeutic potential in lung cancer","volume":"14","author":"Shen","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28135210","article-title":"Glycosides as potential medicinal components for ulcerative colitis: a review","volume":"28","author":"Niu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib82","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.3390\/cells14221758","article-title":"The potential of bioactive plant phytochemicals, pro-resolving anti-inflammatory lipids, and statins in the inhibition of intervertebral disc degeneration, low back pain resolution, disc functional repair, and promotion of intervertebral disc regeneration","volume":"14","author":"Melrose","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.154097_bib80","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/metabo15090589","article-title":"The power of lignans: plant compounds with multifaceted health-promoting effects","volume":"15","author":"Burgberger","year":"2025","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrc.2026.154097_bib83","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3390\/ph18101569","article-title":"Multi-Target therapeutic potential of Arctii Fructus Lignans in diabetes mellitus and its complications: a mechanistic review","volume":"18","author":"Lv","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbrc.2026.154097_bib84","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.2147\/DDDT.S547924","article-title":"Pharmacological potential and molecular targets of tetrahydrofurofuranoid lignans from magnoliae flos","volume":"19","author":"Yi","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2026.154097_bib85","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/molecules30061364","article-title":"Eucommiae cortex comprehensive phytochemical analysis connected with its In vitro anti-inflammatory activity in human immune cells","volume":"30","author":"Ko\u0142tun-Jasion","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib86","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3390\/ijms22062991","article-title":"Plant-Based bioactive molecules in improving health and preventing lifestyle diseases","volume":"22","author":"Acquaviva","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154097_bib87","doi-asserted-by":"crossref","first-page":"625","DOI":"10.5152\/tjg.2024.23526","article-title":"Curcumin induces autophagy-mediated ferroptosis by targeting the PI3K\/AKT\/mTOR signaling pathway in gastric cancer","volume":"35","author":"Zheng","year":"2024","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2026.154097_bib88","first-page":"1","article-title":"Natural products in medicinal chemistry: targeting inflammatory pathways with plant-derived compounds","author":"Amin","year":"2025","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib89","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/cimb47070498","article-title":"The role of plant-derived natural products as a regulator of the tyrosine kinase pathway in the management of lung cancer","volume":"47","author":"Alrumaihi","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.154097_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1177050","article-title":"Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice","volume":"14","author":"Nisar","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib92","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s10787-023-01206-z","article-title":"Crosstalk between phytochemicals and inflammatory signaling pathways","volume":"31","author":"Prasad","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2026.154097_bib93","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.3390\/molecules25245932","article-title":"Phytochemicals as anti-inflammatory agents in animal models of prevalent inflammatory diseases","volume":"25","author":"Shin","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.931914","article-title":"Curcuma longa and Boswellia serrata extracts modulate different and complementary pathways on human chondrocytes in vitro: deciphering of a transcriptomic Study","volume":"13","author":"Sanchez","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib95","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/ptr.8147","article-title":"Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis","volume":"38","author":"Yuandani","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib96","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.154097_bib97","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbi.2020.09.017","article-title":"Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease","volume":"91","author":"Ahmed","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2026.154097_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111931","article-title":"Phytochemicals as regulators of Th17\/Treg balance in inflammatory bowel diseases","volume":"141","author":"Chang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154097_bib99","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.30574\/wjarr.2025.26.1.1444","article-title":"Phytochemicals from anti-diabetic medicinal plants: a comprehensive review of glycemic control mechanisms","volume":"26","author":"Sayem","year":"2025","journal-title":"World J. Adv. Res. Rev."},{"key":"10.1016\/j.bbrc.2026.154097_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1655875","article-title":"Metabolic regulation of obesity by naturally occurring compounds: mechanisms and therapeutic potential","volume":"16","author":"Das","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2026.154097_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115928","article-title":"Berberine protects mice against type 2 diabetes by promoting PPAR\u03b3-FGF21-GLUT2-regulated insulin sensitivity and glucose\/lipid homeostasis","volume":"218","author":"Chen","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib102","doi-asserted-by":"crossref","first-page":"65","DOI":"10.37547\/tajmspr\/Volume07Issue02-09","article-title":"The therapeutic benefits of berberine and its effectiveness compared to metformin","volume":"7","author":"Chubin","year":"2025","journal-title":"The American Journal of Medical Sciences and Pharmaceutical Research"},{"key":"10.1016\/j.bbrc.2026.154097_bib103","doi-asserted-by":"crossref","first-page":"18780","DOI":"10.1021\/acs.jafc.3c05900","article-title":"Phenolic constituents from Black quinoa alleviate insulin resistance in HepG2 cells via regulating IRS1\/PI3K\/Akt\/GLUTs signaling pathways","volume":"71","author":"Cao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.154097_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/biology12070973","article-title":"Berberine and its Study as an antidiabetic compound","volume":"12","author":"Utami","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.bbrc.2026.154097_bib107","doi-asserted-by":"crossref","DOI":"10.2174\/011874205X319474240611070113","article-title":"Nrf2-Mediated signaling as a therapeutic target in alzheimer's disease","volume":"18","author":"Bitra","year":"2024","journal-title":"TONEUJ"},{"key":"10.1016\/j.bbrc.2026.154097_bib105","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1097\/MS9.0000000000003656","article-title":"Role of gut microbiota in the pathogenesis of metabolic syndrome: an updated comprehensive review from mechanisms to clinical implications","volume":"87","author":"Singh","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.bbrc.2026.154097_bib106","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.3390\/nu17243841","article-title":"Therapeutic potentials of phytochemicals in pancreatitis: targeting calcium signaling, ferroptosis, microRNAs, and inflammation with drug-likeness evaluation","volume":"17","author":"Farhat","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154097_bib108","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbrc.2026.154097_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107466","article-title":"The PINK1\/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia\/reperfusion injury","volume":"209","author":"Zhao","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib110","article-title":"Anti-Cancer potential of phytochemicals: the regulation of the epithelial-mesenchymal transition","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202402479","article-title":"Phytochemicals in cancer therapy: a structured review of mechanisms, challenges, and progress in personalized treatment","volume":"22","author":"Aljabali","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bbrc.2026.154097_bib112","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/ijo.2025.5813","article-title":"Therapeutic potentials of plant-based antioxidants on colorectal cancer: challenges and perspectives","volume":"67","author":"Fu","year":"2025","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2026.154097_bib113","article-title":"Medicinal plants and human health: a comprehensive review of bioactive compounds, therapeutic effects, and applications","author":"Latif","year":"2025","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.bbrc.2026.154097_bib114","series-title":"Medicinal Plants in Combination Therapies for Cancer","first-page":"259","author":"Desai","year":"2025"},{"key":"10.1016\/j.bbrc.2026.154097_bib116","article-title":"Natural products in medicinal chemistry: targeting inflammatory pathways with plant-derived compounds","author":"Amin","year":"2025","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bbrc.2026.154097_bib118","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cpt.2025.02.006","article-title":"Phytoconstituents as emerging therapeutics for breast cancer: mechanistic insights and clinical implications","volume":"3","author":"Devaraji","year":"2025","journal-title":"Cancer Pathog. Ther."},{"key":"10.1016\/j.bbrc.2026.154097_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1677380","article-title":"Overcoming cancer drug resistance: insights into apoptotic pathway modulation by plant-based nanoparticle and natural products","volume":"15","author":"Singh","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2026.154097_bib123","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.2147\/IJN.S499893","article-title":"From plant based therapy to plant-derived vesicle-like nanoparticles for cancer treatment: past, present and future","volume":"20","author":"An","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2026.154097_bib121","doi-asserted-by":"crossref","DOI":"10.31083\/JIN23090","article-title":"Current status of plant-based bioactive compounds as therapeutics in alzheimer's diseases","volume":"24","author":"Chen","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154097_bib115","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.2147\/IJN.S499893","article-title":"From plant based therapy to plant-derived vesicle-like nanoparticles for cancer treatment: past, present and future","volume":"20","author":"An","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2026.154097_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1677380","article-title":"Overcoming cancer drug resistance: insights into apoptotic pathway modulation by plant-based nanoparticle and natural products","volume":"15","author":"Singh","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2026.154097_bib119","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/molecules27041351","article-title":"Berberine, a herbal metabolite in the metabolic syndrome: the risk factors, course, and consequences of the disease","volume":"27","author":"Och","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.12944\/CRNFSJ.13.Special-Issue-July.09","article-title":"Phytochemicals as anticancer agents: investigating molecular pathways from preclinical research to clinical relevance","volume":"13","author":"Monica","year":"2025","journal-title":"Current Research in Nutrition and Food Science Journal"},{"key":"10.1016\/j.bbrc.2026.154097_bib124","doi-asserted-by":"crossref","first-page":"141","DOI":"10.12944\/CRNFSJ.13.Special-Issue-July.09","article-title":"Phytochemicals as anticancer agents: investigating molecular pathways from preclinical research to clinical relevance","volume":"13","author":"Monica","year":"2025","journal-title":"Current Research in Nutrition and Food Science Journal"},{"key":"10.1016\/j.bbrc.2026.154097_bib125","doi-asserted-by":"crossref","DOI":"10.31083\/JIN23090","article-title":"Current status of plant-based bioactive compounds as therapeutics in alzheimer's diseases","volume":"24","author":"Chen","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154097_bib126","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1007\/s11101-025-10066-0","article-title":"Ecological and environmental determinants of phytochemical variability in forest trees","volume":"24","author":"Ogwu","year":"2025","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.bbrc.2026.154097_bib127","article-title":"Natural products and phytochemicals in modern drug discovery: mechanistic insights","volume":"1","author":"Ali","year":"2025","journal-title":"Barriers, and Future Opportunities"},{"key":"10.1016\/j.bbrc.2026.154097_bib128","series-title":"Medicinal Plants and Their Bioactives in Human Diseases","first-page":"207","article-title":"Safety, dosage, and regulatory aspects in the use of phytochemicals","author":"Karthikeyan","year":"2025"},{"key":"10.1016\/j.bbrc.2026.154097_bib129","article-title":"Emerging trends in pharmacological research of herbal-based traditional medicine","author":"Nguyen","year":"2025","journal-title":"ADV TRADIT MED (ADTM)"},{"key":"10.1016\/j.bbrc.2026.154097_bib130","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s44371-025-00373-y","article-title":"Integrating phytochemicals and in silico methods for modern drug discovery: a comprehensive review","volume":"2","author":"Babalola","year":"2025","journal-title":"Discov. Chem."},{"key":"10.1016\/j.bbrc.2026.154097_bib131","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3390\/molecules30153177","article-title":"Nano-Phytomedicine: harnessing plant-derived phytochemicals in nanocarriers for targeted human health applications","volume":"30","author":"Parvin","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154097_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.lddd.2026.100363","article-title":"Phytochemicals as promising lead compounds for drug discovery: a comprehensive review of mechanisms and pharmacological potentials","volume":"23","author":"Idakwoji","year":"2026","journal-title":"Lett. Drug Des. Discovery"},{"key":"10.1016\/j.bbrc.2026.154097_bib133","article-title":"Metabolomics-Driven standardization of herbal medicine: advances, applications, and sustainability considerations","volume":"20","author":"Alum","year":"2025","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bbrc.2026.154097_bib134","series-title":"Biotechnology, Multiple Omics, and Precision Breeding in Medicinal Plants","first-page":"135","article-title":"Advancements in medicinal plant research","author":"Kalita","year":"2025"},{"key":"10.1016\/j.bbrc.2026.154097_bib135","series-title":"Advances, and Translational Potential","article-title":"Review of applications","author":"Terkimbi","year":"2025"},{"key":"10.1016\/j.bbrc.2026.154097_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1289901","article-title":"Multi-level advances in databases related to systems pharmacology in traditional Chinese medicine: a 60-year review","volume":"14","author":"Fan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154097_bib137","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5530\/phrev.20252224","article-title":"AI-Guided phytochemical and drug synergy mapping of Peganum harmala and Nigella sativa in cancer therapy","volume":"19","author":"Albukhari","year":"2025","journal-title":"Pharmacogn. Rev."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26008612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:42:44Z","timestamp":1785699764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26008612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":137,"alternative-id":["S0006291X26008612"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154097","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant-derived molecules as multitarget modulators of NF-\u03baB, PI3K\/Akt, MAPK, and AMPK\/mTOR signaling in chronic diseases","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154097"}}