{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:32:04Z","timestamp":1793309524193,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbrc.2026.154515","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:17:33Z","timestamp":1788275853000},"page":"154515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PIEZO1 promotes YAP\/TEAD-dependent profibrotic signaling in POSTN-enriched lung fibroblast activation"],"prefix":"10.1016","volume":"836","author":[{"given":"Xiaohua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aming","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154515_bib1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","article-title":"Idiopathic pulmonary fibrosis","volume":"389","author":"Richeldi","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2026.154515_bib2","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00957-2022","article-title":"Idiopathic pulmonary fibrosis: state of the art for 2023","volume":"61","author":"Podolanczuk","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbrc.2026.154515_bib3","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis","volume":"370","author":"Richeldi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.154515_bib4","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"King","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2026.154515_bib5","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1164\/rccm.201712-2410OC","article-title":"Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis","volume":"199","author":"Reyfman","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2026.154515_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154515_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154515_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl5473","article-title":"Spatial transcriptomic characterization of pathologic niches in IPF","volume":"10","author":"Mayr","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154515_bib9","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1038\/s41588-024-01819-2","article-title":"Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis","volume":"56","author":"Franz\u00e9n","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154515_bib10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41588-025-02080-x","article-title":"Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis","volume":"57","author":"Vannan","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2026.154515_bib11","doi-asserted-by":"crossref","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","article-title":"Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis","volume":"303","author":"Naik","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2026.154515_bib12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1165\/rcmb.2019-0245OC","article-title":"Cross-talk between transforming growth factor-beta and periostin can be targeted for pulmonary fibrosis","volume":"62","author":"Nanri","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2026.154515_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154515_bib14","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2026.154515_bib15","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1038\/s41467-025-61795-x","article-title":"Inhibition of epithelial cell YAP-TEAD\/LOX signaling attenuates pulmonary fibrosis in preclinical models","volume":"16","author":"Wagner","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154515_bib16","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01544-2023","article-title":"YAP\/TAZ are crucial regulators of macrophage-mediated pulmonary inflammation and fibrosis after bleomycin-induced injury","volume":"65","author":"Mia","year":"2025","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbrc.2026.154515_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2026.154515_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184158","article-title":"PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice","volume":"135","author":"Xu","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2026.154515_bib19","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2026.154515_bib20","doi-asserted-by":"crossref","first-page":"28628","DOI":"10.18632\/oncotarget.15614","article-title":"Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells","volume":"8","author":"Dasari","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2026.154515_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12931-018-0857-1","article-title":"Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis","volume":"19","author":"Cecchini","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2026.154515_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/thoraxjnl-2013-204596","article-title":"Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis","volume":"70","author":"DePianto","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.bbrc.2026.154515_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1755-8794-4-70","article-title":"Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle","volume":"4","author":"Meltzer","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.bbrc.2026.154515_bib24","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1038\/s41467-026-70193-w","article-title":"Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154515_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.154515_bib26","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.bbrc.2026.154515_bib27","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2026.154515_bib28","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2026.154515_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/a-2649-9402","article-title":"Peeling back the layers of the bleomycin model of lung fibrosis: lessons learned, factors to consider, and future directions","volume":"46","author":"Brazee","year":"2025","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2026.154515_bib30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J. Clin. Pathol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26012799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:52:56Z","timestamp":1793307176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26012799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":30,"alternative-id":["S0006291X26012799"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154515","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PIEZO1 promotes YAP\/TEAD-dependent profibrotic signaling in POSTN-enriched lung fibroblast activation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154515"}}