{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:26:39Z","timestamp":1787073999145,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12402362"],"award-info":[{"award-number":["12402362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrc.2026.154343","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:00:30Z","timestamp":1784934030000},"page":"154343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Blebbistatin paradoxically induces ROCK-dependent junctional enrichment of p-MLC and adherens junction components in chick embryo epidermis"],"prefix":"10.1016","volume":"831","author":[{"given":"Pengfei","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyikun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tailin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154343_bib1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cell.2013.05.008","article-title":"Forces in tissue morphogenesis and patterning","volume":"153","author":"Heisenberg","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154343_bib2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrm2222","article-title":"Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis","volume":"8","author":"Lecuit","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/1-59259-065-9:101","article-title":"Skin morphogenesis: embryonic chicken skin explant cultures","volume":"II","author":"Chuong","year":"2000","journal-title":"Develop. Biol. Protoc."},{"key":"10.1016\/j.bbrc.2026.154343_bib4","doi-asserted-by":"crossref","DOI":"10.3791\/65580","article-title":"Using avian skin explants to study tissue patterning and organogenesis","author":"Jiang","year":"2023","journal-title":"JoVE J."},{"key":"10.1016\/j.bbrc.2026.154343_bib5","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jid.2025.07.013","article-title":"Embryonic avian skin explant cultures: a versatile model for investigating tissue patterning mechanisms","volume":"145","author":"Yu","year":"2025","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2026.154343_bib6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.aai7868","article-title":"Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin","volume":"357","author":"Shyer","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154343_bib7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrm2786","article-title":"Non-muscle myosin II takes centre stage in cell adhesion and migration","volume":"10","author":"Vicente-Manzanares","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-012-1002-9","article-title":"Nonmuscle myosin-2: mix and match","volume":"70","author":"Heissler","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2026.154343_bib9","doi-asserted-by":"crossref","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","article-title":"Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)","volume":"271","author":"Amano","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154343_bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1083\/jcb.150.4.797","article-title":"Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts","volume":"150","author":"Totsukawa","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib11","doi-asserted-by":"crossref","first-page":"C518","DOI":"10.1152\/ajpcell.00280.2003","article-title":"Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress","volume":"286","author":"Polte","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2026.154343_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.aaw1965","article-title":"A tensile ring drives tissue flows to shape the gastrulating amniote embryo","volume":"367","author":"Saadaoui","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154343_bib13","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41586-024-07934-8","article-title":"Self-organized tissue mechanics underlie embryonic regulation","volume":"633","author":"Caldarelli","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154343_bib14","doi-asserted-by":"crossref","first-page":"35557","DOI":"10.1074\/jbc.M405319200","article-title":"Mechanism of blebbistatin inhibition of myosin II","volume":"279","author":"Kov\u00e1cs","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154343_bib15","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1126\/science.1081412","article-title":"Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor","volume":"299","author":"Straight","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154343_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10974-004-6060-7","article-title":"Specificity of blebbistatin, an inhibitor of myosin II","volume":"25","author":"Limouze","year":"2004","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.bbrc.2026.154343_bib17","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1091\/mbc.e07-12-1286","article-title":"Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation","volume":"19","author":"Kinoshita","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2026.154343_bib18","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s10237-012-0389-4","article-title":"A potential role for differential contractility in early brain development and evolution","volume":"11","author":"Filas","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.bbrc.2026.154343_bib19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nsmb908","article-title":"The structural basis of blebbistatin inhibition and specificity for myosin II","volume":"12","author":"Allingham","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib20","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1016\/j.cub.2018.02.003","article-title":"Tensile forces and mechanotransduction at cell\u2013cell junctions","volume":"28","author":"Charras","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.1254211","article-title":"The minimal cadherin-catenin complex binds to actin filaments under force","volume":"346","author":"Buckley","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154343_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2055","article-title":"\u03b1-Catenin as a tension transducer that induces adherens junction development","volume":"12","author":"Yonemura","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3389\/fphys.2018.00824","article-title":"Cellular mechanotransduction: from tension to function","volume":"9","author":"Martino","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2026.154343_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154343_bib25","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.tcb.2015.09.008","article-title":"Towards a dynamic understanding of cadherin-based mechanobiology","volume":"25","author":"Hoffman","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib27","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.201001149","article-title":"Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II\u2013dependent manner","volume":"189","author":"Le Duc","year":"2010","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.bbrc.2026.154343_bib28","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029140","article-title":"Adherens junctions on the move\u2014membrane trafficking of E-cadherin","volume":"9","author":"Br\u00fcser","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg5579","article-title":"Morphogens enable interacting supracellular phases that generate organ architecture","volume":"382","author":"Yang","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154343_bib30","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.cub.2014.07.070","article-title":"Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers","volume":"24","author":"Shutova","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib31","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260890","article-title":"Non-muscle myosin 2 at a glance","volume":"136","author":"Quintanilla","year":"2023","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2026.154343_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ncb3466","article-title":"Long-range self-organization of cytoskeletal myosin II filament stacks","volume":"19","author":"Hu","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154343_bib33","first-page":"3015","article-title":"Deconstructing the third dimension\u2013how 3D culture microenvironments alter cellular cues","volume":"125","author":"Baker","year":"2012","journal-title":"J. Cell Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:44Z","timestamp":1787071004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26011071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S0006291X26011071"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154343","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blebbistatin paradoxically induces ROCK-dependent junctional enrichment of p-MLC and adherens junction components in chick embryo epidermis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154343"}}