{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:37:15Z","timestamp":1792816635478,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154605","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:23:50Z","timestamp":1790263430000},"page":"154605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Trimethyl chitosan\u2013hyaluronic acid nanoparticle-loaded hydrogel potentiates dendritic cell-based immunotherapy against breast cancer"],"prefix":"10.1016","volume":"838","author":[{"given":"Atefeh","family":"Eteghadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Taghipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simzar","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mahmoud","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Sadat","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154605_bib2","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.3390\/genes14122118","article-title":"Unlocking dendritic cell-based vaccine efficacy through genetic modulation\u2014how soon is now?","volume":"14","author":"Elwakeel","year":"2023","journal-title":"Genes"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154605_bib3","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s11864-023-01143-7","article-title":"Application of engineered dendritic cell vaccines in cancer immunotherapy: challenges and opportunities","volume":"24","author":"Li","year":"2023","journal-title":"Curr. Treat. Options Oncol."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154605_bib4","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1158\/1078-0432.CCR-15-1399","article-title":"Dendritic cell\u2013based immunotherapy: state of the art and beyond","volume":"22","author":"Bol","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"114","key":"10.1016\/j.bbrc.2026.154605_bib5","first-page":"135","article-title":"Immune evasion pathways and the design of dendritic cell-based cancer vaccines","volume":"21","author":"Hanks","year":"2016","journal-title":"Discov. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib6","article-title":"Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination","volume":"2012","author":"Benencia","year":"2012","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2026.154605_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00262-011-1181-5","article-title":"Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells","volume":"61","author":"Hurwitz","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154605_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41551-018-0250-x","article-title":"Towards superior dendritic-cell vaccines for cancer therapy","volume":"2","author":"Saxena","year":"2018","journal-title":"Nat. Biomed. Eng."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154605_bib9","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/vaccines10111906","article-title":"Chitosan-based nanomaterial as immune adjuvant and delivery carrier for vaccines","volume":"10","author":"Gong","year":"2022","journal-title":"Vaccines"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154605_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2010.01.007","article-title":"Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen","volume":"143","author":"Sl\u00fctter","year":"2010","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bbrc.2026.154605_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biomaterials.2016.10.047","article-title":"Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine","volume":"113","author":"Shi","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.154605_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119268","article-title":"Single-injecting, bioinspired nanocomposite hydrogel that can recruit host immune cells in situ to elicit potent and long-lasting humoral immune responses","volume":"216","author":"Korupalli","year":"2019","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.bbrc.2026.154605_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239369","article-title":"Chitosan nanoparticles as antigen vehicles to induce effective tumor specific T cell responses","volume":"15","author":"Walter","year":"2020","journal-title":"PLoS One"},{"issue":"31","key":"10.1016\/j.bbrc.2026.154605_bib14","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1016\/j.biomaterials.2014.07.014","article-title":"Chitosan as an adjuvant-like substrate for dendritic cell culture to enhance antitumor effects","volume":"35","author":"Lin","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.154605_bib15","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.2147\/IJN.S165876","article-title":"Novel application of trimethyl chitosan as an adjuvant in vaccine delivery","author":"Malik","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002371-200401000-00001","article-title":"Role of CD44 and hyaluronic acid (HA) in activation of alloreactive and antigen-specific T cells by bone marrow-derived dendritic cells","volume":"27","author":"Do","year":"2004","journal-title":"J. Immunother."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154605_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601012","article-title":"The CD44\u2010mediated uptake of hyaluronic acid\u2010based carriers in macrophages","volume":"6","author":"Rios De la Rosa","year":"2017","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2011.07.014","article-title":"Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination","volume":"156","author":"Verheul","year":"2011","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154605_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/14760584.2018.1434000","article-title":"Current challenges for cancer vaccine adjuvant development","volume":"17","author":"Bowen","year":"2018","journal-title":"Expert Rev. Vaccine"},{"key":"10.1016\/j.bbrc.2026.154605_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1514595","article-title":"Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy","volume":"12","author":"Liu","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2026.154605_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.actbio.2021.08.014","article-title":"Hydrogel\/nanoadjuvant-mediated combined cell vaccines for cancer immunotherapy","volume":"133","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"issue":"26","key":"10.1016\/j.bbrc.2026.154605_bib22","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.9529","article-title":"Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression","volume":"7","author":"Verma","year":"2016","journal-title":"Oncotarget"},{"issue":"27","key":"10.1016\/j.bbrc.2026.154605_bib23","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1016\/j.biomaterials.2008.05.033","article-title":"Injectable dendritic cell-carrying alginate gels for immunization and immunotherapy","volume":"29","author":"Hori","year":"2008","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154605_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201701469","article-title":"Injectable, tough alginate cryogels as cancer vaccines","volume":"7","author":"Shih","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2026.154605_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146234","article-title":"Synergistic effect of Yes-associated protein siRNA and temozolomide against glioblastoma using a localized nano delivery system","author":"Foroohari","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2026.154605_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2020.102181","article-title":"Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: formulation and in vivo efficacy evaluation","volume":"26","author":"Chaharband","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/1735-5362.329925","article-title":"Comparison of four methods of colon cancer cell lysates preparation for ex vivo maturation of dendritic cells","volume":"17","author":"Roufarshbaf","year":"2022","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.bbrc.2026.154605_bib28","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.2147\/IJN.S372048","article-title":"Synergy of polydopamine nanovaccine and endostar alginate hydrogel for improving antitumor immune responses against colon tumor","volume":"17","author":"Yang","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"28","key":"10.1016\/j.bbrc.2026.154605_bib29","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1016\/j.biomaterials.2009.05.052","article-title":"pH-triggered injectable hydrogels prepared from aqueous N-palmitoyl chitosan: in vitro characteristics and in vivo biocompatibility","volume":"30","author":"Chiu","year":"2009","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154605_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101664","article-title":"Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC)","volume":"3","author":"Sauter","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbrc.2026.154605_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.954955","article-title":"In situ dendritic cell recruitment and T cell activation for cancer immunotherapy","volume":"13","author":"Han","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154605_bib32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/md20030156","article-title":"Enhancing stability and mucoadhesive properties of chitosan nanoparticles by surface modification with sodium alginate and polyethylene glycol for potential oral mucosa vaccine delivery","volume":"20","author":"Amin","year":"2022","journal-title":"Mar. Drugs"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154605_bib33","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nmat3775","article-title":"Engineering synthetic vaccines using cues from natural immunity","volume":"12","author":"Irvine","year":"2013","journal-title":"Nat. Mater."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154605_bib34","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.biomaterials.2012.11.066","article-title":"The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells","volume":"34","author":"Koppolu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2026.154605_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111962","article-title":"Mannosylated polylactic-co-glycolic acid (MN-PLGA) nanoparticles induce potent anti-tumor immunity in murine model of breast cancer","volume":"142","author":"Sheikhzadeh","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154605_bib36","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1021\/acs.biomac.6b01604","article-title":"Hydrogels for therapeutic delivery: current developments and future directions","volume":"18","author":"Buwalda","year":"2017","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154605_bib37","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.biomaterials.2010.12.019","article-title":"Controlled architectural and chemotactic studies of 3D cell migration","volume":"32","author":"Tayalia","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154605_bib38","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/eji.200838645","article-title":"CD11c: not merely a murine DC marker, but also a useful vaccination target","volume":"38","author":"Kurts","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154605_bib39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cyto.2007.11.020","article-title":"A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands","volume":"41","author":"Dowling","year":"2008","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154605_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.imbio.2012.01.021","article-title":"The mouse dendritic cell marker CD11c is down-regulated upon cell activation through toll-like receptor triggering","volume":"218","author":"Singh-Jasuja","year":"2013","journal-title":"Immunobiology"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154605_bib41","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1378\/chest.128.5.3382","article-title":"Prognostic significance of vascular endothelial growth factor, tumor necrosis, and mitotic activity index in malignant pleural mesothelioma","volume":"128","author":"Demirag","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.bbrc.2026.154605_bib42","series-title":"Seminars in Immunology","article-title":"The role of dendritic cells in cancer and anti-tumor immunity","year":"2021"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154605_bib43","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.3390\/ijms21113930","article-title":"Functional role of dendritic cell subsets in cancer progression and clinical implications","volume":"21","author":"Del Prete","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154605_bib44","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.3390\/biomedicines14071588","article-title":"CD86 in dendritic cell-mediated cancer immunity: from maturation marker to functional regulator","volume":"14","author":"Wu","year":"2026","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154605_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101664","article-title":"Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC)","volume":"3","author":"Sauter","year":"2022","journal-title":"STAR Protoc."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154605_bib46","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1039\/D1BM01596F","article-title":"Inhibition of tumor recurrence and metastasis via a surgical tumor-derived personalized hydrogel vaccine","volume":"10","author":"Lu","year":"2022","journal-title":"Biomater. Sci."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154605_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203026","article-title":"Personalized bacteria loaded with autoantigens for the enhancement of tumor immunotherapy","volume":"12","author":"Wu","year":"2023","journal-title":"Adv. Healthcare Mater."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26013719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26013719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:51:17Z","timestamp":1792813877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26013719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0006291X26013719"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154605","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trimethyl chitosan\u2013hyaluronic acid nanoparticle-loaded hydrogel potentiates dendritic cell-based immunotherapy against breast cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154605"}}