{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:15:09Z","timestamp":1788066909378,"version":"build-2784847793"},"reference-count":230,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160240"],"award-info":[{"award-number":["82160240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrc.2026.154363","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:42:09Z","timestamp":1785393729000},"page":"154363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pathogenesis and role of ferroptosis mediated by Nrf2 signaling pathway in ischemic stroke"],"prefix":"10.1016","volume":"832","author":[{"given":"Nitong","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-4611","authenticated-orcid":false,"given":"Tao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-022-00943-7","article-title":"Inflammatory responses after ischemic stroke","volume":"44","author":"DeLong","year":"2022","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41386-023-01659-4","article-title":"Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis","volume":"49","author":"Jiang","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCRESAHA.123.323517","article-title":"MRP1-Dependent extracellular release of glutathione induces cardiomyocyte ferroptosis after ischemia-reperfusion","volume":"133","author":"Ichihara","year":"2023","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050804","article-title":"Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis","volume":"12","author":"Mortensen","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade9585","article-title":"NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8","volume":"9","author":"Anandhan","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154363_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122003","article-title":"Insights into the molecular mechanisms, structure-activity relationships and application prospects of polysaccharides by regulating Nrf2-mediated antioxidant response","volume":"333","author":"Chen","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-023-02738-5","article-title":"Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT\/GSK-3\u03b2\/\u03b2-TrCP\/Nrf2 axis","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2026.154363_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102852","article-title":"Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice","volume":"66","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib11","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.24272\/j.issn.2095-8137.2024.239","article-title":"Ferroptosis in ischemic stroke: animal models and mechanisms","volume":"45","author":"Tuo","year":"2024","journal-title":"Zool. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10571-024-01457-6","article-title":"Progress of ferroptosis in ischemic stroke and therapeutic targets","volume":"44","author":"Tian","year":"2024","journal-title":"Cell. Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41419-022-05043-w","article-title":"Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells","volume":"13","author":"You","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154363_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1113081","article-title":"The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: glutamate accumulation","volume":"16","author":"Fan","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib15","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s12264-022-00859-0","article-title":"Neuronal death mechanisms and therapeutic strategy in ischemic stroke","volume":"38","author":"Mao","year":"2022","journal-title":"Neurosci. Bull."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10571-020-00966-4","article-title":"Role of DAMPs and of leukocytes infiltration in ischemic stroke: insights from animal models and translation to the human disease","volume":"42","author":"Stanzione","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.154363_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1623485","article-title":"Ferroptosis in ischemic stroke: mechanisms, pathological implications, and therapeutic strategies","volume":"19","author":"Long","year":"2025","journal-title":"Front. Neurosci."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib18","article-title":"Ferroptosis in Neurovascular unit of ischemic stroke: multidimensional regulatory mechanisms and targeted interventions","volume":"30","author":"Wang","year":"2025","journal-title":"Front. Biosci. (Landmark Ed.)"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.951","article-title":"Discriminating between apoptosis, necrosis, necroptosis, and ferroptosis by microscopy and flow cytometry","volume":"3","author":"Costigan","year":"2023","journal-title":"Curr. Protoc."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib20","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41419-024-07251-y","article-title":"Seratrodast inhibits ferroptosis by suppressing lipid peroxidation","volume":"15","author":"Tschuck","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib21","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41419-024-06620-x","article-title":"The dual role of mesenchymal stem cells in apoptosis regulation","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154363_bib23","article-title":"Thrombospondin-1 regulates trophoblast necroptosis via NEDD4-Mediated ubiquitination of TAK1 in preeclampsia","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.154363_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106697","article-title":"Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis","volume":"189","author":"Shi","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib25","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154363_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103553","article-title":"Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation","volume":"81","author":"Huang","year":"2025","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib28","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/s41418-023-01198-x","article-title":"Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia\u2012reperfusion injury by inducing ferroptosis propagation","volume":"30","author":"Li","year":"2023","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib29","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41556-020-0565-1","article-title":"Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture","volume":"22","author":"Riegman","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib30","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1038\/s41467-025-58175-w","article-title":"Ferroptosis spreads to neighboring cells via plasma membrane contacts","volume":"16","author":"Roeck","year":"2025","journal-title":"Nat. Commun."},{"issue":"17","key":"10.1016\/j.bbrc.2026.154363_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179352","article-title":"Insights into iron metabolism parameters in ischemic stroke: a single-center prospective cohort study","volume":"25","author":"Boinska","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib32","article-title":"Targeting pro-oxidant iron with exogenously administered apotransferrin provides benefits associated with changes in crucial cellular iron gate protein TfR in a model of intracerebral hemorrhagic stroke in mice","volume":"12","author":"Garc\u00eda-Serran","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118305","article-title":"LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53","volume":"260","author":"Lu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.154363_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117135","article-title":"Chronic hypoxia drives the occurrence of ferroptosis in liver of fat greening (Hexagrammos otakii) by activating HIF-1\u03b1 and promoting iron production","volume":"285","author":"Gao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib35","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1038\/s12276-024-01314-y","article-title":"Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels","volume":"56","author":"Davaanyam","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2026.154363_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.05.082","article-title":"Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism","volume":"124","author":"Zhao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib37","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1021\/jm401915r","article-title":"Potent and selective inhibitors of human reticulocyte 12\/15-lipoxygenase as anti-stroke therapies","volume":"57","author":"Rai","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.154363_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111194","article-title":"The emerging role of 12\/15-lipoxygenase in ischemic stroke","volume":"221","author":"Wang","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib39","first-page":"5601","article-title":"Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2\u03b1 attenuates focal ischemic brain damage in mice","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-023-00636-1","article-title":"Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease","volume":"18","author":"Yu","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbrc.2026.154363_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2024.03.019","article-title":"Edaravone dexborneol protects against cerebral ischemia\/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2\/HO-1\/GPX4 signaling","volume":"217","author":"Xiao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2026.154363_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102347","article-title":"The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke","volume":"54","author":"Kim","year":"2022","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib43","article-title":"Interactions between ferroptosis and oxidative stress in ischemic stroke","volume":"13","author":"Liu","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1615\/CritRevImmunol.2024051934","article-title":"Electroacupuncture suppresses oxidative stress and ferroptosis by activating the mTOR\/SREBP1 pathway in ischemic stroke","volume":"44","author":"Lang","year":"2024","journal-title":"Crit. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","article-title":"Ferroptosis: principles and significance in health and disease","volume":"17","author":"Chen","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib46","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/s12967-023-04370-6","article-title":"Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.154363_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/3400147","article-title":"Organelle-specific mechanisms in crosstalk between apoptosis and ferroptosis","volume":"2023","author":"Wu","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2026.154363_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1080344","article-title":"Ferroptosis: underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage","volume":"17","author":"Cao","year":"2023","journal-title":"Front. Cell. Neurosci."},{"issue":"18","key":"10.1016\/j.bbrc.2026.154363_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25189947","article-title":"Significance of programmed cell death pathways in neurodegenerative diseases","volume":"25","author":"Guo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41420-023-01440-y","article-title":"Targeting pyroptosis as a preventive and therapeutic approach for stroke","volume":"9","author":"Long","year":"2023","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib51","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4103\/1673-5374.389361","article-title":"Crosstalk among mitophagy, pyroptosis, ferroptosis, and necroptosis in central nervous system injuries","volume":"19","author":"Zhang","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210127","article-title":"Induction mechanism of ferroptosis, necroptosis, and pyroptosis: a novel therapeutic target in nervous system diseases","volume":"24","author":"Tang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib53","article-title":"Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke","volume":"11","author":"Du","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2026.154363_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9991001","article-title":"Insight into crosstalk between ferroptosis and necroptosis: novel therapeutics in ischemic stroke","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10571-025-01593-7","article-title":"The crosstalk between ferritinophagy and ferroptosis in ischemic stroke: regulatory mechanisms and therapeutic implications","volume":"45","author":"Shi","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib56","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s11064-024-04161-5","article-title":"Ferritinophagy and ferroptosis in cerebral ischemia reperfusion injury","volume":"49","author":"Liu","year":"2024","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2026.154363_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.577403","article-title":"Crosstalk between autophagy and ferroptosis and its putative role in ischemic stroke","volume":"14","author":"Liu","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154363_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28959","article-title":"Crosstalk between autophagy and ferroptosis mediate injury in ischemic stroke by generating reactive oxygen species","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","article-title":"Ferroptosis: principles and significance in health and disease","volume":"17","author":"Chen","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/0113894501320839240918110656","article-title":"Nrf2 and ferroptosis: exploring translational avenues for therapeutic approaches to neurological diseases","volume":"26","author":"Mohan","year":"2025","journal-title":"Curr. Drug Targets"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167764","article-title":"Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer","volume":"1871","author":"Sahu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib62","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.freeradbiomed.2011.11.003","article-title":"Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: role of glycogen synthase kinase-3","volume":"52","author":"Rojo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41420-021-00425-z","article-title":"Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib64","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","article-title":"RXR\u03b1 inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2024.12.010","article-title":"Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis","volume":"50","author":"Hayes","year":"2025","journal-title":"Trends Biochem. Sci."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14202","article-title":"Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice","volume":"23","author":"Xue","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2026.154363_bib67","article-title":"Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2\/ARE signaling","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030445","article-title":"Evidence of Nrf2\/Keap1 signaling regulation by Mitochodria-Generated reactive oxygen species in RGK1 cells","volume":"13","author":"Indo","year":"2023","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib69","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1128\/MCB.01204-10","article-title":"SCF\/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner","volume":"31","author":"Rada","year":"2011","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib70","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/BST20150011","article-title":"Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of \u03b2-TrCP and GSK-3","volume":"43","author":"Hayes","year":"2015","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25041955","article-title":"Del-1 plays a protective role against COPD development by inhibiting inflammation and apoptosis","volume":"25","author":"Kwak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154363_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155406","article-title":"Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2","volume":"128","author":"Mi","year":"2024","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154363_bib73","article-title":"SENP6-Mediated deSUMOylation of Nrf2 exacerbates neuronal oxidative stress following cerebral ischemia and reperfusion injury","volume":"12","author":"Xia","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13048-025-01639-w","article-title":"Overview of Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties","volume":"18","author":"Ghantabpour","year":"2025","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.bbrc.2026.154363_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116790","article-title":"WWOX-mediated p53\/SAT1 and NRF2\/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma","volume":"233","author":"Yang","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154363_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111334","article-title":"1,25(OH)(2)D(3) inhibited ferroptosis in zebrafish liver cells (ZFL) by regulating Keap1-Nrf2-GPx4 and NF-\u03baB-hepcidin axis","volume":"22","author":"Cheng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154363_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103468","article-title":"Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3\u03b2\/Nrf2 pathway and SMAD159\/Hepcidin\/FTH pathway","volume":"79","author":"Lu","year":"2025","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib78","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s11010-023-04795-z","article-title":"PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis","volume":"479","author":"Cao","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2026.154363_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105701","article-title":"Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression","volume":"139","author":"Liu","year":"2020","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib80","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12948","article-title":"Melatonin MT1 receptors regulate the Sirt1\/Nrf2\/Ho-1\/Gpx4 pathway to prevent \u03b1-synuclein-induced ferroptosis in Parkinson's disease","volume":"76","author":"Lv","year":"2024","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib81","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1074\/jbc.M210664200","article-title":"Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones","volume":"278","author":"Pietsch","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib82","article-title":"Antioxidant systems as modulators of ferroptosis: focus on transcription factors","volume":"13","author":"Punziano","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib83","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11050861","article-title":"Crosstalk between heme Oxygenase-1 and iron metabolism in macrophages: implications for the modulation of inflammation and immunity","volume":"11","author":"Oliveira","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2026.154363_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1615197","article-title":"Ferroptosis and bone metabolic diseases: the dual regulatory role of the Nrf2\/HO-1 signaling axis","volume":"13","author":"Nan","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.154363_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3846217","article-title":"HO-1 contributes to luteolin-triggered ferroptosis in clear cell renal cell carcinoma via increasing the labile iron pool and promoting lipid peroxidation","volume":"2022","author":"Han","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib87","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41419-021-04490-1","article-title":"Double-edge sword roles of iron in driving energy production versus instigating ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"5\u20136","key":"10.1016\/j.bbrc.2026.154363_bib88","first-page":"243","article-title":"Piper betle induced cytoprotective genes and proteins via the Nrf2\/ARE pathway in aging mice","volume":"9","author":"Aliahmat","year":"2016","journal-title":"J. Nutrigenet. Nutrigenom."},{"key":"10.1016\/j.bbrc.2026.154363_bib89","article-title":"Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2\/HO-1\/GPX4 activation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib90","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1248\/bpb.b24-00295","article-title":"NRF2 activation by AR-20007 preserves renal tubular epithelial cells from antimycin A-Induced cell death via glutathione metabolism regulation","volume":"47","author":"Yoo","year":"2024","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2026.154363_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103066","article-title":"Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11\/GSH\/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation","volume":"70","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2026.154363_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111051","article-title":"Exposure to waterborne cadmium induce oxidative stress, autophagy and mitochondrial dysfunction in the liver of procypris merus","volume":"204","author":"Dai","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"22","key":"10.1016\/j.bbrc.2026.154363_bib93","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/s41388-025-03337-9","article-title":"CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3\/NRF2\/GPX2 axis","volume":"44","author":"Bai","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2026.154363_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.115960","article-title":"Astaxanthin activates the Nrf2\/Keap1\/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity","volume":"271","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"18","key":"10.1016\/j.bbrc.2026.154363_bib95","first-page":"4277","article-title":"Melatonin alleviates heme-induced ferroptosis via activating the Nrf2\/HO-1 pathway in neurons","volume":"28","author":"Chen","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib96","article-title":"Brown algae-derived fucoidan exerts oxidative stress-dependent antiproliferation on oral cancer cells","volume":"11","author":"Shiau","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib97","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1038\/s41467-024-49298-7","article-title":"G6PD and ACSL3 are synthetic lethal partners of NF2 in schwann cells","volume":"15","author":"Kyrkou","year":"2024","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097706","article-title":"NADPH oxidase subunit CYBB confers chemotherapy and ferroptosis resistance in mesenchymal glioblastoma via Nrf2\/SOD2 modulation","volume":"24","author":"Su","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib99","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s10565-023-09834-5","article-title":"NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis","volume":"39","author":"Zhang","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib100","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib101","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib102","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","volume":"26","author":"Dai","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib103","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41419-023-06222-z","article-title":"The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib104","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s41419-024-07237-w","article-title":"Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria","volume":"15","author":"Hirata","year":"2024","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib105","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib106","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s41422-023-00879-z","article-title":"FSP1 oxidizes NADPH to suppress ferroptosis","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2026.154363_bib107","article-title":"Targeting FSP1 triggers ferroptosis in lung cancer","author":"Wu","year":"2025","journal-title":"bioRxiv"},{"issue":"23","key":"10.1016\/j.bbrc.2026.154363_bib108","doi-asserted-by":"crossref","DOI":"10.3390\/cells14231889","article-title":"Dihydroorotate dehydrogenase in mitochondrial ferroptosis and cancer therapy","volume":"14","author":"Lee","year":"2025","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib109","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12964-022-01025-9","article-title":"The warburg effect modulates DHODH role in ferroptosis: a review","volume":"21","author":"Amos","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210037","article-title":"Mitochondrial regulation of ferroptosis in cancer therapy","volume":"24","author":"Cheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib111","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00018-025-05958-5","article-title":"Ferroptosis inhibitors: mechanisms of action and therapeutic potential","volume":"82","author":"Duo","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154363_bib112","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1038\/s44319-025-00515-4","article-title":"Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer","volume":"26","author":"Li","year":"2025","journal-title":"EMBO Rep."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib113","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210021","article-title":"ACSL4-Mediated ferroptosis and its potential role in central nervous system diseases and injuries","volume":"24","author":"Jia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154363_bib114","first-page":"47","article-title":"Mechanism of ferroptosis resistance in cancer cells","volume":"7","author":"Wang","year":"2024","journal-title":"Cancer Drug Resist"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib115","article-title":"The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040114","article-title":"The role of NCOA4-Mediated ferritinophagy in health and disease","volume":"11","author":"Santana-Codina","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1631\/jzus.B2300097","article-title":"Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases","volume":"25","author":"Luan","year":"2024","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.bbrc.2026.154363_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1390798","article-title":"A critical appraisal of ferroptosis in Alzheimer's and Parkinson's disease: new insights into emerging mechanisms and therapeutic targets","volume":"15","author":"Soni","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib119","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41420-023-01517-8","article-title":"Ferroptosis and the bidirectional regulatory factor p53","volume":"9","author":"Xu","year":"2023","journal-title":"Cell Death Discov."},{"issue":"14","key":"10.1016\/j.bbrc.2026.154363_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26146588","article-title":"The molecular interplay between p53-Mediated ferroptosis and non-coding RNAs in cancer","volume":"26","author":"Punziano","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib121","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s11658-025-00751-5","article-title":"Bypassing the guardian: regulated cell death pathways in p53-mutant cancers","volume":"30","author":"Chung","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib122","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13578-022-00764-z","article-title":"The dual role of p62 in ferroptosis of glioblastoma according to p53 status","volume":"12","author":"Yuan","year":"2022","journal-title":"Cell Biosci."},{"issue":"22","key":"10.1016\/j.bbrc.2026.154363_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223653","article-title":"Ferroptosis-A new dawn in the treatment of organ ischemia-reperfusion injury","volume":"11","author":"Zhou","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib124","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14462","article-title":"The cell-specific roles of Nrf2 in acute and chronic phases of ischemic stroke","volume":"30","author":"Fadoul","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbrc.2026.154363_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1032140","article-title":"The emerging roles of ferroptosis in cells of the central nervous system","volume":"16","author":"Li","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154363_bib126","article-title":"Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154363_bib127","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.980722","article-title":"Microglia-mediated neuroinflammation and neuroplasticity after stroke","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154363_bib128","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.921705","article-title":"The dual function of microglial polarization and its treatment targets in ischemic stroke","volume":"13","author":"Mo","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbrc.2026.154363_bib129","article-title":"The molecular mechanisms of ferroptosis and its role in blood-brain barrier dysfunction","volume":"16","author":"Chen","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154363_bib130","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7762078","article-title":"Role of glial cell-derived oxidative stress in blood-brain barrier damage after Acute Ischemic stroke","volume":"2022","author":"Hu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2026.154363_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1020918","article-title":"New insights in ferroptosis: potential therapeutic targets for the treatment of ischemic stroke","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154363_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1429836","article-title":"Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges","volume":"15","author":"Gan","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib133","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12860-023-00466-5","article-title":"The dual role of Nrf2 in melanoma: a systematic review","volume":"24","author":"Malakoutikhah","year":"2023","journal-title":"BMC Mol Cell Biol"},{"key":"10.1016\/j.bbrc.2026.154363_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112965","article-title":"The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-\u03baB signaling pathway in the brain of ducks","volume":"228","author":"Wu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbrc.2026.154363_bib135","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/238321","article-title":"Disruption of Nrf2 enhances the upregulation of nuclear factor-kappaB activity, tumor necrosis factor-\u03b1, and matrix metalloproteinase-9 after spinal cord injury in mice","volume":"2010","author":"Mao","year":"2010","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib136","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1038\/s41598-024-53836-0","article-title":"NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation","volume":"14","author":"Fan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154363_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2026.154363_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112774","article-title":"Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: unveiling the PPAR-\u03b3\/Nrf2\/HO-1\/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats","volume":"139","author":"El-Gazar","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"13","key":"10.1016\/j.bbrc.2026.154363_bib139","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/WNR.0000000000001789","article-title":"Bergenin has neuroprotective effects in mice with ischemic stroke through antioxidative stress and anti-inflammation via regulating Sirt1\/FOXO3a\/NF-\u03baB signaling","volume":"33","author":"Zhang","year":"2022","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbrc.2026.154363_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114599","article-title":"TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt\/Nrf2\/HO-1 signaling","volume":"371","author":"Wei","year":"2024","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib141","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11064-019-02933-y","article-title":"Silencing of TXNIP alleviated oxidative stress injury by regulating MAPK-Nrf2 axis in ischemic stroke","volume":"45","author":"Tian","year":"2020","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib142","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/ars.2017.7003","article-title":"A dual AMPK\/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization","volume":"28","author":"Wang","year":"2018","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.bbrc.2026.154363_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109603","article-title":"GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation","volume":"237","author":"Tu","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2026.154363_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154762","article-title":"Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154363_bib145","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/jpp\/rgae038","article-title":"Indobufen alleviates ischemic stroke injury by regulating transcription factor NRF2 and inhibiting ATG5 expression","volume":"76","author":"Wang","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib146","doi-asserted-by":"crossref","first-page":"637","DOI":"10.33549\/physiolres.933780","article-title":"Ulinastatin alleviates neurological deficiencies evoked by transient cerebral ischemia via improving autophagy, Nrf-2-ARE and apoptosis signals in hippocampus","volume":"67","author":"Jiang","year":"2018","journal-title":"Physiol. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib147","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41401-024-01365-x","article-title":"BNIP3-mediated mitophagy attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62-KEAP1-NRF2 pathway activation to maintain iron and redox homeostasis","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib148","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s10571-023-01411-y","article-title":"Nrf2 and ferroptosis: a new research direction for ischemic stroke","volume":"43","author":"Deng","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154363_bib149","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1177\/0960327120984220","article-title":"JZL184 protects hippocampal neurons from oxygen-glucose deprivation-induced injury via activating Nrf2\/ARE signaling pathway","volume":"40","author":"Xu","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.bbrc.2026.154363_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2023.102387","article-title":"Ozone-mediated cerebral protection: unraveling the mechanism through ferroptosis and the NRF2\/SLC7A11\/GPX4 signaling pathway","volume":"136","author":"Zhu","year":"2024","journal-title":"J. Chem. Neuroanat."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib151","first-page":"197","article-title":"Pachymic acid prevents neuronal cell damage induced by hypoxia\/reoxygenation via miR-155\/NRF2\/HO-1 axis","volume":"82","author":"Zhai","year":"2022","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.bbrc.2026.154363_bib152","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad062","article-title":"Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway","volume":"12","author":"Xu","year":"2024","journal-title":"Burns Trauma"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib153","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1177\/0271678X221135419","article-title":"An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2\/BDNF\/glutaminase pathway","volume":"43","author":"Jia","year":"2023","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00600","article-title":"Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects","volume":"22","author":"Chen","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbrc.2026.154363_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.138037","article-title":"BAK ameliorated cerebral infarction\/ischemia-reperfusion injury by activating AMPK\/Nrf2 to inhibit TXNIP\/NLRP3\/caspase-1 axis","volume":"844","author":"Xu","year":"2025","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2026.154363_bib156","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2025.04.047","article-title":"Mechanistic insights into cadmium-induced nephrotoxicity: NRF2-driven HO-1 activation promotes ferroptosis via iron overload and oxidative stress in vitro","volume":"235","author":"Luo","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2026.154363_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124130","article-title":"PM(2.5)-induced ferroptosis by Nrf2\/Hmox1 signaling pathway led to inflammation in microglia","volume":"352","author":"Wei","year":"2024","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib158","article-title":"The role of Nrf2 in the regulation of mitochondrial function and ferroptosis in pancreatic cancer","volume":"13","author":"Baiskhanova","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib159","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1701249","article-title":"Modulating Nrf2 to control lipid peroxidation and ferroptosis: implications for cancer management","volume":"15","author":"Tunc","year":"2025","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib160","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2174\/1570159X21666221129100308","article-title":"The role of Nrf2 in relieving cerebral ischemia-reperfusion injury","volume":"21","author":"Sun","year":"2023","journal-title":"Curr. Neuropharmacol."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib161","article-title":"Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.017","article-title":"NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches","volume":"21","author":"Sivandzade","year":"2019","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib163","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s12035-022-03166-x","article-title":"Is Nrf2 behind endogenous neuroprotection of the hippocampal CA2-4,DG region?","volume":"60","author":"Lewczuk","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154363_bib164","article-title":"Nrf2 pathway and autophagy crosstalk: new insights into therapeutic strategies for ischemic cerebral vascular diseases","volume":"11","author":"Hu","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib165","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2010.11.010","article-title":"Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion","volume":"1370","author":"Tanaka","year":"2011","journal-title":"Brain Res."},{"issue":"44","key":"10.1016\/j.bbrc.2026.154363_bib166","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","article-title":"A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo","volume":"25","author":"Shih","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154363_bib167","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fphar.2019.00153","article-title":"Critical role of Nrf2 in experimental ischemic stroke","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154363_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26165001","article-title":"The Nrf2 pathway in ischemic stroke: a review","volume":"26","author":"Farina","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib169","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5607\/en.2018.27.4.287","article-title":"Spatiotemporal protein atlas of cell death-related molecules in the rat MCAO stroke model","volume":"27","author":"Yoon","year":"2018","journal-title":"Exp. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114170","article-title":"Mesenchymal stem cells-derived exosomes alleviate senescence of retinal pigment epithelial cells by activating PI3K\/AKT-Nrf2 signaling pathway in early diabetic retinopathy","volume":"441","author":"Bai","year":"2024","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib171","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/01635581.2024.2422637","article-title":"Puerarin ameliorates ferroptosis in neuronal injury through the PI3K\/AKT signaling pathway","volume":"77","author":"Hu","year":"2025","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.bbrc.2026.154363_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.151099","article-title":"S100A4 exerts neuroprotective effects by attenuating blood-brain barrier disruption and oxidative stress via the PI3K\/Akt\/Nrf2 axis in ischemic stroke","volume":"742","author":"Ji","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154363_bib173","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainresbull.2015.12.007","article-title":"Preconditioning of H2S inhalation protects against cerebral ischemia\/reperfusion injury by induction of HSP70 through PI3K\/Akt\/Nrf2 pathway","volume":"121","author":"Ji","year":"2016","journal-title":"Brain Res. Bull."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154363_bib174","doi-asserted-by":"crossref","first-page":"757","DOI":"10.21037\/atm-20-4258","article-title":"Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2\/NQO-1\/HO-1\/NF-\u03baB p65 proteins","volume":"8","author":"He","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib175","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/bph.15961","article-title":"Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS\/NF-\u03baB\/ferroptosis pathway","volume":"180","author":"Gao","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154363_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109064","article-title":"Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia\/macrophage polarization through Nrf2 and NF-\u03baB pathways","volume":"212","author":"Dordoe","year":"2022","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib177","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10787-020-00714-6","article-title":"Baicalein exerts neuroprotective effect against ischaemic\/reperfusion injury via alteration of NF-kB and LOX and AMPK\/Nrf2 pathway","volume":"28","author":"Yuan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2026.154363_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1482386","article-title":"The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion","volume":"15","author":"He","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib179","first-page":"55","article-title":"The effect of sinomenine on ERK1\/2, JNK and p38 phosphorylation in LPS-stimulated endothelial cells","volume":"44","author":"Yang","year":"2023","journal-title":"Neuroendocrinol. Lett."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103099","article-title":"The signaling pathways and targets of natural compounds from traditional Chinese medicine in treating ischemic stroke","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154363_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.108975","article-title":"6-Gingerol exerts a protective effect against hypoxic injury through the p38\/Nrf2\/HO-1 and p38\/NF-\u03baB pathway in H9c2 cells","volume":"104","author":"Han","year":"2022","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib182","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1007\/s11011-022-01061-x","article-title":"Salidroside inhibited cerebral ischemia\/reperfusion-induced oxidative stress and apoptosis via Nrf2\/Trx1 signaling pathway","volume":"37","author":"Li","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrc.2026.154363_bib183","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.freeradbiomed.2023.09.009","article-title":"Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation","volume":"208","author":"Dayalan","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2026.154363_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117937","article-title":"Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1\/Nrf2 pathway in HT22 cells","volume":"326","author":"Song","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib185","first-page":"2637","article-title":"Keap1-Nrf2\/ARE signal pathway activated by butylphthalide in the treatment of ischemic stroke","volume":"14","author":"Zhang","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbrc.2026.154363_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115280","article-title":"The SIRT-1\/Nrf2\/HO-1 axis: guardians of neuronal health in neurological disorders","volume":"476","author":"Sethi","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2026.154363_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115057","article-title":"Biliverdin modulates the Nrf2\/A20\/eEF1A2 axis to alleviate cerebral ischemia-reperfusion injury by inhibiting pyroptosis","volume":"165","author":"Bai","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154363_bib188","article-title":"Geraniin protects against cerebral ischemia\/reperfusion injury by suppressing oxidative stress and neuronal apoptosis via regulation of the Nrf2\/HO-1 pathway","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"23","key":"10.1016\/j.bbrc.2026.154363_bib189","doi-asserted-by":"crossref","first-page":"12021","DOI":"10.1039\/D2FO02131E","article-title":"Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H(2)O(2)-injured HT-22 cells","volume":"13","author":"Jiang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.bbrc.2026.154363_bib190","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9925561","article-title":"Astragaloside IV alleviates cerebral ischemia-reperfusion injury through NLRP3 inflammasome-mediated pyroptosis inhibition via activating Nrf2","volume":"2021","author":"Xiao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2026.154363_bib191","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1151196","article-title":"The role of NLRP3 inflammasome-mediated pyroptosis in ischemic stroke and the intervention of traditional Chinese medicine","volume":"14","author":"Long","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib192","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1007\/s12035-024-04105-8","article-title":"Resveratrol ameliorates retinal ischemia-reperfusion injury by modulating the NLRP3 inflammasome and Keap1\/Nrf2\/HO-1 signaling pathway","volume":"61","author":"Feng","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.154363_bib193","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.expneurol.2017.06.011","article-title":"Fumarate decreases edema volume and improves functional outcome after experimental stroke","volume":"295","author":"Clausen","year":"2017","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib194","doi-asserted-by":"crossref","first-page":"375","DOI":"10.21037\/atm.2020.02.10","article-title":"Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke","volume":"8","author":"Hou","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"Pt 1","key":"10.1016\/j.bbrc.2026.154363_bib195","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.freeradbiomed.2022.10.001","article-title":"Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway","volume":"193","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib196","article-title":"Nrf2 plays an essential role in long-term brain damage and neuroprotection of Korean red ginseng in a permanent cerebral ischemia model","volume":"8","author":"Liu","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib197","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2017.01.039","article-title":"ApoE-modified solid lipid nanoparticles: a feasible strategy to cross the blood-brain barrier","volume":"249","author":"Dal Magro","year":"2017","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib198","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12987-022-00315-1","article-title":"Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures","volume":"19","author":"Hernando","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbrc.2026.154363_bib199","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2022.11.036","article-title":"siRNA delivery to lymphatic endothelial cells via ApoE-mediated uptake by lipid nanoparticles","volume":"353","author":"Sakurai","year":"2023","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib200","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.apsb.2021.10.012","article-title":"Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury","volume":"12","author":"Xue","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrc.2026.154363_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111617","article-title":"Amelioration of inflammation through reduction of oxidative stress in rheumatoid arthritis by treating fibroblast-like synoviocytes (FLS) with DMF-loaded PLGA nanoparticles","volume":"129","author":"Royaei","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib202","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3892\/etm.2017.4614","article-title":"Tissue kallikrein protects against ischemic stroke by suppressing TLR4\/NF-\u03baB and activating Nrf2 signaling pathway in rats","volume":"14","author":"Yang","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib203","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/jnc.15308","article-title":"Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke","volume":"157","author":"Cheng","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2026.154363_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113142","article-title":"Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: the role of Nrf2","volume":"325","author":"Yang","year":"2020","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib205","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.7150\/thno.128602","article-title":"Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke","volume":"16","author":"Sun","year":"2026","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib206","article-title":"An RGD-conjugated prodrug nanoparticle with blood-brain-barrier penetrability for neuroprotection against cerebral ischemia-reperfusion injury","volume":"13","author":"Taledaohan","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154363_bib207","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/STROKEAHA.124.048536","article-title":"Thrombolysis for ischemic stroke beyond the 4.5-Hour window: a meta-analysis of randomized clinical trials","volume":"56","author":"G\u00fcnkan","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2026.154363_bib208","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.12688\/f1000research.12111.1","article-title":"Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate","volume":"6","author":"Satoh","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.bbrc.2026.154363_bib209","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9372182","article-title":"Activators and inhibitors of NRF2: a review of their potential for clinical development","volume":"2019","author":"Robledinos-Ant\u00f3n","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib210","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0165-6147(03)00192-5","article-title":"Animal models of stroke: do they have value for discovering neuroprotective agents?","volume":"24","author":"Richard Green","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154363_bib211","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/STROKEAHA.113.004075","article-title":"Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes","volume":"45","author":"Dirnagl","year":"2014","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib212","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1134\/S0006297922010060","article-title":"Lability of the Nrf2\/Keap\/ARE cell defense system in different models of cell aging and age-related pathologies","volume":"87","author":"Shilovsky","year":"2022","journal-title":"Biochemistry (Mosc)"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154363_bib213","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/pr.120.019422","article-title":"On the clinical pharmacology of reactive oxygen species","volume":"72","author":"Casas","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbrc.2026.154363_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108718","article-title":"Perilipin 5 protects against oxygen-glucose deprivation\/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3\u03b2-Nrf2 pathway","volume":"108","author":"Huo","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib215","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12974-018-1125-5","article-title":"Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge","volume":"15","author":"Paraiso","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib216","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12035-019-01760-0","article-title":"Reactive gliosis contributes to Nrf2-Dependent neuroprotection by pretreatment with dimethyl fumarate or Korean red ginseng against hypoxic-ischemia: focus on hippocampal injury","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154363_bib217","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1158\/0008-5472.CAN-19-2888","article-title":"Microenvironmental activation of Nrf2 restricts the progression of Nrf2-Activated malignant tumors","volume":"80","author":"Hayashi","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib218","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2014.06.006","article-title":"Liver enzymes and risk of cardiovascular disease in the general population: a meta-analysis of prospective cohort studies","volume":"236","author":"Kunutsor","year":"2014","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib219","article-title":"The role of concomitant Nrf2 targeting and stem cell therapy in cerebrovascular disease","volume":"11","author":"Gordon","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154363_bib220","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/STROKEAHA.115.009398","article-title":"Dimethyl fumarate protects brain from damage produced by intracerebral hemorrhage by mechanism involving Nrf2","volume":"46","author":"Zhao","year":"2015","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154363_bib221","article-title":"Current landscape of NRF2 biomarkers in clinical trials","volume":"9","author":"Yagishita","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154363_bib222","article-title":"Peripheral blood NRF2 expression as a biomarker in human health and disease","volume":"10","author":"Neilson","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib223","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/acn3.553","article-title":"The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis","volume":"5","author":"Hammer","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"22","key":"10.1016\/j.bbrc.2026.154363_bib224","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262210835","article-title":"From electron imbalance to network collapse: decoding the redox code of ischemic stroke for biomarker-guided precision neuroprotection","volume":"26","author":"Diaconescu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154363_bib225","article-title":"Multi-omics and experimental validation identify GPX7 and glutathione-associated oxidative stress as potential biomarkers in ischemic stroke","volume":"14","author":"Li","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2026.154363_bib226","article-title":"Ferroptosis inhibitors: past, present and future","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154363_bib227","article-title":"Fundamental mechanism of ferroptosis: three unanswered questions","volume":"2","author":"Feinsod","year":"2026","journal-title":"Ferroptosis Oxid Stress"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154363_bib228","article-title":"Targeting ferroptosis as a promising therapeutic strategy for ischemia-reperfusion injury","volume":"11","author":"Pan","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"15","key":"10.1016\/j.bbrc.2026.154363_bib229","doi-asserted-by":"crossref","first-page":"7902","DOI":"10.7150\/thno.113396","article-title":"New insights into acute ischemic stroke from the perspective of spatial omics","volume":"15","author":"Deng","year":"2025","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154363_bib230","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.7150\/ijbs.96262","article-title":"Single-cell and spatial transcriptomics reveals ferroptosis as the Most enriched programmed cell death process in hemorrhage stroke-induced oligodendrocyte-mediated white matter injury","volume":"20","author":"Gu","year":"2024","journal-title":"Int. J. Biol. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:17:41Z","timestamp":1788063461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26011277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":230,"alternative-id":["S0006291X26011277"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154363","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenesis and role of ferroptosis mediated by Nrf2 signaling pathway in ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154363"}}