{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:13:50Z","timestamp":1788952430028,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbrc.2026.154394","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:27:03Z","timestamp":1786145223000},"page":"154394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model"],"prefix":"10.1016","volume":"834","author":[{"given":"Abdul","family":"Qadir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8070-4849","authenticated-orcid":false,"given":"Shahid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-8711","authenticated-orcid":false,"given":"Zaheer","family":"Ul-Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif Maqbool","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sami","family":"Iftikhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Imran","family":"Qayyum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3324","authenticated-orcid":false,"given":"Muhammad","family":"Latif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0638-2271","authenticated-orcid":false,"given":"Nadeem","family":"Irshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbrc.2026.154394_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the global burden of disease study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154394_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12937-025-01075-y","article-title":"Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective","volume":"24","author":"Qin","year":"2025","journal-title":"Nutr. J."},{"issue":"10401","key":"10.1016\/j.bbrc.2026.154394_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154394_bib4","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1038\/s41598-025-89344-y","article-title":"Molecular insights into ulcerative colitis and orbital inflammation","volume":"15","author":"Tan","year":"2025","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154394_bib5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis","volume":"3","author":"Sartor","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154394_bib6","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.cgh.2025.05.019","article-title":"Appropriate use and complications of corticosteroids in inflammatory bowel disease: a comprehensive review","volume":"23","author":"Feuerstein","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154394_bib7","first-page":"521","article-title":"Efficacy and safety of advanced therapies in ulcerative colitis: updated evidence from clinical trials and real-world studies","volume":"166","author":"Sands","year":"2024","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154394_bib8","first-page":"1002","article-title":"Comparative effectiveness of biologics and small molecules for moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis","volume":"22","author":"Singh","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154394_bib9","first-page":"210","article-title":"Loss of response to biologic therapy in inflammatory bowel disease: mechanisms, predictors, and treatment strategies","volume":"18","author":"Verstockt","year":"2024","journal-title":"J. Crohns Colitis"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154394_bib10","article-title":"Limitations of biologic therapy in ulcerative colitis: primary non-response, immunogenicity, and economic burden","volume":"16","author":"Awan","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.bbrc.2026.154394_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.864286","article-title":"Triazoles and their derivatives: chemistry, synthesis, and therapeutic applications","volume":"9","author":"Matin","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bbrc.2026.154394_bib12","first-page":"116","article-title":"Triazole structure\u2013activity relationships in medicinal chemistry","volume":"270","author":"Glomb","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154394_bib13","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/acs.jmedchem.4c00652","article-title":"Triazoles in medicinal chemistry: physicochemical properties, bioisosterism, and application","volume":"67","author":"Guan","year":"2024","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154394_bib14","article-title":"Nuclear factor-\u03baB-importance, induction of inflammation, and effects of pharmacological modulators in Crohn's disease","volume":"71","author":"Szatkowski","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154394_bib15","first-page":"1","article-title":"1,2,4-Triazole derivatives as potent antimicrobial agents: structure\u2013activity relationship and medicinal applications","volume":"44","author":"Soni","year":"2024","journal-title":"Libr. Prog. Int."},{"key":"10.1016\/j.bbrc.2026.154394_bib16","first-page":"1","article-title":"Harnessing virtual screening and MD simulations: a multistage approach to identifying potent and nontoxic agonists for protein kinase A","author":"Ali","year":"2025","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bbrc.2026.154394_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.bbrc.2026.154394_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13065-018-0378-5","article-title":"Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4-triazole hydrazone and sulphonamide novel derivatives","volume":"12","author":"Khalid","year":"2018","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.bbrc.2026.154394_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2022.109748","article-title":"Exploring the light\/dark box test: protocols and implications for neuroscience research","volume":"384","author":"Campos-Cardoso","year":"2023","journal-title":"J. Neurosci. Methods"},{"issue":"221","key":"10.1016\/j.bbrc.2026.154394_bib21","author":"Au - Feng","year":"2025","journal-title":"JoVE J."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154394_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0976-500X.72350","article-title":"Blood sample collection in small laboratory animals","volume":"1","author":"Parasuraman","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154394_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107514","article-title":"The effect of post-biotics-enriched diet on the antioxidant capacity in Mytilus galloprovincialis exposed to Cu2O","volume":"287","author":"Maione","year":"2025","journal-title":"Aquat. Toxicol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154394_bib24","article-title":"Association of serum malondialdehyde levels with lipid profile and liver function in patients with inflammatory bowel disease","volume":"13","author":"Merino","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2026.154394_bib25","series-title":"Methods in Actinobacteriology","first-page":"455","article-title":"Screening for antioxidant activity: nitric oxide scavenging assay","author":"Chelliah","year":"2022"},{"key":"10.1016\/j.bbrc.2026.154394_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.154394_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1746-6148-9-123","article-title":"Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review","volume":"9","author":"Klopfleisch","year":"2013","journal-title":"BMC Vet. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154394_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154394_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cyto.2008.10.014","article-title":"Reproducibility of serum cytokines and growth factors","volume":"45","author":"Gu","year":"2009","journal-title":"Cytokine"},{"issue":"Pt 2","key":"10.1016\/j.bbrc.2026.154394_bib30","article-title":"A novel triazole derivative ameliorates ulcerative colitis by targeting PPAR gamma","volume":"320","author":"Xie","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2026.154394_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.clnesp.2023.09.020","article-title":"Western diet prevents intestinal inflammation and fibrosis in a dss-induced model of colitis","volume":"58","author":"Leboutte","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.bbrc.2026.154394_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117413","article-title":"Curcumin promotes renewal of intestinal epithelium by miR-195-3p","volume":"320","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"15","key":"10.1016\/j.bbrc.2026.154394_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27154745","article-title":"The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice","volume":"27","author":"Bayazid","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2026.154394_bib34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbi.2016.11.004","article-title":"Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle\/Syk signaling in subarachnoid hemorrhage","volume":"60","author":"Xie","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154394_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jgr.2022.01.005","article-title":"Synthesis of ginsenoside Rb1-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides","volume":"46","author":"Liu","year":"2022","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.bbrc.2026.154394_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4137\/CGast.S13125","article-title":"Liver function test abnormalities in patients with inflammatory bowel diseases: a hospital-based survey","volume":"7","author":"Cappello","year":"2014","journal-title":"Clin. Med. Insights Gastroenterol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154394_bib37","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jgh.14356","article-title":"Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis","volume":"34","author":"Zhu","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154394_bib38","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41598-023-32595-4","article-title":"In silico study of HASDI (high-affinity selective DNA intercalator) as a new agent capable of highly selective recognition of the DNA sequence","volume":"13","author":"Zaremba","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154394_bib39","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2147\/OPTH.S355538","article-title":"Advantages of double running sutures in astigmatism after penetrating keratoplasty","volume":"16","author":"Nuzzi","year":"2022","journal-title":"Clin. Ophthalmol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26011587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:33:55Z","timestamp":1788950035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26011587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S0006291X26011587"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154394","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154394"}}