{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:15:40Z","timestamp":1788066940746,"version":"build-2784847793"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGP004\/2026"],"award-info":[{"award-number":["RGP004\/2026"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06874"],"award-info":[{"award-number":["22K06874"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K10197"],"award-info":[{"award-number":["25K10197"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrc.2026.154359","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:38:49Z","timestamp":1785307129000},"page":"154359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A synthetic hydrogel scaffold enhancing stem cell signatures in colorectal cancer cells"],"prefix":"10.1016","volume":"832","author":[{"given":"Qiaochu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cewen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Nonoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-5840","authenticated-orcid":false,"given":"Masamichi","family":"Imajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154359_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2026.154359_bib2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154359_bib3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154359_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","article-title":"Cancer stem cells: advances in knowledge and implications for cancer therapy","volume":"9","author":"Chu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154359_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.stem.2024.04.004","article-title":"Hallmarks of cancer stemness","volume":"31","author":"Loh","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2026.154359_bib6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154359_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-024-01852-x","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154359_bib8","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.actbio.2021.05.010","article-title":"Biomaterials for intestinal organoid technology and personalized disease modeling","volume":"132","author":"Hirota","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrc.2026.154359_bib9","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing cell-compatible hydrogels for biomedical applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154359_bib10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.tibtech.2017.06.015","article-title":"Engineered hydrogels in cancer therapy and diagnosis","volume":"35","author":"Sepantafar","year":"2017","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bbrc.2026.154359_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aas8998","article-title":"Hydrogel microenvironments for cancer spheroid growth and drug screening","volume":"4","author":"Li","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154359_bib12","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41551-021-00692-2","article-title":"Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels","volume":"5","author":"Suzuka","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bbrc.2026.154359_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14235890","article-title":"ERK MAP kinase signaling regulates RAR signaling to confer retinoid resistance on breast cancer cells","volume":"14","author":"Hirota","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2026.154359_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105139","article-title":"Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia","volume":"25","author":"Pingul","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bbrc.2026.154359_bib15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/s41598-023-28870-z","article-title":"Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction","volume":"13","author":"Tanikawa","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154359_bib16","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1038\/emboj.2012.166","article-title":"The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers","volume":"31","author":"Mu\u00f1oz","year":"2012","journal-title":"Embo j"},{"key":"10.1016\/j.bbrc.2026.154359_bib17","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1182\/bloodadvances.2021004469","article-title":"Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia","volume":"5","author":"Zhao","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.bbrc.2026.154359_bib18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2017.12.017","article-title":"Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2026.154359_bib19","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s42003-023-05331-x","article-title":"BRAF(V600E)-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism","volume":"6","author":"Rzasa","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbrc.2026.154359_bib20","first-page":"111","article-title":"Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes","volume":"4","author":"Chekulayev","year":"2015","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bbrc.2026.154359_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.biocel.2014.09.004","article-title":"An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome","volume":"55","author":"Kaldma","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154359_bib22","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1158\/0008-5472.CAN-16-0246","article-title":"MEF2D transduces microenvironment stimuli to ZEB1 to promote epithelial\u2013mesenchymal transition and metastasis in colorectal cancer","volume":"76","author":"Su","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2026.154359_bib23","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41388-021-01774-w","article-title":"MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression","volume":"40","author":"Xiao","year":"2021","journal-title":"Oncogene"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2601123X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2601123X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:19:41Z","timestamp":1788063581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2601123X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":23,"alternative-id":["S0006291X2601123X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154359","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A synthetic hydrogel scaffold enhancing stem cell signatures in colorectal cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154359"}}