{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:02:52Z","timestamp":1785333772749,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrc.2026.154219","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:41:59Z","timestamp":1783060919000},"page":"154219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Suchilactone ameliorates podocyte injury in membranous nephropathy by modulating the JNK\/p38 MAPK pathway in vitro"],"prefix":"10.1016","volume":"830","author":[{"given":"Yingqiu","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiduo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiruo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154219_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-med-050522-034537","article-title":"Novel antigens and clinical updates in membranous nephropathy","volume":"75","author":"Avasare","year":"2024","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbrc.2026.154219_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-pathol-020117-043811","article-title":"Molecular pathogenesis of membranous nephropathy","volume":"15","author":"Ronco","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbrc.2026.154219_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.ajkd.2016.01.030","article-title":"Membranous nephropathy: a journey from bench to bedside","volume":"68","author":"Francis","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2026.154219_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1412826","article-title":"Animal models of membranous nephropathy: more choices and higher similarity","volume":"15","author":"Pan","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154219_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.trsl.2014.07.010","article-title":"Therapeutic targets for treating fibrotic kidney diseases","volume":"165","author":"Lee","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbrc.2026.154219_bib6","article-title":"Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154219_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109412","article-title":"Cytokines network in primary membranous nephropathy","volume":"113","author":"Zhao","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2026.154219_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1445550","article-title":"Evolutionary patterns and research frontiers in autophagy in podocytopathies: a bibliometric analysis","volume":"11","author":"Liu","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrc.2026.154219_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2024.152835","article-title":"HNRNP I promotes IRAK1 degradation to reduce podocyte apoptosis and inflammatory response alleviating renal injury in diabetic nephropathy","volume":"229","author":"Rao","year":"2024","journal-title":"Immunobiology"},{"key":"10.1016\/j.bbrc.2026.154219_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01809","article-title":"Immunological pathogenesis of membranous nephropathy: focus on PLA2R1 and its role","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154219_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-021-00303-z","article-title":"Membranous nephropathy","volume":"7","author":"Ronco","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbrc.2026.154219_bib12","article-title":"Identification of biomarkers related to immune and inflammation in membranous nephropathy: comprehensive bioinformatic analysis and validation","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154219_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ekir.2022.11.011","article-title":"Breaking the barrier\u2013glomerular C5b-9 as a prognostic marker in membranous nephropathy","volume":"8","author":"Trinidad","year":"2023","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.bbrc.2026.154219_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030204","article-title":"Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis","volume":"8","author":"Zhou","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.154219_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.734151","article-title":"Panax Ginseng C.A.Mey. as medicine: the potential use of Panax Ginseng C.A.Mey. as a remedy for kidney protection from a pharmacological perspective","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154219_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2011.04.045","article-title":"Ginsenoside-Rg1 protects podocytes from complement mediated injury","volume":"137","author":"Zhang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2026.154219_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1070738","article-title":"Renal function protection and the mechanism of ginsenosides: current progress and future perspectives","volume":"14","author":"Fan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154219_bib18","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1021\/acs.jafc.6b04451","article-title":"Protective roles of Monsonia angustifolia and its active compounds in experimental models of Alzheimer\u2019s Disease","volume":"65","author":"Chun","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.154219_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jgr.2022.09.001","article-title":"In silico investigation of Panax ginseng lead compounds against COVID-19 associated platelet activation and thromboembolism","volume":"47","author":"Quah","year":"2023","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.bbrc.2026.154219_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/13880209.2021.2017467","article-title":"Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2","volume":"60","author":"Wu","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bbrc.2026.154219_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18074","article-title":"miR\u2010664a\u20105p promotes experimental membranous nephropathy progression through HIPK2\/Calpain1\/GS\u03b1\u2010mediated autophagy inhibition","volume":"28","author":"Shan","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2026.154219_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1172\/JCI116157","article-title":"Soluble complex of complement increases hydraulic conductivity in single microvessels of Rat Lung","volume":"91","author":"Ishikawa","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.154219_bib23","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/ptr.3656","article-title":"Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway","volume":"26","author":"Zheng","year":"2012","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2026.154219_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cca.2021.10.017","article-title":"Urinary podocyte markers in kidney diseases","volume":"523","author":"Zeng","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbrc.2026.154219_bib25","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2459896","article-title":"Modified Huangqi Chifeng decoction alleviates podocyte injury on rat with experimental membranous nephropathy","volume":"47","author":"Chang","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbrc.2026.154219_bib26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3892\/ijmm.2015.2328","article-title":"Shen-Kang protects 5\/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways","volume":"36","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2026.154219_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/13880209.2024.2330602","article-title":"Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-\u03baB pathway","volume":"62","author":"Jia","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bbrc.2026.154219_bib28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cbi.2017.07.011","article-title":"Betulinic acid, isolated from the leaves of Syzygium cumini (L.) skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2\/NF-\u03baB pathways","volume":"274","author":"Sutariya","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2026.154219_bib29","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-\u03baB restricts inflammasome activation via elimination of damaged mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154219_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.154219_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015186","article-title":"Endoplasmic Reticulum stress promotes the expression of TNF-\u03b1 in THP-1 cells by mechanisms involving ROS\/CHOP\/HIF-1\u03b1 and MAPK\/NF-\u03baB pathways","volume":"24","author":"Akhter","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154219_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.kint.2023.10.035","article-title":"Complement activation and effector pathways in membranous nephropathy","volume":"105","author":"Kistler","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2026.154219_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34509-1","article-title":"Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs","volume":"8","author":"Feng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154219_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2371992","article-title":"Astragaloside IV relieves passive heymann nephritis and podocyte injury by suppressing the TRAF6\/NF-\u03bab axis","volume":"46","author":"Ma","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbrc.2026.154219_bib35","article-title":"Mechanistic insights into shenfu injection for COVID-19-Induced ARDS: a combined analysis of GEO database, network pharmacology, and molecular docking","volume":"25","author":"Juan","year":"2025","journal-title":"Infect. Disord. - Drug Targets"},{"key":"10.1016\/j.bbrc.2026.154219_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.70280","article-title":"Efficacy and mechanism of Bazi Bushen Capsule on skin laxity: a combination of clinical and network pharmacology Study","volume":"24","author":"Zhao","year":"2025","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.bbrc.2026.154219_bib37","article-title":"sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK\/mTOR\/ULK1(ser757) signaling pathway","volume":"35","author":"Yang","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2026.154219_bib38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41580-020-00322-w","article-title":"Diversity and versatility of p38 kinase signalling in health and disease","volume":"22","author":"Canovas","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154219_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092196","article-title":"JNK in tumor microenvironment: present findings and challenges in clinical translation","volume":"13","author":"Tam","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2026.154219_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-022-01309-z","article-title":"Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK\/ERK targets in embryonic kidney","volume":"20","author":"Kurtzeborn","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.bbrc.2026.154219_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-025-00784-w","article-title":"Cell death signaling and immune regulation: new perspectives on targeted therapy for sepsis","volume":"30","author":"Wu","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbrc.2026.154219_bib42","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.2147\/DDDT.S213088","article-title":"Renoprotective effects of Isoliquiritin against Cationic bovine serum albumin-induced membranous glomerulonephritis in experimental rat model through its anti-oxidative and anti-inflammatory Properties<\/p>","volume":"13","author":"Liu","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2026.154219_bib43","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10787-019-00569-6","article-title":"Anti-inflammatory and renal protective effect of gingerol in high-fat diet\/streptozotocin-induced diabetic rats via inflammatory mechanism","volume":"27","author":"Song","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2026.154219_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-023-00657-y","article-title":"Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation","volume":"29","author":"Tao","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2026.154219_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115935","article-title":"Alpha-mangostin alleviate renal interstitial fibrosis via suppression of TGF-\u03b21\/Smad\/ERK signaling axis in vitro and in vivo","volume":"218","author":"Juan","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154219_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155252","article-title":"Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death","volume":"123","author":"Shan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.154219_bib47","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00018-019-03332-w","article-title":"Kynurenic acid and cancer: facts and controversies","volume":"77","author":"Walczak","year":"2019","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26009836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26009836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:11:15Z","timestamp":1785330675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26009836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0006291X26009836"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154219","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suchilactone ameliorates podocyte injury in membranous nephropathy by modulating the JNK\/p38 MAPK pathway in vitro","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154219"}}