{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:14:47Z","timestamp":1788952487704,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences & Peking Union Medical College","doi-asserted-by":"publisher","award":["2021-I2M-1-016"],"award-info":[{"award-number":["2021-I2M-1-016"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences & Peking Union Medical College","doi-asserted-by":"publisher","award":["2021YFC2700601"],"award-info":[{"award-number":["2021YFC2700601"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbrc.2026.154464","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:12:11Z","timestamp":1787181131000},"page":"154464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of CASP10 rs13006529 with response to PEG-IFN-\u03b1-based therapy in chronic hepatitis B: Enhanced activity of caspase in HBV burden"],"prefix":"10.1016","volume":"834","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-4522","authenticated-orcid":false,"given":"XiaoPan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154464_bib1","series-title":"Global Hepatitis Report 2026","year":"2026"},{"key":"10.1016\/j.bbrc.2026.154464_bib2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jhep.2025.03.018","article-title":"EASL Clinical practice guidelines on the management of hepatitis B virus infection","volume":"83","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154464_bib3","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/cid\/ciz084","article-title":"GIANT-B global consortium, genome-wide association study identifies genetic variants associated with early and sustained response to (Pegylated) interferon in chronic hepatitis B patients: the GIANT-B Study","volume":"69","author":"Brouwer","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbrc.2026.154464_bib4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/apt.12910","article-title":"Polymorphisms of HLA-DP are associated with response to peginterferon in Caucasian patients with chronic hepatitis B","volume":"40","author":"Brouwer","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2026.154464_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bpg.2017.04.012","article-title":"Current treatment guidelines of chronic hepatitis B: the role of nucleos(t)ide analogues and peginterferon","volume":"31","author":"Ghany","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bbrc.2026.154464_bib6","first-page":"4276","article-title":"Mapping the interactions of HBV cccDNA with host factors","volume":"20","author":"Mohd-Ismail","year":"2019","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.bbrc.2026.154464_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1074-7613(00)80295-2","article-title":"Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes","volume":"4","author":"Guidotti","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154464_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1084\/jem.182.5.1223","article-title":"Involvement of the CD95 (APO-1\/Fas) receptor and ligand in liver damage","volume":"182","author":"Galle","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2026.154464_bib9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0168-8278(03)00265-4","article-title":"Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1\/death receptor 4 expression","volume":"39","author":"Janssen","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2026.154464_bib10","doi-asserted-by":"crossref","first-page":"13884","DOI":"10.1073\/pnas.241358198","article-title":"Caspase-10 is an initiator caspase in death receptor signaling","volume":"98","author":"Wang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.bbrc.2026.154464_bib11","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1093\/emboj\/cdf441","article-title":"Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8","volume":"21","author":"Sprick","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2026.154464_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/v9080230","article-title":"Interference of apoptosis by hepatitis B virus","volume":"9","author":"Lin","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.bbrc.2026.154464_bib13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.celrep.2017.04.010","article-title":"Caspase-10 negatively regulates Caspase-8-Mediated cell death, switching the response to CD95L in favor of NF-\u03baB activation and cell survival","volume":"19","author":"Horn","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154464_bib14","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/humu.20803","article-title":"Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma","volume":"29","author":"Li","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrc.2026.154464_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/147905","article-title":"Single nucleotide polymorphisms in selected apoptotic genes and BPDE-induced apoptotic capacity in apparently normal primary lymphocytes: a genotype-phenotype correlation analysis","volume":"2008","author":"Hu","year":"2008","journal-title":"J. Cancer Epidemiol."},{"key":"10.1016\/j.bbrc.2026.154464_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10495-017-1385-z","article-title":"Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population","volume":"22","author":"Liu","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2026.154464_bib17","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.4238\/2012.November.26.1","article-title":"Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis","volume":"11","author":"Yan","year":"2012","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.bbrc.2026.154464_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12967-016-0837-5","article-title":"Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia","volume":"14","author":"Zheng","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.154464_bib19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1136\/gutjnl-2022-328380","article-title":"Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure","volume":"72","author":"Allweiss","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2026.154464_bib20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nprot.2006.73","article-title":"Southern blotting","volume":"1","author":"Southern","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2026.154464_bib21","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1021\/bi100968m","article-title":"Activation and specificity of human Caspase-10","volume":"49","author":"Wachmann","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2026.154464_bib22","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1038\/cddis.2011.8","article-title":"Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis","volume":"2","author":"M\u00fchlethaler-Mottet","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154464_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41419-024-06679-6","article-title":"Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome","volume":"15","author":"Consonni","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154464_bib24","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1128\/JVI.00653-10","article-title":"Apoptosis of Hepatitis B virus-infected hepatocytes prevents release of infectious virus","volume":"84","author":"Arzberger","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2026.154464_bib25","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41419-021-03924-0","article-title":"Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal hepatitis B viral genome in preclinical models","volume":"12","author":"Clark","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154464_bib26","article-title":"CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1","volume":"6","author":"Taverniti","year":"2024","journal-title":"JHEP Rep."},{"key":"10.1016\/j.bbrc.2026.154464_bib27","article-title":"Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells","volume":"4","author":"Tu","year":"2022","journal-title":"JHEP Rep."},{"key":"10.1016\/j.bbrc.2026.154464_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/hep.31240","article-title":"Rapid turnover of hepatitis B virus covalently closed circular DNA indicated by monitoring emergence and reversion of signature\u2010mutation in treated chronic hepatitis B patients","volume":"73","author":"Huang","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154464_bib29","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","article-title":"Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA","volume":"343","author":"Lucifora","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154464_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.gastro.2011.11.025","article-title":"Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-Positive patients with chronic hepatitis B","volume":"142","author":"Sonneveld","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:36:21Z","timestamp":1788950181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26012283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":30,"alternative-id":["S0006291X26012283"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154464","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of CASP10 rs13006529 with response to PEG-IFN-\u03b1-based therapy in chronic hepatitis B: Enhanced activity of caspase in HBV burden","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154464"}}