{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:35:13Z","timestamp":1786628113527,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"publisher","award":["9BC03"],"award-info":[{"award-number":["9BC03"]}],"id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrc.2026.154176","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:16:55Z","timestamp":1781911015000},"page":"154176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of alcohol cessation on hepatic metabolic signaling during cancer cachexia"],"prefix":"10.1016","volume":"829","author":[{"given":"Abigail L.","family":"Tice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Laudato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery R.","family":"Tangen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana J.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-4017","authenticated-orcid":false,"given":"Bradley S.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-4233","authenticated-orcid":false,"given":"Jennifer L.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154176_bib1","series-title":"Cancer Statistics was Originally Published by the National Cancer Institute","year":"2024"},{"key":"10.1016\/j.bbrc.2026.154176_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093173","article-title":"Alcohol and cancer: epidemiology and biological mechanisms","volume":"13","author":"Rumgay","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154176_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.35946\/arcr.v38.2.01","article-title":"Alcoholic liver disease: pathogenesis and current management","volume":"38","author":"Osna","year":"2017","journal-title":"Alcohol Res."},{"key":"10.1016\/j.bbrc.2026.154176_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-8278(00)80420-1","article-title":"Alcoholic liver disease: new insights in pathogenesis lead to new treatments","volume":"32","author":"Lieber","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154176_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jcsm.12167","article-title":"Prevalence and clinical impact of cachexia in chronic illness in Europe, USA, and Japan: facts and numbers update 2016","volume":"7","author":"von Haehling","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.bbrc.2026.154176_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbrc.2026.154176_bib8","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1016\/j.cell.2025.06.039","article-title":"Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia","volume":"188","author":"Kaltenecker","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154176_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s42255-025-01434-3","article-title":"Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer","volume":"8","author":"Morigny","year":"2026","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbrc.2026.154176_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jhep.2010.08.012","article-title":"Efficiency of oxidative phosphorylation in liver mitochondria is decreased in a rat model of peritoneal carcinosis","volume":"54","author":"Dumas","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154176_bib11","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1038\/s42255-024-01167-9","article-title":"Cancer cachexia: multilevel metabolic dysfunction","volume":"6","author":"Berriel Diaz","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbrc.2026.154176_bib12","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/hep.1840220616","article-title":"The natural history of nonalcoholic fatty liver: a follow-up study","volume":"22","author":"Teli","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154176_bib13","first-page":"1037","article-title":"Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia","volume":"39","author":"Seelaender","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.bbrc.2026.154176_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252211945","article-title":"Metabolic, inflammatory, and molecular impact of cancer cachexia on the liver","volume":"25","author":"Goncalves","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154176_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072321","article-title":"Cancer Cachexia and related metabolic dysfunction","volume":"21","author":"Fonseca","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154176_bib16","doi-asserted-by":"crossref","first-page":"42165","DOI":"10.1074\/jbc.M112.377374","article-title":"Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations","volume":"287","author":"Han","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154176_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hep.32604","article-title":"Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation","volume":"77","author":"Ma","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154176_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2024.11.011","article-title":"An update on animal models of alcohol-associated liver disease","volume":"196","author":"Cao","year":"2026","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2026.154176_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/oxfordjournals.alcalc.a044987","article-title":"The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism","volume":"25","author":"Cunningham","year":"1990","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.bbrc.2026.154176_bib20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/acer.15100","article-title":"Impact of prior alcohol use on the subsequent development of cancer cachexia in male and female mice","volume":"47","author":"Laudato","year":"2023","journal-title":"Alcohol Clin. Exp. Res. (Hoboken)"},{"key":"10.1016\/j.bbrc.2026.154176_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.alcohol.2026.02.003","article-title":"Response of male and female mice to chronic alcohol use before and during cancer","volume":"132","author":"Laudato","year":"2026","journal-title":"Alcohol"},{"key":"10.1016\/j.bbrc.2026.154176_bib22","doi-asserted-by":"crossref","first-page":"100411","DOI":"10.18632\/oncotarget.22243","article-title":"Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2026.154176_bib23","doi-asserted-by":"crossref","first-page":"G509","DOI":"10.1152\/ajpgi.00376.2018","article-title":"Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism","volume":"316","author":"Thomes","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2026.154176_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/07487304221141464","article-title":"Chronic alcohol consumption disrupts the skeletal muscle circadian clock in female mice","volume":"38","author":"Tice","year":"2023","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.bbrc.2026.154176_bib25","doi-asserted-by":"crossref","first-page":"E308","DOI":"10.1152\/ajpendo.2000.278.2.E308","article-title":"Metabolically active components of fat free mass and resting energy expenditure in nonobese adults","volume":"278","author":"Illner","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2026.154176_bib26","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1096\/fj.201700396R","article-title":"Moderate alcohol intake induces thermogenic brown\/beige adipocyte formation via elevating retinoic acid signaling","volume":"31","author":"Wang","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2026.154176_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1152\/physiolgenomics.00124.2019","article-title":"Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia","volume":"52","author":"Khamoui","year":"2020","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.bbrc.2026.154176_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2016.11.020","article-title":"Mitochondrial remodeling in the liver following chronic alcohol feeding to rats","volume":"102","author":"Han","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2026.154176_bib29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ajpath.2018.11.008","article-title":"Dynamin-1-Like protein inhibition drives Megamitochondria formation as an adaptive response in alcohol-induced hepatotoxicity","volume":"189","author":"Palma","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2026.154176_bib30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol effects on hepatic lipid metabolism","volume":"61","author":"Jeon","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2026.154176_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1043-2760(01)00427-1","article-title":"Fatty acid transport proteins: a current view of a growing family","volume":"12","author":"Stahl","year":"2001","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2026.154176_bib32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2026.154176_bib33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41419-021-03596-w","article-title":"The fatty acid receptor CD36 promotes HCC progression through activating Src\/PI3K\/AKT axis-dependent aerobic glycolysis","volume":"12","author":"Luo","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154176_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.940974","article-title":"Pathogenesis of alcohol-associated fatty liver: lessons from transgenic mice","volume":"13","author":"Ferdouse","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2026.154176_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1123567","article-title":"Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy","volume":"13","author":"Fang","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2026.154176_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj20020430","article-title":"New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c","volume":"366","author":"Foufelle","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2026.154176_bib37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1139\/apnm-2019-0407","article-title":"Hepatic alterations during the development and progression of cancer cachexia","volume":"45","author":"Rosa-Caldwell","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bbrc.2026.154176_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/emmm.201201869","article-title":"TSC22D4 is a molecular output of hepatic wasting metabolism","volume":"5","author":"Jones","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbrc.2026.154176_bib39","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41467-024-44924-w","article-title":"Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154176_bib40","doi-asserted-by":"crossref","first-page":"25250","DOI":"10.1073\/pnas.1911189116","article-title":"Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake","volume":"116","author":"Gaucher","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.154176_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2600940X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2600940X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:54:44Z","timestamp":1786625684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2600940X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S0006291X2600940X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154176","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of alcohol cessation on hepatic metabolic signaling during cancer cachexia","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154176"}}