{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:00:55Z","timestamp":1790240455928,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["ldyyyn2025-88"],"award-info":[{"award-number":["ldyyyn2025-88"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016305","name":"The First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["24JRRA299"],"award-info":[{"award-number":["24JRRA299"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbrc.2026.154477","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:15:44Z","timestamp":1787552144000},"page":"154477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatocyte NAT10-mediated ac4C regulation contributes to TGF\u03b21-associated Kupffer cell \u2013HSC communication in steatotic liver disease"],"prefix":"10.1016","volume":"835","author":[{"given":"Miaomiao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanlin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3298-0042","authenticated-orcid":false,"given":"Bangxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154477_bib1","article-title":"Global burden of metabolic dysfunction-associated steatotic liver disease, 1990-2023, and projections to 2050: a systematic analysis for the global burden of disease study 2023","year":"2026","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154477_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/jama.2025.19615","article-title":"Metabolic dysfunction-associated steatotic liver disease in adults: a review","volume":"335","author":"Tilg","year":"2026","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154477_bib3","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.apsb.2023.01.012","article-title":"Pathophysiology of obesity and its associated diseases","volume":"13","author":"Jin","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154477_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/17474124.2021.1887730","article-title":"Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease","volume":"15","author":"Carranza-Trejo","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154477_bib5","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41423-025-01313-7","article-title":"Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells","volume":"22","author":"Kostallari","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2026.154477_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1705503","article-title":"Novel regulators of hepatic macrophages in liver fibrosis","volume":"16","author":"Tang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154477_bib7","article-title":"Possible involvement of liver resident macrophages (Kupffer cells) in the pathogenesis of both intrahepatic and extrahepatic inflammation","volume":"2017","author":"Kakinuma","year":"2017","journal-title":"Chin. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/hep.30401","article-title":"Dietary lipids differentially shape nonalcoholic steatohepatitis progression and the transcriptome of kupffer cells and infiltrating macrophages","volume":"70","author":"McGettigan","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154477_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-026-01288-0","article-title":"Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers","author":"Araujo David","year":"2026","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib10","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41598-022-04971-z","article-title":"Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model","volume":"12","author":"Herrera-Marcos","year":"2022","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154477_bib11","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.12998\/wjcc.v10.i12.3662","article-title":"Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis","volume":"10","author":"Garbuzenko","year":"2022","journal-title":"World J. Clin. Cases"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154477_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167914","article-title":"Extracellular vesicle-dependent crosstalk between hepatic stellate cells and Kupffer cells promotes their mutual activation","volume":"1871","author":"Wang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154477_bib13","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ajpath.2025.02.003","article-title":"Crosstalk between hepatic stellate cells and hepatic macrophages in metabolic dysfunction-associated steatohepatitis","volume":"195","author":"Zhong","year":"2025","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154477_bib14","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000753","article-title":"Communication initiated by hepatocytes: the driver of HSC activation and liver fibrosis","volume":"9","author":"Lan","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbrc.2026.154477_bib15","article-title":"Hepatocytes: a key role in liver inflammation","volume":"13","author":"Gong","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154477_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/cmi.2015.97","article-title":"Hepatocytes: a key cell type for innate immunity","volume":"13","author":"Zhou","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2026.154477_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.omtn.2023.03.023","article-title":"Mechanisms of NAT10 as ac4C writer in diseases","volume":"32","author":"Xie","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib18","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1038\/s41467-023-42135-3","article-title":"NAT10-dependent N(4)-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154477_bib19","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41556-024-01548-y","article-title":"NAT10-mediated mRNA N(4)-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s40164-025-00721-9","article-title":"NAT10-mediated lipid metabolic reprogramming drives EGFR-TKI resistance in non-small cell lung cancer via ac4C-dependent mRNA stabilization","volume":"14","author":"Fang","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s12944-024-02360-1","article-title":"NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and scap mRNA","volume":"23","author":"Wang","year":"2024","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13073-025-01520-x","article-title":"Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGF\u03b21 mRNA","volume":"17","author":"Peng","year":"2025","journal-title":"Genome Med."},{"key":"10.1016\/j.bbrc.2026.154477_bib23","doi-asserted-by":"crossref","DOI":"10.1007\/s12072-025-10998-x","article-title":"NAT10 promotes the activation of hepatic stellate cells by modulating the TGF-\u03b21-ac4C-COL1A1 axis","author":"Zhang","year":"2026","journal-title":"Hepatol. Int."},{"issue":"18","key":"10.1016\/j.bbrc.2026.154477_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186420","article-title":"MASH: the nexus of metabolism, inflammation, and fibrosis","volume":"135","author":"Steinberg","year":"2025","journal-title":"J. Clin. Investig."},{"issue":"715","key":"10.1016\/j.bbrc.2026.154477_bib25","doi-asserted-by":"crossref","first-page":"eade3157","DOI":"10.1126\/scitranslmed.ade3157","article-title":"Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis","volume":"15","author":"Mooring","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154477_bib26","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.cell.2018.10.030","article-title":"Acetylation of cytidine in mRNA promotes translation efficiency","volume":"175","author":"Arango","year":"2018","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bbrc.2026.154477_bib27","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/s41418-025-01483-x","article-title":"NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis","volume":"32","author":"Wan","year":"2025","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154477_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108626","article-title":"Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH","volume":"34","author":"Daemen","year":"2021","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154477_bib29","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jhep.2022.06.004","article-title":"Soluble TREM2 levels reflect the recruitment and expansion of TREM2(+) macrophages that localize to fibrotic areas and limit NASH","volume":"77","author":"Hendrikx","year":"2022","journal-title":"J. Hepatol."},{"issue":"7783","key":"10.1016\/j.bbrc.2026.154477_bib30","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"82","key":"10.1016\/j.bbrc.2026.154477_bib31","doi-asserted-by":"crossref","first-page":"eadd8945","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci. Immunol."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154477_bib32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/glycob\/cwg068","article-title":"Molecular characterization of the rat Kupffer cell glycoprotein receptor","volume":"13","author":"Fadden","year":"2003","journal-title":"Glycobiology"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154477_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065070","article-title":"CLEC4F is an inducible C-type lectin in F4\/80-positive cells and is involved in alpha-galactosylceramide presentation in liver","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154477_bib34","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2026.154477_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111556","article-title":"The liver fibrosis niche: novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix","volume":"143","author":"Matsuda","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154477_bib36","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cmet.2019.11.013","article-title":"Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis","volume":"31","author":"Cai","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154477_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154477_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/j.gastro.2023.03.228","article-title":"Macrophage-derived osteopontin (SPP1) protects from Nonalcoholic steatohepatitis","volume":"165","author":"Han","year":"2023","journal-title":"Gastroenterology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:13:24Z","timestamp":1790237604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26012416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0006291X26012416"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154477","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte NAT10-mediated ac4C regulation contributes to TGF\u03b21-associated Kupffer cell \u2013HSC communication in steatotic liver disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154477"}}