{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:00:57Z","timestamp":1790240457514,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2023QN08041"],"award-info":[{"award-number":["2023QN08041"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2025ZD01903004"],"award-info":[{"award-number":["2025ZD01903004"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbrc.2026.154511","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:23:47Z","timestamp":1787984627000},"page":"154511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of RING finger protein-related biomarkers in sepsis based on explainable machine learning: A comprehensive analysis"],"prefix":"10.1016","volume":"835","author":[{"given":"Xiaolei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154511_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2026.154511_bib2","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00134-024-07694-z","article-title":"Sepsis: key insights, future directions, and immediate goals. A review and expert opinion","volume":"50","author":"Martin-Loeches","year":"2024","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbrc.2026.154511_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41419-025-07714-w","article-title":"Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154511_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/ACO.0000000000000958","article-title":"Epidemiology of sepsis and septic shock","volume":"34","author":"Chiu","year":"2021","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.bbrc.2026.154511_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/CNQ.0000000000000570","article-title":"Sepsis epidemiology, definitions, scoring systems, and diagnostic markers","volume":"48","author":"Modugula","year":"2025","journal-title":"Crit. Care Nurs. Q."},{"key":"10.1016\/j.bbrc.2026.154511_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2025.10.001","article-title":"Defining sepsis: past, present, and future","volume":"47","author":"Munroe","year":"2026","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.bbrc.2026.154511_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1042","article-title":"Potential biomarker for diagnosis and therapy of sepsis: lactylation","volume":"11","author":"Sun","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.bbrc.2026.154511_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.31729\/jnma.7324","article-title":"Progress in diagnosis and treatment of neonatal sepsis: a review article","volume":"60","author":"Yadav","year":"2022","journal-title":"JNMA J Nepal Med Assoc"},{"key":"10.1016\/j.bbrc.2026.154511_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s12519-023-00689-8","article-title":"Sepsis heterogeneity","volume":"19","author":"Wang","year":"2023","journal-title":"World J Pediatr"},{"key":"10.1016\/j.bbrc.2026.154511_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41392-022-01152-2","article-title":"The RING finger protein family in health and disease","volume":"7","author":"Cai","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2026.154511_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2026.104104","article-title":"Neutrophil Irgm1 ameliorates sepsis-induced myocardial dysfunction by promoting Alox15 degradation","volume":"92","author":"Wang","year":"2026","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2026.154511_bib12","article-title":"RETREG1-Mediated reticulophagy is essential for dendritic cell maturation and function in sepsis","volume":"13","author":"Yao","year":"2026","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrc.2026.154511_bib13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2147\/JIR.S482213","article-title":"The role of Dectin-1-Akt-RNF146 pathway in \u03b2-Glucan induced immune trained state of monocyte in sepsis","volume":"18","author":"Guo","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2026.154511_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/HYPERTENSIONAHA.124.19468","article-title":"AI, machine learning, and ChatGPT in hypertension","volume":"81","author":"Layton","year":"2024","journal-title":"Hypertension"},{"issue":"Suppl 2","key":"10.1016\/j.bbrc.2026.154511_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/ijlh.14110","article-title":"Applied machine learning in hematopathology","volume":"45","author":"Dehkharghanian","year":"2023","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.bbrc.2026.154511_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158050","article-title":"Sidaxue ameliorates rheumatoid arthritis by inhibiting synovial neutrophil migration: insights from an integrated multi-omics analysis","volume":"154","author":"Xu","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.154511_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.154013","article-title":"Identification of zinc finger protein-related feature genes in ischemic stroke via explainable machine learning: a comprehensive analysis","volume":"828","author":"Wang","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154511_bib18","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154511_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10194-024-01828-w","article-title":"Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine","volume":"25","author":"Sun","year":"2024","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.bbrc.2026.154511_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi8577","article-title":"Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes","volume":"390","author":"DeMeo","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154511_bib21","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.154511_bib22","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bbrc.2026.154511_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-021-03855-y","article-title":"Rare variant contribution to human disease in 281,104 UK Biobank exomes","volume":"597","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154511_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948860","article-title":"RNF152 positively regulates TLR\/IL\u20101R signaling by enhancing MyD88 oligomerization","volume":"21","author":"Xiong","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2026.154511_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbrc.2017.05.033","article-title":"RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling","volume":"488","author":"Gao","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154511_bib26","first-page":"1","article-title":"Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury","author":"Fang","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2026.154511_bib27","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1038\/s41418-025-01527-2","article-title":"RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection","volume":"32","author":"Li","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2026.154511_bib28","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/genes14030713","article-title":"Genome-wide scan of wool production traits in akkaraman sheep","volume":"14","author":"Arzik","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbrc.2026.154511_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211001146","article-title":"Identification of hub ubiquitin ligase genes affecting Alzheimer's disease by analyzing transcriptome data from multiple brain regions","volume":"104","author":"Liu","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.bbrc.2026.154511_bib30","article-title":"Targeting the chemokine-microglia nexus: a novel strategy for modulating neuroinflammation in Alzheimer's disease","volume":"9","author":"Xu","year":"2025","journal-title":"J Alzheimers Dis Rep"},{"key":"10.1016\/j.bbrc.2026.154511_bib31","article-title":"Development of an individualized ubiquitin prognostic signature for clear cell renal cell carcinoma","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.154511_bib32","article-title":"Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset","volume":"44","author":"Wang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154511_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1130009","article-title":"Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets","volume":"14","author":"Heidarian","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2026.154511_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","article-title":"Biomarkers of sepsis: time for a reappraisal","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbrc.2026.154511_bib35","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s11255-017-1644-5","article-title":"Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis","volume":"49","author":"Gong","year":"2017","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bbrc.2026.154511_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1517\/14656560903413542","article-title":"Tadalafil for the treatment of pulmonary arterial hypertension","volume":"11","author":"Rosenzweig","year":"2010","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154511_bib37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/joim.20012","article-title":"Tadalafil use is associated with a lower incidence of Type 2 diabetes in men with benign prostatic hyperplasia: a population-based cohort study","volume":"296","author":"Takayama","year":"2024","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbrc.2026.154511_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/JCMA.0000000000001205","article-title":"Potential beneficial impacts of tadalafil on cardiovascular diseases","volume":"88","author":"Lan","year":"2025","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.bbrc.2026.154511_bib39","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jconrel.2024.03.004","article-title":"Placenta-anchored tadalafil liposomes rescues intrauterine growth restriction through continuous placental blood perfusion improvement","volume":"368","author":"Tang","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bbrc.2026.154511_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2026.1776589","article-title":"Phosphodiesterase-5 inhibitors for cerebral small vessel disease-related ischemic stroke and cognitive decline: systematic review and meta-analysis","volume":"17","author":"Yan","year":"2026","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbrc.2026.154511_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4266\/acc.002904","article-title":"Impact of tadalafil on cardiovascular and organ dysfunction induced by experimental sepsis","volume":"40","author":"Nakashima","year":"2025","journal-title":"Acute Crit Care"},{"key":"10.1016\/j.bbrc.2026.154511_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1590\/s1677-5538.ibju.2016.0075","article-title":"The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study","volume":"43","author":"Benli","year":"2017","journal-title":"Int. Braz. J. Urol."},{"key":"10.1016\/j.bbrc.2026.154511_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2025.106403","article-title":"OIP5-AS1 expression profiles in different stages of oral squamous cell carcinoma","volume":"180","author":"K P","year":"2025","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2026.154511_bib44","doi-asserted-by":"crossref","first-page":"326","DOI":"10.23736\/S2724-6329.23.04824-6","article-title":"Prospective study: expression levels of microRNA-7-3p and its target STAT3 in head and neck cancer","volume":"72","author":"Anees","year":"2023","journal-title":"Minerva Dent Oral Sci"},{"key":"10.1016\/j.bbrc.2026.154511_bib45","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/10408363.2025.2561071","article-title":"The MicroRNA network in sepsis: from biomarker discovery to novel targeted therapeutic strategies","volume":"63","author":"Xie","year":"2026","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.bbrc.2026.154511_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.23736\/S2724-6329.23.04840-4","article-title":"Expression profiling of signal transducer and activator of transcription3 in oral squamous cell carcinoma in south Indian population","volume":"73","author":"Thomas","year":"2024","journal-title":"Minerva Dent Oral Sci"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:13:38Z","timestamp":1790237618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26012751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":46,"alternative-id":["S0006291X26012751"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154511","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of RING finger protein-related biomarkers in sepsis based on explainable machine learning: A comprehensive analysis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154511"}}